Lrp2 (LDL receptor related protein 2) - Rat Genome Database

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Gene: Lrp2 (LDL receptor related protein 2) Rattus norvegicus
Analyze
Symbol: Lrp2
Name: LDL receptor related protein 2
RGD ID: 68407
Description: Enables several functions, including PDZ domain binding activity; insulin-like growth factor I binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including chemoattraction of axon; positive regulation of transport; and protein transport. Located in several cellular components, including axonal growth cone; brush border membrane; and cell surface. Part of receptor complex. Used to study hypertension. Biomarker of autosomal dominant polycystic kidney disease; end stage renal disease; membranous glomerulonephritis; and nephrosis. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; INTERACTS WITH (S)-colchicine; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glycoprotein 330; gp330; low density lipoprotein receptor-related protein 2; low density lipoprotein-related protein 2; low-density lipoprotein receptor-related protein 2; LRP-2; megalin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,597,148 - 74,754,535 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl374,597,148 - 74,754,535 (-)EnsemblGRCr8
mRatBN7.2354,189,305 - 54,346,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl354,189,308 - 54,346,708 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx357,588,938 - 57,746,695 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0366,172,509 - 66,330,296 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,935,221 - 64,092,679 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,665,153 - 55,822,484 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)Ensemblrn6Rnor6.0
Rnor_5.0362,271,279 - 62,434,959 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4351,563,764 - 51,724,478 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera353,751,431 - 53,907,374 (-)NCBICelera
RGSC_v3.1351,460,135 - 51,620,850 (-)NCBI
Cytogenetic Map3q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
afimoxifene  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinol  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
aspartame  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
carbamazepine  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (ISO)
cholic acid  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diiodine  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
guggulsterone  (ISO)
hydrogen peroxide  (ISO)
lithocholic acid  (ISO)
manganese(II) chloride  (EXP)
methimazole  (EXP,ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phosgene  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP,ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vitamin D  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (IMP)
animal organ regeneration  (IEP)
aorta development  (ISO)
cell population proliferation  (ISO)
cellular response to growth factor stimulus  (IMP)
chemoattraction of axon  (IEA,IMP)
coronary artery morphogenesis  (IEA,ISO,ISS)
coronary vasculature development  (ISO)
cranial skeletal system development  (ISO)
endocytic hemoglobin import into cell  (IMP)
endocytosis  (IEA,IMP)
endosomal transport  (IMP)
epithelium development  (IEA)
folate import across plasma membrane  (IEA,ISO,ISS)
forebrain development  (ISO)
gene expression  (ISO)
heart development  (ISO)
kidney development  (IEA,ISO)
male gonad development  (IEA,ISO,ISS)
metal ion transport  (IDA,IEA,ISO)
metanephric proximal tubule development  (IEP)
negative regulation of apoptotic process  (ISO)
negative regulation of BMP signaling pathway  (IEA,ISO,ISS)
negative regulation of thrombin-activated receptor signaling pathway  (IC)
nervous system development  (IEA)
neural tube closure  (IEA,ISO,ISS)
