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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729 Species: Rattus norvegicus RGD Object: Gene Symbol: Gpx1 Name: glutathione peroxidase 1

Acc ID: CHEBI:15756 Term: palmitic acid Definition: A straight-chain, sixteen-carbon, saturated long-chain fatty acid. CasRN: 57-10-3 Chemical ID: MESH:D019308

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:737005	6480464	CTD	Palmitic Acid results in decreased expression of GPX1 mRNA	PMID:18155663
multiple interactions	ISO	RGD:737005	6480464	CTD	rosiglitazone inhibits the reaction [Palmitic Acid results in decreased expression of GPX1 mRNA]	PMID:18155663