Egf (epidermal growth factor) - Rat Genome Database

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Gene: Egf (epidermal growth factor) Rattus norvegicus
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Symbol: Egf
Name: epidermal growth factor
RGD ID: 2542
Description: Enables epidermal growth factor receptor binding activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; and positive regulation of fibroblast proliferation. Acts upstream of or within regulation of protein transport. Located in extracellular space. Used to study perinatal necrotizing enterocolitis. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103691699; pro-epidermal growth factor; uncharacterized LOC103691699
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82220,893,660 - 220,976,331 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2220,893,660 - 220,976,297 (-)EnsemblGRCr8
mRatBN7.22218,219,408 - 218,302,359 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2218,219,415 - 218,302,064 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2225,907,754 - 225,986,699 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02223,807,431 - 223,886,385 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,665,094 - 218,744,036 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0268,820,616 - 68,895,537 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0288,549,746 - 88,621,570 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0274,746,752 - 74,783,449 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.02253,481,574 - 253,482,579 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42227,103,900 - 227,195,062 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2210,511,076 - 210,588,041 (-)NCBICelera
RGSC_v3.12227,090,579 - 227,181,742 (-)NCBI
RH 3.4 Map21556.7RGD
Cytogenetic Map2q43NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
adenocarcinoma  (ISO)
AIDS-Associated Nephropathy  (ISO)
Alzheimer's disease  (ISO)
autistic disorder  (ISO)
Breast Neoplasms  (ISO)
cholangiocarcinoma  (ISO)
cleft palate  (ISO)
dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
Disease Progression  (ISO)
endometrial cancer  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Liver Cirrhosis  (ISO)
gallbladder cancer  (ISO)
gastric ulcer  (ISO)
Genetic Predisposition to Disease  (ISO)
glioblastoma  (ISO)
Helicobacter Infections  (ISO)
hepatocellular carcinoma  (ISO)
hereditary renal cell carcinoma  (ISO)
high grade glioma  (ISO)
inclusion body myopathy with Paget disease of bone and frontotemporal dementia  (ISO)
juvenile rheumatoid arthritis  (ISO)
kidney disease  (ISO)
lung adenocarcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Metaplasia  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
oligodendroglioma  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (IDA)
pneumonia  (ISO)
pre-malignant neoplasm  (ISO)
primary hypomagnesemia  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
renal hypomagnesemia 3  (ISO)
renal hypomagnesemia 4  (ISO)
renal hypomagnesemia 5 with ocular involvement  (ISO)
Reperfusion Injury  (ISO)
schizophrenia  (ISO)
shigellosis  (ISO)
Tympanic Membrane Perforation  (ISO)
Wounds and Injuries  (IEP,ISO)
Zollinger-Ellison syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R)-noradrenaline  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2',3'-dideoxyadenosine  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-arachidonoylglycerol  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-dihydrocoumarin  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4,5-dianilinophthalimide  (EXP)
4-tert-Octylphenol  (EXP)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chrysenamine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
8-Hydroxyguanosine  (EXP)
acetaldehyde  (ISO)
actinomycin D  (EXP)
adenosine  (ISO)
afatinib  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
amsacrine  (ISO)
androgen antagonist  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
asparagine  (EXP)
atrazine  (ISO)
auranofin  (ISO)
bacitracin  (EXP)
bafilomycin A1  (EXP)
baicalein  (ISO)
baicalin  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoic acid  (ISO)
berberine  (ISO)
bexarotene  (EXP)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butan-1-ol  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Calphostin C  (EXP)
canertinib  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
CGP 52608  (ISO)
chelerythrine  (ISO)
CHIR 99021  (ISO)
chlordecone  (ISO)
chlorogenic acid  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chrysin  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
Clivoline  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cordycepin  (ISO)
cortisol  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP,ISO)
cyproterone acetate  (EXP)
cytochalasin D  (ISO)
D-glucose  (ISO)
dactolisib  (ISO)
daunorubicin  (ISO)
DDE  (EXP)
DDT  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
entinostat  (ISO)
enzacamene  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
erlotinib hydrochloride  (EXP,ISO)
erythrosin B  (ISO)
ethanol  (ISO)
ethanolamine  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
farnesol  (ISO)
finasteride  (EXP)
flurbiprofen  (ISO)
flutamide  (EXP)
fructose  (EXP)
fulvestrant  (EXP,ISO)
galangin  (ISO)
gallic acid  (ISO)
