Cyp26a1 (cytochrome P450, family 26, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp26a1 (cytochrome P450, family 26, subfamily a, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp26a1
Name: cytochrome P450, family 26, subfamily a, polypeptide 1
RGD ID: 620161
Description: Predicted to enable monooxygenase activity and retinoic acid binding activity. Involved in kidney development; response to retinoic acid; and response to vitamin A. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human CYP26A1 (cytochrome P450 family 26 subfamily A member 1); PARTICIPATES IN retinoic acid metabolic pathway; retinol metabolic pathway; vitamin A deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cyp26; cytochrome P450, 26, retinoic acid; retinoic acid hydrolase; retinoic acid hydroxylase
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,883,822 - 244,887,657 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1244,883,752 - 244,887,657 (+)EnsemblGRCr8
mRatBN7.21235,471,368 - 235,475,204 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,471,298 - 235,475,204 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1243,856,469 - 243,860,304 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01250,788,639 - 250,792,474 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,626,842 - 243,630,677 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01256,382,861 - 256,386,729 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1256,382,791 - 256,386,729 (+)Ensemblrn6Rnor6.0
Rnor_5.01263,865,285 - 263,869,103 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41241,945,472 - 241,949,220 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1232,563,995 - 232,567,749 (+)NCBICelera
RGSC_v3.11242,135,064 - 242,138,791 (-)NCBI
Cytogenetic Map1q53NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethyl-4-tridecylmorpholine  (ISO)
2,6-dinitrotoluene  (EXP)
2-Ethylhexanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldrin  (ISO)
all-trans-4-hydroxyretinoic acid  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aphidicolin  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
belinostat  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP,ISO)
bictegravir  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
calciol  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dolutegravir  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP,ISO)
endrin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenarimol  (EXP)
fenpropidin  (ISO)
fipronil  (ISO)
fluconazole  (ISO)
flusilazole  (EXP)
folic acid  (ISO)
fonofos  (ISO)
gentamycin  (EXP)
glycine betaine  (ISO)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
iron dichloride  (ISO)
isotretinoin  (ISO)
ketoconazole  (EXP,ISO)
L-methionine  (ISO)
liarozole  (ISO)
lipopolysaccharide  (EXP)
lithocholic acid  (ISO)
mercaptopurine  (EXP)
methoxyacetic acid  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naled  (ISO)
nicotine  (ISO)
Nonylphenol  (ISO)
oleic acid  (ISO)
paracetamol  (ISO)
parathion  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
promegestone  (ISO)
propanal  (ISO)
propiconazole  (EXP,ISO)
purine-6-thiol  (EXP)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
riddelliine  (EXP)
rifampicin  (ISO)
Ro 41-5253  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
spiroxamine  (ISO)
streptozocin  (EXP)
tamoxifen  (EXP,ISO)
tebuconazole  (EXP)
terbufos  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (EXP,ISO)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A novel role for the retinoic acid-catabolizing enzyme CYP26A1 in Barrett's associated adenocarcinoma. Chang CL, etal., Oncogene. 2008 May 8;27(21):2951-60. doi: 10.1038/sj.onc.1210969. Epub 2007 Dec 3.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Expression of retinoic acid-synthesizing and -metabolizing enzymes during nephrogenesis in the rat. Marlier A and Gilbert T, Gene Expr Patterns. 2004 Dec;5(2):179-85.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development. Niederreither K, etal., Nat Genet 2002 May;31(1):84-8.
9. Enhanced expression of retinoic acid-metabolizing enzyme CYP26A1 in sunlight-damaged human skin. Osanai M and Lee GH, Med Mol Morphol. 2011 Dec;44(4):200-6. doi: 10.1007/s00795-010-0528-x. Epub 2011 Dec 17.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Vitamin A deficiency causes hyperglycemia and loss of pancreatic ß-cell mass. Trasino SE, etal., J Biol Chem. 2015 Jan 16;290(3):1456-73. doi: 10.1074/jbc.M114.616763. Epub 2014 Dec 1.
17. Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo. Wang Y, etal., Arch Biochem Biophys 2002 May 15;401(2):235-43.
18. cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450. White JA, etal., J Biol Chem 1997 Jul 25;272(30):18538-41.
19. Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung. Wu L and Ross AC, J Lipid Res. 2010 Feb;51(2):378-87. Epub 2009 Aug 20.
