RGD Reference Report - SLC2A2 gene expression in kidney of diabetic rats is regulated by HNF-1alpha and HNF-3beta. - Rat Genome Database

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SLC2A2 gene expression in kidney of diabetic rats is regulated by HNF-1alpha and HNF-3beta.

Authors: Freitas, HS  Schaan, BD  David-Silva, A  Sabino-Silva, R  Okamoto, MM  Alves-Wagner, AB  Mori, RC  Machado, UF 
Citation: Freitas HS, etal., Mol Cell Endocrinol. 2009 Jun 16;305(1-2):63-70. Epub 2009 Mar 4.
RGD ID: 2312358
Pubmed: PMID:19433262   (View Abstract at PubMed)
DOI: DOI:10.1016/j.mce.2009.02.014   (Journal Full-text)

We hypothesize that, in kidney of diabetic rats, hepatocyte nuclear factors (HNF-1alpha and HNF-3beta) play a critical role in the overexpression of solute carrier 2A2 (SLC2A2) gene. Diabetic rats submitted or not to rapid (up to 12h) and short-term (1, 4 and 6 days) insulin treatment were investigated. Twofold increase in GLUT2 mRNA was observed in diabetic, accompanied by significant increases in HNF-1alpha and HNF-3beta expression and binding activity. Additional 2-fold increase in GLUT2 mRNA and HNF-3beta expression/activity was observed in 12-h insulin-treated rats. Six-day insulin treatment decreased GLUT2 mRNA and HNF-1alpha expression and activity to levels of non-diabetic rats, whereas HNF-3beta decreased to levels of non-insulin-treated diabetic rats. Our results provide evidence for a link between the overexpression of SLC2A2 gene and the transcriptional activity of HNF-1alpha and HNF-3beta in kidney of diabetic rats. Furthermore, recovery of SLC2A2 gene after 6-day insulin treatment also involves HNF-1alpha and HNF-3beta activity.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISOFoxa2 (Rattus norvegicus)2312358; 2312358mRNA:increased expression:kidney cortexRGD 
Experimental Diabetes Mellitus  IEP 2312358mRNA:increased expression:kidney cortexRGD 
Experimental Diabetes Mellitus  ISOSlc2a2 (Rattus norvegicus)2312358; 2312358mRNA:increased expression:kidneyRGD 
Experimental Diabetes Mellitus  IEP 2312358mRNA:increased expression:kidneyRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to insulin  IEP 2312358 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Foxa2  (forkhead box A2)
Slc2a2  (solute carrier family 2 member 2)

Genes (Mus musculus)
Foxa2  (forkhead box A2)
Slc2a2  (solute carrier family 2 (facilitated glucose transporter), member 2)

Genes (Homo sapiens)
FOXA2  (forkhead box A2)
SLC2A2  (solute carrier family 2 member 2)


Additional Information