RGD Reference Report - Modulation of transforming growth factor beta2 (TGF-beta2) by inositol hexaphosphate in colon carcinogenesis in rats. - Rat Genome Database

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Modulation of transforming growth factor beta2 (TGF-beta2) by inositol hexaphosphate in colon carcinogenesis in rats.

Authors: Marks, Guido  Aydos, Ricardo Dutra  Fagundes, Djalma José  Pontes, Elenir Rose Jardim Cury  Takita, Luiz Carlos  Amaral, Eva Glória Abrão Siufi do  Rossini, Airton  Ynouye, Celso Massaschi 
Citation: Marks G, etal., Acta Cir Bras. 2006;21 Suppl 4:51-6.
RGD ID: 13432080
Pubmed: PMID:17293967   (View Abstract at PubMed)


PURPOSE: To evaluate modulation in the expression of Transforming growth factor beta2 (TGF-beta2) in short-term colon carcinogenesis.
METHODS: 64 male rats was used, comprising 4 groups of 16 animals each: group 1 received Inositol hexaphosphate (IP6) and azoxymethane (AOM); group 2, AOM alone; group 3, IP6 alone; group 4 was used as control. Groups 1 and 3 were given 1% IP6 in drinking water for 6 weeks. AOM was administered subcutaneously at weeks 3 and 4 of the experiment at 20 mg/kg of body weight each week. Immunohistochemical processing was performed with the use of anti-TGF-beta2 primary antibodies in right colon samples and quantitation of TGF-beta2 as percentage of expression, through computer-assisted image processing.
RESULTS: mean values of TGF-beta2 expression were 9.0 +/- 3.9% for group 4 (control), 12.7 +/- 4.0% for group 3 (IP6), 19.3 +/- 6.2% for group 2 (AOM), and 13.1 +/- 5.3% for group 1 (IP6+AOM). The value of p was calculated as 0.0001 for a 5% or lower significance level.
CONCLUSION: the experiment revealed a significant increase in TGF-beta2 expression in right colon with the administration of AOM, and a significant decrease in TGF-beta2 expression when IP6 was administered with AOM.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TGFB2HumanAberrant Crypt Foci treatmentISOTgfb2 (Rattus norvegicus) RGD 
Tgfb2RatAberrant Crypt Foci treatmentIEP  RGD 
Tgfb2MouseAberrant Crypt Foci treatmentISOTgfb2 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tgfb2  (transforming growth factor, beta 2)

Genes (Mus musculus)
Tgfb2  (transforming growth factor, beta 2)

Genes (Homo sapiens)
TGFB2  (transforming growth factor beta 2)


Additional Information