gefitinib  (ISO)
geldanamycin  (EXP,ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
geranylgeraniol  (ISO)
glafenine  (EXP)
glucose  (ISO)
glutathione  (EXP)
Glutethimide  (EXP)
glycidol  (EXP,ISO)
Goe 6976  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (ISO)
heparin  (ISO)
homocysteine  (EXP)
hydrogen peroxide  (ISO)
hydroxamic acid  (ISO)
ibuprofen  (ISO)
icariside II  (ISO)
ICI-164384  (ISO)
indometacin  (ISO)
inulin  (ISO)
ionomycin  (ISO)
ketoconazole  (ISO)
L-arginine  (EXP)
L-aspartic acid  (EXP)
L-isoleucine  (EXP)
L-leucine  (EXP)
L-lysine  (EXP)
L-methionine  (EXP)
L-phenylalanine  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
leptomycin B  (ISO)
leupeptin  (ISO)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
Maduramicin  (EXP)
magnesium dichloride  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
mestranol  (EXP)
methoxyacetic acid  (ISO)
methyl beta-cyclodextrin  (ISO)
methylmercury chloride  (ISO)
mibolerone  (ISO)
midostaurin  (ISO)
mifepristone  (EXP,ISO)
mitomycin C  (ISO)
ML-7  (EXP)
monensin A  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
muramyl dipeptide  (ISO)
myricetin  (ISO)
N(6)-butyryl-cAMP  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nafenopin  (EXP)
naringin  (ISO)
nefazodone  (EXP)
nevirapine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nimesulide  (EXP)
nitenpyram  (ISO)
nitrofen  (EXP)
nocodazole  (ISO)
okadaic acid  (EXP,ISO)
omeprazole  (ISO)
oridonin  (ISO)
ornithine  (EXP)
Osajin  (ISO)
osimertinib  (ISO)
oxidopamine  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
pamidronate  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perifosine  (ISO)
permethrin  (EXP)
peroxides  (EXP)
Pervanadate  (EXP)
phenanthrolines  (EXP)
phencyclidine  (ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidic acid  (EXP)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
Pomiferin  (ISO)
primaquine  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
prostaglandin D2  (EXP)
prostaglandin E2  (ISO)
protein kinase inhibitor  (EXP)
pterostilbene  (ISO)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
Ro 31-8220  (EXP)
Rosavin  (ISO)
rose bengal  (ISO)
rotenone  (EXP,ISO)
Ruscogenin  (ISO)
rutin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (EXP)
sepantronium  (ISO)
silmitasertib  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
Sodium salicylate  (ISO)
sorafenib  (ISO)
sotorasib  (ISO)
stattic  (ISO)
staurosporine  (EXP,ISO)
streptozocin  (ISO)
sulfasalazine  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (EXP)
Swertiamarin  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
tephrosin  (ISO)
teriflunomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (ISO)
theaflavin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tyrosine  (EXP)
tyrphostin AG 1478  (EXP,ISO)
UNC0642  (ISO)
urethane  (ISO)
valine  (EXP)
valproic acid  (ISO)
vancomycin  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
wortmannin  (EXP,ISO)
WP1066  (ISO)
XL147  (ISO)
Y-27632  (EXP)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
animal organ development  (IEA)
branching morphogenesis of an epithelial tube  (ISO)
epidermal growth factor receptor signaling pathway  (IBA,IDA,IEA,ISO)
ERBB2-EGFR signaling pathway  (IEA,ISO)
ERK1 and ERK2 cascade  (IEA,ISO)
intracellular signal transduction  (TAS)
kidney development  (IEP)
mammary gland alveolus development  (ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of secretion  (IEA,ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IBA,IEA,ISO,ISS)
positive regulation of cerebellar granule cell precursor proliferation  (ISO)
positive regulation of DNA biosynthetic process  (IDA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of endothelial cell migration  (IEA,ISO)
positive regulation of endothelial cell proliferation  (IEA,ISO)
positive regulation of epithelial tube formation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of fibroblast proliferation  (IDA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of hyaluronan biosynthetic process  (IEA,ISO)
positive regulation of macromolecule metabolic process  (IEA)
positive regulation of MAPK cascade  (IBA,IEA,ISO,ISS)
positive regulation of mitotic nuclear division  (IEA,ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of phosphorylation  (IEA,ISO)
positive regulation of protein localization to early endosome  (IEA,ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of receptor internalization  (IEA,ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (ISO)
regulation of calcium ion import  (IEA,ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of primary metabolic process  (IEA)
regulation of protein localization to cell surface  (IEA,ISO)
regulation of protein transport  (IDA)
regulation of receptor signaling pathway via JAK-STAT  (ISO,ISS)
regulation of transport  (IEA)
signal transduction  (IEA)
system development  (IEA)

Cellular Component
extracellular exosome  (IEA,ISO)
extracellular space  (IDA,IEA,ISO)
membrane  (IEA)
plasma membrane  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Serum levels of epidermal growth factor, transforming growth factor, and c-erbB2 in ovarian cancer. Balcan E, etal., Int J Gynecol Cancer. 2012 Sep;22(7):1138-42. doi: 10.1097/IGC.0b013e31825b7dcc.
