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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:64163
Term: diquat
Definition: The organic cation formed formally by addition of an ethylene bridge between the nitrogen atoms of 2,2'-bipyridine. Most often available as the dibromide.
Chemical ID: MESH:D004178
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1affects response to substanceISOGpx1 (Mus musculus)6480464CTDGPX1 protein affects the susceptibility to DiquatPMID:11672444
Gpx1decreases expressionISOGpx1 (Mus musculus)6480464CTDDiquat results in decreased expression of GPX1 mRNA; Diquat results in decreased expression of GPX1 proteinPMID:11672444 PMID:35268077
Gpx1decreases response to substanceISOGpx1 (Mus musculus)6480464CTDGPX1 protein results in decreased susceptibility to DiquatPMID:11568445
Gpx1increases response to substanceISOGpx1 (Mus musculus)6480464CTDGPX1 gene mutant form results in increased susceptibility to Diquat; GPX1 protein results in increased susceptibility to DiquatPMID:10490281 PMID:15182862
Gpx1multiple interactionsISOGpx1 (Mus musculus)6480464CTDEllagic Acid inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA]; GPX1 protein affects the reaction [Diquat results in decreased activity of SOD1 protein]; GPX1 protein affects the reaction [Diquat results in increased abundance of F2-Isoprostanes]; GPX1 protein affects the reaction [Diquat results in increased activity of SOD2 protein]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; GPX1 protein affects the susceptibility to [Diquat co-treated with S-Nitroso-N-Acetylpenicillamine]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased expression of GPX1 protein]PMID:10490281 PMID:11672444 PMID:35268077
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