Myc Rat Gene (myelocytomatosis oncogene)

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Keyword

Gene:
Myc ( Rattus norvegicus )
myelocytomatosis oncogene
Description: DNA binding protein; regulates transcription
Synonyms: myelocytomatosis viral oncogene homolog (avian); c-myc; RNCMYC; mMyc; MGC105490; Avian myelocytomatosis viral (v-myc) oncogene homolog; v-myc avian myelocytomatosis viral oncogene homolog ;  (details...)
ArrayIDs: 6410640; 6218948; A_42_P493380; Y00396mRNA_g_at; 6745472; 6350923; 5670447; GE19854; Y00396mRNA_at; 6189374; 1368308_at; 6611276; 6442901;  (details...)
Gene Type: protein-coding
Strain: W-Tg(MT2A-Myc)1Ys  W-Tg(MT2A-Myc)2Ys

Additional Data

Candidate gene for: Ept7 - Estrogen-induced pituitary tumorigenesis QTL 7
Teswt1 - Testicular weight QTL 1
Lnnr1 - Liver neoplastic nodule remodeling QTL 1
Hcas1 - Hepatocarcinoma susceptibility QTL 1

Markers: D7Arb5 D7Kyo1 D7Mit27 D7Wox14 D7Wox15 D7Wox29

Homologs
Homo sapiens: MYC     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Myc     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Myc genome assembly 3.1 7 98987371 - 98992287
Rat Celera Assembly 7 90263903 - 90268823
RGSC genome assembly v3.4 7 98953142 - 98958060
Cytogenetic 7 q33
Mus musculus Myc Mouse genome assembly build 36.1 15 61816896 - 61821916
Cytogenetic 15 15 D2-D3
Homo sapiens MYC human genome assembly 8 128817685 - 128822853
Human genome assembly build 36.2 8 128817498 - 128822856
Cytogenetic 8 q24.21

View comparative maps:      NCBI MapViewer

Genome
View:

Browsers:

Other Map Data:
Associated SSLP Map Locations
STS D7Arb5 Rat cytogenetic map 7
RGSC genome assembly v3.4 7 98955064 - 98955268
genome assembly 3.1 7 98989294 - 98989498
No mapping information currently available in RGD for D7Kyo1
STS D7Mit27 genome assembly 3.1 7 98989298 - 98989508
RH 3.4 7 653.02
RGSC genome assembly v3.4 7 98955068 - 98955278
RH 2.0 7 540.8
STS D7Wox14 genome assembly 3.1 7 98989314 - 98989445
RH 3.4 7 654.7
Rat cytogenetic map 7
RGSC genome assembly v3.4 7 98955084 - 98955215
RH 2.0 7 541.5
STS D7Wox15 RGSC genome assembly v3.4 7 98955057 - 98955216
RH 2.0 7 544.5
genome assembly 3.1 7 98989287 - 98989446
STS D7Wox29 RGSC genome assembly v3.4 7 98955070 - 98955189
RH 2.0 7 540.1
genome assembly 3.1 7 98989300 - 98989419

Annotation
Molecular Function

Note Reference

binds to TFIIIB, a pol III-specific general transcription factor 729124

binds to DNA 70227, 625485

Gene Ontology

sequence-specific DNA binding,  protein binding,  transcription factor activity ... (details...)
Biological Process

Note Reference

may repress transcription of target genes of the apopototic pathway which leads to cell death following DNA damage 625509

has a role in growth competence, differentiation, and apoptosis 70227, 625485

plays a role in beta-cell de-differentiation 70227, 625485

Gene Ontology

negative regulation of survival gene product expression,  detection of mechanical stimulus involved in sensory perception of sound,  pigmentation ... (details...)
Cellular Component

Gene Ontology

nucleus,  nucleolus,  axon ... (details...)
Disease

Ontology

Multiple Myeloma,  Leukemia, Plasmacytic,  Burkitt Lymphoma (details...)
Regulation

Note Reference

expression in beta-cells increased by cytokines such as interleukin1-beta and interferon-gamma, this is prevented by blocking NF-kappaB activation but not by an iNO blocker 69897, 70227

