Tgfb2 (transforming growth factor beta 2) - Rat Genome Database

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Pathways
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Gene: Tgfb2 (transforming growth factor beta 2) Heterocephalus glaber
Analyze
Symbol: Tgfb2
Name: transforming growth factor beta 2
RGD ID: 18902128
Description: ENCODES a protein that exhibits identical protein binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN activation-induced cell death of T cells (ortholog); ascending aorta morphogenesis (ortholog); atrial septum morphogenesis (ortholog); PARTICIPATES IN glypican signaling pathway; Hedgehog signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); aortic aneurysm (ortholog); aortic disease (ortholog); FOUND IN axon (ortholog); basement membrane (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transforming growth factor beta-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248352,363,139 - 2,437,643 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248352,363,059 - 2,436,536 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation-induced cell death of T cells  (ISO)
animal organ morphogenesis  (IEA)
ascending aorta morphogenesis  (ISO)
atrial septum morphogenesis  (ISO)
atrial septum primum morphogenesis  (ISO)
atrioventricular valve morphogenesis  (ISO)
axon guidance  (ISO)
blood vessel development  (ISO)
blood vessel remodeling  (ISO)
cardiac epithelial to mesenchymal transition  (IEA)
cardiac muscle cell proliferation  (IEA)
cardiac right ventricle morphogenesis  (ISO)
cardioblast differentiation  (IEA)
cartilage condensation  (ISO)
cell migration  (IEA)
cell morphogenesis  (IEA)
cell-cell junction organization  (IEA)
collagen fibril organization  (IEA)
cranial skeletal system development  (ISO)
digestive tract development  (ISO)
dopamine biosynthetic process  (ISO)
embryonic digestive tract development  (IEA)
embryonic limb morphogenesis  (ISO)
embryonic neurocranium morphogenesis  (ISO)
endocardial cushion fusion  (ISO)
endocardial cushion morphogenesis  (ISO)
epithelial cell differentiation  (IEA,ISO)
epithelial to mesenchymal transition  (IEA)
extracellular matrix organization  (ISO)
extrinsic apoptotic signaling pathway  (IEA)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
eye development  (IEA)
face morphogenesis  (ISO)
female pregnancy  (ISO)
frontal suture morphogenesis  (ISO)
glial cell migration  (IEA)
hair follicle development  (IEA,ISO)
hair follicle morphogenesis  (ISO)
heart development  (IEA,ISO)
heart morphogenesis  (IEA)
heart valve morphogenesis  (ISO)
hemopoiesis  (ISO)
hindbrain development  (ISO)
inner ear development  (ISO)
kidney development  (ISO)
male gonad development  (ISO)
membranous septum morphogenesis  (ISO)
negative regulation of angiogenesis  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of cartilage development  (ISO)
negative regulation of cell growth  (IEA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of epithelial cell proliferation  (IEA)
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
negative regulation of gene expression  (IEA)
negative regulation of macrophage cytokine production  (IEA)
negative regulation of Ras protein signal transduction  (ISO)
negative regulation of release of sequestered calcium ion into cytosol  (ISO)
neural retina development  (ISO)
neural tube closure  (ISO)
neuron development  (ISO)
neuron fate commitment  (ISO)
neutrophil chemotaxis  (ISO)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (ISO)
pancreas development  (ISO)
pericyte cell differentiation  (ISO)
pharyngeal arch artery morphogenesis  (ISO)
positive regulation of activation-induced cell death of T cells  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cardiac epithelial to mesenchymal transition  (ISO)
positive regulation of cardioblast differentiation  (IEA)
positive regulation of cell adhesion mediated by integrin  (IEA)
positive regulation of cell cycle  (ISO)
positive regulation of cell division  (IEA)
positive regulation of cell growth  (IEA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of epithelial cell migration  (IEA)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
positive regulation of extracellular matrix disassembly  (ISO)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of heart contraction  (IEA)
positive regulation of immune response  (ISO)
positive regulation of integrin biosynthetic process  (IEA)
positive regulation of miRNA transcription  (IEA)
positive regulation of neuron apoptotic process  (IEA)
positive regulation of Notch signaling pathway  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein secretion  (IEA)
positive regulation of SMAD protein signal transduction  (IEA)
positive regulation of stress-activated MAPK cascade  (IEA)
positive regulation of timing of catagen  (IEA)
pulmonary valve morphogenesis  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of apoptotic process  (ISO)
regulation of apoptotic process involved in outflow tract morphogenesis  (ISO)
regulation of cell population proliferation  (IEA)
regulation of complement-dependent cytotoxicity  (ISO)
regulation of extracellular matrix organization  (ISO)
regulation of timing of catagen  (IEA)
regulation of transforming growth factor beta2 production  (IEA)
response to cytokine  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to hypoxia  (IEA)
response to laminar fluid shear stress  (ISO)
response to organonitrogen compound  (ISO)
response to progesterone  (IEA)
response to retinoic acid  (ISO)
response to vitamin D  (ISO)
response to wounding  (IEA)
response to xenobiotic stimulus  (ISO)
salivary gland morphogenesis  (IEA)
secondary palate development  (ISO)
signaling  (IEA)
skeletal muscle tissue development  (ISO)
skeletal system development  (ISO)
somatic stem cell division  (ISO)
substantia propria of cornea development  (ISO)
thyroid gland development  (ISO)
tissue development  (IEA)
transforming growth factor beta receptor signaling pathway  (IEA)
tube development  (IEA)
