Gpx1 (glutathione peroxidase 1) - Rat Genome Database

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Gene: Gpx1 (glutathione peroxidase 1) Rattus norvegicus
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Symbol: Gpx1
Name: glutathione peroxidase 1
RGD ID: 2729
Description: Enables glutathione peroxidase activity. Involved in several processes, including cellular response to glucose stimulus; response to estradiol; and response to vitamin. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Predicted to colocalize with Lewy body. Used to study several diseases, including cataract; gestational diabetes; hypertension; hyperthyroidism; and hypothyroidism. Biomarker of several diseases, including hyperhomocysteinemia; iron deficiency anemia; obesity; steatotic liver disease; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); nutritional deficiency disease (multiple); and respiratory system cancer (multiple). Orthologous to human GPX1 (glutathione peroxidase 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (+)-taxifolin.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cellular glutathione peroxidase; GPx-1; GSHPx; GSHPx-1; phospholipid-hydroperoxide glutathione peroxidase GPX1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,905,462 - 117,906,588 (+)NCBIGRCr8
mRatBN7.28109,026,905 - 109,028,031 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,026,905 - 109,028,024 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,654,127 - 114,655,253 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,853,454 - 112,854,580 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,696,094 - 110,697,220 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,117,430 - 117,118,528 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,117,430 - 117,118,522 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,466,118 - 116,467,216 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,329,847 - 108,330,945 (+)ENTREZGENECelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
Aicardi-Goutieres Syndrome 1  (ISO)
alpha thalassemia  (ISO)
anemia  (IDA,ISO)
Anorexia  (ISO)
arteriosclerosis  (ISO)
autistic disorder  (ISO)
Binge Drinking  (IEP)
Brain Injuries  (IEP)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Cadmium Poisoning  (IEP)
calcinosis  (ISO)
Carbon Tetrachloride Poisoning  (IEP)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
carotid stenosis  (ISO)
cataract  (IDA)
Chronic Hepatitis  (ISO)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (ISO)
colon cancer  (ISO)
colorectal cancer  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
depressive disorder  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (IEP,ISO)
dilated cardiomyopathy  (ISO)
epilepsy  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
gestational diabetes  (IDA)
Glutathione Peroxidase Deficiency, Hemolytic Anemia possibly due to  (ISO)
glycine encephalopathy  (ISO)
hairy cell leukemia  (ISO)
Head and Neck Neoplasms  (ISO)
Hemolysis  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (IEP)
hyperinsulinism  (ISO)
hypertension  (IDA,IEP,ISO)
Hyperthermia  (ISO)
hyperthyroidism  (IDA,ISO)
hypothyroidism  (IDA)
iron deficiency anemia  (IEP,ISO)
Iron Overload  (ISO)
Keshan disease  (ISO)
laryngeal squamous cell carcinoma  (ISO)
larynx cancer  (ISO)
leukemia  (ISO)
Liver Injury  (IDA)
Liver Neoplasms  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Mercury Poisoning  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
multiple myeloma  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
nasopharynx carcinoma  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (IEP)
non-Hodgkin lymphoma  (ISO)
obesity  (IEP,ISO)
oral squamous cell carcinoma  (ISO)
osteoporosis  (ISO)
Parkinson's disease  (ISO)
Pierson syndrome  (ISO)
pre-eclampsia  (ISO)
pseudoxanthoma elasticum  (ISO)
Reperfusion Injury  (ISO)
Reticulocytosis  (ISO)
senile cataract  (ISO)
sickle cell anemia  (ISO)
skin melanoma  (ISO)
squamous cell carcinoma  (ISO)
steatotic liver disease  (IEP,ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
vascular dementia  (IEP)
Venous Thrombosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-quinic acid  (ISO)
(E)-thiamethoxam  (EXP,ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (EXP)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4,7-triazonane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
11-deoxycorticosterone  (EXP)
12(S)-HPETE  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-tert-butylhydroquinone  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3-(Methylthio)-1-propene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP,ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acetylcholine  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha,alpha-trehalose  (EXP)