Drugs

Note Reference

mRNA degradation is stopped by the inhibition of protein synthesis by cycloheximide which results in the accumalation os mRNA in various cells 69897, 70227

Mutation/over- and underexpression

Note Reference

overexpression or deregulation causes unlimited growth of the cancer cells 69897, 70227

External Links
Databases
DATABASE ID SOURCE
SMART: HLH IPI
PROSITE: HLH IPI
UNIPARC: UPI000057B85E IPI
KEGG Report: rno:24577 ENTREZGENE
HomoloGene Group ID: 31092 ENTREZGENE
Germonline: 3130
Pfam: Myc_N IPI
Pfam: Myc-LZ IPI
Pfam: HLH IPI
KEGG Pathway: 05213 ENTREZGENE
KEGG Pathway: 05210 ENTREZGENE
KEGG Pathway: 04012 ENTREZGENE
KEGG Pathway: 04630 ENTREZGENE
KEGG Pathway: 04010 ENTREZGENE
KEGG Pathway: 05222 ENTREZGENE
KEGG Pathway: 05200 ENTREZGENE
KEGG Pathway: 04310 ENTREZGENE
KEGG Pathway: 05216 ENTREZGENE
KEGG Pathway: 04350 ENTREZGENE
KEGG Pathway: 05220 ENTREZGENE
KEGG Pathway: 04110 ENTREZGENE
KEGG Pathway: 05219 ENTREZGENE
KEGG Pathway: 05221 ENTREZGENE
InterPro: HLH_basic. IPI
InterPro: Tscrpt_reg_Myc_N. IPI
InterPro: Tscrpt_reg_Myc. IPI
InterPro: Myc-LZ. IPI
InterPro: HLH_DNA_bd. IPI
Ensembl Protein: ENSRNOP00000006188 IPI
IPI: IPI00214655 IPI
Gene3D-CATH: HLH_DNA_bd IPI
Entrez Gene: Myc ENTREZGENE
IMAGE_CLONE: IMAGE:7303974 IMAGE-MGC_LOAD
MGC_CLONE: MGC:105490 IMAGE-MGC_LOAD
Ensembl Genes: ENSRNOG00000004500 IPI
TIGR: TC231200
UniProt: Q6WDF7_RAT IPI
UniProt: MYC_RAT IPI
Superfamily-SCOP: HLH_basic IPI
RatMap: 34197 ENTREZGENE
PRINTS: LEUZIPPRMYC. IPI
Sequences
Nucleotide: BC091699 Get FASTA Search GEO Profiles
Nucleotide: AY679730 Get FASTA Search GEO Profiles
Nucleotide: AY679729 Get FASTA Search GEO Profiles
Nucleotide: Y00396 Get FASTA Search GEO Profiles
Nucleotide: M18819 Get FASTA Search GEO Profiles
Nucleotide: CH473950 Get FASTA Search GEO Profiles
Nucleotide: AY294970 Get FASTA Search GEO Profiles
Nucleotide: NM_012603 Get FASTA Search GEO Profiles
(View all 8 Nucleotide Accessions)
Protein: Q6WDF7 Get FASTA
Protein: P09416 Get FASTA
Protein: AAH91699 Get FASTA
Protein: AAT92512 Get FASTA
Protein: AAT92511 Get FASTA
Protein: CAA68459 Get FASTA
Protein: EDM16184 Get FASTA
Protein: AAQ57167 Get FASTA
Protein: NP_036735 Get FASTA
(View all 9 Protein Accessions)
Clusters
UniGene: 12072

References
Curated References
24 references in RGD related to Myc

Other References
57 other references at PubMed related to Myc

Database Information
RGD ID 3130
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

13-FEB-08: Myc myelocytomatosis oncogene Myc myelocytomatosis viral oncogene homolog (avian) APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863

14-DEC-04: Myc myelocytomatosis viral oncogene homolog (avian) v-myc avian myelocytomatosis viral oncogene homolog APPROVED Name updated 1299863

10-JUN-02: Myc v-myc avian myelocytomatosis viral oncogene homolog PROVISIONAL Name updated 70585