Ppp2ca (protein phosphatase 2 catalytic subunit alpha) - Rat Genome Database

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Gene: Ppp2ca (protein phosphatase 2 catalytic subunit alpha) Rattus norvegicus
Analyze
Symbol: Ppp2ca (Ensembl: Ppp2cb)
Name: protein phosphatase 2 catalytic subunit alpha (Ensembl:protein phosphatase 2 catalytic subunit beta)
RGD ID: 3380
Description: Enables several functions, including beta-2 adrenergic receptor binding activity; enzyme binding activity; and protein antigen binding activity. Involved in several processes, including cellular response to ethanol; cellular response to follicle-stimulating hormone stimulus; and negative regulation of protein import into nucleus. Acts upstream of or within regulation of protein autophosphorylation; regulation of protein catabolic process; and regulation of signaling receptor activity. Located in terminal bouton. Part of protein phosphatase type 2A complex. Biomarker of type 2 diabetes mellitus. Orthologous to human PPP2CA (protein phosphatase 2 catalytic subunit alpha); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; dopamine signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103694903; PP2A-alpha; Pp2a1; Protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2a, catalytic subunit, alpha isoform; protein phosphatase-2A-alpha; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,856,534 - 36,878,789 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21036,358,110 - 36,377,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,358,101 - 36,377,862 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1041,052,411 - 41,072,171 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,542,376 - 40,562,136 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01036,046,099 - 36,065,860 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01037,534,449 - 37,554,861 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,535,871 - 37,554,664 (-)Ensemblrn6Rnor6.0
Rnor_5.01037,324,233 - 37,343,985 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41037,621,256 - 37,641,008 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1035,713,154 - 35,732,937 (+)NCBICelera
RGSC_v3.11037,627,685 - 37,647,436 (+)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
5-methoxypsoralen  (ISO)
7,12-dimethyltetraphene  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camptothecin  (ISO)
chloroquine  (ISO)
choline  (ISO)
clofibric acid  (EXP)
clozapine  (EXP)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
daunorubicin  (ISO)
dehydroepiandrosterone  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
dobutamine  (ISO)
donepezil hydrochloride  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
estragole  (EXP)
ethanol  (EXP,ISO)
fenthion  (ISO)
fingolimod hydrochloride  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (EXP)
gentamycin  (EXP)
glycine betaine  (ISO)
haloperidol  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
imipramine  (EXP)
ionomycin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
lipopolysaccharide  (ISO)
Maduramicin  (EXP)
memantine  (ISO)
Mesaconitine  (EXP)
methidathion  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Morroniside  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
okadaic acid  (EXP,ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
razoxane  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tadalafil  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
tolonium chloride  (ISO)
toluene  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
uranium atom  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac ventricle development  (IEP)
cellular response to calcium ion  (IEP)
cellular response to cytokine stimulus  (IEP)
cellular response to ethanol  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to glucose stimulus  (IEP,IMP)
cellular response to insulin stimulus  (IEP)
cellular response to steroid hormone stimulus  (IEP)
heart development  (IEP)
meiotic cell cycle  (IEA)
mesoderm development  (ISO)
mitotic cell cycle  (IBA)
negative regulation of calcium ion transmembrane transporter activity  (IMP)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of glycolytic process through fructose-6-phosphate  (ISO)
negative regulation of hippo signaling  (ISO,ISS)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
negative regulation of protein import into nucleus  (IMP)
negative regulation of protein phosphorylation  (IMP)
peptidyl-threonine dephosphorylation  (ISO)
positive regulation of dephosphorylation  (IMP)
positive regulation of extrinsic apoptotic signaling pathway  (IMP)
positive regulation of NLRP3 inflammasome complex assembly  (ISO,ISS)
protein dephosphorylation  (IDA,ISO)
regulation of G1/S transition of mitotic cell cycle  (ISO)
regulation of microtubule polymerization  (IEA,IMP)
regulation of protein autophosphorylation  (IMP)
regulation of protein catabolic process  (IMP)
regulation of protein phosphorylation  (IMP)
regulation of signaling receptor activity  (IMP)
regulation of transcription by RNA polymerase II  (IEA)
regulation of transcription elongation by RNA polymerase II  (ISO)
response to lead ion  (IDA)
RNA polymerase II transcription initiation surveillance  (ISO,ISS)
T cell homeostasis  (ISO,ISS)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam. Arif M, etal., Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1144-9. doi: 10.1073/pnas.1322614111. Epub 2014 Jan 6.
2. Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET. Arnaud L, etal., FEBS Lett. 2011 Sep 2;585(17):2653-9. doi: 10.1016/j.febslet.2011.07.020. Epub 2011 Jul 28.
3. High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 beta-cells by increasing the posttranslational carboxylmethylation of its catalytic subunit. Arora DK, etal., Endocrinology. 2014 Feb;155(2):380-91. doi: 10.1210/en.2013-1773. Epub 2013 Nov 21.
4. ATM protein kinase: the linchpin of cellular defenses to stress. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
5. Prolactin activates mammalian target-of-rapamycin through phosphatidylinositol 3-kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 in lymphoma cells. Bishop JD, etal., J Endocrinol. 2006 Aug;190(2):307-12.
6. PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway. Chan PM, etal., J Biol Chem. 2008 Sep 5;283(36):24949-61. doi: 10.1074/jbc.M801728200. Epub 2008 Jun 27.
7. An NMDA receptor signaling complex with protein phosphatase 2A. Chan SF and Sucher NJ, J Neurosci. 2001 Oct 15;21(20):7985-92.
8. I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. Chen S, etal., J Biol Chem. 2008 Apr 18;283(16):10513-21. doi: 10.1074/jbc.M709852200. Epub 2008 Feb 1.
9. Expression of replication factor C 40-kDa subunit is down-regulated during neonatal development in rat ventricular myocardium. Chim SS, etal., J Cell Biochem 2000 Jun 12;78(4):533-40.
10. Deregulation of CREB signaling pathway induced by chronic hyperglycemia downregulates NeuroD transcription. Cho IS, etal., PLoS One. 2012;7(4):e34860. doi: 10.1371/journal.pone.0034860. Epub 2012 Apr 3.
11. Protein phosphatase 2A is associated with class C L-type calcium channels (Cav1.2) and antagonizes channel phosphorylation by cAMP-dependent protein kinase. Davare MA, etal., J Biol Chem. 2000 Dec 15;275(50):39710-7.
12. Free fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolism. Galbo T, etal., PLoS One. 2011;6(11):e27424. doi: 10.1371/journal.pone.0027424. Epub 2011 Nov 7.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations. Goedert M, etal., J Neurochem. 2000 Nov;75(5):2155-62.
15. Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain. Gong CX, etal., Brain Res. 2000 Jan 24;853(2):299-309.
16. Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation. Hall DD, etal., Biochemistry. 2006 Mar 14;45(10):3448-59.
17. AMP-activated protein kinase: also regulated by ADP? Hardie DG, etal., Trends Biochem Sci. 2011 Sep;36(9):470-7. doi: 10.1016/j.tibs.2011.06.004. Epub 2011 Jul 23.
18. Expression and mapping of protein phosphatase 2A alpha in the developing rat heart. Heller FA, etal., Pediatr Res. 1998 Jan;43(1):68-76.
19. A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer. Hellwinkel OJ, etal., BJU Int. 2008 Jun;101(11):1454-60. Epub 2008 Mar 11.
20. Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases. Ishida A, etal., Br J Pharmacol. 2008 Jun;154(4):729-40. doi: 10.1038/bjp.2008.127. Epub 2008 May 5.
21. siRNA-mediated depletion of endogenous protein phosphatase 2Acalpha markedly attenuates ceramide-activated protein phosphatase activity in insulin-secreting INS-832/13 cells. Jangati GR, etal., Biochem Biophys Res Commun. 2006 Sep 22;348(2):649-52. doi: 10.1016/j.bbrc.2006.07.100. Epub 2006 Jul 28.
22. Molecular cloning of cDNA for the catalytic subunit of rat liver type 2A protein phosphatase, and detection of high levels of expression of the gene in normal and cancer cells. Kitagawa Y, etal., Biochim Biophys Acta 1988 Nov 10;951(1):123-9.
23. Carboxymethylation of nuclear protein serine/threonine phosphatase X. Kloeker S, etal., Biochem J. 1997 Oct 15;327 ( Pt 2):481-6.