neuron projection arborization  (IEA,ISO,ISS)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (IEA,ISO,ISS)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of endocytosis  (IEA,IMP)
positive regulation of lipoprotein transport  (IMP)
positive regulation of lysosomal protein catabolic process  (ISO)
positive regulation of neurogenesis  (IEA,ISO,ISS)
positive regulation of oligodendrocyte progenitor proliferation  (IEA,ISO,ISS)
protein import  (IMP,ISO)
protein transport  (IEA,ISO)
pulmonary artery morphogenesis  (IEA,ISO,ISS)
receptor-mediated endocytosis  (IBA,IDA,IEA,IMP,ISO)
response to leptin  (IEA,IMP,ISO)
response to retinoic acid  (IEP)
response to vitamin D  (IEP)
response to X-ray  (IDA)
response to xenobiotic stimulus  (IEP)
secondary heart field specification  (IEA,ISO,ISS)
sensory perception of sound  (IEA,ISO,ISS)
transcytosis  (IMP)
tube development  (IEA)
vagina development  (IEA,ISO,ISS)
ventricular compact myocardium morphogenesis  (IEA,ISO,ISS)
ventricular septum development  (ISO)
vitamin metabolic process  (ISO)

Cellular Component
apical part of cell  (IEA,ISO)
apical plasma membrane  (IBA,IDA,IEA,ISO)
axon  (IEA,ISO,ISS)
axonal growth cone  (IDA,IEA)
brush border  (IDA,IEA,ISO)
brush border membrane  (IDA,IEA,ISO)
cell surface  (IDA,IEA)
clathrin-coated pit  (IEA,ISO)
dendrite  (IEA,ISO,ISS)
endocytic vesicle  (IEA,ISO)
endoplasmic reticulum  (IEA,ISO)
endosome  (IDA,IEA,ISO)
endosome lumen  (IEA)
external side of plasma membrane  (IEA,ISO,ISS)
extracellular space  (IDA)
Golgi apparatus  (IEA,ISO)
membrane  (IEA,ISO)
plasma membrane  (IBA,IDA,IEA,ISO)
protein-containing complex  (IDA)
receptor complex  (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Megalin is a receptor for albumin in astrocytes and is required for the synthesis of the neurotrophic factor oleic acid. Bento-Abreu A, etal., J Neurochem. 2008 Aug;106(3):1149-59. doi: 10.1111/j.1471-4159.2008.05462.x. Epub 2008 May 5.
2. Megalin binds and mediates cellular internalization of folate binding protein. Birn H, etal., FEBS J. 2005 Sep;272(17):4423-30. doi: 10.1111/j.1742-4658.2005.04857.x.
3. Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I. Carro E, etal., J Neurosci. 2005 Nov 23;25(47):10884-93. doi: 10.1523/JNEUROSCI.2909-05.2005.
4. Hedgehog signaling update. Cohen MM, Am J Med Genet A. 2010 Aug;152A(8):1875-914. doi: 10.1002/ajmg.a.32909.
5. Megalin mediates the transport of leptin across the blood-CSF barrier. Dietrich MO, etal., Neurobiol Aging. 2008 Jun;29(6):902-12. Epub 2007 Feb 26.
6. Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M. Faber K, etal., Mol Endocrinol. 2006 Jan;20(1):212-8. Epub 2005 Aug 11.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin. Gburek J, etal., Am J Physiol Renal Physiol 2003 Sep;285(3):F451-8. Epub 2003 Apr 29.
9. Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin. Gburek J, etal., J Am Soc Nephrol. 2002 Feb;13(2):423-30.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Megalin binds and internalizes angiotensin II. Gonzalez-Villalobos R, etal., Am J Physiol Renal Physiol. 2005 Feb;288(2):F420-7. Epub 2004 Oct 5.
12. Megalin binds and internalizes angiotensin-(1-7). Gonzalez-Villalobos R, etal., Am J Physiol Renal Physiol. 2006 May;290(5):F1270-5. Epub 2005 Dec 27.
13. Evidence indicating that renal tubular metabolism of leptin is mediated by megalin but not by the leptin receptors. Hama H, etal., Endocrinology. 2004 Aug;145(8):3935-40. Epub 2004 May 6.
14. Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins. Hammad SM, etal., J Biol Chem. 2000 Apr 21;275(16):12003-8.
15. Role of endocytosis in cellular uptake of sex steroids. Hammes A, etal., Cell. 2005 Sep 9;122(5):751-62.
16. Gentamicin inhibits rat renal cortical homotypic endosomal fusion: role of megalin. Hammond TG, etal., Am J Physiol. 1997 Jan;272(1 Pt 2):F117-23.
17. Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells. Hosaka K, etal., Kidney Int. 2009 Jun;75(12):1308-15. Epub 2009 Apr 1.
