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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620161
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp26a1
Name: cytochrome P450, family 26, subfamily a, polypeptide 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp26a1affects expressionISOCYP26A1 (Homo sapiens)6480464CTDValproic Acid affects the expression of CYP26A1 mRNAPMID:25979313
Cyp26a1affects expressionISOCyp26a1 (Mus musculus)6480464CTDValproic Acid affects the expression of CYP26A1 mRNAPMID:27693483
Cyp26a1decreases expressionISOCYP26A1 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of CYP26A1 mRNAPMID:23179753 PMID:24383497 PMID:24935251 PMID:28001369
Cyp26a1decreases expressionISOCyp26a1 (Mus musculus)6480464CTDValproic Acid results in decreased expression of CYP26A1 mRNAPMID:19136453 PMID:20546886 PMID:31445079
Cyp26a1increases expressionISOCYP26A1 (Homo sapiens)6480464CTDValproic Acid results in increased expression of CYP26A1 mRNAPMID:26272509
Cyp26a1increases methylationISOCYP26A1 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of CYP26A1 genePMID:29501571
Cyp26a1multiple interactionsISOCYP26A1 (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP26A1 mRNAPMID:27188386
Cyp26a1multiple interactionsISOCyp26a1 (Mus musculus)6480464CTD4-(2-(5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl)ethen-1-yl)benzoic acid inhibits the reaction [Valproic Acid results in increased expression of CYP26A1 mRNA]; [Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] affects the expression of CYP26A1 mRNAPMID:27693483
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