DOPAMINE SIGNALING PATHWAY (PW:0000394)

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Description

Dopamine (DA) acts a neurotransmitter and neuromodulator in the brain and peripherally as an autocrine/paracrine hormone. Dopamine exerts its major role in the nervous system where it is involved in motor control and action selection, reward and motivation, behavior, memory and cognition. The many effects are achieved through the projections dopaminergic (DA-producing) neurons establish and the inputs they receive and which shape DA release. DA neurons in midbrain areas such as the substantia ni

Pathway Diagram:

Elsevier Inc. Ptpn5 ventral tegmental area (VTA) <--> prefrontal cortex (PFC) substantia nigra pars compacta (SNc) ---> prefrontal cortex (PFC) ventral tegmental area (VTA) substantia nigra pars compacta (SNc) dopamine dopamine biosynthetic pathway Gnao1 Gnai2 Gnal G protein mediated signaling pathway via Galphas family G protein mediated signaling pathway via Galphai family D1-like receptor Arrb2 ---> G protein independent DA signaling D2-like receptor ventral tegmental area (VTA) <--> nucleus accumbens (NAc) substantia nigra pars compacta (SNc) ---> dorsal striatum/caudate-putamen D1-like receptor ---- dopamine D2-like receptor ---- dopamine DA receptor heteromer ---- dopamine Ca2+ protein kinase C (PKC) signaling pathway calcium/calcium-mediated signaling pathway calcium transport pathway protein kinase A (PKA) signaling pathway Ppp1r1b kinases/phosphatases nucleus accumbens (NAc) prefrontal cortex (PFC) the extracellular signal-regulated Raf/Mek/Erk signaling pathway G protein mediated signaling pathway via Galphaq family thalamus --+> cortical areas DA receptor heteromer cortical areas G protein independent DA signaling motivation prefrontal cortex (PFC) --+> nucleus accumbens (NAc) reward action selection, motor function substantia nigra pars reticulata (SNr) ---| thalamus nucleus accumbens (NAc) ---> ventral pallidum (VP) ventral pallidum (VP) ---> cortical areas GRK in DA signaling Ppp1c Ptpn5 ---| the extracellular signal-regulated Raf/Mek/Erk signaling pathway Ppp1c --+> Ptpn5 globus pallidus, external (GPe) subthalamic nucleus (STN) --+> substantia nigra pars reticulata (SNr) subthalamic nucleus (STN) thalamus Ppp1r1b kinases/phosphatases ---> Ppp1r1b Ppp1r1b ---> protein kinase A (PKA) signaling pathway protein kinase A (PKA) signaling pathway ---> Ppp1r1b GRK in DA signaling ---> D2-like receptor cortical areas --+> dorsal striatum/caudate-putamen dorsal striatum/caudate-putamen globus pallidus, external (GPe) ---| subthalamic nucleus (STN) Ppp1r1b ---| Ppp1c dorsal striatum/caudate-putamen ---| substantia nigra pars reticulata (SNr) dorsal striatum/caudate-putamen ---| globus pallidus, external (GPe) Ppp1r1b kinases/phosphatases ---> Ppp1r1b nucleus accumbens (NAc) ---> substantia nigra pars reticulata (SNr) diacylglycerol --+> protein kinase C (PKC) signaling pathway Arrb2 ---- D1-like receptor Arrb2 ---- D2-like receptor Arrb1 ---- D1-like receptor Arrb1 Arrb1 ---- D2-like receptor GRK in DA signaling ---> D1-like receptor Arrb2 Ppp1r1b