24. PP2A-mediated dephosphorylation of p107 plays a critical role in chondrocyte cell cycle arrest by FGF. Kolupaeva V, etal., PLoS One. 2008;3(10):e3447. doi: 10.1371/journal.pone.0003447. Epub 2008 Oct 17.
25. Differential gene expression in skeletal muscle after induction of heart failure: impact of cytokines on protein phosphatase 2A expression. Krankel N, etal., Mol Genet Metab. 2003 Sep-Oct;80(1-2):262-71.
26. FSH-induced phosphoprotein phosphatase 2A-mediated deactivation of particulate phosphodiesterase-4 activities is abolished after alteration in proteoglycan synthesis in immature rat Sertoli cells. Levallet G, etal., J Endocrinol. 2008 Apr;197(1):45-54. doi: 10.1677/JOE-07-0497.
27. A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C. Li D, etal., J Neurosci. 2005 Feb 23;25(8):1914-23.
28. Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation. Liangpunsakul S, etal., Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1173-81. doi: 10.1152/ajpgi.90349.2008. Epub 2008 Oct 2.
29. Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels. Liangpunsakul S, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G1004-12. doi: 10.1152/ajpgi.00482.2009. Epub 2010 Mar 11.
30. Melatonin relieves neuropathic allodynia through spinal MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent epigenetic modification of hmgb1 transcription. Lin TB, etal., J Pineal Res. 2016 Apr;60(3):263-76. doi: 10.1111/jpi.12307. Epub 2016 Jan 29.
31. Induced TRPC1 expression increases protein phosphatase 2A sensitizing intestinal epithelial cells to apoptosis through inhibition of NF-kappaB activation. Marasa BS, etal., Am J Physiol Cell Physiol. 2008 May;294(5):C1277-87. doi: 10.1152/ajpcell.90635.2007. Epub 2008 Mar 5.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Role of protein phosphatases in malignant transformation. Nagao M, etal., Princess Takamatsu Symp. 1989;20:177-84.
34. A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A. Nakashima A, etal., FEBS Lett. 2013 Sep 17;587(18):2924-9. doi: 10.1016/j.febslet.2013.07.027. Epub 2013 Jul 24.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. Overexpression of the mTOR alpha4 phosphoprotein activates protein phosphatase 2A and increases Stat1alpha binding to PIAS1. Nien WL, etal., Mol Cell Endocrinol. 2007 Jan 15;263(1-2):10-7. Epub 2006 Nov 2.
37. Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells. O'Malley PG, etal., Biochem J. 2005 Sep 15;390(Pt 3):665-73.
38. Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation. Pallottini V, etal., Mech Ageing Dev. 2007 Nov-Dec;128(11-12):688-95. Epub 2007 Oct 16.
39. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Rahman A, etal., Neurotoxicology. 2012 Jun;33(3):370-83. doi: 10.1016/j.neuro.2012.02.014. Epub 2012 Mar 1.
43. Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats. Ramamoorthy S, etal., Biochem Biophys Res Commun. 2010 Jan 15;391(3):1517-21. doi: 10.1016/j.bbrc.2009.12.110. Epub 2009 Dec 24.
44. GOA pipeline RGD automated data pipeline
45. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Seshacharyulu P, etal., Cancer Lett. 2013 Jul 10;335(1):9-18. doi: 10.1016/j.canlet.2013.02.036. Epub 2013 Feb 20.
48. Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression. Shi K, etal., Biochem Biophys Res Commun. 2007 Nov 23;363(3):626-32. Epub 2007 Sep 17.
49. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
50. Modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor alpha by dehydroepiandrosterone and other peroxisome proliferators. Tamasi V, etal., Mol Pharmacol. 2008 Mar;73(3):968-76. Epub 2007 Dec 13.
51. Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Ugi S, etal., Mol Cell Biol 2002 Apr;22(7):2375-87.
52. The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Van Kanegan MJ and Strack S, Mol Cell Biol. 2009 Feb;29(3):662-74. doi: 10.1128/MCB.01242-08. Epub 2008 Nov 24.
53. Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity. Wang D, etal., FASEB J. 2010 Sep;24(9):3511-21. doi: 10.1096/fj.10-156661. Epub 2010 Apr 15.
54. Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Wheat WH, etal., Mol Cell Biol. 1994 Sep;14(9):5881-90.
55. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
56. The alpha4-containing form of protein phosphatase 2A in liver and hepatic cells. Yoo SJ, etal., J Cell Biochem. 2008 Sep 1;105(1):290-300. doi: 10.1002/jcb.21830.
57. Protein phosphatase 2A facilitates axonogenesis by dephosphorylating CRMP2. Zhu LQ, etal., J Neurosci. 2010 Mar 10;30(10):3839-48. doi: 10.1523/JNEUROSCI.5174-09.2010.
Additional References at PubMed
PMID:2174876   PMID:2554255   PMID:2554256   PMID:9770493   PMID:9847399   PMID:9882488   PMID:9920888   PMID:10781942   PMID:11590243   PMID:12606433   PMID:12885400   PMID:15194871  
PMID:15489334   PMID:15661743   PMID:15865439   PMID:16030137   PMID:16123140   PMID:16129692   PMID:16258073   PMID:16420440   PMID:16549018   PMID:16717086   PMID:16754670   PMID:16822951  
PMID:17055435   PMID:17158207   PMID:17174897   PMID:17255109   PMID:17259072   PMID:18084284   PMID:18388891   PMID:18550542   PMID:18835920   PMID:20017541   PMID:20080667   PMID:20106966  
PMID:20458337   PMID:20485545   PMID:20684275   PMID:21080067   PMID:21257729   PMID:22031698   PMID:22082260   PMID:22242112   PMID:22892311   PMID:22892312   PMID:23020770   PMID:23716589  
PMID:23840384   PMID:24475092   PMID:24625528   PMID:25007834   PMID:25038454   PMID:25869568   PMID:26316108   PMID:26378614   PMID:27459928   PMID:27572322   PMID:28442576   PMID:30595372  
PMID:30611118   PMID:31974600   PMID:35043508   PMID:36555780   PMID:37722489  


Genomics

Comparative Map Data
Ppp2ca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,856,534 - 36,878,789 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21036,358,110 - 36,377,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,358,101 - 36,377,862 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1041,052,411 - 41,072,171 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,542,376 - 40,562,136 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01036,046,099 - 36,065,860 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01037,534,449 - 37,554,861 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,535,871 - 37,554,664 (-)Ensemblrn6Rnor6.0
Rnor_5.01037,324,233 - 37,343,985 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41037,621,256 - 37,641,008 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1035,713,154 - 35,732,937 (+)NCBICelera
RGSC_v3.11037,627,685 - 37,647,436 (+)NCBI
Cytogenetic Map10q22NCBI
PPP2CA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385134,194,332 - 134,226,073 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5134,193,978 - 134,226,083 (-)Ensemblhg38GRCh38
GRCh375133,530,023 - 133,561,764 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365133,560,047 - 133,589,849 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345133,560,046 - 133,589,849NCBI
Celera5129,655,849 - 129,685,663 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5128,717,117 - 128,746,747 (-)NCBIHuRef
CHM1_15132,964,711 - 132,994,524 (-)NCBICHM1_1
T2T-CHM13v2.05134,717,969 - 134,749,722 (-)NCBIT2T-CHM13v2.0
Ppp2ca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391151,989,651 - 52,013,576 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1151,989,508 - 52,018,605 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381152,098,824 - 52,122,749 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,098,681 - 52,127,778 (+)Ensemblmm10GRCm38
MGSCv371151,912,326 - 51,936,251 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361151,942,247 - 51,966,172 (+)NCBIMGSCv36mm8
Celera1156,667,217 - 56,691,076 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.86NCBI
Ppp2ca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554085,433,268 - 5,460,361 (-)Ensembl
ChiLan1.0NW_0049554085,435,117 - 5,460,361 (-)NCBIChiLan1.0ChiLan1.0
PPP2CA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24129,495,422 - 129,527,796 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15127,634,159 - 127,667,358 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05129,599,606 - 129,629,312 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15135,751,964 - 135,761,395 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5135,751,958 - 135,765,786 (-)EnsemblpanPan2panpan1.1