18. The interaction between megalin and ClC-5 is scaffolded by the Na(+)-H(+) exchanger regulatory factor 2 (NHERF2) in proximal tubule cells. Hryciw DH, etal., Int J Biochem Cell Biol. 2012 May;44(5):815-23. doi: 10.1016/j.biocel.2012.02.007. Epub 2012 Feb 13.
19. The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. Hvidberg V, etal., FEBS Lett. 2005 Jan 31;579(3):773-7.
20. Soluble megalin is accumulated in the lumen of the rat endolymphatic sac. Ishida T, etal., Cell Struct Funct. 2006;31(2):77-85. Epub 2006 Oct 23.
21. Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2. Johanns M, etal., Sci Rep. 2017 Jun 28;7(1):4328. doi: 10.1038/s41598-017-04648-y.
22. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
23. Megalin-mediated endocytosis of cystatin C in proximal tubule cells. Kaseda R, etal., Biochem Biophys Res Commun. 2007 Jun 15;357(4):1130-4. Epub 2007 Apr 19.
24. The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Kerjaschki D and Farquhar MG, Proc Natl Acad Sci U S A. 1982 Sep;79(18):5557-61.
25. Megalin mediates renal uptake of heavy metal metallothionein complexes. Klassen RB, etal., Am J Physiol Renal Physiol. 2004 Sep;287(3):F393-403. Epub 2004 May 4.
26. Identification of functionally important sites in the first intracellular loop of the NaPi-IIa cotransporter. Kohler K, etal., Am J Physiol Renal Physiol. 2002 Apr;282(4):F687-96.
27. Low-density Lipoprotein Receptor-related Proteins in a Novel Mechanism of Axon Guidance and Peripheral Nerve Regeneration. Landowski LM, etal., J Biol Chem. 2016 Jan 15;291(3):1092-102. doi: 10.1074/jbc.M115.668996. Epub 2015 Nov 23.
28. Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release. Lisi S, etal., Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14858-63. Epub 2003 Dec 1.
29. Regulation of gp330/megalin expression by vitamins A and D. Liu W, etal., Eur J Clin Invest. 1998 Feb;28(2):100-7.
30. GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. Lou X, etal., J Am Soc Nephrol. 2002 Apr;13(4):918-27.
31. Proximal tubule Na transporter responses are the same during acute and chronic hypertension. Magyar CE, etal., Am J Physiol Renal Physiol. 2000 Aug;279(2):F358-69.
32. Serum antibodies against megalin (GP330) in patients with autoimmune thyroiditis. Marino M, etal., J Clin Endocrinol Metab. 1999 Jul;84(7):2468-74.
33. Megalin functions as an endocytic sonic hedgehog receptor. McCarthy RA, etal., J Biol Chem. 2002 Jul 12;277(28):25660-7. Epub 2002 Apr 18.
34. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
35. Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells. Minocha E, etal., In Vitro Cell Dev Biol Anim. 2019 Feb;55(2):138-147. doi: 10.1007/s11626-018-00315-2. Epub 2019 Jan 15.
36. Epithelial trafficking of Sonic hedgehog by megalin. Morales CR, etal., J Histochem Cytochem. 2006 Oct;54(10):1115-27. Epub 2006 Jun 26.
37. The adaptor protein ARH escorts megalin to and through endosomes. Nagai M, etal., Mol Biol Cell. 2003 Dec;14(12):4984-96. Epub 2003 Oct 3.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. Age-related change of endocytic receptors megalin and cubilin in the kidney in rats. Odera K, etal., Biogerontology. 2007 Apr 24;.
40. Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin. Oleinikov AV, etal., Biochem J. 2000 May 1;347 Pt 3:613-21.
41. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
44. GOA pipeline RGD automated data pipeline
45. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. Saito A, etal., Proc Natl Acad Sci U S A 1994 Oct 11;91(21):9725-9.
48. Na+-H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalin. Slattery C, etal., Cell Physiol Biochem. 2011;27(2):171-8. doi: 10.1159/000325219. Epub 2011 Feb 11.
49. Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2. Stefansson S, etal., J Biol Chem. 1996 Apr 5;271(14):8215-20.