alpha-D-galactose  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
AM-251  (ISO)
aminoglutethimide  (ISO)
aminoguanidine  (EXP)
amiodarone  (EXP,ISO)
amitrole  (EXP)
amlexanox  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
ampicillin  (EXP)
apigenin  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
asiatic acid  (EXP)
atrasentan  (EXP)
atrazine  (EXP,ISO)
auranofin  (ISO)
barium chloride  (EXP)
benidipine  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzopyran  (EXP)
berberine  (EXP)
Bergenin  (ISO)
beta-naphthoflavone  (EXP)
bifenthrin  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bosentan  (ISO)
bromobenzene  (EXP)
brucine  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium dichloride  (ISO)
camphene  (EXP)
cannabidiol  (ISO)
capecitabine  (EXP)
capsaicin  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carnosic acid  (ISO)
carnosine  (ISO)
carteolol  (ISO)
carvacrol  (EXP)
celecoxib  (ISO)
chitosan  (EXP)
chloramine T  (EXP)
chloroform  (EXP)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
Cholestane-3,5,6-triol  (EXP)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
ciprofibrate  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
coenzyme Q10  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumarin  (EXP)
crotonaldehyde  (EXP)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
Cyanoginosin  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (EXP,ISO)
cypermethrin  (EXP,ISO)
cyprodinil  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
daunorubicin  (ISO)
DDE  (EXP)
Dendrobine  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dieldrin  (EXP,ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
difenoconazole  (EXP)
dihydrogen  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
diosmin  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
Diphenyl disulfide  (ISO)
diprotium  (ISO)
diprotium oxide  (ISO)
diquat  (ISO)
disodium cromoglycate  (EXP)
disodium selenite  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
emamectin benzoate  (EXP)
emodin  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
enniatin  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
fludioxonil  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fructose  (EXP)
galactose  (ISO)
Galbanic acid  (ISO)
gallein  (EXP)
geneticin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (EXP)
ginkgolide B  (ISO)
ginsenoside Re  (ISO)
Ginsenoside Rh4  (ISO)
glafenine  (EXP)
glucoraphanin  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glyphosate  (EXP)
GW 4064  (ISO)
haloperidol  (ISO)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hypochlorous acid  (ISO)
ifosfamide  (EXP)
iloprost  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-acetic acid  (ISO)
indometacin  (EXP,ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoflavones  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
jaspamide  (ISO)
kainic acid  (ISO)
ketorolac tromethamine  (EXP)
kojic acid  (EXP)
kresoxim-methyl  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leptomycin B  (ISO)
levetiracetam  (EXP)
limonene  (EXP)
linoleic acid hydroperoxide  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lovastatin  (ISO)
lutein  (ISO)
luteolin  (ISO)
LY294002  (EXP)
lycopene  (ISO)
magnesium sulfate  (EXP)
Magnolol  (EXP)
mancozeb  (ISO)
maneb  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mephedrone  (EXP,ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylglyoxal  (EXP)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (ISO)
metronidazole  (EXP)
microcystin  (EXP)
microcystin-LR  (ISO)
minocycline  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (ISO)
morin  (EXP)
motexafin gadolinium  (ISO)
myricitrin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (ISO)
naringin  (ISO)
nefazodone  (EXP)
neomycin  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel subsulfide  (ISO)
nicotine  (EXP,ISO)
nimesulide  (EXP,ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
nitroglycerin  (ISO)
Nodularin  (ISO)
NONOate(1-)  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
NSC 23766  (ISO)
Nutlin-3  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
omeprazole  (EXP)
organoselenium compound  (ISO)
orlistat  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (EXP)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
peroxynitrous acid  (ISO)
phencyclidine  (ISO)
phenobarbital  (EXP,ISO)
phenylpropanolamine  (EXP)
PhIP  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphamidon  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP)
porphyrins  (ISO)
