FYN (FYN proto-oncogene, Src family tyrosine kinase) - Rat Genome Database

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Pathways
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Gene: FYN (FYN proto-oncogene, Src family tyrosine kinase) Pan paniscus
Analyze
Symbol: FYN
Name: FYN proto-oncogene, Src family tyrosine kinase
RGD ID: 11825903
Description: ENCODES a protein that exhibits CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); enzyme binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to glycine (ortholog); PARTICIPATES IN altered Reelin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); Alzheimer's disease (ortholog); Burns (ortholog); FOUND IN dendrite (ortholog); glutamatergic synapse (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: FYN oncogene related to SRC, FGR, YES; tyrosine-protein kinase Fyn
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25131,675,357 - 131,889,692 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16129,561,361 - 129,775,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06109,469,750 - 109,684,086 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16113,545,944 - 113,732,893 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6113,545,944 - 113,604,451 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (IEA,ISO)
cell differentiation  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cell surface receptor signaling pathway  (IEA,ISO)
cellular response to amyloid-beta  (IEA)
cellular response to glycine  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to L-glutamate  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
dendrite morphogenesis  (IEA,ISO)
detection of mechanical stimulus involved in sensory perception of pain  (IEA,ISO)
forebrain development  (IEA,ISO)
G protein-coupled glutamate receptor signaling pathway  (ISO)
gene expression  (IEA,ISO)
heart process  (IEA)
innate immune response  (IEA)
intracellular signal transduction  (IEA)
modulation of chemical synaptic transmission  (IEA)
negative regulation of dendritic spine maintenance  (IEA)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of gene expression  (IEA)
negative regulation of hydrogen peroxide biosynthetic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of protein catabolic process  (IEA,ISO)
negative regulation of protein ubiquitination  (IEA,ISO)
neuron migration  (IEA,ISO)
neuron projection development  (IEA,ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of neuron projection development  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein localization to nucleus  (IEA,ISO)
positive regulation of protein targeting to membrane  (IEA)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA)
protein autophosphorylation  (ISO)
protein catabolic process  (IEA,ISO)
protein ubiquitination  (IEA,ISO)
regulation of calcium ion import across plasma membrane  (IEA)
regulation of cell shape  (IEA,ISO)
regulation of glutamate receptor signaling pathway  (IEA)
regulation of peptidyl-tyrosine phosphorylation  (IEA)
response to amyloid-beta  (IEA)
response to ethanol  (IEA,ISO)
response to singlet oxygen  (ISO)
response to xenobiotic stimulus  (ISO)
T cell receptor signaling pathway  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FYN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25131,675,357 - 131,889,692 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16129,561,361 - 129,775,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06109,469,750 - 109,684,086 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16113,545,944 - 113,732,893 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6113,545,944 - 113,604,451 (-)Ensemblpanpan1.1panPan2
FYN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386111,660,332 - 111,873,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6111,660,332 - 111,873,452 (-)EnsemblGRCh38hg38GRCh38
GRCh376111,981,535 - 112,194,655 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366112,089,178 - 112,301,320 (-)NCBINCBI36Build 36hg18NCBI36
Build 346112,089,179 - 112,186,978NCBI
Celera6112,729,071 - 112,941,209 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6109,554,123 - 109,767,060 (-)NCBIHuRef
CHM1_16112,244,349 - 112,457,405 (-)NCBICHM1_1
T2T-CHM13v2.06112,843,350 - 113,056,537 (-)NCBIT2T-CHM13v2.0
Fyn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391039,245,735 - 39,441,377 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1039,244,851 - 39,441,377 (+)EnsemblGRCm39 Ensembl
GRCm381039,369,743 - 39,565,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1039,368,855 - 39,565,381 (+)EnsemblGRCm38mm10GRCm38
MGSCv371039,089,605 - 39,285,187 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361039,059,502 - 39,254,797 (+)NCBIMGSCv36mm8
Celera1040,254,667 - 40,450,960 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1020.51NCBI
Fyn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82044,322,635 - 44,514,498 (+)NCBIGRCr8
mRatBN7.22042,767,733 - 42,960,903 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2042,766,369 - 42,959,911 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2044,517,354 - 44,708,655 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02044,176,580 - 44,367,880 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02044,909,156 - 45,110,016 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02044,436,354 - 44,630,316 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2044,436,403 - 44,630,317 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02046,160,734 - 46,353,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42043,501,853 - 43,695,567 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12043,524,863 - 43,718,578 (+)NCBI
Celera2043,482,980 - 43,675,123 (+)NCBICelera
Cytogenetic Map20q12NCBI
