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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620161
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp26a1
Name: cytochrome P450, family 26, subfamily a, polypeptide 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp26a1decreases response to substanceISOCYP26A1 (Homo sapiens)6480464CTDCYP26A1 protein results in decreased susceptibility to Hydrogen PeroxidePMID:15703382
Cyp26a1multiple interactionsISOCYP26A1 (Homo sapiens)6480464CTDCYP26A1 protein inhibits the reaction [[Tretinoin co-treated with Hydrogen Peroxide] results in increased expression of CDKN1A protein]; CYP26A1 protein inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 protein]; CYP26A1 protein inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; CYP26A1 protein inhibits the reaction [Tretinoin promotes the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 protein]]PMID:15703382
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