potassium iodide  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
probucol  (EXP,ISO)
propanal  (ISO)
propiconazole  (EXP)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
pterostilbene  (ISO)
purines  (EXP)
Pyridostigmine bromide  (ISO)
pyrimethanil  (ISO)
pyrogallol  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
raspberry ketone  (ISO)
reactive oxygen species  (EXP,ISO)
resolvin D1  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SB-239063  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenic acid  (ISO)
selenium atom  (EXP,ISO)
selenomethionine  (EXP,ISO)
silicic acid  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP,ISO)
stanozolol  (EXP)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
sucrose  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
T-2 toxin  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
tannic acid  (EXP)
tert-butyl ethyl ether  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thalidomide  (EXP)
Theaflavin 3,3'-digallate  (ISO)
theophylline  (EXP)
thiacloprid  (EXP)
thiamethoxam  (EXP,ISO)
thioacetamide  (EXP,ISO)
thiomalic acid  (ISO)
thymoquinone  (EXP,ISO)
thyroxine  (EXP)
titanium atom  (ISO)
titanium dioxide  (EXP)
triadimefon  (EXP)
tributyl phosphate  (EXP)
Tributyltin oxide  (EXP)
trichlorfon  (EXP)
triclosan  (ISO)
trilobatin  (EXP)
triolein  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (EXP,ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
uranium atom  (EXP,ISO)
usnic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vancomycin  (EXP)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
water  (ISO)
zearalenone  (EXP)
zerumbone  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis involved in wound healing  (IEA,ISO)
apoptotic process  (ISO)
arachidonic acid metabolic process  (IEA,ISO,ISS)
biological process involved in interaction with symbiont  (IEA,ISO)
blood vessel endothelial cell migration  (IEA,ISO)
cell redox homeostasis  (IEA,ISO)
cellular oxidant detoxification  (IEA)
cellular response to glucose stimulus  (IDA)
endothelial cell development  (IEA,ISO)
epigenetic regulation of gene expression  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
glutathione metabolic process  (IBA,IEA,ISO)
heart contraction  (IEA,ISO)
hydrogen peroxide catabolic process  (IBA,IEA,ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IEA,ISO)
lipid metabolic process  (ISO)
lipoxygenase pathway  (IEA,ISO,ISS)
myoblast differentiation  (IEA,ISO)
myoblast proliferation  (IEA,ISO)
myotube differentiation  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
negative regulation of inflammatory response to antigenic stimulus  (IEA,ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of release of cytochrome c from mitochondria  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
regulation of mammary gland epithelial cell proliferation  (IEA,ISO)
regulation of proteasomal protein catabolic process  (IEA,ISO)
response to estradiol  (IEP)
response to folic acid  (IEP)
response to gamma radiation  (IEA,ISO)
response to glucose  (IEP)
response to hormone  (IEP)
response to hydrogen peroxide  (IBA,IEA,ISO)
response to hydroperoxide  (IEA,ISO)
response to nicotine  (IEP)
response to organic cyclic compound  (IEP)
response to oxidative stress  (ISO)
response to reactive oxygen species  (ISO)
response to selenium ion  (IBA,IEA,IEP,ISO)
response to symbiotic bacterium  (IEA,ISO)
response to toxic substance  (ISO)
response to vitamin E  (IEP)
response to wounding  (ISO)
response to xenobiotic stimulus  (IEA,ISO)
sensory perception of sound  (IEA,ISO)
skeletal muscle fiber development  (IEA,ISO)
skeletal muscle tissue regeneration  (IEA,ISO)
temperature homeostasis  (IEA,ISO)
triglyceride metabolic process  (IEA,ISO)
UV protection  (IEA,ISO)
vasodilation  (IEA,ISO)

Cellular Component
cytoplasm  (ISO)
cytosol  (IBA,IEA,ISO,ISS)
Lewy body  (IEA,ISO)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
amyotrophic lateral sclerosis pathway  (IEA)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (IEA,ISO)
celecoxib pharmacodynamics pathway  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
glutathione metabolic pathway  (IEA,ISO)
glutathione synthase deficiency pathway  (ISO)
glutathionuria disease pathway   (ISO)
Huntington's disease pathway  (IEA)
ibuprofen pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway   (ISO)
paracetamol drug pathway  (ISO)
piroxicam pharmacodynamics pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)

References

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115. Pyrimidine 5'nucleotidase and several other red cell enzyme activities in beta-thalassaemia trait. Vives Corrons JL, etal., Br J Haematol. 1984 Mar;56(3):483-94.
