Ccl5 (C-C motif chemokine ligand 5) - Rat Genome Database

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Gene: Ccl5 (C-C motif chemokine ligand 5) Rattus norvegicus
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Symbol: Ccl5 (Ensembl: Mmp28)
Name: C-C motif chemokine ligand 5 (Ensembl:matrix metallopeptidase 28)
RGD ID: 69069
Description: Enables chemokine activity and heparin binding activity. Involved in several processes, including lymphocyte migration; positive regulation of cell differentiation; and positive regulation of leukocyte chemotaxis. Located in extracellular space. Used to study Chagas disease; bronchiolitis obliterans; kidney disease; metabolic dysfunction-associated steatotic liver disease; and orchitis. Biomarker of several diseases, including artery disease (multiple); cardiac arrest; liver disease (multiple); lung disease (multiple); and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including human immunodeficiency virus infectious disease; liver disease (multiple); pancreatitis; pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5); PARTICIPATES IN syndecan signaling pathway; Chagas disease pathway; chemokine mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-C motif chemokine 5; chemokine (C-C motif) ligand 5; RANTES; regulated upon activation normal T-cell expressed and secreted; Scya5; SIS-delta; small inducible cytokine A5; small inducible cytokine A5 (RANTES); small-inducible cytokine A5; T-cell-specific protein RANTES
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau3 Bp299 Eau9
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,820,330 - 68,824,906 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1068,738,651 - 68,824,884 (-)EnsemblGRCr8
mRatBN7.21068,322,826 - 68,327,380 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,322,829 - 68,327,377 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1072,942,820 - 72,947,359 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,448,203 - 72,452,742 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,912,255 - 67,916,794 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,739,764 - 70,744,303 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,739,800 - 70,744,315 (-)Ensemblrn6Rnor6.0
Rnor_5.01070,373,353 - 70,377,892 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41071,605,791 - 71,610,330 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1067,264,203 - 67,268,742 (-)NCBICelera
RGSC_v3.11071,620,206 - 71,624,712 (-)NCBI
Cytogenetic Map10q26NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
alcoholic hepatitis  (IEP,ISO)
allergic conjunctivitis  (IEP)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
Animal Toxoplasmosis  (IEP)
anti-basement membrane glomerulonephritis  (IEP)
antiphospholipid syndrome  (ISO)
arteriosclerosis  (IEP,ISO)
asthma  (IEP,ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autoimmune hepatitis  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (IEP,IMP)
bronchopneumonia  (ISO)
cardiac arrest  (IEP)
Chagas disease  (IMP)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic inflammatory demyelinating polyradiculoneuropathy  (ISO)
chronic obstructive pulmonary disease  (ISO)
cocaine abuse  (ISO)
COVID-19  (ISO)
Cytomegalovirus Infections  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (IEP)
endometriosis  (IEP)
Endotoxemia  (IEP)
exercise-induced bronchoconstriction  (ISO)
Experimental Arthritis  (IEP,IMP)
Experimental Autoimmune Encephalomyelitis  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Seizures  (IEP)
extrinsic allergic alveolitis  (ISO)
Fever  (IDA)
genital herpes  (ISO)
glomerulonephritis  (ISO)
glucose intolerance  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Hermansky-Pudlak syndrome  (ISO)
Herpesviridae Infections  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (IDA,IEP)
Hyperoxaluria  (IEP,ISO)
hypertension  (ISO)
Hypoventilation  (ISO)
Immediate Hypersensitivity  (IEP)
Inflammation  (IEP,ISO)
interstitial lung disease  (ISO)
invasive ductal carcinoma  (ISO)
kidney disease  (IMP)
liver cirrhosis  (ISO)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (IEP)
Lung Injury  (ISO)
malignant mesothelioma  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,IMP,ISO)
Metabolic Syndrome  (IEP)
multiple sclerosis  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
myocardial infarction  (IEP)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
obesity  (IEP)
obstructive sleep apnea  (ISO)
orchitis  (IDA)
Ovarian Neoplasms  (ISO)
Pain  (IMP)
pancreatic cancer  (ISO)
pancreatitis  (IEP,ISO)
Paramyxoviridae Infections  (ISO)
peptic esophagitis  (IEP)
pleurisy  (ISO)
Pneumococcal Pneumonia  (ISO)
posterior uveitis  (IEP)
pre-eclampsia  (IEP)
primary biliary cholangitis  (ISO)
Pseudomonas Infections  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (IEP,ISO)
Respiration Disorders  (ISO)
respiratory syncytial virus infectious disease  (ISO)
sciatic neuropathy  (IEP)