20. Vitamin A status affects obesity development and hepatic expression of key genes for fuel metabolism in Zucker fatty rats. Zhang Y, etal., Biochem Cell Biol. 2012 Aug;90(4):548-57. doi: 10.1139/o2012-012. Epub 2012 May 3.
Additional References at PubMed
PMID:9250660   PMID:9442090   PMID:9716180   PMID:10823918   PMID:15531370   PMID:15680360   PMID:17067568   PMID:17185629   PMID:18816858   PMID:20682464   PMID:20940140   PMID:22020119  
PMID:24325348   PMID:26937021  


Genomics

Comparative Map Data
Cyp26a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,883,822 - 244,887,657 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1244,883,752 - 244,887,657 (+)EnsemblGRCr8
mRatBN7.21235,471,368 - 235,475,204 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,471,298 - 235,475,204 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1243,856,469 - 243,860,304 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01250,788,639 - 250,792,474 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,626,842 - 243,630,677 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01256,382,861 - 256,386,729 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1256,382,791 - 256,386,729 (+)Ensemblrn6Rnor6.0
Rnor_5.01263,865,285 - 263,869,103 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41241,945,472 - 241,949,220 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1232,563,995 - 232,567,749 (+)NCBICelera
RGSC_v3.11242,135,064 - 242,138,791 (-)NCBI
Cytogenetic Map1q53NCBI
CYP26A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381093,073,475 - 93,077,885 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1093,073,475 - 93,077,885 (+)Ensemblhg38GRCh38
GRCh371094,833,232 - 94,837,642 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,823,222 - 94,827,631 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341094,823,221 - 94,827,631NCBI
Celera1088,574,439 - 88,578,848 (+)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1088,460,761 - 88,465,170 (+)NCBIHuRef
CHM1_11095,115,931 - 95,120,340 (+)NCBICHM1_1
T2T-CHM13v2.01093,953,370 - 93,957,780 (+)NCBIT2T-CHM13v2.0
Cyp26a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391937,686,186 - 37,689,984 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1937,686,246 - 37,689,984 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381937,697,738 - 37,701,536 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,697,798 - 37,701,536 (+)Ensemblmm10GRCm38
MGSCv371937,772,298 - 37,776,026 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361937,762,998 - 37,766,680 (+)NCBIMGSCv36mm8
Celera1938,484,789 - 38,488,516 (+)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.36NCBI
CYP26A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28105,109,727 - 105,113,815 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110105,101,325 - 105,119,130 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01089,817,623 - 89,822,024 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11093,330,460 - 93,334,105 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1093,330,460 - 93,334,105 (+)EnsemblpanPan2panpan1.1
CYP26A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1287,423,955 - 7,432,359 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl287,428,772 - 7,432,370 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha287,605,185 - 7,608,930 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0287,688,620 - 7,692,365 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl287,688,780 - 7,692,376 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1287,408,839 - 7,412,573 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0287,446,115 - 7,449,848 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0287,607,985 - 7,611,730 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101977861
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721340,177,867 - 40,181,785 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366011,809,992 - 1,814,074 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366011,810,572 - 1,815,927 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP26A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14104,563,195 - 104,567,095 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114104,561,394 - 104,567,099 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214114,201,978 - 114,205,507 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP26A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1986,310,142 - 86,328,622 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl986,325,401 - 86,328,775 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604847,091,899 - 47,095,645 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101699044
