RGD Reference Report - Prepubertal onset of diabetes prevents expression of renal cortical connective tissue growth factor. - Rat Genome Database

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Prepubertal onset of diabetes prevents expression of renal cortical connective tissue growth factor.

Authors: Langer, WJ  Devish, K  Carmines, PK  Lane, PH 
Citation: Langer WJ, etal., Pediatr Nephrol. 2008 Feb;23(2):275-83. Epub 2007 Nov 21.
RGD ID: 7207459
Pubmed: PMID:18030501   (View Abstract at PubMed)
DOI: DOI:10.1007/s00467-007-0642-8   (Journal Full-text)

Puberty unmasks or accelerates the nephropathy of diabetes mellitus (DM). We performed focused microarray analysis to test the hypothesis that one or more genes in the transforming growth factor beta (TGF-beta) signaling system would be differentially regulated in male rats depending on their age at onset of DM. Littermates were started on the 6-week protocol at 4 weeks or 14 weeks of age. Renal cortical RNA was isolated and analyzed using gene chips with more than 30,000 transcripts. Age-specific effects of DM were demonstrated for 1,760 transcripts. Analysis then focused on 89 genes involved in the TGF-beta signaling pathway. Three of these genes showed age-dependent responses to DM, confirmed by quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Connective tissue growth factor (CTGF) mRNA and protein were both increased approximately 30% in the renal cortex 6 weeks after adult-onset DM, with no alteration in either parameter after juvenile onset. Follistatin and avian myelocytomatosis viral oncogene homolog mRNA both showed a similar age-related pattern of response to DM, but protein levels did not parallel mRNA for either of these gene products. Given the known roles of CTGF in progressive nephropathies, it is an attractive candidate to explain pubertal acceleration or unmasking of the kidney disease of diabetes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISOMyc (Rattus norvegicus)7207459; 7207459mRNA:increased expression:renal cortex (rat)RGD 
Experimental Diabetes Mellitus  IEP 7207459mRNA:increased expression:renal cortex (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Myc  (MYC proto-oncogene, bHLH transcription factor)

Genes (Mus musculus)
Myc  (myelocytomatosis oncogene)

Genes (Homo sapiens)
MYC  (MYC proto-oncogene, bHLH transcription factor)


Additional Information