cortical areas --+> nucleus accumbens (NAc) RGS in DA signaling ---| Gnal RGS in DA signaling ---| Gnai2 RGS in DA signaling RGS in DA signaling ---| Gnao1 cAMP --+> protein kinase A (PKA) signaling pathway G protein mediated signaling pathway via Galphas family --+> Adcy5 ATP ---> cAMP Adcy5 G protein mediated signaling pathway via Galphai family ---| Adcy5 IP3 --+> Ca2+ G protein mediated signaling pathway via Galphaq family --+> IP3 G protein mediated signaling pathway via Galphaq family --+> diacylglycerol substantia nigra pars reticulata (SNr) associative learning cognitive flexibility working memory ventral pallidum (VP) ATP cAMP IP3 diacylglycerol
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dopamine signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdk5 cyclin-dependent kinase 5 JBrowse link 4 7,282,945 7,287,427 RGD:11041163
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:11041163
G Drd1 dopamine receptor D1 JBrowse link 17 11,099,736 11,104,352 RGD:1600981
RGD:1625010
RGD:11041142
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:1581445
RGD:1625010
RGD:1625068
RGD:11041142
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:1625068
G Drd4 dopamine receptor D4 JBrowse link 1 214,278,296 214,282,818 RGD:1625010
G Drd5 dopamine receptor D5 JBrowse link 14 77,220,579 77,222,006 RGD:1600981
RGD:11041142
G Ppp1ca protein phosphatase 1 catalytic subunit alpha JBrowse link 1 219,439,953 219,443,570 RGD:11041163
G Ppp1cb protein phosphatase 1 catalytic subunit beta JBrowse link 6 23,548,507 23,581,136 RGD:11041163
G Ppp1cc protein phosphatase 1 catalytic subunit gamma JBrowse link 12 39,864,302 39,882,030 RGD:11041163
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B JBrowse link 10 86,303,727 86,312,770 RGD:11041134
RGD:11041163
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:11041163
G Ppp2cb protein phosphatase 2 catalytic subunit beta JBrowse link 16 62,273,276 62,294,767 RGD:11041163
G Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha JBrowse link 8 109,481,352 109,621,462 RGD:11041163
G Ppp2r5d protein phosphatase 2, regulatory subunit B', delta JBrowse link 9 16,580,995 16,610,425 RGD:11041163
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:11041163
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:11041163
G Ppp3cc protein phosphatase 3 catalytic subunit gamma JBrowse link 15 51,896,427 51,968,075 RGD:11041163
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:11041163
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:11041163
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 JBrowse link 1 103,197,918 103,258,309 RGD:11041134
G Slc6a3 solute carrier family 6 member 3 JBrowse link 1 32,323,011 32,363,983 RGD:1358582
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:1581410
dopamine signaling pathway via D1 family of receptors term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcy2 adenylate cyclase 2 JBrowse link 1 37,043,071 37,698,390 RGD:10402751
G Adcy5 adenylate cyclase 5 JBrowse link 11 68,695,839 68,842,452 RGD:11041137
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:11041134
