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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1affects expressionEXP 6480464CTDbisphenol A affects the expression of GPX1 mRNAPMID:30903817
Gpx1increases expressionEXP 6480464CTDbisphenol A results in increased expression of GPX1 mRNAPMID:25181051 PMID:28721559 PMID:32145629
Gpx1multiple interactionsEXP 6480464CTD[Resveratrol analog co-treated with bisphenol A] results in increased expression of GPX1 mRNAPMID:34067838
Gpx1affects expressionISOGpx1 (Mus musculus)6480464CTDbisphenol A affects the expression of GPX1 mRNAPMID:26049153
Gpx1decreases expressionISOGpx1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of GPX1 mRNA; bisphenol A results in decreased expression of GPX1 proteinPMID:31756439 PMID:36451259
Gpx1decreases expressionISOGPX1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of GPX1 mRNA; bisphenol A results in decreased expression of GPX1 proteinPMID:29964091 PMID:30953815 PMID:37567409
Gpx1increases expressionISOGpx1 (Mus musculus)6480464CTDbisphenol A results in increased expression of GPX1 mRNAPMID:26746108
Gpx1multiple interactionsISOGpx1 (Mus musculus)6480464CTDCaffeine promotes the reaction [bisphenol A results in decreased expression of GPX1 mRNA]PMID:31756439
Gpx1multiple interactionsISOGPX1 (Homo sapiens)6480464CTD[bisphenol A co-treated with cylindrospermopsin] results in increased expression of GPX1 mRNA; bisphenol A results in decreased expression of and results in decreased activity of GPX1 proteinPMID:28490175 PMID:32244372
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