scrapie  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (IEP)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (ISO)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
Tissue Adhesions  (IMP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (IEP)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-anisomycin  (ISO)
(-)-demecolcine  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-Aminopyrene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-naphthylamine  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
8-chloro-2'-deoxyguanosine  (ISO)
9,10-anthraquinone  (ISO)
9-hydroxycanthin-6-one  (ISO)
acetamide  (EXP)
acrolein  (ISO)
adenine  (ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
alexidine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (EXP)
aluminium hydroxide  (ISO)
ammonium chloride  (EXP)
amorolfine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
arecoline  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atropine  (ISO)
Bardoxolone methyl  (ISO)
beclomethasone  (ISO)
benazepril  (EXP)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-Funaltrexamine  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
Brevianamide A  (ISO)
budesonide  (ISO)
butanal  (ISO)
butenafine  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carrageenan  (EXP,ISO)
catechol  (ISO)
celecoxib  (ISO)
cephaeline  (ISO)
cerium trichloride  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chloroquine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clopidogrel  (ISO)
cobalt atom  (ISO)
codeine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cytidine  (ISO)
D-glucose  (ISO)
D-penicillamine  (EXP)
dantrolene  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dequalinium  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dibutylstannane  (ISO)
dichlorine  (ISO)
dichloromethane  (EXP)
Didecyldimethylammonium  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
diflorasone  (ISO)
digitoxigenin  (ISO)
digoxin  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dinitrogen  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
emetine  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
Erionite  (ISO)
ethambutol  (EXP)
ethanol  (ISO)
ethionamide  (EXP)
ethyl acetate  (ISO)
Ethyl icosapentate  (ISO)
ethylbenzene  (EXP)
ethylene glycol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenofibrate  (ISO)
ferric oxide  (EXP)
Fexofenadine hydrochloride  (ISO)
flavonoids  (EXP)
flunisolide  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
fragrance  (ISO)
fucoidan  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gemfibrozil  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glutathione  (ISO)
glycine betaine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
GW 1929  (ISO)
Harpagoside  (ISO)
helenalin  (ISO)
heparan sulfate  (ISO)
hesperetin  (ISO)
hesperidin  (ISO)
hexadecanoic acid  (ISO)
homocysteine  (EXP,ISO)
hyaluronic acid  (ISO)
hydrazines  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxytyrosol  (ISO)
ibuprofen  (EXP)
indometacin  (EXP)
ionomycin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isotretinoin  (EXP,ISO)
itraconazole  (ISO)
ivermectin  (ISO)
Jujuboside A  (ISO)
kaempferol  (ISO)
ketamine  (ISO)
ketoconazole  (EXP,ISO)
lanatoside C  (ISO)
lanthanum trichloride  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
leukotriene B4  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
losartan  (EXP)
Luliconazole  (ISO)
LY294002  (ISO)
lycopene  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
maraviroc  (ISO)
masoprocol  (EXP)
mechlorethamine  (EXP)
meclocycline  (ISO)
melatonin  (ISO)
menadione  (EXP)
mercaptopurine  (EXP)
mercury dichloride  (EXP)
metam  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methionine sulfoximine  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
Methylbenzethonium chloride  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (EXP,ISO)
midazolam  (ISO)
minocycline  (ISO)
Moniliformin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP)
monodansylcadaverine  (ISO)
monoethyl phthalate  (ISO)
morphine  (ISO)
mycophenolic acid  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naloxone  (ISO)
naringin  (ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nitrogen dioxide  (ISO)
o-anisidine  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
oxytetracycline  (ISO)
ozone  (ISO)
palmatine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parthenolide  (ISO)
PCB138  (EXP)
PD123319  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
Pentoxifylline  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
pevonedistat  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP)
phenylarsine oxide  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
prazosin  (ISO)
procyanidin B3  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
propidium  (ISO)
Proscillaridin  (ISO)
prostaglandin E2  (ISO)
purine-6-thiol  (EXP)
pyocyanine  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rifampicin  (EXP)