2. Serum calprotectin, CD26 and EGF to establish a panel for the diagnosis of lung cancer. Blanco-Prieto S, etal., PLoS One. 2015 May 18;10(5):e0127318. doi: 10.1371/journal.pone.0127318. eCollection 2015.
3. [Effects of Wenshen Jianpi Recipe on chronic wound healing in rats]. Cao YQ, etal., Zhong Xi Yi Jie He Xue Bao. 2005 May;3(3):220-4.
4. Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease. Chen-Plotkin AS, etal., Ann Neurol. 2011 Apr;69(4):655-63. doi: 10.1002/ana.22271. Epub 2010 Nov 29.
5. Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure. Cibrian D, etal., Clin Sci (Lond). 2006 May;110(5):563-73.
6. Association between functional EGF+61 polymorphism and glioma risk. Costa BM, etal., Clin Cancer Res. 2007 May 1;13(9):2621-6. doi: 10.1158/1078-0432.CCR-06-2606.
7. Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy. da Silveira Fd, etal., J Cancer Res Clin Oncol. 2012 Aug;138(8):1347-54. doi: 10.1007/s00432-012-1203-5. Epub 2012 Apr 6.
8. Cytokine profiling in patients with VCP-associated disease. Dec E, etal., Clin Transl Sci. 2014 Feb;7(1):29-32. doi: 10.1111/cts.12117. Epub 2013 Oct 3.
9. Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts. DiCamillo SJ, etal., J Biol Chem 2002 May 24;277(21):18938-46. Epub 2002 Mar 11.
10. Epidermal growth factor improves survival and prevents intestinal injury in a murine model of pseudomonas aeruginosa pneumonia. Dominguez JA, etal., Shock. 2011 Oct;36(4):381-9.
11. Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model. Dvorak B, etal., Am J Physiol Gastrointest Liver Physiol 2002 Jan;282(1):G156-64.
12. Comparison of epidermal growth factor and heparin-binding epidermal growth factor-like growth factor for prevention of experimental necrotizing enterocolitis. Dvorak B, etal., J Pediatr Gastroenterol Nutr. 2008 Jul;47(1):11-8. doi: 10.1097/MPG.0b013e3181788618.
13. [Expression of epidermal growth factor receptor and concentrations of epidermal growth factor and melatonin in endometrial carcinoma]. Dznelashvili N, etal., Georgian Med News. 2014 Oct;(235):17-24.
14. Common genetic variability in ESR1 and EGF in relation to endometrial cancer risk and survival. Einarsdóttir K, etal., Br J Cancer. 2009 Apr 21;100(8):1358-64. doi: 10.1038/sj.bjc.6604984. Epub 2009 Mar 24.
15. Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs. Fukamachi K, etal., J Biol Chem 2002 Nov 15;277(46):43549-52.
16. Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients. Futamura T, etal., Mol Psychiatry. 2002;7(7):673-82.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia. Groenestege WM, etal., J Clin Invest. 2007 Aug;117(8):2260-7.
20. Epidermal growth factor-induced activation of the insulin-like growth factor I receptor in rat hepatocytes. Hallak H, etal., Hepatology 2002 Dec;36(6):1509-18.
21. Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells. Harthill JE, etal., Biochem J 2002 Dec 1;368(Pt 2):565-72.
22. Control of the epidermal growth factor receptor and its ligands during renal injury. Hise MK, etal., Nephron. 2001 May;88(1):71-9.