116. [Association of genetic polymorphisms in selenoprotein GPX1 and TXNRD2 with genetic susceptibility of gastric cancer]. Wang J, etal., Zhonghua Yu Fang Yi Xue Za Zhi. 2008 Jul;42(7):511-4.
117. Quercetin reduces oxidative stress and inhibits activation of c‑Jun N‑terminal kinase/activator protein‑1 signaling in an experimental mouse model of abdominal aortic aneurysm. Wang L, etal., Mol Med Rep. 2014 Feb;9(2):435-42. doi: 10.3892/mmr.2013.1846. Epub 2013 Dec 6.
118. Oxidative stress in rats with hyperhomo-cysteinemia and intervention effect of lutein. Wang S, etal., Eur Rev Med Pharmacol Sci. 2014;18(3):359-64.
119. Spermatozoa have decreased antioxidant enzymatic capacity and increased reactive oxygen species production during aging in the Brown Norway rat. Weir CP and Robaire B, J Androl. 2007 Mar-Apr;28(2):229-40. Epub 2006 Oct 4.
120. Glutathione peroxidase 1 genotype is associated with an increased risk of coronary artery disease. Winter JP, etal., Coron Artery Dis. 2003 Apr;14(2):149-53.
121. Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence. Wolf N, etal., Exp Eye Res. 2005 Sep;81(3):276-85.
122. Expression of selenium-containing proteins in human colon carcinoma tissue. Yagublu V, etal., Anticancer Res. 2011 Sep;31(9):2693-8.
123. Glutathione pathway genes and lung cancer risk in young and old populations. Yang P, etal., Carcinogenesis. 2004 Oct;25(10):1935-44. doi: 10.1093/carcin/bgh203. Epub 2004 Jun 10.
124. Evaluation of glutathione metabolic genes on outcomes in advanced non-small cell lung cancer patients after initial treatment with platinum-based chemotherapy: an NCCTG-97-24-51 based study. Yang P, etal., J Thorac Oncol. 2009 Apr;4(4):479-85. doi: 10.1097/jto.0b013e31819c7a2c.
125. O-GlcNAcylation regulates hyperglycemia-induced GPX1 activation. Yang WH, etal., Biochem Biophys Res Commun. 2010 Jan 1;391(1):756-61. doi: 10.1016/j.bbrc.2009.11.133. Epub 2009 Nov 26.
126. Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion. Ye S, etal., Mol Med Rep. 2014 Sep;10(3):1635-41. doi: 10.3892/mmr.2014.2355. Epub 2014 Jun 26.
127. DNA low-density array analysis of colchicine neurotoxicity in rat cerebellar granular neurons. Yeste-Velasco M, etal., Neurotoxicology. 2008 Mar;29(2):309-17. Epub 2007 Dec 31.
128. Determination of nucleotide sequence of cDNA coding rat glutathione peroxidase and diminished expression of the mRNA in selenium deficient rat liver. Yoshimura S, etal., Biochem Biophys Res Commun 1988 Aug 15;154(3):1024-8.
129. Altered uterine perfusion is involved in fetal outcome of diabetic rats. Zabihi S, etal., Placenta. 2008 May;29(5):413-21. Epub 2008 Apr 2.
130. Decreased antioxidant activity in hypercholesterolemic children with nephrotic syndrome. Zachwieja J, etal., Med Sci Monit. 2003 Jun;9(6):CR235-9.
131. Pseudoxanthoma elasticum: genetic variations in antioxidant genes are risk factors for early disease onset. Zarbock R, etal., Clin Chem. 2007 Oct;53(10):1734-40. Epub 2007 Aug 10.
