RETINOIC ACID METABOLIC PATHWAY (PW:0001004)

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Description

Animal species cannot synthesize retinol or vitamin A. They derive it from precursor carotenoids such as beta-carotene via retinal and they can store it as retinyl esters (REs) which they can hydrolyze (liver is the largest REs storage). Thus, both plant and animal dietary sources can provide vitamin A. Vitamin A metabolites such as retinal and retinoic acid play essential roles in vision and a range of cellular processes. More recently, a role for retinol in mitochondrial signaling where it may

Pathway Diagram:

Ariadne Genomics Inc. retinal dehydrogenases circ_retinol ---> cell_retinol atRA CYPs retinoic acid signaling pathway retinyl esters all-trans retinoic acid retinol dehydrogenases CES1 Lrat all-trans retinoic acid ---> atRA CYPs all-trans retinoic acid ---> retinoic acid signaling pathway retinal Stra6 Ttr Rbp4 Crabp2 apo_Rbp1 apo_Rbp1 ---| Lrat retinyl esters ---> cell_retinol Rbp1 Fabp5 all-trans retinoic acid ---> retinoic acid signaling pathway all-trans retinoic acid ---- Crabp2 all-trans retinoic acid ---- Fabp5 atRAs catabolism all-trans retinoic acid ---- Crabp1 retinal ---> all-trans retinoic acid Rbp4 ---- Stra6 cell_retinol ---- Rbp1 Rbp1 ---- retinal retinal <--> cell_retinol circ_retinol ---- Ttr circ_retinol ---- Rbp4 Rbp4 ---- Ttr cell_retinol ---> retinyl esters apo_Rbp1 --+> CES1 circ_retinol cell_retinol Crabp1
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Genes in Pathway:

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retinoic acid metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 JBrowse link 1 238,222,689 238,264,381 RGD:6484672
RGD:6771354
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 JBrowse link 8 77,640,234 77,719,488 RGD:6484672
RGD:6771322
RGD:6771354
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 JBrowse link 1 127,302,920 127,337,828 RGD:6484672
RGD:6771322
RGD:6771354
G Crabp1 cellular retinoic acid binding protein 1 JBrowse link 8 59,344,097 59,352,135 RGD:6484672
G Crabp2 cellular retinoic acid binding protein 2 JBrowse link 2 187,322,416 187,326,794 RGD:6484672
RGD:6771322
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 JBrowse link 1 256,382,861 256,386,729 RGD:6484672
RGD:6484694
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 JBrowse link 4 116,261,796 116,278,615 RGD:6484672
RGD:6484694
RGD:6771354
G Cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 JBrowse link 1 256,369,410 256,380,649 RGD:6484672
G Dhrs9 dehydrogenase/reductase 9 JBrowse link 3 55,623,671 55,645,883 RGD:6484672
RGD:6771322
RGD:6771354
G Fabp5 fatty acid binding protein 5 JBrowse link 2 93,981,662 93,985,322 RGD:6484672
G Lrat lecithin retinol acyltransferase JBrowse link 2 181,896,304 181,905,366 RGD:6484672
RGD:6484694
G Rbp1 retinol binding protein 1 JBrowse link 8 106,449,321 106,470,842 RGD:6484672
RGD:6771322
G Rbp4 retinol binding protein 4 JBrowse link 1 256,806,476 256,813,678 RGD:6484671
RGD:6484672
G Rdh10 retinol dehydrogenase 10 JBrowse link 5 2,605,265 2,631,905 RGD:6484672
RGD:6771354
G Rdh16 retinol dehydrogenase 16 (all-trans) JBrowse link 7 71,058,150 71,072,685 RGD:6771354
G Rdh7 retinol dehydrogenase 7 JBrowse link 7 71,125,358 71,164,014 RGD:6484672
G Stra6 stimulated by retinoic acid 6 JBrowse link 8 62,925,364 62,944,438 RGD:6484671
RGD:6484672
RGD:6484694
G Ttr transthyretin JBrowse link 18 15,532,963 15,542,180 RGD:6484671

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small Moleculecirc_retinolcirculating retinol
Functional Classretinol dehydrogenasesenzymes that catalyze the reversible conversion of retinol to retinal
Small Moleculecell_retinolintracellular retinol
Functional ClassatRA CYPsthe cytochrome P450 family 26 members involved in the catabolism of retinoic acid
Functional Classretinal dehydrogenasesthe enzymes the catalyze the irreversible conversion of retinal to retinoic acid