23. Matrix metalloproteinase-2 and epidermal growth factor are decreased in platelets of Alzheimer patients. Hochstrasser T, etal., Curr Alzheimer Res. 2012 Oct;9(8):982-9.
24. Variant forms of rat epidermal growth factor present in the urine of nude rats bearing human tumors. Hudgins WR, etal., Cancer Res. 1988 Mar 15;48(6):1428-34.
25. Gene Data File Integration of LocusLink data, October 12, 2001
26. The impact of Helicobacter pylori on EGF, EGF receptor, and the c-erb-B2 expression. Jurkowska G, etal., Adv Med Sci. 2014 Sep;59(2):221-6. doi: 10.1016/j.advms.2014.01.006. Epub 2014 Jun 9.
27. Changes in hepatic cell junctions structure during experimental necrotizing enterocolitis: effect of EGF treatment. Khailova L, etal., Pediatr Res. 2009 Aug;66(2):140-4.
28. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
29. A functional polymorphism in the epidermal growth factor gene is associated with risk for glioma in a Chinese population. Li Y, etal., Genet Test Mol Biomarkers. 2012 May;16(5):449-52. doi: 10.1089/gtmb.2011.0258. Epub 2011 Nov 22.
30. Exploration of disease mechanism in acute kidney injury using a multiplex bead array assay: a nested case-control pilot study. Liangos O, etal., Biomarkers. 2010 Aug;15(5):436-45.
31. Interstitial vascular rarefaction and reduced VEGF-A expression in human diabetic nephropathy. Lindenmeyer MT, etal., J Am Soc Nephrol. 2007 Jun;18(6):1765-76. Epub 2007 May 2.
32. Neuritogenesis induced by thyroid hormone-treated astrocytes is mediated by epidermal growth factor/mitogen-activated protein kinase-phosphatidylinositol 3-kinase pathways and involves modulation of extracellular matrix proteins. Martinez R and Gomes FC, J Biol Chem 2002 Dec 20;277(51):49311-8.
33. Clinical Implication of EGF A61G Polymorphism in the Risk of Non Small Cell Lung Adenocarcinoma Patients: A Case Control Study. Masroor M, etal., Asian Pac J Cancer Prev. 2015;16(17):7529-34.
34. Sequence-specific 1H-n.m.r. assignments and peptide backbone conformation in rat epidermal growth factor. Mayo KH, etal., Biochem J. 1989 Jan 1;257(1):197-205.
35. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
36. Epidermal Growth Factor Receptor-Responsive Indoleamine 2,3-Dioxygenase Confers Immune Homeostasis During Shigella flexneri Infection. Mukherjee T, etal., J Infect Dis. 2019 May 5;219(11):1841-1851. doi: 10.1093/infdis/jiz009.
37. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
38. Ontogeny of epidermal growth factor, transforming growth factor-alpha, epidermal growth factor receptor, and thyroid hormone receptor RNA levels in rat kidney and changes in those levels induced by early thyroxine treatment. North D, etal., Pediatr Res. 1992 Apr;31(4 Pt 1):330-4.
39. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
40. Alpha 1-adrenergic and cholinergic agonists activate MAPK by separate mechanisms to inhibit secretion in lacrimal gland. Ota I, etal., Am J Physiol Cell Physiol 2003 Jan;284(1):C168-78.
41. Epidermal Growth Factor Serum Levels and the 61 G/A Polymorphism in Patients with Acute Pancreatitis. Papachristou GI, etal., Dig Dis Sci. 2010 Feb 3.
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
44. Expression of EGF and EGFR strongly correlates with metastasis of pancreatic ductal carcinoma. Pryczynicz A, etal., Anticancer Res. 2008 Mar-Apr;28(2B):1399-404.
45. Molecular markers of injury in kidney biopsy specimens of patients with lupus nephritis. Reich HN, etal., J Mol Diagn. 2011 Mar;13(2):143-51.
46. GOA pipeline RGD automated data pipeline
47. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
48. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
49. A Phase III Clinical Trial of the Epidermal Growth Factor Vaccine CIMAvax-EGF as Switch Maintenance Therapy in Advanced Non-Small Cell Lung Cancer Patients. Rodriguez PC, etal., Clin Cancer Res. 2016 Aug 1;22(15):3782-90. doi: 10.1158/1078-0432.CCR-15-0855. Epub 2016 Feb 29.
