RGD Reference Report - Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET. - Rat Genome Database

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Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET.

Authors: Arnaud, L  Chen, S  Liu, F  Li, B  Khatoon, S  Grundke-Iqbal, I  Iqbal, K 
Citation: Arnaud L, etal., FEBS Lett. 2011 Sep 2;585(17):2653-9. doi: 10.1016/j.febslet.2011.07.020. Epub 2011 Jul 28.
RGD ID: 8554474
Pubmed: PMID:21806989   (View Abstract at PubMed)
PMCID: PMC3181127   (View Article at PubMed Central)
DOI: DOI:10.1016/j.febslet.2011.07.020   (Journal Full-text)

Protein phosphatase-2A (PP2A) activity, which is compromised in Alzheimer disease brain, is regulated by two endogenous inhibitors, one of them being I(2)(PP2A), a 277 amino acid long protein also known as SET. Here we report that both the amino terminal fragment (I(2NTF); aa 1-175) and the carboxy terminal fragment (I(2CTF); aa 176-277) of I(2)(PP2A) inhibit PP2A by binding to its catalytic subunit PP2Ac and cause hyperphosphorylation of tau. The C-terminal acidic region in I(2CTF) and Val 92 in I(2NTF) are essential for their association with PP2Ac and inhibition of the phosphatase activity.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding enablesIPIUniProtKB:P396878554474PMID:21806989IntAct 

Objects Annotated

Genes (Rattus norvegicus)
Ppp2ca  (protein phosphatase 2 catalytic subunit alpha)


Additional Information