Gene:	Slc2a2 ( Rattus norvegicus ) solute carrier family 2 (facilitated glucose transporter), member 2
Description:	acts as a sodium-independent glucose transporter; plays a role in intestinal glucose transport
Synonyms:	Solute carrier family 2 A2 (gkucose transporter type 2); GTT2; Glut2; Solute carrier family 2 A2 (gkucose transporter, type 2);  (details...)
ArrayIDs:	A_44_P488355; 6489641; 6350948; 1387228_at; 6409080; L28135_at; 6211450; 6433153; 5674169; 6457650; 6070558; 5797048; 6745050; A_43_P11600; 5789368; 6177400; 5861619; A_44_P226612; 5982753; GE20030;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: SLC2A2     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Slc2a2     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Slc2a2 genome assembly 3.1 2 115981388 - 116010832     Rat Celera Assembly 2 106794546 - 106828205     RGSC genome assembly v3.4 2 116036427 - 116065870     Cytogenetic 2 q24 Mus musculus Slc2a2 Mouse genome assembly build 36.1 3 28596899 - 28627252     Cytogenetic 3 3 A3 Homo sapiens SLC2A2 human genome assembly 3 172196838 - 172227470     Human genome assembly build 36.2 3 172196831 - 172227462     Cytogenetic 3 q26.1-q26.2   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Note Reference functions as a transporter of glucose, galactose and fructose 625552 Gene Ontology D-glucose transmembrane transporter activity,  transporter activity,  dehydroascorbic acid transporter activity ...  (details...)
Biological Process	Note Reference has low substrate affinity and Km value in the range of 16-20 mM 625552 involved in hexose transport into enterocytes 625552 may play a role in hexose transport across intestinal brush border membranes   Gene Ontology transmembrane transport,  fructose transport,  sugar utilization ...  (details...)
Cellular Component	Note Reference protein localized to jejunal brush border membranes 625552 localized to apical plasma membrane and basolateral membrane 625552 Gene Ontology brush border,  endosome,  cytoplasm ...  (details...)
Disease	Ontology Diabetes Mellitus, Experimental,  Neural Tube Defects,  Glycogen Storage Disease ...  (details...)
Expression	Note Reference expressed in jejunal brush-border membrane 625552
Pathway	Ontology facilitative sugar transporter mediated glucose transport pathway,  insulin secretion pathway (details...)
Regulation	Note Reference regulated by vascular GLP-2 and/or luminal glucose 625552 glucose transporter activity is inhibited by the flavonol quercetin 730195
External Links
Databases	DATABASE ID SOURCE PROSITE: SUGAR_TRANSPORT_2 IPI PROSITE: MFS IPI PROSITE: SUGAR_TRANSPORT_1 IPI UNIPARC: UPI000004ECD1 IPI UNIPARC: UPI0001B7BC03 IPI UNIPARC: UPI0000419E61 IPI UNIPARC: UPI0001B7BC02 IPI UNIPARC: UPI00000E6C62 IPI KEGG Report: rno:25351 ENTREZGENE HomoloGene Group ID: 68047 ENTREZGENE Germonline: 3705 Pfam: Sugar_tr IPI KEGG Pathway: 04950 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE InterPro: MFS_general_subst_transpt. IPI InterPro: Major_facilitator_SF. IPI InterPro: Glc_transpt_2. IPI InterPro: Sugar/inositol_transpt. IPI InterPro: Sub_transporter. IPI InterPro: Sugar_transporter_CS. IPI Ensembl Protein: ENSRNOP00000062196 IPI Ensembl Protein: ENSRNOP00000061413 IPI Ensembl Protein: ENSRNOP00000015866 IPI IPI: IPI00196643 IPI IPI: IPI00949465 IPI IPI: IPI00949103 IPI IPI: IPI00882410 IPI IPI: IPI00882453 IPI Entrez Gene: Slc2a2 ENTREZGENE IMAGE_CLONE: IMAGE:7127751 IMAGE-MGC_LOAD MGC_CLONE: MGC:93555 IMAGE-MGC_LOAD Ensembl Genes: ENSRNOG00000011875 IPI TIGR: TC205552 UniProt: Q63235_RAT IPI UniProt: Q68FZ1_RAT IPI UniProt: GTR2_RAT IPI UniProt: Q6LEA4_RAT IPI UniProt: Q6LEA3_RAT IPI UniProt: Q6LEA2_RAT IPI UniProt: Q6LEA1_RAT IPI UniProt: Q6LEA0_RAT IPI UniProt: Q6LE99_RAT IPI UniProt: Q6LE97_RAT IPI Superfamily-SCOP: MFS_gen_substrate_transporter IPI RatMap: 41236 ENTREZGENE TIGRFAMs: SP IPI PRINTS: SUGRTRNSPORT. IPI PRINTS: GLUCTRSPORT2. IPI
Sequences	Nucleotide: J03145 Get FASTA Search GEO Profiles Nucleotide: BC078875 Get FASTA Search GEO Profiles Nucleotide: L28678 Get FASTA Search GEO Profiles Nucleotide: L28135 Get FASTA Search GEO Profiles Nucleotide: L28134 Get FASTA Search GEO Profiles Nucleotide: L28133 Get FASTA Search GEO Profiles Nucleotide: L28132 Get FASTA Search GEO Profiles Nucleotide: L28131 Get FASTA Search GEO Profiles Nucleotide: L28130 Get FASTA Search GEO Profiles Nucleotide: L28129 Get FASTA Search GEO Profiles Nucleotide: L28128 Get FASTA Search GEO Profiles Nucleotide: L28127 Get FASTA Search GEO Profiles Nucleotide: L28126 Get FASTA Search GEO Profiles Nucleotide: CH473961 Get FASTA Search GEO Profiles Nucleotide: NM_012879 Get FASTA Search GEO Profiles Nucleotide: XM_001063900 Get FASTA Search GEO Profiles (View all 16 Nucleotide Accessions) Protein: Q6LEA4 Get FASTA Protein: Q6LEA3 Get FASTA Protein: Q6LEA2 Get FASTA Protein: Q6LEA1 Get FASTA Protein: Q6LEA0 Get FASTA Protein: Q6LE99 Get FASTA Protein: Q6LE97 Get FASTA Protein: Q68FZ1 Get FASTA Protein: Q63235 Get FASTA Protein: P12336 Get FASTA Protein: AAA41298 Get FASTA Protein: AAH78875 Get FASTA Protein: AAA99959 Get FASTA Protein: AAA99958 Get FASTA Protein: AAA99957 Get FASTA Protein: AAA99956 Get FASTA Protein: AAA99955 Get FASTA Protein: AAA99954 Get FASTA Protein: AAA99953 Get FASTA Protein: AAA99952 Get FASTA Protein: AAA99951 Get FASTA Protein: AAB05001 Get FASTA Protein: EDM01139 Get FASTA Protein: EDM01138 Get FASTA Protein: EDM01137 Get FASTA Protein: NP_037011 Get FASTA Protein: XP_001063900 Get FASTA (View all 27 Protein Accessions)
Clusters	UniGene: 89295
References
Curated References	22 references in RGD related to Slc2a2
Other References	29 other references at PubMed related to Slc2a2
Database Information
RGD ID	3705
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-SEP-04: Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 solute carrier family 2, member 2 APPROVED Name updated 1299863 09-APR-03: Slc2a2 solute carrier family 2, member 2 Solute carrier family 2 A2 (gkucose transporter, type 2) APPROVED Name updated 629478 10-JUN-02: Slc2a2 Solute carrier family 2 A2 (gkucose transporter, type 2) APPROVED Symbol and Name status set to approved 70586