50. CIMAvax-EGF: A New Therapeutic Vaccine for Advanced Non-Small Cell Lung Cancer Patients. Saavedra D and Crombet T, Front Immunol. 2017 Mar 13;8:269. doi: 10.3389/fimmu.2017.00269. eCollection 2017.
51. Cloning and sequencing of the rat preproepidermal growth factor cDNA: comparison with mouse and human sequences. Saggi SJ, etal., DNA Cell Biol 1992 Jul-Aug;11(6):481-7.
52. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Santos SD, etal., Nat Cell Biol. 2007 Mar;9(3):324-30. Epub 2007 Feb 18.
53. Salivary and gastric epidermal growth factor in patients with Zollinger-Ellison syndrome: its protective potential. Sarosiek J, etal., Am J Gastroenterol. 2000 May;95(5):1158-65.
54. Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). Sato M, etal., J Biol Chem. 2009 Nov 6;284(45):31431-40. doi: 10.1074/jbc.M109.014068. Epub 2009 Sep 1.
55. Isolation of rat epidermal growth factor (r-EGF): chemical, biological and immunological comparisons with mouse and human EGF. Schaudies RP and Savage CR Jr, Comp Biochem Physiol B. 1986;84(4):497-505.
56. Identification and partial characterization of multiple forms of biologically active EGF in rat milk. Schaudies RP, etal., Am J Physiol. 1990 Dec;259(6 Pt 1):G1056-61.
57. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93.
58. A urinary biomarker profile for children with HIV-associated renal diseases. Soler-Garcia AA, etal., Kidney Int. 2009 Jul;76(2):207-14. Epub 2009 Apr 8.
59. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
60. Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis. Tanabe KK, etal., JAMA. 2008 Jan 2;299(1):53-60. doi: 10.1001/jama.2007.65.
61. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
62. Altered secretion and processing of epidermal growth factor in adrenergic-induced growth of the rat submandibular gland. Thulesen J, etal., Regul Pept 2002 Jun 15;106(1-3):105-14.
63. Genetic susceptibility of epidermal growth factor +61A>G and transforming growth factor beta1 -509C>T gene polymorphisms with gallbladder cancer. Vishnoi M, etal., Hum Immunol. 2008 Jun;69(6):360-7. Epub 2008 May 6.
64. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
65. Association of epidermal growth factor and epidermal growth factor receptor polymorphisms with the risk of hepatitis B virus-related hepatocellular carcinoma in the population of North China. Wu J, etal., Genet Test Mol Biomarkers. 2013 Aug;17(8):595-600. doi: 10.1089/gtmb.2013.0031. Epub 2013 Jun 22.
66. The immunohistochemical expressions of epidermal growth factors, epidermal growth factor receptors and c-erbB-2 oncoprotein in human pancreatic cancer. Yamanaka Y Nippon Ika Daigaku Zasshi. 1992 Feb;59(1):51-61.
67. Expression of oncogene products and growth factors in early gallbladder cancer, advanced gallbladder cancer, and chronic cholecystitis. Yukawa M, etal., Hum Pathol. 1993 Jan;24(1):37-40.
68. Effects of aging on growth factors gene and protein expression in the dorsal and ventral lobes of rat prostate. Zhao H, etal., Biochem Biophys Res Commun 2002 Mar 29;292(2):482-91.
