RGD Reference Report - A high-selenium diet induces insulin resistance in gestating rats and their offspring. - Rat Genome Database

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A high-selenium diet induces insulin resistance in gestating rats and their offspring.

Authors: Zeng, MS  Li, X  Liu, Y  Zhao, H  Zhou, JC  Li, K  Huang, JQ  Sun, LH  Tang, JY  Xia, XJ  Wang, KN  Lei, XG 
Citation: Zeng MS, etal., Free Radic Biol Med. 2012 Apr 15;52(8):1335-42. doi: 10.1016/j.freeradbiomed.2012.01.017. Epub 2012 Feb 1.
RGD ID: 11353780
Pubmed: PMID:22342560   (View Abstract at PubMed)
PMCID: PMC3505681   (View Article at PubMed Central)
DOI: DOI:10.1016/j.freeradbiomed.2012.01.017   (Journal Full-text)

Although supranutrition of selenium (Se) is considered a promising anti-cancer strategy, recent human studies have shown an intriguing association between high body Se status and diabetic risk. This study was done to determine if a prolonged high intake of dietary Se actually induced gestational diabetes in rat dams and insulin resistance in their offspring. Forty-five 67-day-old female Wistar rats (n=15/diet) were fed a Se-deficient (0.01 mg/kg) corn-soy basal diet (BD) or BD+Se (as Se-yeast) at 0.3 or 3.0mg/kg from 5 weeks before breeding to day 14 postpartum. Offspring (n=8/diet) of the 0.3 and 3.0mg Se/kg dams were fed with the same respective diet until age 112 days. Compared with the 0.3mg Se/kg diet, the 3.0mg/kg diet induced hyperinsulinemia (P<0.01), insulin resistance (P<0.01), and glucose intolerance (P<0.01) in the dams at late gestation and/or day 14 postpartum and in the offspring at age 112 days. These impairments concurred with decreased (P<0.05) mRNA and/or protein levels of six insulin signal proteins in liver and muscle of dams and/or pups. Dietary Se produced dose-dependent increases in Gpx1 mRNA or GPX1 activity in pancreas, liver, and erythrocytes of dams. The 3.0mg Se/kg diet decreased Selh (P<0.01), Sepp1 (P=0.06), and Sepw1 (P<0.01), but increased Sels (P<0.05) mRNA levels in the liver of the offspring, compared with the 0.3mg Se/kg diet. In conclusion, supranutrition of Se as a Se-enriched yeast in rats induced gestational diabetes and insulin resistance. Expression of six selenoprotein genes, in particular Gpx1, was linked to this metabolic disorder.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
gestational diabetes  ISOGpx1 (Rattus norvegicus)11353780; 11353780 RGD 
gestational diabetes  IDA 11353780 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gpx1  (glutathione peroxidase 1)

Genes (Mus musculus)
Gpx1  (glutathione peroxidase 1)

Genes (Homo sapiens)
GPX1  (glutathione peroxidase 1)


Additional Information