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247374,325,755 - 4,329,758 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247374,324,964 - 4,329,488 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116893788
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1236,060,638 - 36,064,306 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cyp26a1
8 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:219
Count of miRNA genes:143
Interacting mature miRNAs:157
Transcripts:ENSRNOT00000022549
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
Cyp26a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81244,886,000 - 244,886,830 (+)Marker Load Pipeline
Rnor_6.01256,385,040 - 256,385,902NCBIRnor6.0
Rnor_5.01263,867,464 - 263,868,276UniSTSRnor5.0
RGSC_v3.41241,946,299 - 241,947,041UniSTSRGSC3.4
Celera1232,566,174 - 232,566,922UniSTS
Cytogenetic Map1q53UniSTS
UniSTS:462985  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,471,578 - 235,472,403 (+)MAPPERmRatBN7.2
Rnor_6.01256,383,072 - 256,383,896NCBIRnor6.0
Rnor_5.01263,865,496 - 263,866,320UniSTSRnor5.0
RGSC_v3.41241,948,185 - 241,949,009UniSTSRGSC3.4
Celera1232,564,206 - 232,565,030UniSTS
Cytogenetic Map1q53UniSTS
Cyp26a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,471,563 - 235,471,846 (+)MAPPERmRatBN7.2
Rnor_6.01256,383,057 - 256,383,339NCBIRnor6.0
Rnor_5.01263,865,481 - 263,865,763UniSTSRnor5.0
RGSC_v3.41241,948,742 - 241,949,024UniSTSRGSC3.4
Celera1232,564,191 - 232,564,473UniSTS
Cytogenetic Map1q53UniSTS
Cyp26a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,471,325 - 235,472,693 (+)MAPPERmRatBN7.2
Rnor_6.01256,382,819 - 256,384,186NCBIRnor6.0
Rnor_5.01263,865,243 - 263,866,610UniSTSRnor5.0
RGSC_v3.41241,947,895 - 241,949,262UniSTSRGSC3.4
Celera1232,563,953 - 232,565,320UniSTS
Cytogenetic Map1q53UniSTS
Cyp26a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41241,948,225 - 241,948,587UniSTSRGSC3.4
Cytogenetic Map1q53UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 11 59 125 83 89 59 50 59 5 288 132 9 106 76 89 30 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000022549   ⟹   ENSRNOP00000022549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1244,883,752 - 244,887,657 (+)Ensembl
mRatBN7.2 Ensembl1235,471,298 - 235,475,204 (+)Ensembl
Rnor_6.0 Ensembl1256,382,791 - 256,386,729 (+)Ensembl
RefSeq Acc Id: NM_130408   ⟹   NP_569092
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81244,883,822 - 244,887,657 (+)NCBI
mRatBN7.21235,471,368 - 235,475,204 (+)NCBI
Rnor_6.01256,382,861 - 256,386,729 (+)NCBI
Rnor_5.01263,865,285 - 263,869,103 (+)NCBI
RGSC_v3.41241,945,472 - 241,949,220 (-)RGD
Celera1232,563,995 - 232,567,749 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_569092 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL32056 (Get FASTA)   NCBI Sequence Viewer  
  ABB42998 (Get FASTA)   NCBI Sequence Viewer  
  ABC48786 (Get FASTA)   NCBI Sequence Viewer  
  EDM13204 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022549
  ENSRNOP00000022549.3
RefSeq Acc Id: NP_569092   ⟸   NM_130408
- UniProtKB: Q8VIL0 (UniProtKB/TrEMBL),   A6I173 (UniProtKB/TrEMBL),   G3V861 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022549   ⟸   ENSRNOT00000022549

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V861-F1-model_v2 AlphaFold G3V861 1-497 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620161 AgrOrtholog
BioCyc Gene G2FUF-55801 BioCyc
Ensembl Genes ENSRNOG00000016750 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022549 ENTREZGENE
  ENSRNOT00000022549.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
KEGG Report rno:154985 UniProtKB/TrEMBL
NCBI Gene 154985 ENTREZGENE
PANTHER CYTOCHROME P450 26 UniProtKB/TrEMBL
  CYTOCHROME P450 26A1 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp26a1 PhenoGen
PRINTS EP450IV UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016750 RatGTEx
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt A6I173 ENTREZGENE, UniProtKB/TrEMBL
  G3V861 ENTREZGENE, UniProtKB/TrEMBL
  Q2PMW7_RAT UniProtKB/TrEMBL
  Q304P5_RAT UniProtKB/TrEMBL
  Q8VIL0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp26a1  cytochrome P450, family 26, subfamily a, polypeptide 1  Cyp26a1  cytochrome P450, family 26, subfamily A, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 Cyp26a1        Symbol and Name status set to provisional 70820 PROVISIONAL
2004-12-06   cytochrome P450, family 26, subfamily A, polypeptide 1  Cyp26a1  cytochrome P450, 26, retinoic acid  Name updated 1299863 APPROVED
2004-09-10 Cyp26a1  cytochrome P450, 26, retinoic acid  Cyp26    Symbol and Name updated 1299863 APPROVED
2002-08-07 Cyp26  cytochrome P450, 26, retinoic acid      Symbol and Name status set to provisional 70820 PROVISIONAL