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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2542 Species: Rattus norvegicus RGD Object: Gene Symbol: Egf Name: epidermal growth factor

Acc ID: CHEBI:9516 Term: thapsigargin Definition: A hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations. CasRN: 67526-95-8 Chemical ID: MESH:D019284

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:736832	6480464	CTD	Thapsigargin inhibits the reaction [EGF protein affects the localization of PRKCB protein]	PMID:17991733