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:11041134
G Drd1 dopamine receptor D1 JBrowse link 17 11,099,736 11,104,352 RGD:10402751
RGD:11041134
G Drd5 dopamine receptor D5 JBrowse link 14 77,220,579 77,222,006 RGD:11041134
G Gnal G protein subunit alpha L JBrowse link 18 62,805,406 62,946,133 RGD:11041135
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:10402751
G Gnb1 G protein subunit beta 1 JBrowse link 5 172,914,025 172,981,403 RGD:10402751
G Gng12 G protein subunit gamma 12 JBrowse link 4 97,634,925 97,763,478 RGD:10402751
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:11041134
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:11041134
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:11041134
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:11041134
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:10402751
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:11041134
G Rgs4 regulator of G-protein signaling 4 JBrowse link 13 88,054,817 88,061,108 RGD:11041134
G Rgs7 regulator of G-protein signaling 7 JBrowse link 13 93,095,659 93,534,452 RGD:11041134
G Rgs7bp regulator of G-protein signaling 7 binding protein JBrowse link 2 35,072,081 35,619,085 RGD:11041134
G Rgs9 regulator of G-protein signaling 9 JBrowse link 10 97,509,971 97,582,188 RGD:11041134
dopamine signaling pathway via D2 family of receptors term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcy5 adenylate cyclase 5 JBrowse link 11 68,695,839 68,842,452 RGD:11041137
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:11041134
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:11041134
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:11041134
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:11041134
G Drd4 dopamine receptor D4 JBrowse link 1 214,278,296 214,282,818 RGD:11041134
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:11041136
G Gnao1 G protein subunit alpha o1 JBrowse link 19 11,513,201 11,669,578 RGD:11041136
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:11041134
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:11041134
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:11041134
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:11041134
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:11041134
G Rgs4 regulator of G-protein signaling 4 JBrowse link 13 88,054,817 88,061,108 RGD:11041134
G Rgs7 regulator of G-protein signaling 7 JBrowse link 13 93,095,659 93,534,452 RGD:11041134
G Rgs7bp regulator of G-protein signaling 7 binding protein JBrowse link 2 35,072,081 35,619,085 RGD:11041134
G Rgs9 regulator of G-protein signaling 9 JBrowse link 10 97,509,971 97,582,188 RGD:11041134

Pathway Gene Annotations

Disease Annotations Associated with Genes in the dopamine signaling pathway
Disease TermsGene Symbols
Adenocarcinoma of LungPpp3ca
Adrenal Gland NeoplasmsPrkaca
AlbuminuriaDrd1
AlcoholismDrd2
Alzheimer DiseaseCsnk1a1 , Drd1 , Drd2 , Drd3 , Drd4 , Drd5 , Ptpn5
AmnesiaDrd3
Amphetamine-Related DisordersDrd1 , Drd2 , Drd3 , Drd4 , Slc6a3
Amyotrophic Lateral SclerosisCdk5
Anxiety DisordersDrd2 , Slc6a3