Fyn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541136,401,842 - 36,512,054 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541136,403,156 - 36,597,660 (-)NCBIChiLan1.0ChiLan1.0
FYN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11268,105,060 - 68,316,630 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1268,075,184 - 68,316,541 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1267,924,675 - 68,136,151 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01268,986,784 - 69,198,525 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1268,987,778 - 69,174,188 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11268,338,226 - 68,549,311 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01268,184,783 - 68,396,306 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01268,510,644 - 68,722,405 (-)NCBIUU_Cfam_GSD_1.0
Fyn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946103,155,533 - 103,356,140 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936679387,387 - 443,880 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936679388,500 - 588,518 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FYN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl177,585,439 - 77,810,581 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1177,584,675 - 77,810,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,249,062 - 87,253,260 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2187,146,809 - 87,191,215 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1p13NCBI
FYN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11361,988,265 - 62,218,756 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1362,159,874 - 62,219,672 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604034,319,593 - 34,528,593 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fyn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624933389,627 - 456,520 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624933248,298 - 456,933 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000048254   ⟹   ENSPPAP00000025427
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6113,545,944 - 113,604,451 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000048262   ⟹   ENSPPAP00000025435
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6113,545,944 - 113,604,451 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000048271   ⟹   ENSPPAP00000025444
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6113,546,402 - 113,604,451 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000048283   ⟹   ENSPPAP00000025456
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6113,546,402 - 113,604,451 (-)Ensembl
RefSeq Acc Id: XM_034962716   ⟹   XP_034818607
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25131,675,357 - 131,889,692 (-)NCBI
NHGRI_mPanPan16129,561,361 - 129,775,652 (-)NCBI
Mhudiblu_PPA_v06109,469,750 - 109,684,086 (-)NCBI
RefSeq Acc Id: XM_034962718   ⟹   XP_034818609
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25131,675,357 - 131,889,528 (-)NCBI
NHGRI_mPanPan16129,561,361 - 129,775,316 (-)NCBI
Mhudiblu_PPA_v06109,469,750 - 109,683,752 (-)NCBI
RefSeq Acc Id: XM_034962720   ⟹   XP_034818611
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25131,675,357 - 131,889,671 (-)NCBI
NHGRI_mPanPan16129,561,361 - 129,775,304 (-)NCBI
Mhudiblu_PPA_v06109,469,750 - 109,683,733 (-)NCBI
RefSeq Acc Id: XM_057302577   ⟹   XP_057158560
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25131,675,357 - 131,889,662 (-)NCBI
NHGRI_mPanPan16129,561,361 - 129,775,304 (-)NCBI
RefSeq Acc Id: XM_057302578   ⟹   XP_057158561
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25131,675,357 - 131,790,343 (-)NCBI
NHGRI_mPanPan16129,561,361 - 129,641,059 (-)NCBI
RefSeq Acc Id: XM_063604991   ⟹   XP_063461061
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25131,675,357 - 131,889,627 (-)NCBI
RefSeq Acc Id: XM_063604992   ⟹   XP_063461062
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25131,675,357 - 131,755,187 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034818607   ⟸   XM_034962716
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B759 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034818609   ⟸   XM_034962718
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B759 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034818611   ⟸   XM_034962720
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BAX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000025456   ⟸   ENSPPAT00000048283
RefSeq Acc Id: ENSPPAP00000025427   ⟸   ENSPPAT00000048254
RefSeq Acc Id: ENSPPAP00000025435   ⟸   ENSPPAT00000048262
RefSeq Acc Id: ENSPPAP00000025444   ⟸   ENSPPAT00000048271
RefSeq Acc Id: XP_057158560   ⟸   XM_057302577
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B759 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_057158561   ⟸   XM_057302578
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B759 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063461061   ⟸   XM_063604991
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BAX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063461062   ⟸   XM_063604992
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BAX8 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035740 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000048254.1 UniProtKB/TrEMBL
  ENSPPAT00000048262.1 UniProtKB/TrEMBL
  ENSPPAT00000048271.1 UniProtKB/TrEMBL
  ENSPPAT00000048283.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Fyn/Yrk_SH2 UniProtKB/TrEMBL
  Fyn/Yrk_SH3 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
NCBI Gene FYN ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE FYN UniProtKB/TrEMBL
Pfam PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9B759 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B8P4_PANPA UniProtKB/TrEMBL
  A0A2R9BAX8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BEL8_PANPA UniProtKB/TrEMBL