Additional References at PubMed
PMID:3000782   PMID:3262867   PMID:6315706   PMID:7641815   PMID:7678348   PMID:7736574   PMID:8240367   PMID:8702723   PMID:9030684   PMID:10027293   PMID:10331984   PMID:10559227  
PMID:11278445   PMID:11867627   PMID:11940581   PMID:12115579   PMID:12456804   PMID:12579338   PMID:12700634   PMID:12834262   PMID:14523024   PMID:14559717   PMID:14561752   PMID:14630916  
PMID:14712229   PMID:15051883   PMID:15156153   PMID:15254973   PMID:15331766   PMID:15361518   PMID:15380929   PMID:15509736   PMID:15611079   PMID:15695332   PMID:15701816   PMID:15793571  
PMID:15803132   PMID:15831470   PMID:15968738   PMID:16126730   PMID:16314496   PMID:16332692   PMID:16339969   PMID:16502470   PMID:16760267   PMID:16885413   PMID:16944045   PMID:17203207  
PMID:17324121   PMID:17349580   PMID:17626015   PMID:17631610   PMID:17897319   PMID:17962899   PMID:17975113   PMID:17982486   PMID:18332871   PMID:18401831   PMID:18441095   PMID:18567582  
PMID:18722344   PMID:18848961   PMID:19056867   PMID:19433789   PMID:19996314   PMID:20037141   PMID:20142421   PMID:20208556   PMID:20302655   PMID:20353436   PMID:20388803   PMID:20967565  
PMID:21082674   PMID:21186272   PMID:21187008   PMID:22298428   PMID:22514047   PMID:22645946   PMID:22732145   PMID:22926925   PMID:23376485   PMID:23467299   PMID:23533145   PMID:23599382  
PMID:23821047   PMID:23932386   PMID:24763928   PMID:24967966   PMID:25309082   PMID:25678558   PMID:25920966   PMID:32301281   PMID:33172955   PMID:33238452   PMID:34688693  


Genomics

Comparative Map Data
Egf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82220,893,660 - 220,976,331 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2220,893,660 - 220,976,297 (-)EnsemblGRCr8
mRatBN7.22218,219,408 - 218,302,359 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2218,219,415 - 218,302,064 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2225,907,754 - 225,986,699 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02223,807,431 - 223,886,385 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,665,094 - 218,744,036 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0268,820,616 - 68,895,537 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0288,549,746 - 88,621,570 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0274,746,752 - 74,783,449 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.02253,481,574 - 253,482,579 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42227,103,900 - 227,195,062 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2210,511,076 - 210,588,041 (-)NCBICelera
RGSC_v3.12227,090,579 - 227,181,742 (-)NCBI
RH 3.4 Map21556.7RGD
Cytogenetic Map2q43NCBI
EGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384109,912,883 - 110,013,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4109,912,883 - 110,013,766 (+)Ensemblhg38GRCh38
GRCh374110,834,039 - 110,934,922 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,053,499 - 111,152,868 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344111,191,653 - 111,291,023NCBI
Celera4108,127,771 - 108,227,842 (+)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4106,566,131 - 106,666,223 (+)NCBIHuRef
CHM1_14110,810,552 - 110,910,629 (+)NCBICHM1_1
T2T-CHM13v2.04113,214,975 - 113,315,858 (+)NCBIT2T-CHM13v2.0
Egf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,471,223 - 129,548,971 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3129,471,214 - 129,548,965 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383129,677,574 - 129,755,322 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,677,565 - 129,755,316 (-)Ensemblmm10GRCm38
MGSCv373129,380,493 - 129,458,240 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363129,669,600 - 129,747,338 (-)NCBIMGSCv36mm8
Celera3136,187,440 - 136,268,006 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map358.5NCBI
Egf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955496328,075 - 401,569 (-)Ensembl
ChiLan1.0NW_004955496325,954 - 401,430 (-)NCBIChiLan1.0ChiLan1.0
EGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23108,005,905 - 108,105,686 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14108,299,162 - 108,398,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04102,410,724 - 102,509,691 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14112,977,565 - 113,075,761 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4112,977,565 - 113,076,460 (+)EnsemblpanPan2panpan1.1
EGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13230,073,541 - 30,166,904 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3230,073,950 - 30,166,295 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3211,863,120 - 11,956,432 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03230,294,579 - 30,388,079 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,294,820 - 30,388,248 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,288,558 - 30,381,524 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03230,031,820 - 30,125,429 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,723,676 - 9,817,337 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Egf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530110,767,839 - 10,855,510 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365631,058,803 - 1,181,393 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8112,234,386 - 112,330,046 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18112,235,607 - 112,330,062 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28120,384,625 - 120,413,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8q2.3-q2.7NCBI
EGF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1757,810,110 - 57,911,361 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl757,811,728 - 57,911,516 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603736,484,638 - 36,584,482 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Egf
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1329,553,123 - 29,632,437 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Egf
596 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:60
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000046113
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2212145502231732847Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
1302789Stl26Serum triglyceride level QTL 263.10.0035blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)2206613059226891081Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2209350500221678003Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2219814164239320906Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2205135267225627153Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat

Markers in Region
D2Rat61  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82220,931,218 - 220,931,416 (+)Marker Load Pipeline
mRatBN7.21879,924,734 - 79,925,127 (+)MAPPERmRatBN7.2
Rnor_6.0268,865,414 - 68,866,454NCBIRnor6.0
Rnor_5.0288,594,475 - 88,595,515UniSTSRnor5.0
RGSC_v3.42227,150,051 - 227,150,248RGDRGSC3.4
RGSC_v3.42227,150,052 - 227,150,249UniSTSRGSC3.4
Celera2210,543,293 - 210,543,469UniSTS
RGSC_v3.12227,136,731 - 227,136,928RGD
RH 3.4 Map21546.8RGD
RH 3.4 Map21546.8UniSTS
RH 2.0 Map21129.9RGD
SHRSP x BN Map288.6498RGD
FHH x ACI Map2101.7399RGD
Cytogenetic Map2q42-q43UniSTS
RH133380  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22218,219,545 - 218,219,763 (+)MAPPERmRatBN7.2
Rnor_6.02235,049,473 - 235,049,690NCBIRnor6.0
Rnor_6.02234,159,671 - 234,159,888NCBIRnor6.0
Rnor_5.0274,870,658 - 74,870,875UniSTSRnor5.0
Rnor_5.02253,481,697 - 253,481,914UniSTSRnor5.0
RGSC_v3.42227,104,023 - 227,104,240UniSTSRGSC3.4
Celera2210,511,199 - 210,511,416UniSTS
RH 3.4 Map21556.0UniSTS
Cytogenetic Map2q42-q43UniSTS
RH94666  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22218,302,670 - 218,302,935 (+)MAPPERmRatBN7.2
mRatBN7.22218,302,670 - 218,302,935 (-)MAPPERmRatBN7.2
Rnor_6.0268,819,745 - 68,820,009NCBIRnor6.0
Rnor_6.02235,177,882 - 235,178,146NCBIRnor6.0
Rnor_5.0274,745,886 - 74,746,150UniSTSRnor5.0
Rnor_5.0288,548,875 - 88,549,139UniSTSRnor5.0
RGSC_v3.42227,195,669 - 227,195,933UniSTSRGSC3.4
Celera2210,588,648 - 210,588,912UniSTS
RH 3.4 Map21556.7UniSTS
Cytogenetic Map2q42-q43UniSTS


Related Rat Strains
The following Strains have been annotated to Egf
W    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
20 12 65 167 89 88 57 86 57 6 390 189 16 142 116 89 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000083713   ⟹   ENSRNOP00000074125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl268,821,004 - 68,895,535 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087007   ⟹   ENSRNOP00000073099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl268,820,615 - 68,892,944 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089504   ⟹   ENSRNOP00000075379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2220,893,660 - 220,976,297 (-)Ensembl
mRatBN7.2 Ensembl2218,219,415 - 218,302,049 (-)Ensembl
Rnor_6.0 Ensembl268,820,631 - 68,895,920 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093153   ⟹   ENSRNOP00000076305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2220,893,660 - 220,976,297 (-)Ensembl
mRatBN7.2 Ensembl2218,219,423 - 218,302,064 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000134259   ⟹   ENSRNOP00000108900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2220,893,660 - 220,976,297 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000137380   ⟹   ENSRNOP00000103818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2220,896,688 - 220,976,154 (-)Ensembl
RefSeq Acc Id: NM_012842   ⟹   NP_036974
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82220,893,660 - 220,976,297 (-)NCBI
mRatBN7.22218,219,408 - 218,302,051 (-)NCBI
Rnor_6.0268,820,616 - 68,895,537 (+)NCBI
Rnor_5.0288,549,746 - 88,621,570 (+)NCBI
Rnor_5.02253,481,574 - 253,482,579 (-)NCBI
RGSC_v3.42227,103,900 - 227,195,062 (-)RGD