uterus development  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tgfb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248352,363,139 - 2,437,643 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248352,363,059 - 2,436,536 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TGFB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381218,345,336 - 218,444,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1218,345,336 - 218,444,619 (+)EnsemblGRCh38hg38GRCh38
GRCh371218,518,678 - 218,617,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361216,586,491 - 216,681,596 (+)NCBINCBI36Build 36hg18NCBI36
Build 341214,908,262 - 215,003,365NCBI
Celera1191,735,848 - 191,834,418 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1189,186,842 - 189,286,057 (+)NCBIHuRef
CHM1_11219,791,024 - 219,890,484 (+)NCBICHM1_1
T2T-CHM13v2.01217,580,100 - 217,679,392 (+)NCBIT2T-CHM13v2.0
Tgfb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,354,984 - 186,441,504 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1186,354,989 - 186,438,186 (-)EnsemblGRCm39 Ensembl
GRCm381186,622,787 - 186,709,697 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,622,792 - 186,705,989 (-)EnsemblGRCm38mm10GRCm38
MGSCv371188,447,065 - 188,529,871 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361188,324,430 - 188,406,777 (-)NCBIMGSCv36mm8
Celera1193,563,609 - 193,649,724 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map189.95NCBI
Tgfb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813100,691,540 - 100,793,227 (-)NCBIGRCr8
mRatBN7.21398,160,075 - 98,261,771 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1398,160,087 - 98,261,405 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13100,678,931 - 100,778,632 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013102,066,560 - 102,165,910 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01399,261,239 - 99,360,947 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013105,039,639 - 105,142,010 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13105,039,853 - 105,141,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013109,679,866 - 109,792,609 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413102,718,703 - 102,818,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113102,907,748 - 103,007,811 (-)NCBI
Celera1397,669,691 - 97,769,426 (-)NCBICelera
Cytogenetic Map13q26NCBI
Tgfb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955406172,814 - 249,248 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955406174,949 - 249,248 (-)NCBIChiLan1.0ChiLan1.0
TGFB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2130,962,733 - 31,060,610 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1130,925,280 - 31,023,656 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01193,907,398 - 194,005,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11198,758,718 - 198,856,853 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1198,758,751 - 198,859,041 (+)Ensemblpanpan1.1panPan2
TGFB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13813,430,832 - 13,511,655 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3813,429,148 - 13,510,242 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3813,472,728 - 13,552,654 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03813,464,207 - 13,544,357 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3813,464,807 - 13,545,256 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13813,473,487 - 13,553,481 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03813,819,811 - 13,899,809 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03814,128,921 - 14,209,014 (+)NCBIUU_Cfam_GSD_1.0
Tgfb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934458,300,141 - 58,383,975 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936628308,691 - 394,007 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936628310,720 - 394,002 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl108,305,539 - 8,390,341 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1108,306,136 - 8,435,307 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21010,353,794 - 10,476,143 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap10p16NCBI
TGFB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12511,163,651 - 11,259,868 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2511,163,100 - 11,258,470 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605511,574,533 - 11,672,282 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000004042   ⟹   ENSHGLP00000003984
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248352,363,139 - 2,437,643 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000004043   ⟹   ENSHGLP00000003985
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248352,363,611 - 2,433,636 (+)Ensembl
RefSeq Acc Id: XM_004867392   ⟹   XP_004867449
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248352,363,059 - 2,436,132 (+)NCBI
RefSeq Acc Id: XR_002390047
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248352,363,059 - 2,436,536 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004867449 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000003984
  ENSHGLP00100003673
  ENSHGLP00100034493
GenBank Protein JAN98401 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004867449   ⟸   XM_004867392
- UniProtKB: A0A0P6K2D3 (UniProtKB/TrEMBL),   G5ATT1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000003985   ⟸   ENSHGLT00000004043
RefSeq Acc Id: ENSHGLP00000003984   ⟸   ENSHGLT00000004042


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000002933 Ensembl, ENTREZGENE
  ENSHGLG00100002798 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000004042 ENTREZGENE
  ENSHGLT00100003733 UniProtKB/TrEMBL
  ENSHGLT00100077181 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/TrEMBL
  TGF-beta UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb2 UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
KEGG Report hgl:101707457 UniProtKB/TrEMBL
NCBI Gene Tgfb2 ENTREZGENE
PANTHER PTHR11848 UniProtKB/TrEMBL
  TRANSFORMING GROWTH FACTOR BETA-2 PROPROTEIN UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PIRSF TGF-beta UniProtKB/TrEMBL
PRINTS TGFBETA UniProtKB/TrEMBL
  TGFBETA2 UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A0P6K2D3 ENTREZGENE, UniProtKB/TrEMBL
  G5ATT1 ENTREZGENE, UniProtKB/TrEMBL