Pathway Gene Annotations

Disease Annotations Associated with Genes in the retinoic acid metabolic pathway
Disease TermsGene Symbols
Abortion, SpontaneousRbp4
AdenocarcinomaCyp26a1
Adenomatous Polyposis ColiCyp26a1
Alzheimer DiseaseTtr
Amyloid NeuropathiesTtr
Amyloid Neuropathies, FamilialTtr
AmyloidosisTtr
Amyloidosis, FamilialTtr
Amyloidosis, Hereditary, Transthyretin-RelatedTtr
Anophthalmia with Pulmonary HypoplasiaStra6
AnophthalmosStra6
Autistic DisorderAldh1a3
Barrett EsophagusCyp26a1
Brain IschemiaTtr
CarcinomaRbp1 , Rbp4
Carcinoma, Ductal, BreastLrat
Carcinoma, HepatocellularFabp5
Carcinoma, Renal CellAldh1a1 , Crabp1
CardiomyopathiesTtr
Cardiovascular AbnormalitiesStra6
Carpal Tunnel SyndromeTtr
Colonic NeoplasmsCyp26a1
Craniofacial AbnormalitiesRdh10 , Stra6
Creutzfeldt-Jakob SyndromeAldh1a1
Diabetes Mellitus, Type 2Rbp4
DiGeorge SyndromeAldh1a2
Drug EruptionsTtr
Drug-Induced Liver InjuryLrat , Rbp1 , Ttr
Dystransthyretinemic Euthyroidal HyperthyroxinemiaTtr
EndometriosisCyp26a1
Esophageal NeoplasmsCyp26a1
Esophageal Squamous Cell CarcinomaCrabp1
Eye Diseases, HereditaryLrat
Fetal DeathRdh10
Focal Facial Dermal Dysplasia 4Cyp26c1
Heart Defects, CongenitalStra6
Heart FailureRbp4
Hernia, DiaphragmaticStra6
Intellectual DisabilityStra6
KeloidCrabp1
KeratomalaciaRbp4
Kidney DiseasesRbp4
Leber Congenital AmaurosisLrat , Rbp1
Leber Congenital Amaurosis 14Lrat
Liver Cirrhosis, ExperimentalAldh1a1 , Cyp26a1 , Lrat , Rdh10
Liver Diseases, AlcoholicRbp4
Liver NeoplasmsCrabp1
Lung DiseasesStra6
Lung NeoplasmsTtr
Mammary Neoplasms, AnimalRbp1 , Rbp4
Mammary Neoplasms, ExperimentalRbp1 , Rbp4
MeningomyeloceleAldh1a2
Methylmalonic AcidemiaCrabp2
Microphthalmia, Isolated 8Aldh1a3
MICROPHTHALMIA, ISOLATED, WITH COLOBOMA 10Rbp4
Microphthalmia, Syndromic 1Cyp26c1 , Stra6
MicrophthalmosStra6
Mouth DiseasesCyp26b1
Myocardial IschemiaFabp5
NecrosisRbp4
ObesityCyp26b1 , Rbp4
Optic Atrophy, Hereditary, LeberLrat
OsteoarthritisAldh1a2
Pancreatic NeoplasmsAldh1a1
Parkinsonian DisordersAldh1a1 , Aldh1a2
Persistent Fetal Circulation SyndromeStra6
Polycystic Ovary SyndromeRbp4
Prostatic NeoplasmsAldh1a2 , Fabp5
PsoriasisFabp5
Radiohumeral Fusions with Other Skeletal and Craniofacial AnomaliesCyp26b1
RecurrenceCrabp2
Retinal DystrophiesLrat
Retinal Dystrophy, Iris Coloboma, and Comedogenic Acne SyndromeRbp4
Retinitis PigmentosaLrat
SchizophreniaAldh1a3
Spinal DysraphismCyp26a1
Stomach NeoplasmsAldh1a3 , Rbp1 , Rbp4
Vision DisordersRbp4
Vitamin A DeficiencyLrat , Rbp4
Pathway Annotations Associated with Genes in the retinoic acid metabolic pathway
Pathway TermsGene Symbols
altered retinoid cycle metabolic pathwayLrat
arginine and proline metabolic pathwayAldh1a1
ascorbate and aldarate metabolic pathwayAldh1a1
beta-alanine metabolic pathwayAldh1a1 , Aldh1a3
cyclophosphamide pharmacodynamics pathwayAldh1a1
cyclophosphamide pharmacokinetics pathwayAldh1a1
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaFabp5
fatty acid metabolic pathwayAldh1a1
forkhead class A signaling pathwayTtr
gluconeogenesis pathwayAldh1a1 , Aldh1a3
glycerolipid metabolic pathwayAldh1a1
glycolysis pathwayAldh1a1 , Aldh1a3
glycolysis/gluconeogenesis pathwayAldh1a1 , Aldh1a3
histidine metabolic pathwayAldh1a1 , Aldh1a3
ifosfamide pharmacodynamics pathwayAldh1a1
ifosfamide pharmacokinetics pathwayAldh1a1
lysine degradation pathwayAldh1a1
neviparine pharmacokinetics pathwayAldh1a1
pentose and glucuronate interconversion pathwayAldh1a1
phase I biotransformation pathway via cytochrome P450Aldh1a3
phenylalanine metabolic pathwayAldh1a3
propanoate metabolic pathwayAldh1a1
pyruvate metabolic pathwayAldh1a1
retinitis pigmentosa pathwayLrat
retinoic acid metabolic pathwayAldh1a1 , Aldh1a2 , Aldh1a3 , Crabp1 , Crabp2 , Cyp26a1 , Cyp26b1 , Cyp26c1 , Dhrs9 , Fabp5 , Lrat , Rbp1 , Rbp4 , Rdh10 , Rdh16 , Rdh7 , Stra6 , Ttr
retinoid cycle metabolic pathwayLrat , Rbp1 , Rdh10
retinol metabolic pathwayAldh1a1 , Aldh1a2 , Cyp26a1 , Cyp26b1 , Cyp26c1 , Dhrs9 , Lrat , Rdh10 , Rdh16 , Rdh7
tryptophan metabolic pathwayAldh1a1
tyrosine metabolic pathwayAldh1a3
valine, leucine and isoleucine degradation pathwayAldh1a1
vitamin A deficiency pathwayAldh1a1 , Aldh1a2 , Cyp26a1 , Dhrs9 , Lrat , Rdh16
Phenotype Annotations Associated with Genes in the retinoic acid metabolic pathway
Phenotype TermsGene Symbols
alcohol preferenceAldh1a1

References Associated with the retinoic acid metabolic pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: