Gene:	Fyn ( Rattus norvegicus ) FYN oncogene related to SRC, FGR, YES
Description:	may mediate tyrosine phosphorylation of Cbl protein in cerebellum in response to ethanol administration
Synonyms:	fyn proto-oncogene;
ArrayIDs:	1373683_at; 6217688; rc_AI009191_at; 6216940; 6594300; rc_AI230396_at; 5692753; 5680480; 5772442; 6185660; 5893545; 5899771; 5720837; 5915174; 6618575; 6621427; A_44_P149080; 1369103_at; 5988447; 6335724; A_44_P149087; GE19946; 6142516; 6625403; 6008002; 5767200; 6093145; 6017183;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: FYN     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Fyn     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Fyn genome assembly 3.1 20 43524863 - 43718578     Rat Celera Assembly 20 43622361 - 43675785     RGSC genome assembly v3.4 20 43501853 - 43695567     Cytogenetic 20 q13 Mus musculus Fyn Mouse genome assembly build 36.1 10 39089892 - 39285187     Cytogenetic 10 10 B1 Homo sapiens FYN human genome assembly 6 112089179 - 112186978     Human genome assembly build 36.2 6 112089178 - 112301320     Cytogenetic 6 q21   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology protein kinase activity,  nucleotide binding,  kinase activity ...  (details...)
Biological Process	Gene Ontology detection of mechanical stimulus involved in sensory perception of pain,  multicellular organismal development,  regulation of cell shape ...  (details...)
Cellular Component	Gene Ontology endosome,  mitochondrial envelope,  plasma membrane ...  (details...)
Disease	Ontology Schizophrenia,  Alzheimer Disease (details...)
Phenotype	Ontology reduced kindling behavior,  abnormal nursing (details...)
Pathway	Ontology vascular endothelial growth factor signaling pathway (details...)
Physical interaction	Note Reference coexpressed with and binds to Cbl protein in the cerebellum 632732
External Links
Databases	DATABASE ID SOURCE SMART: TyrKc IPI SMART: SH3 IPI SMART: SH2 IPI PROSITE: SH2 IPI PROSITE: PROTEIN_KINASE_DOM IPI PROSITE: SH3 IPI PROSITE: PROTEIN_KINASE_ATP IPI PROSITE: PROTEIN_KINASE_TYR IPI UNIPARC: UPI000017E518 IPI UNIPARC: UPI00000E715E IPI KEGG Report: rno:25150 ENTREZGENE HomoloGene Group ID: 48068 ENTREZGENE Germonline: 2641 Pfam: Pkinase_Tyr IPI Pfam: SH3_1 IPI Pfam: SH2 IPI KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04360 ENTREZGENE KEGG Pathway: 04520 ENTREZGENE KEGG Pathway: 05020 ENTREZGENE InterPro: Tyr_kinase_non-rcpt_Fyn. IPI InterPro: SH3_region. IPI InterPro: SH3_domain. IPI InterPro: SH2. IPI InterPro: Tyr_prot_kinase_cat_dom. IPI InterPro: Prot_kinase_cat_dom. IPI InterPro: Kinase-like_dom. IPI InterPro: Tyr_prot_kinase. IPI InterPro: Tyr_prot_kinase_AS. IPI InterPro: Protein_kinase_ATP_BS. IPI InterPro: Tyr_prot_kinase_subgr_cat_dom. IPI Ensembl Protein: ENSRNOP00000000733 IPI Ensembl Protein: ENSRNOP00000000732 IPI IPI: IPI00209210 IPI IPI: IPI00189160 IPI Gene3D-CATH: SH2 IPI Entrez Gene: Fyn ENTREZGENE Ensembl Genes: ENSRNOG00000000596 IPI TIGR: TC207354 UniProt: FYN_RAT IPI RatMap: 39703 ENTREZGENE Superfamily-SCOP: SH3 IPI Superfamily-SCOP: Kinase_like IPI PANTHER: Tyr_kinase_non-rcpt_Fyn IPI PANTHER: Tyr_prot_kinase IPI PRINTS: SH2DOMAIN. IPI PRINTS: SH3DOMAIN. IPI
Sequences	Nucleotide: U35365 Get FASTA Search GEO Profiles Nucleotide: NM_012755 Get FASTA Search GEO Profiles Nucleotide: CH474051 Get FASTA Search GEO Profiles Nucleotide: XM_001062721 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: EDL87819 Get FASTA Protein: NP_036887 Get FASTA Protein: EDL87815 Get FASTA Protein: Q62844 Get FASTA Protein: AAA82942 Get FASTA Protein: XP_001062721 Get FASTA Protein: EDL87818 Get FASTA Protein: EDL87817 Get FASTA Protein: EDL87816 Get FASTA (View all 9 Protein Accessions)
Clusters	UniGene: 19361
References
Curated References	21 references in RGD related to Fyn
Other References	28 other references at PubMed related to Fyn
Database Information
RGD ID	2641
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 18-SEP-08: Fyn FYN oncogene related to SRC, FGR, YES Fyn fyn proto-oncogene APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 10-JUN-02: Fyn Fyn proto-oncogene APPROVED Symbol and Name status set to approved 70586