PPP2CA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11122,388,327 - 22,410,052 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1122,385,257 - 22,410,052 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1121,134,537 - 21,156,029 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01123,189,481 - 23,211,243 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1123,188,436 - 23,211,451 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11121,889,485 - 21,911,229 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01121,754,643 - 21,776,444 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01122,397,162 - 22,418,841 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppp2ca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213114,028,481 - 114,052,523 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366471,031,119 - 1,055,149 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366471,031,118 - 1,055,961 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP2CA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2136,494,541 - 136,522,646 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12136,497,780 - 136,522,630 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22142,095,024 - 142,123,724 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP2CA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12336,999,110 - 37,028,916 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2336,997,078 - 37,029,280 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603440,904,228 - 40,936,193 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp2ca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473338,012,392 - 38,036,914 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473338,012,694 - 38,033,745 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppp2ca
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1934,685,976 - 34,706,593 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppp2ca
210 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:80
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000007621
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH127380  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,279,884 - 82,280,069 (+)MAPPERmRatBN7.2
mRatBN7.21036,377,586 - 36,377,771 (+)MAPPERmRatBN7.2
mRatBN7.21036,377,586 - 36,377,771 (-)MAPPERmRatBN7.2
mRatBN7.21182,279,884 - 82,280,069 (-)MAPPERmRatBN7.2
Rnor_6.01186,422,634 - 86,422,818NCBIRnor6.0
Rnor_6.01037,535,201 - 37,535,385NCBIRnor6.0
Rnor_5.01189,523,373 - 89,523,557UniSTSRnor5.0
Rnor_5.01037,343,708 - 37,343,892UniSTSRnor5.0
RGSC_v3.41037,640,731 - 37,640,915UniSTSRGSC3.4
RGSC_v3.41184,271,502 - 84,271,686UniSTSRGSC3.4
Celera1181,056,435 - 81,056,619UniSTS
Celera1035,732,660 - 35,732,844UniSTS
Cytogenetic Map10q22UniSTS
PMC22838P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,278,463 - 82,278,570 (+)MAPPERmRatBN7.2
mRatBN7.21036,358,300 - 36,358,407 (+)MAPPERmRatBN7.2
mRatBN7.21036,358,300 - 36,358,407 (-)MAPPERmRatBN7.2
mRatBN7.21182,278,463 - 82,278,570 (-)MAPPERmRatBN7.2
Rnor_6.01186,421,213 - 86,421,319NCBIRnor6.0
Rnor_6.01037,554,564 - 37,554,670NCBIRnor6.0
Rnor_5.01189,521,952 - 89,522,058UniSTSRnor5.0
Rnor_5.01037,324,424 - 37,324,530UniSTSRnor5.0
RGSC_v3.41037,621,447 - 37,621,553UniSTSRGSC3.4
RGSC_v3.41184,270,081 - 84,270,187UniSTSRGSC3.4
Celera1181,056,065 - 81,056,171UniSTS
Celera1035,713,345 - 35,713,451UniSTS
Cytogenetic Map10q22UniSTS
Ppp2ca  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,278,604 - 82,279,072 (+)MAPPERmRatBN7.2
Rnor_6.01186,421,354 - 86,421,821NCBIRnor6.0
Rnor_5.01189,522,093 - 89,522,560UniSTSRnor5.0
RGSC_v3.41184,270,222 - 84,270,689UniSTSRGSC3.4
Cytogenetic Map10q22UniSTS
Ppp2ca  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,373,858 - 36,373,905 (+)MAPPERmRatBN7.2
mRatBN7.21182,279,039 - 82,279,090 (+)MAPPERmRatBN7.2
Rnor_6.01186,421,789 - 86,421,839NCBIRnor6.0
Rnor_5.01189,522,528 - 89,522,578UniSTSRnor5.0
RGSC_v3.41184,270,657 - 84,270,707UniSTSRGSC3.4
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 6 40 151 77 72 43 86 43 12 308 166 11 125 76 87 29 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC130253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY749432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M33114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M58438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000007621   ⟹   ENSRNOP00000007621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,358,110 - 36,377,862 (+)Ensembl
