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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3705
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc2a2
Name: solute carrier family 2 member 2
Acc ID: CHEBI:17276
Term: phloretin
Definition: A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'.
Chemical ID: MESH:D010693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc2a2multiple interactionsEXP 6480464CTDPhloretin inhibits the reaction [SLC2A2 protein results in increased uptake of Glucose]PMID:17272349
Slc2a2decreases expressionISOSLC2A2 (Homo sapiens)6480464CTDPhloretin results in decreased expression of SLC2A2 proteinPMID:26616219
Slc2a2multiple interactionsISOSlc2a2 (Mus musculus)6480464CTDPhloretin inhibits the reaction [Fluorouracil promotes the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]]; Phloretin inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]PMID:15986457
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