CCL5 (C-C motif chemokine ligand 5) - Rat Genome Database

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Gene: CCL5 (C-C motif chemokine ligand 5) Pan paniscus
Analyze
Symbol: CCL5
Name: C-C motif chemokine ligand 5
RGD ID: 11678301
Description: ENCODES a protein that exhibits chemokine activity (ortholog); heparin binding (ortholog); INVOLVED IN cellular response to alkyl hydroperoxide (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to cytokine stimulus (ortholog); PARTICIPATES IN syndecan signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); alcoholic hepatitis (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: C-C motif chemokine 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21928,596,811 - 28,605,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11730,476,222 - 30,484,892 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01720,915,198 - 20,923,530 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11721,210,798 - 21,219,172 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1721,210,798 - 21,219,172 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
alcoholic hepatitis  (ISO)
allergic conjunctivitis  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
Animal Toxoplasmosis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
antiphospholipid syndrome  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autoimmune hepatitis  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (ISO)
bronchopneumonia  (ISO)
cardiac arrest  (ISO)
Chagas disease  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic inflammatory demyelinating polyradiculoneuropathy  (ISO)
chronic obstructive pulmonary disease  (ISO)
cocaine abuse  (ISO)
COVID-19  (ISO)
Cytomegalovirus Infections  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
exercise-induced bronchoconstriction  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Seizures  (ISO)
extrinsic allergic alveolitis  (ISO)
Fever  (ISO)
genetic disease  (ISO)
genital herpes  (ISO)
glomerulonephritis  (ISO)
glucose intolerance  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Hermansky-Pudlak syndrome  (ISO)
Herpesviridae Infections  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Hyperoxaluria  (ISO)
hypertension  (ISO)
Hypoventilation  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (ISO)
interstitial lung disease  (ISO)
invasive ductal carcinoma  (ISO)
kidney disease  (ISO)
liver cirrhosis  (ISO)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
malignant mesothelioma  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
multiple sclerosis  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
myocardial infarction  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
non-alcoholic fatty liver  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
orchitis  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
Paramyxoviridae Infections  (ISO)
peptic esophagitis  (ISO)
pleurisy  (ISO)
Pneumococcal Pneumonia  (ISO)
posterior uveitis  (ISO)
pre-eclampsia  (ISO)
primary biliary cholangitis  (ISO)
Pseudomonas Infections  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (ISO)
Respiration Disorders  (ISO)
respiratory syncytial virus infectious disease  (ISO)
sciatic neuropathy  (ISO)
scrapie  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (ISO)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
Tissue Adhesions  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (ISO)
Viral Bronchiolitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion transport  (IEA)
cell-cell signaling  (IEA)
cellular response to alkyl hydroperoxide  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to ethanol  (ISO)
cellular response to fibroblast growth factor stimulus  (IEA)
cellular response to high density lipoprotein particle stimulus  (ISO)
cellular response to interleukin-1  (IEA)
cellular response to lipid  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to morphine  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to type II interferon  (IEA)
cellular response to virus  (IEA)
cellular response to vitamin K  (ISO)
chemokine-mediated signaling pathway  (IEA)
chemotaxis  (IEA)
chronic inflammatory response  (ISO)
dibenzo-p-dioxin metabolic process  (ISO)
eosinophil chemotaxis  (IEA)
epithelial cell proliferation  (ISO)
exocytosis  (IEA)
G protein-coupled receptor signaling pathway  (IEA)
immune response  (IEA)
inflammatory response  (ISO)
intracellular calcium ion homeostasis  (IEA)
leukocyte cell-cell adhesion  (IEA)
lymphocyte chemotaxis  (ISO)
negative regulation by host of viral transcription  (IEA)
negative regulation of cellular process  (ISO)
negative regulation of chemokine-mediated signaling pathway  (IEA)
negative regulation of G protein-coupled receptor signaling pathway  (IEA)
negative regulation of macrophage apoptotic process  (ISO)
negative regulation of T cell apoptotic process  (IEA)
negative regulation of viral genome replication  (IEA)
neutrophil activation  (IEA)
positive chemotaxis  (IEA)
positive regulation of angiogenesis  (ISO)
positive regulation of calcium ion transport  (IEA)
positive regulation of cell adhesion  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell-cell adhesion mediated by integrin  (IEA)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of fever generation  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of homotypic cell-cell adhesion  (IEA)
positive regulation of macrophage chemotaxis  (IEA)
positive regulation of mast cell chemotaxis  (ISO)
positive regulation of monocyte chemotaxis  (IEA)
positive regulation of natural killer cell chemotaxis  (IEA)
positive regulation of neuron differentiation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of phosphorylation  (IEA)
positive regulation of smooth muscle cell migration  (IEA)
positive regulation of smooth muscle cell proliferation  (IEA)
positive regulation of T cell apoptotic process  (IEA)
positive regulation of T cell chemotaxis  (IEA)
positive regulation of T cell migration  (IEA,ISO)
positive regulation of T cell proliferation  (IEA)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA)
pseudopodium assembly  (ISO)
regulation of insulin secretion  (IEA)
regulation of programmed cell death  (ISO)
regulation of T cell activation  (IEA)
response to activity  (ISO)
response to alcohol  (ISO)
response to bacterium  (ISO)