rofecoxib  (ISO)
rutin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitrosoglutathione  (ISO)
salubrinal  (ISO)
SB 203580  (ISO)
serotonin  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium cholate  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
Sodium oleate  (ISO)
Soman  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sucrose  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tacrine  (EXP)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
taurocholic acid  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
terameprocol  (ISO)
terbinafine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
Tetramethylthiourea  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (EXP,ISO)
topotecan  (EXP)
trametinib  (ISO)
tremolite asbestos  (ISO)
triadimefon  (EXP)
triamcinolone acetonide  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
vanadyl sulfate  (ISO)
verteporfin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
wortmannin  (ISO)
WR-1065  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antimicrobial humoral immune response mediated by antimicrobial peptide  (IBA)
calcium ion transport  (ISO)
cell chemotaxis  (IEA)
cell-cell signaling  (ISO)
cellular response to alkyl hydroperoxide  (IEP)
cellular response to amino acid stimulus  (IEP)
cellular response to cytokine stimulus  (IEP)
cellular response to ethanol  (IEP)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to high density lipoprotein particle stimulus  (IEP)
cellular response to interleukin-1  (ISO)
cellular response to lipid  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to morphine  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP,ISO)
cellular response to type II interferon  (ISO)
cellular response to vitamin K  (IEP)
chemokine (C-C motif) ligand 5 signaling pathway  (ISO)
chemokine-mediated signaling pathway  (IBA,ISO,ISS)
chemotaxis  (IEA)
chronic inflammatory response  (IEP)
dibenzo-p-dioxin metabolic process  (IEP)
eosinophil chemotaxis  (IBA,ISO)
exocytosis  (ISO)
G protein-coupled receptor signaling pathway  (ISO,ISS)
immune response  (IEA)
inflammatory response  (IBA,IEA,ISO)
intracellular calcium ion homeostasis  (ISO)
leukocyte cell-cell adhesion  (ISO)
lymphocyte chemotaxis  (IDA)
negative regulation of cellular process  (IMP)
negative regulation of chemokine-mediated signaling pathway  (IEA)
negative regulation of G protein-coupled receptor signaling pathway  (ISO)
negative regulation of macrophage apoptotic process  (ISO)
negative regulation of T cell apoptotic process  (ISO)
negative regulation of viral genome replication  (ISO)
neutrophil activation  (ISO)
phospholipase D-activating G protein-coupled receptor signaling pathway  (ISO)
positive chemotaxis  (IEA)
positive regulation of angiogenesis  (IMP)
positive regulation of calcium ion transport  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (IBA,ISO)
positive regulation of cell-cell adhesion mediated by integrin  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of fever generation  (IDA)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of gene expression  (IDA,IMP)
positive regulation of homotypic cell-cell adhesion  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of mast cell chemotaxis  (IDA)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of natural killer cell chemotaxis  (ISO)
positive regulation of neuroinflammatory response  (ISO)
positive regulation of neuron differentiation  (IMP)
positive regulation of osteoclast differentiation  (IDA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA,ISO)
positive regulation of receptor signaling pathway via STAT  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of T cell apoptotic process  (ISO)
positive regulation of T cell chemotaxis  (IDA,ISO)
positive regulation of T cell migration  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of TOR signaling  (ISO)
pseudopodium assembly  (IDA)
regulation of insulin secretion  (ISO,ISS)
regulation of programmed cell death  (IMP)
regulation of T cell activation  (ISO)
response to activity  (IEP)
response to alcohol  (IEP)
response to bacterium  (IEP)
response to cholesterol  (IEP)
response to cyclophosphamide  (IEP)
response to cytokine  (IEP,ISO)
response to estrogen  (IEP)
response to glucocorticoid  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IEP)
response to nutrient levels  (IEP)
response to salt stress  (IEP)
response to toxic substance  (ISO)
response to tumor necrosis factor  (ISO)
response to type II interferon  (IDA)
response to xenobiotic stimulus  (IEP)
signal transduction  (IEA)
T-helper 1 cell diapedesis  (IDA)

Cellular Component
cytoplasm  (ISO)
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)
membrane  (ISO)

References

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129. Inhibition of metastasis by inhibition of tumor-derived CCL5. Stormes KA, etal., Breast Cancer Res Treat. 2005 Jan;89(2):209-12. doi: 10.1007/s10549-004-5328-3.
130. Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice. Stowell NC, etal., Respir Res. 2009 Jun 1;10:43.
131. RANTES plays an important role in the evolution of allograft transplant-induced fibrous airway obliteration. Suga M, etal., Am J Respir Crit Care Med. 2000 Nov;162(5):1940-8.
132. A novel rat model to determine interaction between reflux oesophagitis and bronchial asthma. Sugawa T, etal., Gut. 2008 May;57(5):575-81. Epub 2008 Jan 25.
133. The impact of steroids given with macrolide therapy on experimental Mycoplasma pneumoniae respiratory infection. Tagliabue C, etal., J Infect Dis. 2008 Oct 15;198(8):1180-8.
134. Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer. Tan MC, etal., J Immunol. 2009 Feb 1;182(3):1746-55.
135. Minocycline reduces neuronal death and attenuates microglial response after pediatric asphyxial cardiac arrest. Tang M, etal., J Cereb Blood Flow Metab. 2010 Jan;30(1):119-29. Epub 2009 Sep 16.
136. Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome. Tang NL, etal., Clin Chem. 2005 Dec;51(12):2333-40. doi: 10.1373/clinchem.2005.054460. Epub 2005 Sep 29.
137. Differential sensitivities of pyrogenic chemokine fevers to CC chemokine receptor 5 antibodies. Tavares E and Minano FJ, Fundam Clin Pharmacol. 2004 Apr;18(2):163-9.
138. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
139. Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B. Thio CL, etal., J Immunol. 2008 Dec 1;181(11):7944-7. doi: 10.4049/jimmunol.181.11.7944.
140. Metalworking fluid with mycobacteria and endotoxin induces hypersensitivity pneumonitis in mice. Thorne PS, etal., Am J Respir Crit Care Med. 2006 Apr 1;173(7):759-68. Epub 2005 Dec 30.
141. Effect of variation in RANTES promoter on serum RANTES levels and risk of recurrent wheezing after RSV bronchiolitis in children from Han, Southern China. Tian M, etal., Eur J Pediatr. 2009 Aug;168(8):963-7. Epub 2008 Nov 13.
142. Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension. Tinsley JH, etal., Am J Hypertens. 2009 Oct;22(10):1107-14. Epub 2009 Jul 16.
143. NF-kappaB and chemokine-cytokine expression in renal tubulointerstitium in experimental hyperoxaluria. Role of the renin-angiotensin system. Toblli JE, etal., Urol Res. 2005 Nov;33(5):358-67. Epub 2005 Nov 13.
144. Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35. Tribouillard-Tanvier D, etal., J Virol. 2012 Oct;86(19):10377-83. doi: 10.1128/JVI.01340-12. Epub 2012 Jul 11.
145. Th1- and Th2-related chemokine and chemokine receptor expression on the ocular surface in endotoxin-induced uveitis. Trinh L, etal., Mol Vis. 2008;14:2428-34. Epub 2008 Dec 19.
146. Acetaminophen inhibits neuronal inflammation and protects neurons from oxidative stress. Tripathy D and Grammas P, J Neuroinflammation. 2009 Mar 16;6:10.
147. RANTES upregulation in the Alzheimer's disease brain: a possible neuroprotective role. Tripathy D, etal., Neurobiol Aging. 2010 Jan;31(1):8-16. Epub 2008 Apr 28.
148. CCL5-28, CCL5-403, and CCR5 genetic polymorphisms and their synergic effect with alcohol and tobacco consumptions increase susceptibility to hepatocellular carcinoma. Tsai HT, etal., Med Oncol. 2012 Dec;29(4):2771-9. doi: 10.1007/s12032-012-0189-9. Epub 2012 Feb 29.
149. CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. Tyner JW, etal., Nat Med. 2005 Nov;11(11):1180-7. Epub 2005 Oct 2.
150. Early phase resolution of mucosal eosinophilic inflammation in allergic rhinitis. Uller L, etal., Respir Res. 2010 May 9;11(1):54.
151. Cytokine and chemokine expression in a rat endometriosis is similar to that in human endometriosis. Umezawa M, etal., Cytokine. 2008 Aug;43(2):105-9. Epub 2008 Jul 1.
152. Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice. Veillard NR, etal., Circ Res. 2004 Feb 6;94(2):253-61. Epub 2003 Dec 1.
153. Upregulation of macrophage migration inhibitory factor (MIF) and CD74, receptor for MIF, in rat bladder during persistent cyclophosphamide-induced inflammation. Vera PL, etal., Exp Biol Med (Maywood). 2008 May;233(5):620-6. Epub 2008 Mar 28.
154. Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS. Wang CH, etal., Respir Res. 2005 May 11;6:42. doi: 10.1186/1465-9921-6-42.
155. Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis. Wang Y, etal., Br J Pharmacol. 2009 Jul;157(6):1004-13. Epub 2009 Jun 5.
156. Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis. Wang Y, etal., Int Immunopharmacol. 2006 Dec 5;6(12):1825-32. Epub 2006 Aug 31.
157. Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids. Ward SE, etal., Antivir Ther. 2005;10(2):263-75.
158. Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C. Wasmuth HE, etal., Hepatology. 2004 Aug;40(2):327-34. doi: 10.1002/hep.20322.
159. [Changes of RANTES levels in livers of patients with chronic hepatitis B: the clinical significance and the possible mechanisms]. Wei XQ, etal., Zhonghua Gan Zang Bing Za Zhi. 2007 Aug;15(8):585-8.
160. Altered levels of CC chemokines during pulmonary CMV predict BOS and mortality post-lung transplantation. Weigt SS, etal., Am J Transplant. 2008 Jul;8(7):1512-22.
161. Opposite action of peroxisome proliferator-activated receptor-gamma in regulating renal inflammation: functional switch by its ligand. Wen X, etal., J Biol Chem. 2010 Sep 24;285(39):29981-8. Epub 2010 Jul 27.
162. Concentration of chemokines in peripheral blood in first trimester of diabetic pregnancy. Wender-Ozegowska E, etal., Acta Obstet Gynecol Scand. 2008;87(1):14-9.
163. RANTES is required for ischaemia-induced angiogenesis, which may hamper RANTES-targeted anti-atherosclerotic therapy. Westerweel PE, etal., Thromb Haemost. 2008 Apr;99(4):794-5.
164. Chemokine decoy receptor d6 plays a negative role in human breast cancer. Wu FY, etal., Mol Cancer Res. 2008 Aug;6(8):1276-88.
165. DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy. Wu H, etal., Kidney Int. 2005 Jun;67(6):2178-86.
166. [Effect of epimedium herb on RANTES and monocyte chemotactic protein-3 expression in lung tissue of asthmatic rats] Xie JY, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Mar;28(3):238-41.
167. Role of the extracellular signal-regulated kinase 1/2 signaling pathway in regulating the secretion of bronchial smooth muscle cells in a rat model of chronic asthma. Xie M, etal., Chin Med J (Engl). 2008 Jan 5;121(1):73-7.
168. Genetic variants in chemokine CC subfamily genes influence hepatitis C virus viral clearance. Yao Y, etal., J Hum Genet. 2018 Jul;63(7):831-839. doi: 10.1038/s10038-018-0452-9. Epub 2018 Apr 27.
169. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. Yeligar SM, etal., J Immunol. 2009 Nov 1;183(9):5964-76. Epub 2009 Oct 14.
170. Sinomenine, an antirheumatic alkaloid, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalolmyelitis. Zeng Y, etal., Biol Pharm Bull. 2007 Aug;30(8):1438-44.
171. [Study on the association between RANTES-403G/A as well as -28C/G gene polymorphism and their susceptibility to the hepatitis B virus infections in Dong and Han ethnicities in Guizhou, China]. Zhang C, etal., Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Dec;33(12):1279-82.
172. Oxidized high-density lipoprotein enhances inflammatory activity in rat mesangial cells. Zhang M, etal., Diabetes Metab Res Rev. 2010 Sep;26(6):455-63.
173. RANTES gene polymorphisms and asthma risk: A meta-analysis. Zhang YG, etal., Arch Med Res. 2010 Jan;41(1):50-8.
174. [Association of RANTES gene promoter -28C/G polymorphism with respiratory syncytial virus bronchiolitis]. Zhao DY, etal., Zhonghua Er Ke Za Zhi. 2008 Feb;46(2):89-93.
175. Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes. Zhernakova A, etal., Genes Immun. 2006 Oct;7(7):544-9. Epub 2006 Jul 20.