Anxiety, SeparationDrd4
Aortic Valve StenosisPpp3cb
Arthritis, ExperimentalDrd1 , Drd2
AsthmaPpp2ca
Attention Deficit and Disruptive Behavior DisordersDrd4
Attention Deficit Disorder with HyperactivityDrd2 , Drd4 , Drd5 , Slc6a3
Autistic DisorderDrd1 , Drd3
Autonomic Nervous System DiseasesDrd4
Basal Ganglia DiseasesDrd2 , Drd3
Benign Essential BlepharospasmDrd5
Biliary Tract NeoplasmsPrkacb
Bipolar DisorderDrd1 , Drd5
BlepharospasmDrd5
BradycardiaDrd2
Brain InjuriesDrd2 , Ppp3ca
Brain IschemiaCdk5 , Drd2 , Prkaca , Prkacb , Src
Breast NeoplasmsSrc
Carcinoma, Intraductal, NoninfiltratingSrc
Cardiac Output, LowPpp1ca
CardiomegalyPpp3ca , Src
Cardiomyopathy, DilatedPpp1ca
Cardiomyopathy, HypertrophicPrkaca
CatalepsyDrd1 , Drd2 , Ppp1r1b
Child Development Disorders, PervasiveDrd4 , Drd5
CholangiocarcinomaPrkaca , Prkacb
Cocaine-Related DisordersCdk5 , Drd1 , Drd2 , Drd3 , Slc6a3
Cognition DisordersDrd2 , Drd3
ColitisSrc
Colonic NeoplasmsSrc
Craniofacial AbnormalitiesCsnk1a1
DementiaDrd2 , Slc6a3
Depressive DisorderDrd1 , Drd2 , Drd5
Developmental DisabilitiesDrd2
Diabetes Mellitus, ExperimentalDrd1 , Drd2
Diabetes Mellitus, Type 2Drd2 , Ppp2ca , Src
Disruptive, Impulse Control, and Conduct DisordersDrd2 , Drd3
Dyskinesia, Drug-InducedDrd1 , Drd2 , Drd3
DyskinesiasDrd2 , Ppp1r1b
DystoniaDrd2
Essential TremorDrd3
FeverDrd1
GamblingDrd3
GliomaSlc6a3
Heart DiseasesPpp2ca
Heart FailurePpp1ca , Ppp2ca , Prkaca
Hepatolenticular DegenerationPpp3ca , Ppp3cb
Heroin DependenceDrd2
Huntington DiseaseDrd1 , Drd2 , Drd3 , Drd5 , Ppp3ca
HyperalgesiaDrd3
HyperglycemiaDrd1
HyperkinesisDrd1 , Drd2 , Drd3 , Slc6a3
HyperprolactinemiaDrd2
HypertensionDrd1 , Drd2 , Drd3 , Drd5 , Slc6a3 , Src
Hypertrophy, Left VentricularPpp3ca , Ppp3cb
Hypertrophy, Right VentricularPpp3ca , Ppp3cb
Hypoglossal Nerve InjuriesPrkaca , Prkacb
HypotensionDrd1 , Drd2
Hypoxia-Ischemia, BrainPtpn5
Insulin ResistanceDrd1
Ischemic Attack, TransientPtpn5
Kidney Failure, ChronicDrd1 , Drd2
Kidney Reperfusion InjurySrc
Language DisordersDrd2
Leukemia-Lymphoma, Adult T-CellCsnk1a1
Liver Neoplasms, ExperimentalPpp2ca
Major Affective Disorder 1Slc6a3
MelanomaPpp2ca
Melanoma, Cutaneous Malignant, Susceptibility To, 1Ppp2ca
Memory DisordersDrd2 , Slc6a3
Mental Retardation, Autosomal Dominant 35Ppp2r5d
Micronuclei, Chromosome-DefectiveSlc6a3
Migraine with AuraDrd2
Morphine DependenceDrd2
Movement DisordersDrd1 , Drd2 , Drd3
Myocardial IschemiaPpp2ca
Myoclonic DystoniaDrd2
Myositis, Inclusion BodyCsnk1a1
Neoplasm InvasivenessSrc
Neoplasm MetastasisSrc
Nerve DegenerationPtpn5 , Slc6a3
Nervous System DiseasesSlc6a3
NeuralgiaDrd1 , Drd2
Neurotoxicity SyndromesDrd2
Nocturnal EnuresisDrd4
Novelty Seeking Personality TraitDrd4
ObesityDrd1 , Drd2 , Drd4 , Slc6a3
Optic Nerve InjuriesPtpn5
Ovarian NeoplasmsPpp1cc
PainDrd2
PancreatitisPpp3ca
Paranoid DisordersSlc6a3
Parkinson DiseaseDrd1 , Drd2 , Drd3 , Drd5 , Ppp2ca , Slc6a3
Parkinson Disease, Late-OnsetDrd4
Parkinsonian DisordersDrd2 , Drd3 , Slc6a3 , Src
Parkinsonism-Dystonia, InfantileSlc6a3
Pigmented Nodular Adrenocortical Disease, Primary, 4Prkaca
Pituitary NeoplasmsDrd2