response to cholesterol  (ISO)
response to cytokine  (ISO)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to salt stress  (ISO)
response to toxic substance  (IEA)
response to tumor necrosis factor  (ISO)
response to type II interferon  (ISO)
response to xenobiotic stimulus  (ISO)
T-helper 1 cell diapedesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CCL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21928,596,811 - 28,605,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11730,476,222 - 30,484,892 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01720,915,198 - 20,923,530 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11721,210,798 - 21,219,172 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1721,210,798 - 21,219,172 (+)Ensemblpanpan1.1panPan2
CCL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,871,491 - 35,880,360 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1735,871,491 - 35,880,793 (-)EnsemblGRCh38hg38GRCh38
GRCh371734,198,495 - 34,207,364 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,222,608 - 31,231,490 (-)NCBINCBI36Build 36hg18NCBI36
Celera1731,108,052 - 31,116,934 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1730,383,508 - 30,392,390 (-)NCBIHuRef
CHM1_11734,263,060 - 34,271,942 (-)NCBICHM1_1
T2T-CHM13v2.01736,819,399 - 36,828,268 (-)NCBIT2T-CHM13v2.0
Ccl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,416,604 - 83,421,344 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,416,604 - 83,421,344 (-)EnsemblGRCm39 Ensembl
GRCm381183,525,778 - 83,530,518 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,525,778 - 83,530,518 (-)EnsemblGRCm38mm10GRCm38
MGSCv371183,339,280 - 83,344,020 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361183,341,974 - 83,346,692 (-)NCBIMGSCv36mm8
Celera1193,127,305 - 93,132,049 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.66NCBI
Ccl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,820,330 - 68,824,906 (-)NCBIGRCr8
mRatBN7.21068,322,826 - 68,327,380 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,322,829 - 68,327,377 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,942,820 - 72,947,359 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,448,203 - 72,452,742 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,912,255 - 67,916,794 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,739,764 - 70,744,303 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,739,800 - 70,744,315 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01070,373,353 - 70,377,892 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,605,791 - 71,610,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,620,206 - 71,624,712 (-)NCBI
Celera1067,264,203 - 67,268,742 (-)NCBICelera
Cytogenetic Map10q26NCBI
Ccl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495548110,293,399 - 10,301,143 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495548110,293,758 - 10,301,118 (-)NCBIChiLan1.0ChiLan1.0
CCL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1937,817,409 - 37,823,852 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl937,817,305 - 37,823,852 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha937,039,892 - 37,046,335 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0938,627,353 - 38,633,796 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl938,627,249 - 38,633,796 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,410,157 - 37,416,605 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0937,695,725 - 37,702,162 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0937,783,127 - 37,789,578 (+)NCBIUU_Cfam_GSD_1.0
Ccl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560236,815,103 - 36,821,857 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936490253,034 - 259,965 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936490253,279 - 259,947 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1239,648,598 - 39,659,118 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11239,652,731 - 39,659,121 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,218,074 - 41,228,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11629,351,214 - 29,361,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666075615,422 - 624,588 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccl5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248753,334,078 - 3,341,614 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248753,334,136 - 3,342,085 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000065582   ⟹   ENSPPAP00000042652
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1721,210,798 - 21,219,172 (+)Ensembl
RefSeq Acc Id: XM_003817975   ⟹   XP_003818023
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21928,596,833 - 28,605,632 (+)NCBI
NHGRI_mPanPan11730,476,222 - 30,484,892 (+)NCBI
Mhudiblu_PPA_v01720,915,253 - 20,923,318 (+)NCBI
PanPan1.11721,210,798 - 21,219,172 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008971258   ⟹   XP_008969506
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21928,596,811 - 28,605,632 (+)NCBI
NHGRI_mPanPan11730,476,233 - 30,484,892 (+)NCBI
Mhudiblu_PPA_v01720,915,198 - 20,923,530 (+)NCBI
PanPan1.11721,210,811 - 21,219,172 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003818023 (Get FASTA)   NCBI Sequence Viewer  
  XP_008969506 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000042652
  ENSPPAP00000042652.1
Reference Protein Sequences
RefSeq Acc Id: XP_003818023   ⟸   XM_003817975
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CSX1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008969506   ⟸   XM_008971258
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSPPAP00000042652   ⟸   ENSPPAT00000065582
Protein Domains
Chemokine interleukin-8-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000043880 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000065582.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/TrEMBL
  Chemokine_CC_CS UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/TrEMBL
KEGG Report pps:100968258 UniProtKB/TrEMBL
NCBI Gene CCL5 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 5 UniProtKB/TrEMBL
  PTHR12015 UniProtKB/TrEMBL
Pfam IL8 UniProtKB/TrEMBL
PROSITE SMALL_CYTOKINES_CC UniProtKB/TrEMBL
SMART SCY UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/TrEMBL
UniProt A0A2R9CSX1 ENTREZGENE, UniProtKB/TrEMBL