176. RANTES in exhaled breath condensate of allergic asthma patients with exercise-induced bronchoconstriction. Zietkowski Z, etal., Respiration. 2010;80(6):463-71. Epub 2009 Dec 7.
177. [Detection of ICAM-1 and RANTES in infants with bronchiolitis]. Zou LP and Zhang SL, Zhongguo Dang Dai Er Ke Za Zhi. 2010 Mar;12(3):181-3.
Additional References at PubMed
PMID:1375672   PMID:1699135   PMID:7517217   PMID:7544376   PMID:7545673   PMID:8558019   PMID:8631850   PMID:8699119   PMID:9139699   PMID:9407497   PMID:9417081   PMID:9469451  
PMID:10488085   PMID:10490959   PMID:10660125   PMID:10734056   PMID:10841574   PMID:10910894   PMID:12477932   PMID:12899200   PMID:15001559   PMID:15504940   PMID:15530372   PMID:15557190  
PMID:15718270   PMID:16778803   PMID:16830364   PMID:17001303   PMID:17218081   PMID:18337562   PMID:18832695   PMID:19779041   PMID:20132097   PMID:21147091   PMID:21148126   PMID:21167894  
PMID:21297082   PMID:21827949   PMID:22292067   PMID:22450806   PMID:22752444   PMID:22960654   PMID:23460747   PMID:23480650   PMID:23498802   PMID:23620790   PMID:23696660   PMID:23979485  
PMID:24656930   PMID:25635831   PMID:28146100   PMID:28381538   PMID:31032369   PMID:36483459   PMID:37903803   PMID:38797830  


Genomics

Comparative Map Data
Ccl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,820,330 - 68,824,906 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1068,738,651 - 68,824,884 (-)EnsemblGRCr8
mRatBN7.21068,322,826 - 68,327,380 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,322,829 - 68,327,377 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1072,942,820 - 72,947,359 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,448,203 - 72,452,742 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,912,255 - 67,916,794 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,739,764 - 70,744,303 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,739,800 - 70,744,315 (-)Ensemblrn6Rnor6.0
Rnor_5.01070,373,353 - 70,377,892 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41071,605,791 - 71,610,330 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1067,264,203 - 67,268,742 (-)NCBICelera
RGSC_v3.11071,620,206 - 71,624,712 (-)NCBI
Cytogenetic Map10q26NCBI
CCL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,871,491 - 35,880,360 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1735,871,491 - 35,880,793 (-)Ensemblhg38GRCh38
GRCh371734,198,495 - 34,207,364 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,222,608 - 31,231,490 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1731,108,052 - 31,116,934 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1730,383,508 - 30,392,390 (-)NCBIHuRef
CHM1_11734,263,060 - 34,271,942 (-)NCBICHM1_1
T2T-CHM13v2.01736,819,399 - 36,828,268 (-)NCBIT2T-CHM13v2.0
Ccl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,416,604 - 83,421,344 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,416,604 - 83,421,344 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381183,525,778 - 83,530,518 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,525,778 - 83,530,518 (-)Ensemblmm10GRCm38
MGSCv371183,339,280 - 83,344,020 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361183,341,974 - 83,346,692 (-)NCBIMGSCv36mm8
Celera1193,127,305 - 93,132,049 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.66NCBI
Ccl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495548110,293,399 - 10,301,143 (-)Ensembl
ChiLan1.0NW_00495548110,293,758 - 10,301,118 (-)NCBIChiLan1.0ChiLan1.0
CCL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21928,596,811 - 28,605,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11730,476,222 - 30,484,892 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01720,915,198 - 20,923,530 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11721,210,798 - 21,219,172 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1721,210,798 - 21,219,172 (+)EnsemblpanPan2panpan1.1
CCL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1937,817,409 - 37,823,852 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl937,817,305 - 37,823,852 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha937,039,892 - 37,046,335 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0938,627,353 - 38,633,796 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl938,627,249 - 38,633,796 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,410,157 - 37,416,605 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0937,695,725 - 37,702,162 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0937,783,127 - 37,789,578 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ccl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560236,815,103 - 36,821,857 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936490253,034 - 259,965 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936490253,279 - 259,947 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1239,648,598 - 39,659,118 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11239,652,731 - 39,659,121 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,218,074 - 41,228,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11629,351,214 - 29,361,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666075615,422 - 624,588 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccl5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248753,334,078 - 3,341,614 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248753,334,136 - 3,342,085 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ccl5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1987,159,440 - 87,164,155 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ccl5
19 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:32
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000014865
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106743947373950209Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)106747660873695498Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)106747660873695498Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Chm184  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,328,123 - 68,328,363 (+)MAPPERmRatBN7.2
Rnor_6.01070,745,062 - 70,745,301NCBIRnor6.0
Rnor_5.01070,378,651 - 70,378,890UniSTSRnor5.0
RGSC_v3.41071,611,089 - 71,611,328UniSTSRGSC3.4
Celera1067,269,501 - 67,269,740UniSTS
Cytogenetic Map10q26UniSTS
RH129414  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,322,907 - 68,323,098 (+)MAPPERmRatBN7.2
Rnor_6.01070,739,846 - 70,740,036NCBIRnor6.0
Rnor_5.01070,373,435 - 70,373,625UniSTSRnor5.0
RGSC_v3.41071,605,873 - 71,606,063UniSTSRGSC3.4
Celera1067,264,285 - 67,264,475UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 55 124 85 84 53 92 53 6 330 179 10 96 74 88 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000014865   ⟹   ENSRNOP00000014865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1068,322,829 - 68,327,377 (-)Ensembl
Rnor_6.0 Ensembl1070,739,800 - 70,744,315 (-)Ensembl
RefSeq Acc Id: NM_031116   ⟹   NP_112378
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,820,330 - 68,824,884 (-)NCBI
mRatBN7.21068,322,826 - 68,327,380 (-)NCBI
Rnor_6.01070,739,764 - 70,744,303 (-)NCBI
Rnor_5.01070,373,353 - 70,377,892 (-)NCBI
RGSC_v3.41071,605,791 - 71,610,330 (-)RGD
Celera1067,264,203 - 67,268,742 (-)RGD
Sequence:
RefSeq Acc Id: XM_063269955   ⟹   XP_063126025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,820,675 - 68,824,906 (-)NCBI
RefSeq Acc Id: NP_112378   ⟸   NM_031116
- Peptide Label: precursor
- UniProtKB: Q6PED1 (UniProtKB/TrEMBL),   A1EC65 (UniProtKB/TrEMBL),   A1ECA0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014865   ⟸   ENSRNOT00000014865
RefSeq Acc Id: XP_063126025   ⟸   XM_063269955
- Peptide Label: isoform X1
- UniProtKB: F7FLW4 (UniProtKB/TrEMBL)
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50231-F1-model_v2 AlphaFold P50231 1-92 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697533
Promoter ID:EPDNEW_R8058
Type:single initiation site
Name:Ccl5_1
Description:C-C motif chemokine ligand 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01070,744,318 - 70,744,378EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69069 AgrOrtholog
BioCyc Gene G2FUF-23874 BioCyc
Ensembl Genes ENSRNOG00000010906 Ensembl
  ENSRNOG00000047940 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000014865 ENTREZGENE
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6921268 IMAGE-MGC_LOAD
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
MGC_CLONE MGC:72786 IMAGE-MGC_LOAD
NCBI Gene 81780 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 5 UniProtKB/Swiss-Prot
  PTHR12015 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PhenoGen Ccl5 PhenoGen
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010906 RatGTEx
  ENSRNOG00000047940 RatGTEx
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
TIGR TC218419
UniProt A1EC65 ENTREZGENE, UniProtKB/TrEMBL
  A1ECA0 ENTREZGENE, UniProtKB/TrEMBL
  CCL5_RAT UniProtKB/Swiss-Prot
  F7FLW4 ENTREZGENE
  P50231 ENTREZGENE
  Q6PED1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ccl5  C-C motif chemokine ligand 5  Ccl5  chemokine (C-C motif) ligand 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Ccl5  chemokine (C-C motif) ligand 5  Scya5  small inducible cytokine A5  Symbol and Name updated 629477 APPROVED
2002-06-10 Scya5  small inducible cytokine A5      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression increases during renal allografts 61510
gene_expression increases during renal allografts 68880
gene_expression mRNA expression in testicular somatic cells increases in response to Sendai virus infection 704384