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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3380
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppp2ca
Name: protein phosphatase 2 catalytic subunit alpha
Acc ID: CHEBI:44658
Term: okadaic acid
Definition: A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.
Chemical ID: MESH:D019319
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp2cadecreases response to substanceEXP 6480464CTDPPP2CA protein mutant form results in decreased susceptibility to Okadaic AcidPMID:29241734
Ppp2cadecreases activityISOPPP2CA (Homo sapiens)6480464CTDOkadaic Acid results in decreased activity of PPP2CA proteinPMID:15965230 PMID:22205926
Ppp2camultiple interactionsISOPPP2CA (Homo sapiens)6480464CTD[Okadaic Acid results in decreased activity of PPP2CA protein] which results in decreased susceptibility to Dexamethasone; morroniside inhibits the reaction [Okadaic Acid results in decreased methylation of and results in increased phosphorylation of and results in decreased activity of [PPP2CA protein binds to PPP2CB protein]]; Okadaic Acid inhibits the reaction [Arsenic Trioxide promotes the reaction [AKT1 protein binds to PPP2CA protein]]; Okadaic Acid results in decreased activity of [PPP2CA protein binds to PPP2CB protein]; Okadaic Acid results in decreased methylation of and results in increased phosphorylation of and results in decreased activity of [PPP2CA protein binds to PPP2CB protein]PMID:21655183 PMID:22205926 PMID:26836014
Ppp2camultiple interactionsISOPpp2ca (Mus musculus)6480464CTD[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Okadaic Acid co-treated with Fingolimod Hydrochloride co-treated with Memantine] results in increased expression of PPP2CA mRNA; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Okadaic Acid co-treated with Fingolimod Hydrochloride co-treated with Memantine] results in increased expression of PPP2CA protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Okadaic Acid co-treated with Fingolimod Hydrochloride] results in decreased expression of PPP2CA protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Okadaic Acid co-treated with Fingolimod Hydrochloride] results in increased expression of PPP2CA mRNAPMID:33069748
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