50. Identification of an apical sorting determinant in the cytoplasmic tail of megalin. Takeda T, etal., Am J Physiol Cell Physiol. 2003 May;284(5):C1105-13. Epub 2003 Jan 8.
51. Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis. Tanimura A, etal., J Med Invest. 2011 Feb;58(1-2):140-7.
52. Cubilin and megalin co-localize in the neonatal inner ear. Tauris J, etal., Audiol Neurootol. 2009;14(4):267-78. doi: 10.1159/000199446. Epub 2009 Feb 6.
53. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
54. Reduced albumin reabsorption in the proximal tubule of early-stage diabetic rats. Tojo A, etal., Histochem Cell Biol. 2001 Sep;116(3):269-76.
55. Modulation of gene expression by moxonidine in rats with chronic renal failure. Vonend O, etal., Nephrol Dial Transplant. 2004 Sep;19(9):2217-22. Epub 2004 Jul 20.
56. Impaired endocytosis may represent an obstacle to gene therapy in polycystic kidney disease. Witzgall R, etal., Kidney Int. 2002 Jan;61(1 Suppl):132-7.
57. Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. Xu C, etal., Sci Signal. 2012 May 29;5(226):ra39. doi: 10.1126/scisignal.2002979.
58. Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy. Yammani RR, etal., Am J Physiol Endocrinol Metab 2001 Nov;281(5):E900-7.
59. Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiation. Yammani RR, etal., Am J Physiol Regul Integr Comp Physiol. 2002 Aug;283(2):R339-46.
60. Functional characterization of rat gp600/megalin promoter: combination of proximal Sp1 site and JCV repeat is important in rat gp600/megalin promoter activation. Zhao J, etal., Gene 2001 Mar 7;265(1-2):123-31.
Additional References at PubMed
PMID:7510321   PMID:7544804   PMID:9228033   PMID:10052453   PMID:10662735   PMID:12707383   PMID:12809172   PMID:12815097   PMID:12846736   PMID:14764706   PMID:15082773   PMID:15286052  
PMID:15342463   PMID:15616221   PMID:15623804   PMID:16027047   PMID:17228368   PMID:17245526   PMID:17457373   PMID:17846082   PMID:17897319   PMID:17990981   PMID:18174160   PMID:18927221  
PMID:19056867   PMID:20460439   PMID:20637285   PMID:20966072   PMID:21938401   PMID:22354480   PMID:23275343   PMID:23376485   PMID:23382219   PMID:23533145   PMID:23677864   PMID:23825075  
PMID:23836931   PMID:24586199   PMID:24639464   PMID:25807483   PMID:26025362   PMID:26173747   PMID:26248135   PMID:26822476   PMID:27241555   PMID:28289043   PMID:29187367   PMID:29286200  
PMID:29949391   PMID:32200675   PMID:36922642   PMID:37702891  


Genomics

Comparative Map Data
Lrp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,597,148 - 74,754,535 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl374,597,148 - 74,754,535 (-)EnsemblGRCr8
mRatBN7.2354,189,305 - 54,346,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl354,189,308 - 54,346,708 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx357,588,938 - 57,746,695 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0366,172,509 - 66,330,296 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,935,221 - 64,092,679 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,665,153 - 55,822,484 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)Ensemblrn6Rnor6.0
Rnor_5.0362,271,279 - 62,434,959 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4351,563,764 - 51,724,478 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera353,751,431 - 53,907,374 (-)NCBICelera
RGSC_v3.1351,460,135 - 51,620,850 (-)NCBI
Cytogenetic Map3q21NCBI
LRP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382169,127,109 - 169,362,534 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2169,127,109 - 169,362,534 (-)Ensemblhg38GRCh38
GRCh372169,983,619 - 170,219,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,691,865 - 169,927,368 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342169,810,367 - 170,044,520NCBI
Celera2163,608,960 - 163,839,028 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2161,880,497 - 162,110,457 (-)NCBIHuRef
CHM1_12169,989,632 - 170,225,372 (-)NCBICHM1_1
T2T-CHM13v2.02169,602,803 - 169,838,534 (-)NCBIT2T-CHM13v2.0
Lrp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,254,679 - 69,416,373 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl269,254,684 - 69,416,409 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38269,424,335 - 69,586,029 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,424,340 - 69,586,065 (-)Ensemblmm10GRCm38