Polycystic Kidney, Autosomal RecessiveSrc
Prostatic NeoplasmsPpp2ca , Ppp3ca , Prkacb , Src
Psychoses, Substance-InducedSlc6a3
Psychotic DisordersDrd5
Renal InsufficiencyDrd1
Reperfusion InjuryPpp3ca , Ppp3cb , Src
SchizophreniaDrd1 , Drd2 , Drd3 , Drd4 , Ppp3cc , Slc6a3
SeizuresDrd1 , Drd2 , Drd3
Sleep Wake DisordersSlc6a3
Smith-Magenis SyndromePpp1r1b
Status EpilepticusSrc
StrokeSrc
Substance Withdrawal SyndromeDrd1 , Drd2
Substance-Related DisordersDrd2
TachycardiaDrd2
Tachycardia, VentricularPpp3ca
Testicular DiseasesPpp3ca
Tic DisordersDrd4 , Slc6a3
Tobacco Addiction, Susceptibility ToSlc6a3
Tobacco Use DisorderDrd2
TorticollisDrd5
Tourette SyndromeDrd2 , Drd3
Tracheal StenosisDrd1
Tremor Hereditary Essential, 1Drd3
Ureteral ObstructionDrd1
Urinary Bladder NeoplasmsSrc
Weight GainDrd2
Pathway Annotations Associated with Genes in the dopamine signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayPrkaca
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayPpp1ca , Ppp1cb , Ppp2ca
adenosine signaling pathwayPrkacb
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayPrkaca
alfentanil pharmacodynamics pathwayDrd1 , Slc6a3
altered Reelin signaling pathwaySrc
Alzheimer disease pathwayCdk5 , Ppp3ca , Ppp3cb , Ppp3cc
amiodarone pharmacodynamics pathwayPrkaca
amlodipine pharmacodynamics pathwayPrkaca
amyotrophic lateral sclerosis disease pathwayPpp3ca , Ppp3cb , Ppp3cc
apoptotic cell death pathwayPpp3ca , Ppp3cb , Ppp3cc , Prkaca , Prkacb
ataxia telangiectasia-mutated (ATM) signaling pathwayPpp2ca
atenolol pharmacodynamics pathwayPrkaca
B cell receptor signaling pathwayPpp3ca , Ppp3cb , Ppp3cc
betaxolol pharmacodynamics pathwayPrkaca
bile acid transport pathwayPrkaca , Prkacb
bisoprolol pharmacodynamics pathwayPrkaca
Bone morphogenetic proteins signaling pathwayPpp1ca
bupivacaine pharmacodynamics pathwayDrd1 , Slc6a3
bupranolol drug pathwayPrkaca
bupranolol pharmacodynamics pathwayPrkaca
buprenorphine pharmacodynamics pathwayDrd1 , Slc6a3
calcineurin signaling pathwayPpp3ca , Ppp3cb , Ppp3cc
calcium/calcium-mediated signaling pathwayDrd1 , Drd5 , Ppp3ca , Ppp3cb , Ppp3cc , Prkaca , Prkacb
calcium/calmodulin dependent kinase 2 signaling pathwayPpp1cc , Ppp2ca
carvedilol pharmacodynamics pathwayPrkaca
chemokine mediated signaling pathwayPrkaca , Prkacb
chloroprocaine pharmacodynamics pathwayDrd1 , Slc6a3
citalopram pharmacodynamics pathwayDrd1 , Slc6a3
cocaine pharmacodynamics pathwayDrd1 , Slc6a3
codeine and morphine pharmacodynamics pathwayDrd1 , Slc6a3
desipramine pharmacodynamics pathwayDrd1 , Slc6a3
dilated cardiomyopathy pathwayPrkaca , Prkacb
diltiazem pharmacodynamics pathwayPrkaca
diphenoxylate pharmacodynamics pathwayDrd1 , Slc6a3
disopyramide pharmacodynamics pathwayPrkaca
dobutamine pharmacodynamics pathwayPrkaca
dopamine signaling pathwayCdk5 , Csnk1a1 , Drd1 , Drd2 , Drd3 , Drd4 , Drd5 , Ppp1ca , Ppp1cb , Ppp1cc , Ppp1r1b , Ppp2ca , Ppp2cb , Ppp2r3a , Ppp2r5d , Ppp3ca , Ppp3cb , Ppp3cc , Prkaca , Prkacb , Ptpn5 , Slc6a3 , Src
dopamine signaling pathway via D1 family of receptorsDrd1 , Drd5 , Prkacb
dopamine signaling pathway via D2 family of receptorsDrd2 , Drd3 , Drd4
