RGD Reference Report - Effects of high dose retinoic acid on TGF-beta2 expression during pancreatic organogenesis. - Rat Genome Database

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Effects of high dose retinoic acid on TGF-beta2 expression during pancreatic organogenesis.

Authors: Colakoglu, N  Kukner, A  Oner, J  Sonmez, MF  Oner, H  Ozan, E 
Citation: Colakoglu N, etal., J Mol Histol. 2005 Sep;36(6-7):413-8. Epub 2006 Feb 15.
RGD ID: 2302093
Pubmed: PMID:16479313   (View Abstract at PubMed)
DOI: DOI:10.1007/s10735-005-9013-6   (Journal Full-text)

The aim of this study was to investigate the effects of excess all-trans retinoic acid, a vitamin A metabolite, on pancreatic organogenesis and TGF-beta2 expression during prenatal development in rats.First group of animals used as control while a single dose of 60 mg/kg all-trans retinoic acid was ingested by the mothers, at day 8 of gestation (before the neurulation period) in group II and at day 12 of gestation (after the neurulation period) in group III, and all embryos were sacrificed at day 18 of gestation. TGF-beta2 expression was detected in the capsule, acini and Langerhans islets in the control group. In the pancreas of group II, dilatation and congestion of interlobular vessels were observed. Langerhans islet structures were completely absent. Moreover acinar TGF-beta2 immune reactivity was not determined. In group III, acinar expression of TGF-beta2 in acid was similar to that in the controls but their Langerhans islets TGF-beta2 immune reactivity was significantly less than the controls.In view of the present findings we suggest that TGF-beta2 plays important role in pancreatic morphogenesis and administration of excess all-trans retinoic acid before neurulation inhibit TGF-beta2 expression disrupted pancreatic morphogenesis particularly Langerhans islets. However, its administration after neurulation had less adverse affect on pancreatic organogenesis and TGF-beta2 immune reactivity.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Tgfb2Ratpancreas development  IEP  RGD 
Tgfb2Ratresponse to retinoic acid  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tgfb2  (transforming growth factor, beta 2)


Additional Information