132. Effects of peroxisome proliferator-activated receptor-beta activation in endothelin-dependent hypertension. Zarzuelo MJ, etal., Cardiovasc Res. 2013 Sep 1;99(4):622-31. doi: 10.1093/cvr/cvt152. Epub 2013 Jun 10.
133. A high-selenium diet induces insulin resistance in gestating rats and their offspring. Zeng MS, etal., Free Radic Biol Med. 2012 Apr 15;52(8):1335-42. doi: 10.1016/j.freeradbiomed.2012.01.017. Epub 2012 Feb 1.
134. Effect of oestrogen on reactive oxygen species production in the aortas of ovariectomized Dahl salt-sensitive rats. Zhang L, etal., J Hypertens. 2007 Feb;25(2):407-14.
135. Pyrroloquinoline Quinone Inhibits Oxidative Stress in Rats with Diabetic Nephropathy. Zhang M, etal., Med Sci Monit. 2020 Jun 27;26:e924372. doi: 10.12659/MSM.924372.
136. High Gpx1 expression predicts poor survival in laryngeal squamous cell carcinoma. Zhang Q, etal., Auris Nasus Larynx. 2018 Feb;45(1):13-19. doi: 10.1016/j.anl.2017.05.012. Epub 2017 Jun 20.
137. [Lipid peroxidation and activity of antioxidative enzymes in patients with multiple myeloma]. Zima T, etal., Cas Lek Cesk. 1996 Jan 4;135(1):14-7.
138. Levels of selenium, zinc, copper, and antioxidant enzyme activity in patients with leukemia. Zuo XL, etal., Biol Trace Elem Res. 2006 Winter;114(1-3):41-53.
Additional References at PubMed
PMID:6217842   PMID:8889548   PMID:9126277   PMID:9386101   PMID:9788901   PMID:10428770   PMID:10490281   PMID:10627575   PMID:10754271   PMID:10833429   PMID:10915565   PMID:10915653  
PMID:11115402   PMID:11311045   PMID:11518697   PMID:11545230   PMID:11562367   PMID:11579147   PMID:11893559   PMID:12117267   PMID:12196344   PMID:12221075   PMID:12368211   PMID:12477932  
PMID:12521604   PMID:12646716   PMID:12751788   PMID:12751789   PMID:12810669   PMID:12829378   PMID:12893824   PMID:14651853   PMID:14713308   PMID:14732290   PMID:15182862   PMID:15203190  
PMID:15663476   PMID:15777843   PMID:15821744   PMID:15827346   PMID:16132718   PMID:16189290   PMID:16229841   PMID:16373599   PMID:16723478   PMID:16934683   PMID:16945136   PMID:16962942  
PMID:17097614   PMID:17145560   PMID:18226427   PMID:18267129   PMID:18614015   PMID:18853169   PMID:19398061   PMID:19855070   PMID:20063054   PMID:20524817   PMID:22614831   PMID:22905402  
PMID:22981416   PMID:23376485   PMID:23472740   PMID:23911387   PMID:24389817   PMID:24401635   PMID:24740756   PMID:24867493   PMID:24962481   PMID:26142204   PMID:28755400   PMID:29016640  
PMID:35968584   PMID:36868433   PMID:37761814  


Genomics

Comparative Map Data
Gpx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,905,462 - 117,906,588 (+)NCBIGRCr8
mRatBN7.28109,026,905 - 109,028,031 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,026,905 - 109,028,024 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,654,127 - 114,655,253 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,853,454 - 112,854,580 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,696,094 - 110,697,220 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,117,430 - 117,118,528 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,117,430 - 117,118,522 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,466,118 - 116,467,216 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,329,847 - 108,330,945 (+)ENTREZGENECelera
Cytogenetic Map8q32NCBI
GPX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,357,176 - 49,358,353 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,357,174 - 49,358,605 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,394,609 - 49,395,786 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,369,613 - 49,370,795 (-)NCBINCBI36Build 36hg18NCBI36
Build 34349,369,614 - 49,370,795NCBI
Celera349,359,484 - 49,360,663 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,454,091 - 49,455,270 (-)NCBIHuRef
CHM1_1349,347,422 - 49,348,601 (-)NCBICHM1_1
T2T-CHM13v2.0349,386,555 - 49,387,726 (-)NCBIT2T-CHM13v2.0
Gpx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,216,279 - 108,217,541 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,216,102 - 108,217,542 (+)EnsemblGRCm39 Ensembl