MGSCv37269,262,392 - 69,424,124 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36269,225,174 - 69,386,906 (-)NCBIMGSCv36mm8
Celera271,089,849 - 71,251,632 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map240.74NCBI
Lrp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,160,946 - 5,314,948 (+)Ensembl
ChiLan1.0NW_0049554495,155,109 - 5,314,886 (+)NCBIChiLan1.0ChiLan1.0
LRP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21371,791,193 - 72,028,996 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B71,806,164 - 72,043,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B56,407,871 - 56,640,471 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B173,873,454 - 174,103,911 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,873,767 - 174,103,697 (-)EnsemblpanPan2panpan1.1
LRP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,910,450 - 14,107,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,911,865 - 14,107,546 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3613,921,313 - 14,118,067 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03614,026,860 - 14,223,177 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3614,025,608 - 14,223,772 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13614,111,272 - 14,307,564 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03614,099,044 - 14,295,347 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03614,212,187 - 14,408,758 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lrp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303131,178,787 - 131,372,907 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646910,244,881 - 10,438,935 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646910,245,001 - 10,438,933 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,565,303 - 75,716,694 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11575,565,299 - 75,754,604 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,725,590 - 84,788,031 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11054,672,876 - 54,889,374 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1054,711,517 - 54,889,208 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040144,669,443 - 144,856,881 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247876,798,938 - 6,998,697 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247876,797,462 - 6,998,859 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lrp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1546,732,163 - 46,887,606 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lrp2
2061 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)37359251285062403Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
D3Rat239  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8374,727,330 - 74,727,630 (+)Marker Load Pipeline
mRatBN7.2354,319,500 - 54,319,800 (+)MAPPERmRatBN7.2
Rnor_6.0355,795,318 - 55,795,617NCBIRnor6.0
Rnor_5.0362,407,260 - 62,407,559UniSTSRnor5.0
RGSC_v3.4351,697,010 - 51,697,309UniSTSRGSC3.4
RGSC_v3.4351,697,009 - 51,697,309RGDRGSC3.4
Celera353,880,411 - 53,880,710UniSTS
RGSC_v3.1351,593,353 - 51,593,777RGD
FHH x ACI Map339.47UniSTS
FHH x ACI Map339.47RGD
Cytogenetic Map3q21UniSTS
RH140983  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8374,598,474 - 74,598,823 (+)Marker Load Pipeline
mRatBN7.2354,190,634 - 54,190,983 (+)MAPPERmRatBN7.2
Rnor_6.0355,666,480 - 55,666,828NCBIRnor6.0
Rnor_5.0362,272,606 - 62,272,954UniSTSRnor5.0
RGSC_v3.4351,565,091 - 51,565,439UniSTSRGSC3.4
Celera353,752,758 - 53,753,106UniSTS
Cytogenetic Map3q21UniSTS
UniSTS:485602  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22024,385,485 - 24,385,544 (+)MAPPERmRatBN7.2
mRatBN7.2354,309,254 - 54,309,840 (+)MAPPERmRatBN7.2
Rnor_6.0355,785,073 - 55,785,657NCBIRnor6.0
Rnor_6.02025,862,227 - 25,862,285NCBIRnor6.0
Rnor_5.0362,397,014 - 62,397,599UniSTSRnor5.0
Rnor_5.02027,932,273 - 27,932,331UniSTSRnor5.0
RGSC_v3.4351,686,764 - 51,687,349UniSTSRGSC3.4
Celera353,870,165 - 53,870,750UniSTS
Celera2025,718,227 - 25,718,285UniSTS
Cytogenetic Map20p11-q11UniSTS