E-cadherin signaling pathwaySrc
eicosanoid signaling pathwayPrkaca , Src
endocytosis pathwaySrc
endothelin signaling pathwaySrc
Entamoeba histolyca infection pathwayPrkaca , Prkacb
ephrin - ephrin receptor bidirectional signaling axisCdk5 , Src
epidermal growth factor/neuregulin signaling pathwaySrc
escitalopram pharmacodynamics pathwayDrd1 , Slc6a3
esmolol pharmacodynamics pathwayPrkaca
estrogen signaling pathwaySrc
ethylmorphine pharmacodynamics pathwayDrd1 , Slc6a3
excitatory synaptic transmission pathwayDrd2 , Drd4
FasL mediated signaling pathwaySrc
fentanyl pharmacodynamics pathwayDrd1 , Slc6a3
fibroblast growth factor signaling pathwaySrc
flecainde pharmacodynamics pathwayPrkaca
fluoxetine pharmacodynamics pathwayDrd1 , Slc6a3
follicle-stimulating hormone signaling pathwayPpp1ca , Prkacb
fosphenytoin pharmacodynamics pathwayPrkaca
G protein mediated signaling pathway via Galphai familyDrd2 , Drd3 , Drd4
G protein mediated signaling pathway via Galphaq familyDrd1 , Drd2 , Drd5
G protein mediated signaling pathway via Galphas familyDrd1 , Drd5
glutamate signaling pathwayPpp3ca , Ppp3cb , Ppp3cc , Prkaca , Prkacb
glycogen biosynthetic pathwayPpp1ca , Ppp1cb , Ppp1cc
glycogen degradation pathwayPpp1ca , Ppp1cb , Ppp1cc
glypican signaling pathwaySrc
gonadotropin-releasing hormone signaling pathwayPrkaca , Prkacb , Src
granulocyte-macrophage colony-stimulating factor signaling pathwayPrkaca , Prkacb
Hedgehog signaling pathwayCsnk1a1 , Prkaca , Prkacb
hepatitis C virus infection pathwayPpp2ca , Ppp2cb
heroin pharmacodynamics pathwayDrd1 , Slc6a3
histamine signaling pathway, immunologicalPpp1ca , Prkacb
hydrocodone pharmacodynamics pathwayDrd1 , Slc6a3
hydromorphone pharmacodynamics pathwayDrd1 , Slc6a3
ibutilide pharmacodynamics pathwayPrkaca
imipramine pharmacodynamics pathwayDrd1 , Slc6a3
insulin responsive facilitative sugar transporter mediated glucose transport pathwayPpp1cc
insulin signaling pathwayPpp1ca , Ppp1cb , Ppp1cc , Prkaca , Prkacb
interleukin-12 signaling pathwayPpp3ca , Ppp3cb
interleukin-2 signaling pathwayPpp2r5d
interleukin-3 signaling pathwayPrkaca , Prkacb
isoprenaline pharmacodynamics pathwayPrkaca
isradipine pharmacodynamics pathwayPrkaca
levacetylmethadol pharmacodynamics pathwayDrd1 , Slc6a3
levobunolol pharmacodynamics pathwayPrkaca
levobupivacaine phgarmacodynamics pathwayDrd1 , Slc6a3
levorphanol pharmacodynamics pathwayDrd1 , Slc6a3
lidocaine pharmacodynamics pathwayDrd1 , Prkaca , Slc6a3
long term depressionDrd1 , Drd5 , Ppp2ca , Ppp2cb
long term potentiationDrd1 , Drd5 , Ppp1ca , Ppp1cb , Ppp1cc , Ppp3ca , Ppp3cb , Ppp3cc , Prkaca , Prkacb
luteinizing hormone signaling pathwayPpp1ca , Prkacb
melanocortin system pathwayPrkacb
mepivacaine pharmacodynamics pathwayDrd1 , Slc6a3
methadone pharmacodynamics pathwayDrd1 , Slc6a3
metoprolol pharmacodynamics pathwayPrkaca
mexiletine pharmacodynamics pathwayPrkaca
mitochondrial autophagy pathwaySrc
mitogen activated protein kinase signaling pathwayPpp3ca , Ppp3cb , Ppp3cc , Prkaca , Prkacb , Ptpn5
mRNA decay pathwayPpp2ca , Ppp2cb , Ppp2r3a , Ppp2r5d
Mycobacterium tuberculosis infection pathwayPpp3ca , Ppp3cb , Ppp3cc , Src
