RGD Reference Report - NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. - Rat Genome Database

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NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1.

Authors: Yaka, R  Thornton, C  Vagts, AJ  Phamluong, K  Bonci, A  Ron, D 
Citation: Yaka R, etal., Proc Natl Acad Sci U S A 2002 Apr 16;99(8):5710-5. Epub 2002 Apr 9.
RGD ID: 1358552
Pubmed: PMID:11943848   (View Abstract at PubMed)
PMCID: PMC122836   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.062046299   (Journal Full-text)

Phosphorylation regulates the function of ligand-gated ion channels such as the N-methyl d-aspartate (NMDA) receptor. Here we report a mechanism for modulation of the phosphorylation state and function of the NMDA receptor via an inhibitory scaffolding protein, RACK1. We found that RACK1 binds both the NR2B subunit of the NMDA receptor and the nonreceptor protein tyrosine kinase, Fyn. RACK1 inhibits Fyn phosphorylation of NR2B and decreases NMDA receptor-mediated currents in CA1 hippocampal slices. Peptides that disrupt the interactions between RACK1, NR2B, and Fyn induce phosphorylation and potentiate NMDA receptor-mediated currents. Therefore, RACK1 is a regulator of NMDA receptor function and may play a role in synaptic plasticity, addiction, learning, and memory.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding  IPIRack1 (Rattus norvegicus)1358552 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fyn  (FYN proto-oncogene, Src family tyrosine kinase)

Objects referenced in this article
Gene Grin2b glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus
Gene Grin2c glutamate ionotropic receptor NMDA type subunit 2C Rattus norvegicus
Gene Rack1 receptor for activated C kinase 1 Rattus norvegicus

Additional Information