GRCm389108,339,080 - 108,340,342 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,338,903 - 108,340,343 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,241,607 - 108,242,671 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,197,368 - 108,198,432 (+)NCBIMGSCv36mm8
Celera9107,948,378 - 107,949,442 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.24NCBI
Gpx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555321,298,336 - 1,298,830 (-)NCBIChiLan1.0ChiLan1.0
GPX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,334,513 - 49,336,253 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,339,284 - 49,340,757 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,280,038 - 49,281,455 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,360,736 - 50,362,274 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,360,947 - 50,361,826 (-)Ensemblpanpan1.1panPan2
GPX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,889,165 - 39,890,253 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,889,174 - 39,890,260 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,807,516 - 39,808,604 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,245,494 - 40,246,582 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,245,503 - 40,246,589 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,612,973 - 39,614,061 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,016,432 - 40,017,520 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,296,220 - 40,297,308 (+)NCBIUU_Cfam_GSD_1.0
Gpx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,237,446 - 64,238,592 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529998,150 - 998,987 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936529997,943 - 999,123 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,916,246 - 31,917,433 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,916,269 - 31,917,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,147,277 - 35,148,345 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,754,976 - 10,756,617 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041156,259,200 - 156,261,033 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,313,972 - 3,314,626 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,313,773 - 3,314,870 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpx1
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:33
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000073247
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat

Markers in Region
PMC302051P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,027,242 - 109,027,461 (+)MAPPERmRatBN7.2
Rnor_6.08117,117,741 - 117,117,959NCBIRnor6.0
Rnor_5.08116,466,429 - 116,466,647UniSTSRnor5.0
Celera8108,330,158 - 108,330,376UniSTS
PMC305564P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,026,997 - 109,027,817 (+)MAPPERmRatBN7.2
Rnor_6.08117,117,496 - 117,118,315NCBIRnor6.0
Rnor_5.08116,466,184 - 116,467,003UniSTSRnor5.0
Celera8108,329,913 - 108,330,732UniSTS
WI-18922  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,025,491 - 109,025,637 (+)MAPPERmRatBN7.2
Rnor_6.08117,115,990 - 117,116,135NCBIRnor6.0
Rnor_5.08116,464,678 - 116,464,823UniSTSRnor5.0
Celera8108,328,407 - 108,328,552UniSTS
Cytogenetic Map16q12.5UniSTS
RH127950  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,027,817 - 109,028,004 (+)MAPPERmRatBN7.2
Rnor_6.08117,118,316 - 117,118,502NCBIRnor6.0
Rnor_5.08116,467,004 - 116,467,190UniSTSRnor5.0
Celera8108,330,733 - 108,330,919UniSTS
RH 3.4 Map81118.6UniSTS
RH129553  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,027,823 - 109,028,011 (+)MAPPERmRatBN7.2
Rnor_6.08117,118,322 - 117,118,509NCBIRnor6.0
Rnor_5.08116,467,010 - 116,467,197UniSTSRnor5.0
Celera8108,330,739 - 108,330,926UniSTS
RH 3.4 Map81120.9UniSTS
AI195024  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,027,572 - 109,027,660 (+)MAPPERmRatBN7.2
Rnor_6.08117,118,071 - 117,118,158NCBIRnor6.0
Rnor_5.08116,466,759 - 116,466,846UniSTSRnor5.0
Celera8108,330,488 - 108,330,575UniSTS
PMC164851P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,027,109 - 109,027,605 (+)MAPPERmRatBN7.2
