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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620161
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp26a1
Name: cytochrome P450, family 26, subfamily a, polypeptide 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp26a1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of CYP26A1 mRNAPMID:21839799
Cyp26a1affects methylationISOCYP26A1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CYP26A1 promoterPMID:27901495
Cyp26a1increases expressionISOCyp26a1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CYP26A1 mRNAPMID:32417428
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