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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl5
Name: C-C motif chemokine ligand 5
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl5decreases expressionEXP 6480464CTDQuercetin results in decreased expression of CCL5 mRNAPMID:10688038
Ccl5multiple interactionsEXP 6480464CTD[Quercetin co-treated with Mycophenolic Acid] results in decreased expression of CCL5 mRNA; Quercetin inhibits the reaction [Carrageenan results in increased expression of CCL5 protein]PMID:10688038 PMID:14654164
Ccl5increases expressionISOCcl5 (Mus musculus)6480464CTDQuercetin results in increased expression of CCL5 mRNAPMID:16455785
Ccl5multiple interactionsISOCCL5 (Homo sapiens)6480464CTD[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of CCL5 mRNAPMID:16797527
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