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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620161
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp26a1
Name: cytochrome P450, family 26, subfamily a, polypeptide 1
Acc ID: CHEBI:80656
Term: all-trans-4-oxoretinoic acid
Definition: A retinoid that consists of all-trans-retinoic acid bearing an oxo substituent at position 4 on the cyclohexenyl ring.
Chemical ID: MESH:C002202
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp26a1increases chemical synthesisISOCYP26A1 (Homo sapiens)6480464CTDCYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid; CYP26A1 protein results in increased chemical synthesis of 4-oxoretinoic acidPMID:12091498 PMID:17460545 PMID:25492813
Cyp26a1increases expressionISOCYP26A1 (Homo sapiens)6480464CTD4-oxoretinoic acid results in increased expression of CYP26A1 mRNAPMID:25492813
Cyp26a1increases metabolic processingISOCYP26A1 (Homo sapiens)6480464CTDCYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid; CYP26A1 protein results in increased metabolism of 4-oxoretinoic acidPMID:12091498 PMID:25492813
Cyp26a1multiple interactionsISOCYP26A1 (Homo sapiens)6480464CTD[[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid; [[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid; [R 115866 results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid]PMID:12091498 PMID:25492813
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