Rnor_6.0 Ensembl1037,535,871 - 37,554,664 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079985   ⟹   ENSRNOP00000071286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,359,000 - 36,377,862 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101942   ⟹   ENSRNOP00000084457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,358,101 - 36,376,782 (+)Ensembl
RefSeq Acc Id: NM_017039   ⟹   NP_058735
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,859,037 - 36,878,789 (+)NCBI
mRatBN7.21036,358,110 - 36,377,864 (+)NCBI
Rnor_6.01037,535,108 - 37,554,861 (-)NCBI
Rnor_5.01037,324,233 - 37,343,985 (+)NCBI
RGSC_v3.41037,621,256 - 37,641,008 (+)RGD
Celera1035,713,154 - 35,732,937 (+)RGD
Sequence:
RefSeq Acc Id: XM_063268417   ⟹   XP_063124487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,856,534 - 36,878,789 (+)NCBI
RefSeq Acc Id: XM_063268418   ⟹   XP_063124488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,859,560 - 36,878,789 (+)NCBI
RefSeq Acc Id: XM_063268419   ⟹   XP_063124489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,873,224 - 36,878,789 (+)NCBI
RefSeq Acc Id: XM_063268420   ⟹   XP_063124490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,856,534 - 36,873,748 (+)NCBI
RefSeq Acc Id: NP_058735   ⟸   NM_017039
- UniProtKB: P63331 (UniProtKB/Swiss-Prot),   A6HE97 (UniProtKB/TrEMBL),   A0A8I5ZZ39 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007621   ⟸   ENSRNOT00000007621
Ensembl Acc Id: ENSRNOP00000084457   ⟸   ENSRNOT00000101942
Ensembl Acc Id: ENSRNOP00000071286   ⟸   ENSRNOT00000079985
RefSeq Acc Id: XP_063124487   ⟸   XM_063268417
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063124490   ⟸   XM_063268420
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063124488   ⟸   XM_063268418
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063124489   ⟸   XM_063268419
- Peptide Label: isoform X3
Protein Domains
Serine/threonine specific protein phosphatases

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63331-F1-model_v2 AlphaFold P63331 1-309 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3380 AgrOrtholog
BioCyc Gene G2FUF-25177 BioCyc
Ensembl Genes ENSRNOG00000005389 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007621.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096821 IMAGE-MGC_LOAD
  IMAGE:7104697 IMAGE-MGC_LOAD
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot
  Metallo-depent_PP-like UniProtKB/Swiss-Prot
  PPA2-like UniProtKB/Swiss-Prot
  Ser/Thr-sp_prot-phosphatase UniProtKB/Swiss-Prot
KEGG Report rno:24672 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91734 IMAGE-MGC_LOAD
  MGC:91735 IMAGE-MGC_LOAD
NCBI Gene 24672 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED UniProtKB/Swiss-Prot
Pfam Metallophos UniProtKB/Swiss-Prot
PhenoGen Ppp2ca PhenoGen
PRINTS STPHPHTASE UniProtKB/Swiss-Prot
PROSITE SER_THR_PHOSPHATASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005389 RatGTEx
SMART PP2Ac UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56300 UniProtKB/Swiss-Prot
UniProt A0A8I5ZZ39 ENTREZGENE
  A0A8L2R3S5 ENTREZGENE, UniProtKB/TrEMBL
  A6HE97 ENTREZGENE, UniProtKB/TrEMBL
  A6HE98_RAT UniProtKB/TrEMBL
  P63331 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O88591 UniProtKB/Swiss-Prot
  P13353 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-02 Ppp2ca  protein phosphatase 2 catalytic subunit alpha  LOC103694903  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform  Data merged from RGD:9257421 737654 PROVISIONAL
2016-02-17 Ppp2ca  protein phosphatase 2 catalytic subunit alpha  Ppp2ca  protein phosphatase 2, catalytic subunit, alpha isozyme  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103694903  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-06-26 Ppp2ca  protein phosphatase 2, catalytic subunit, alpha isozyme  Ppp2ca  protein phosphatase 2, catalytic subunit, alpha isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Ppp2ca  protein phosphatase 2, catalytic subunit, alpha isoform  Ppp2ca  protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ppp2ca  protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform    protein phosphatase 2a, catalytic subunit, alpha isoform  Name updated 1299863 APPROVED
2002-06-10 Ppp2ca  Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform      Symbol and Name status set to approved 70586 APPROVED