nadolol pharmacodynamics pathwayPrkaca
nalbuphine pharmacodynamics pathwayDrd1 , Slc6a3
naloxone pharmacodynamics pathwayDrd1 , Slc6a3
naltrexone pharmacodynamics pathwayDrd1 , Slc6a3
nebivolol pharmacodynamics pathwayPrkaca
nerve growth factor signaling pathwaySrc
nicotine pharmacodynamics pathwayDrd1 , Slc6a3
nifedipine pharmacodynamics pathwayPrkaca
nimodipine pharmacodynamics pathwayPrkaca
nisoldipine pharmacodynamics pathwayPrkaca
nitrendipine pharmacodynamics pathwayPrkaca
nuclear factor kappa B signaling pathwaySrc
oxybuprocaine pharmacodynamics pathwayDrd1 , Slc6a3
oxycodone pharmacodynamics pathwayDrd1 , Slc6a3
oxymorphone pharmacodynamics pathwayDrd1 , Slc6a3
p53 signaling pathwayCsnk1a1 , Ppp2ca
Parkinson disease pathwaySlc6a3
penbutolol pharmacodynamics pathwayPrkaca
pentazocine pharmacodynamics pathwayDrd1 , Slc6a3
phenytoin pharmacodynamics pathwayPrkaca
phosphatidylinositol 3-kinase class I signaling pathwaySrc
phosphatidylinositol 3-kinase-Akt signaling pathwayPpp2ca , Ppp2cb , Prkaca , Src
pindolol pharmacodynamics pathwayPrkaca
platelet-derived growth factor signaling pathwayPpp2ca , Src
prilocaine pharmacodynamics pathwayDrd1 , Slc6a3
prion diseases pathwayPrkaca , Prkacb
procainamide pharmacodynamics pathwayPrkaca
procaine pharmacodynamics pathwayDrd1 , Slc6a3
propranolol pharmacodynamics pathwayPrkaca
prostaglandin D2 signaling pathwayPrkacb
prostaglandin I2 signaling pathwayPrkacb
protein kinase A (PKA) signaling pathwayPrkaca , Prkacb
quinidine pharmacodynamics pathwayPrkaca
Reelin signaling pathwayCdk5 , Src
remifentanil pharmacodynamics pathwayDrd1 , Slc6a3
ropivacaine pharmacodynamics pathwayDrd1 , Slc6a3
scatter factor/hepatocyte growth factor signaling pathwaySrc
schizophrenia pathwayPpp3cc
serotonin signaling pathway via receptors engaging G alphas protein familyPpp1ca , Prkacb
signaling pathway pertinent to the brain and nervous systemSrc
somatostatin signaling pathwaySrc
sotalol pharmacodynamics pathwayPrkaca
sphingosine 1-phosphate signaling pathwaySrc
syndecan signaling pathwayPrkaca , Src
T cell receptor signaling pathwayPpp3ca , Ppp3cb , Ppp3cc
timolol pharmacodynamics pathwayPrkaca
tramadol pharmacodynamics pathwayDrd1 , Slc6a3
transforming growth factor-beta Smad dependent signaling pathwayPpp1ca , Ppp2ca , Ppp2cb
transforming growth factor-beta superfamily mediated signaling pathwayPpp2ca , Ppp2cb
Trypanosoma cruzi infection pathwayPpp2ca , Ppp2cb
ubiquitin/proteasome degradation pathwaySrc
vascular endothelial growth factor signaling pathwayPpp3ca , Ppp3cb , Ppp3cc , Prkaca , Src
vasopressin signaling pathway via receptor type 2Prkaca , Prkacb
verapamil pharmacodynamics pathwayPrkaca
Wnt signaling pathwayCsnk1a1 , Ppp2ca , Ppp2cb , Ppp2r5d , Ppp3ca , Ppp3cb , Ppp3cc , Prkaca , Prkacb
Wnt signaling, canonical pathwayCsnk1a1
Wnt signaling, non-canonical pathwayCsnk1a1
Phenotype Annotations Associated with Genes in the dopamine signaling pathway

References Associated with the dopamine signaling pathway:

Ontology Path Diagram:

paths to the root

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