Cytogenetic Map3q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 8 63 162 91 90 59 91 59 6 343 181 9 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000082624   ⟹   ENSRNOP00000075159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl374,597,148 - 74,754,535 (-)Ensembl
mRatBN7.2 Ensembl354,189,308 - 54,346,708 (-)Ensembl
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113902   ⟹   ENSRNOP00000080818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl354,189,308 - 54,339,408 (-)Ensembl
RefSeq Acc Id: NM_030827   ⟹   NP_110454
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,597,148 - 74,754,535 (-)NCBI
mRatBN7.2354,189,308 - 54,346,708 (-)NCBI
Rnor_6.0355,665,153 - 55,822,484 (-)NCBI
Rnor_5.0362,271,279 - 62,434,959 (-)NCBI
RGSC_v3.4351,563,764 - 51,724,478 (-)RGD
Celera353,751,431 - 53,907,374 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_110454 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA51369 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075159
GenBank Protein P98158 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_110454   ⟸   NM_030827
- Peptide Label: precursor
- UniProtKB: P98158 (UniProtKB/Swiss-Prot),   A0A0G2K9W7 (UniProtKB/TrEMBL),   A6HM07 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075159   ⟸   ENSRNOT00000082624
Ensembl Acc Id: ENSRNOP00000080818   ⟸   ENSRNOT00000113902
Protein Domains
EGF-like   LDL-receptor class A

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692114
Promoter ID:EPDNEW_R2639
Type:multiple initiation site
Name:Lrp2_1
Description:LDL receptor related protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0355,822,498 - 55,822,558EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68407 AgrOrtholog
BIND 133316
BioCyc Gene G2FUF-49510 BioCyc
Ensembl Genes ENSRNOG00000056184 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000082624 ENTREZGENE
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot
  4.10.400.10 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot
  cEGF UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  EGF_LRP2 UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  LDL_receptor-like_sf UniProtKB/Swiss-Prot
  LDLR-related UniProtKB/Swiss-Prot
  LDLR_class-A_CS UniProtKB/Swiss-Prot
  LDLR_classB_rpt UniProtKB/Swiss-Prot
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot
  NOTCH1_EGF-like UniProtKB/Swiss-Prot
KEGG Report rno:29216 UniProtKB/Swiss-Prot
NCBI Gene 29216 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/Swiss-Prot
Pfam cEGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  EGF_LRP2 UniProtKB/Swiss-Prot
  FXa_inhibition UniProtKB/Swiss-Prot
  Ldl_recept_a UniProtKB/Swiss-Prot
  Ldl_recept_b UniProtKB/Swiss-Prot
PharmGKB LRP2 RGD
PhenoGen Lrp2 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LDLRA_1 UniProtKB/Swiss-Prot
  LDLRA_2 UniProtKB/Swiss-Prot
  LDLRB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000056184 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LDLa UniProtKB/Swiss-Prot
  SM00135 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
  SSF57424 UniProtKB/Swiss-Prot
  YWTD domain UniProtKB/Swiss-Prot
TIGR TC229506
UniProt A0A0G2K9W7 ENTREZGENE, UniProtKB/TrEMBL
  A6HM07 ENTREZGENE, UniProtKB/TrEMBL
  LRP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-11 Lrp2  LDL receptor related protein 2  Lrp2  low density lipoprotein receptor-related protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Lrp2  low density lipoprotein receptor-related protein 2  Lrp2  low density lipoprotein-related protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Lrp2  low density lipoprotein-related protein 2  Lrp2  low density lipoprotein receptor-related protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Lrp2  low density lipoprotein receptor-related protein 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the rat yolk sac carcinoma cells and in the distal intestine 628443
gene_physical_interaction binds with cubilin to bring about endocytosis and cobalamin transportation through the endoplasmic reticulum 628443
gene_process may be involved in the process of receptor-mediated endocytosis 68274
gene_process may be involved in the process of receptor-mediated endocytosis 68711