Celera2210,511,076 - 210,588,041 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101781   ⟹   XP_038957709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82220,924,712 - 220,976,331 (-)NCBI
mRatBN7.22218,250,460 - 218,302,359 (-)NCBI
RefSeq Acc Id: XM_063281339   ⟹   XP_063137409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82220,893,663 - 220,976,321 (-)NCBI
RefSeq Acc Id: XR_005500244
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82220,920,009 - 220,976,329 (-)NCBI
mRatBN7.22218,245,757 - 218,302,356 (-)NCBI
RefSeq Acc Id: XR_005500245
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82220,923,479 - 220,976,331 (-)NCBI
mRatBN7.22218,249,225 - 218,302,359 (-)NCBI
RefSeq Acc Id: NP_036974   ⟸   NM_012842
- Peptide Label: precursor
- UniProtKB: A0A0G2KAF5 (UniProtKB/TrEMBL),   Q6P6T8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038957709   ⟸   XM_039101781
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000075379   ⟸   ENSRNOT00000089504
Ensembl Acc Id: ENSRNOP00000076305   ⟸   ENSRNOT00000093153
Ensembl Acc Id: ENSRNOP00000074125   ⟸   ENSRNOT00000083713
Ensembl Acc Id: ENSRNOP00000073099   ⟸   ENSRNOT00000087007
RefSeq Acc Id: XP_063137409   ⟸   XM_063281339
- Peptide Label: isoform X1
- UniProtKB: A0A1W2Q6M4 (UniProtKB/TrEMBL),   Q6P6T8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108900   ⟸   ENSRNOT00000134259
Ensembl Acc Id: ENSRNOP00000103818   ⟸   ENSRNOT00000137380
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07522-F1-model_v2 AlphaFold P07522 1-1133 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691200
Promoter ID:EPDNEW_R1722
Type:single initiation site
Name:Egf_1
Description:epidermal growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1723  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0268,820,617 - 68,820,677EPDNEW
RGD ID:13691201
Promoter ID:EPDNEW_R1723
Type:single initiation site
Name:Egf_2
Description:epidermal growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1722  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0268,820,963 - 68,821,023EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2542 AgrOrtholog
BioCyc Gene G2FUF-51242 BioCyc
Ensembl Genes ENSRNOG00000053979 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000089504 ENTREZGENE
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623849 IMAGE-MGC_LOAD
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot
  Cueball_EGF_LRP_Nidogen UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  LDLR_classB_rpt UniProtKB/Swiss-Prot
  NOTCH1_EGF-like UniProtKB/Swiss-Prot
  Pro-epidermal_GF UniProtKB/Swiss-Prot
KEGG Report rno:25313 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72539 IMAGE-MGC_LOAD
NCBI Gene 25313 ENTREZGENE
PANTHER PRO-EPIDERMAL GROWTH FACTOR UniProtKB/Swiss-Prot
  VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED UniProtKB/Swiss-Prot
Pfam EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  FXa_inhibition UniProtKB/Swiss-Prot
  Ldl_recept_b UniProtKB/Swiss-Prot
PharmGKB EGF RGD
PhenoGen Egf PhenoGen
PIRSF Pro-epidermal_growth_factor UniProtKB/Swiss-Prot
PRINTS EGFTGF UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LDLRB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000053979 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  SM00135 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
  YWTD domain UniProtKB/Swiss-Prot
TIGR TC220642
UniProt A0A0G2KAF5 ENTREZGENE, UniProtKB/TrEMBL
  A0A1W2Q6M4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LG96_RAT UniProtKB/TrEMBL
  A0ABK0M2G1_RAT UniProtKB/TrEMBL
  A6HVP3_RAT UniProtKB/TrEMBL
  A6HVP4_RAT UniProtKB/TrEMBL
  EGF_RAT UniProtKB/Swiss-Prot
  J9SG97_RAT UniProtKB/TrEMBL
  P07522 ENTREZGENE
  Q6P6T8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q63183 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Egf  epidermal growth factor  LOC103691699  uncharacterized LOC103691699  Data merged from RGD:9170085 737654 PROVISIONAL
2014-08-25 LOC103691699  uncharacterized LOC103691699      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Egf  epidermal growth factor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression lacking in the stroma of dorsal and ventral lobes of young prostates but present in both the stroma and epithelium of aging prostates 70812
gene_expression present in many body fluids, especially in maternal milk including colostrum 70301
gene_physical_interaction present in the fetal and neonatal GI tract 70301
gene_physical_interaction stimulates several proteins to bind to 14-3-3 in the PI-3- kinase dependent pathway 629545
gene_process responsible for proliferation and differentiation of epithelial cells 70301
gene_process responsible for proliferation and differentiation of epithelial cells 70812
gene_process responsible for the healing of damaged gastrointestinal mucosa 70301
gene_process responsible for the healing of damaged gastrointestinal mucosa 70812
gene_process induces the activation of Mapk in lacrimal gland acinar cells 629545