Rnor_6.08117,117,608 - 117,118,103NCBIRnor6.0
Rnor_5.08116,466,296 - 116,466,791UniSTSRnor5.0
Celera8108,330,025 - 108,330,520UniSTS
D3S1330E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,025,162 - 109,025,271 (+)MAPPERmRatBN7.2
Rnor_6.08117,115,661 - 117,115,769NCBIRnor6.0
Rnor_5.08116,464,349 - 116,464,457UniSTSRnor5.0
Celera8108,328,078 - 108,328,186UniSTS
Cytogenetic Map16q12.5UniSTS
UniSTS:532286  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,025,304 - 109,025,687 (+)MAPPERmRatBN7.2
Rnor_6.08117,115,803 - 117,116,185NCBIRnor6.0
Rnor_5.08116,464,491 - 116,464,873UniSTSRnor5.0
Celera8108,328,220 - 108,328,602UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2 24 24 5 24 1
Medium 3 41 33 17 14 17 8 11 74 34 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_030826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB004231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC128721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI281978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB579218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ139913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S50336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000073247   ⟹   ENSRNOP00000066577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,026,905 - 109,028,024 (+)Ensembl
Rnor_6.0 Ensembl8117,117,430 - 117,118,522 (+)Ensembl
RefSeq Acc Id: NM_030826   ⟹   NP_110453
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,905,462 - 117,906,588 (+)NCBI
mRatBN7.28109,026,905 - 109,028,031 (+)NCBI
Rnor_6.08117,117,430 - 117,118,528 (+)NCBI
Rnor_5.08116,466,118 - 116,467,216 (+)NCBI
Celera8108,329,847 - 108,330,945 (+)ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_110453   ⟸   NM_030826
- UniProtKB: Q4PIY2 (UniProtKB/Swiss-Prot),   O08946 (UniProtKB/Swiss-Prot),   Q91WZ5 (UniProtKB/Swiss-Prot),   P04041 (UniProtKB/Swiss-Prot),   M0RAM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066577   ⟸   ENSRNOT00000073247

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696297
Promoter ID:EPDNEW_R6821
Type:initiation region
Name:Gpx1_1
Description:glutathione peroxidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,117,462 - 117,117,522EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2729 AgrOrtholog
BioCyc Gene G2FUF-29147 BioCyc
BioCyc Pathway DETOX1-PWY-1 [reactive oxygen species degradation] BioCyc
  PWY-4081 [glutathione-peroxide redox reactions] BioCyc
BioCyc Pathway Image DETOX1-PWY-1 BioCyc
  PWY-4081 BioCyc
Ensembl Genes ENSRNOG00000048812 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055013502 UniProtKB/Swiss-Prot
  ENSRNOG00060022938 UniProtKB/Swiss-Prot
  ENSRNOG00065006611 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073247 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000073247.3 UniProtKB/Swiss-Prot
  ENSRNOT00055023147 UniProtKB/Swiss-Prot
  ENSRNOT00060039711 UniProtKB/Swiss-Prot
  ENSRNOT00065010211 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6918849 IMAGE-MGC_LOAD
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_AS UniProtKB/Swiss-Prot
  GPX_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24404 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72654 IMAGE-MGC_LOAD
NCBI Gene 24404 ENTREZGENE
PANTHER GLUTATHIONE PEROXIDASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GSHPx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GPX1 RGD
PhenoGen Gpx1 PhenoGen
PIRSF Glutathion_perox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048812 RatGTEx
  ENSRNOG00055013502 RatGTEx
  ENSRNOG00060022938 RatGTEx
  ENSRNOG00065006611 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GPX1_RAT UniProtKB/Swiss-Prot
  M0RAM5 ENTREZGENE, UniProtKB/TrEMBL
  O08946 ENTREZGENE
  P04041 ENTREZGENE
  Q4PIY2 ENTREZGENE
  Q6PDW8_RAT UniProtKB/TrEMBL
  Q91WZ5 ENTREZGENE
UniProt Secondary O08946 UniProtKB/Swiss-Prot
  Q4PIY2 UniProtKB/Swiss-Prot
  Q91WZ5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gpx1  Glutathione peroxidase 1      Symbol and Name status set to approved 70586 APPROVED