RGD Reference Report - Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung. - Rat Genome Database

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Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung.

Authors: Wu, L  Ross, AC 
Citation: Wu L and Ross AC, J Lipid Res. 2010 Feb;51(2):378-87. Epub 2009 Aug 20.
RGD ID: 6484694
Pubmed: PMID:19700416   (View Abstract at PubMed)
PMCID: PMC2803240   (View Article at PubMed Central)
DOI: DOI:10.1194/jlr.M001222   (Journal Full-text)

Vitamin A (VA) is essential for fetal lung development and postnatal lung maturation. VA is stored mainly as retinyl esters (REs), which may be mobilized for production of retinoic acid (RA). This study was designed 1) to evaluate several acidic retinoids for their potential to increase RE in the lungs of VA-supplemented neonatal rats, and 2) to determine the expression of retinoid homeostatic genes related to retinol uptake, esterification, and catabolism as possible mechanisms. When neonatal rats were treated with VA combined with any one of several acidic retinoids (RA, 9-cis-RA, or Am580, a stable analog of RA), lung RE increased approximately 5-7 times more than after an equal amount of VA alone. Retinol uptake and esterification during the period of absorption correlated with increased expression of both STRA6 (retinol-binding protein receptor) and LRAT (retinol esterification), while a reduction in RE after 12 h in Am580-treated, VA-supplemented rats correlated with a strong and persistent increase in CYP26B1 (RA hydroxylase). We conclude that neonatal lung RE can be increased synergistically by VA combined with both natural and synthetic acidic retinoids, concomitant with induction of the dyad of STRA6 and LRAT. However, the pronounced and prolonged induction of CYP26B1 by Am580 may counteract lung RE accumulation after the absorption process is completed.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to retinoic acid  IEP 6484694; 6484694; 6484694; 6484694 RGD 
response to vitamin A  IEP 6484694; 6484694; 6484694 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cyp26a1  (cytochrome P450, family 26, subfamily a, polypeptide 1)
Cyp26b1  (cytochrome P450, family 26, subfamily b, polypeptide 1)
Lrat  (lecithin retinol acyltransferase)
Stra6  (signaling receptor and transporter of retinol STRA6)

Objects referenced in this article
Gene CYP26A1 cytochrome P450 family 26 subfamily A member 1 Homo sapiens
Gene CYP26B1 cytochrome P450 family 26 subfamily B member 1 Homo sapiens
Gene LRAT lecithin retinol acyltransferase Homo sapiens
Gene STRA6 signaling receptor and transporter of retinol STRA6 Homo sapiens
Gene Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 Mus musculus
Gene Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus
Gene Lrat lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) Mus musculus
Gene Stra6 stimulated by retinoic acid gene 6 Mus musculus

Additional Information