Gene:	Camk2a ( Rattus norvegicus ) calcium/calmodulin-dependent protein kinase II alpha
Description:	serine/threonine kinase that transduces signals about intracellular calcium concentrations through binding to calcium/calmodulin; important in learning and memory, may be involved in retinal development and channel properties of NMDA receptor subunit 2B during ischemia
Synonyms:	calcium/calmodulin-dependent protein kinase II, alpha; Ca2+/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase II alpha subunit; PKCCD; PK2CDD; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha;
ArrayIDs:	1388187_at; 1381637_at; 1368935_at; J02942_at; M16960_s_at; rc_AI171449_at;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: CAMK2A     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Camk2a     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Camk2a genome assembly 3.1 18 56951478 - 57020769     Rat Celera Assembly 18 52533226 - 52592130     RGSC genome assembly v3.4 18 56879247 - 56948537     Cytogenetic 18 q11 Mus musculus Camk2a Mouse genome assembly build 36.1 18 61085286 - 61147798     Cytogenetic 18 18 E1 Homo sapiens CAMK2A human genome assembly 5 149579247 - 149649529     Human genome assembly build 36.2 5 149579248 - 149649529     Cytogenetic 5 q32   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Note Reference kinase subunit 634689 phosphorylates N-methyl-D-aspartate receptor subunit 2B on serine 634689 autophosphorylates on threonine (T286) 1299829 Gene Ontology calmodulin-dependent protein kinase activity,  calmodulin binding,  nucleotide binding ...  (details...)
Biological Process	Note Reference may regulate channel properties of N-methyl-D-aspartate receptor subunit 2B during ischemia via phosphorylation 634689 transduces cellular signals corresponding to fluctuations in intracellular calcium levels in conjuction with calmodulin 1299829 important in learning and memory 1299829 may play a role in the development of the retina 634688 Gene Ontology G1/S transition of mitotic cell cycle,  protein amino acid phosphorylation,  positive regulation of NF-kappaB transcription factor activity ...  (details...)
Cellular Component	Gene Ontology synapse,  plasma membrane,  cell junction ...  (details...)
Expression	Note Reference expression in hippocampal cells strongly induced upon ischemic insult 634689 expressed at high levels in neurons 1299829
Regulation	Note Reference activity is regulated by calcium/calmodulin binding and autophosphorylation 1299829
Physical interaction	Note Reference binds to and is activated by calcium/calmodulin 1299829
External Links
Databases	DATABASE ID SOURCE SMART: S_TKc IPI PROSITE: PROTEIN_KINASE_DOM IPI PROSITE: PROTEIN_KINASE_ST IPI PROSITE: PROTEIN_KINASE_ATP IPI UNIPARC: UPI0000001521 IPI UNIPARC: UPI0001B79D36 IPI KEGG Report: rno:25400 ENTREZGENE HomoloGene Group ID: 56577 ENTREZGENE Germonline: 2261 Pfam: Pkinase IPI Pfam: CaMKII_AD IPI KEGG Pathway: 04912 ENTREZGENE KEGG Pathway: 04720 ENTREZGENE KEGG Pathway: 04916 ENTREZGENE KEGG Pathway: 04740 ENTREZGENE KEGG Pathway: 05214 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 04020 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE InterPro: Ser/Thr_prot_kinase_AS. IPI InterPro: Se/Thr_prot_kinase-like_dom. IPI InterPro: Protein_kinase_ATP_BS. IPI InterPro: Prot_kinase_cat_dom. IPI InterPro: Kinase-like_dom. IPI InterPro: Ca/CaM-dep_prot_kinase_2. IPI InterPro: Ca/CaM-dep_prot_kinase-like. IPI InterPro: Ca/CaM-dep_prot_kinase-assoc. IPI InterPro: Ser/Thr_prot_kinase_dom. IPI Ensembl Protein: ENSRNOP00000025283 IPI Ensembl Protein: ENSRNOP00000041940 IPI IPI: IPI00779826 IPI IPI: IPI00192337 IPI Entrez Gene: Camk2a ENTREZGENE TIGR: TC228753 UniProt: Q924T0_RAT IPI UniProt: KCC2A_RAT IPI Ensembl Genes: ENSRNOG00000018712 IPI RatMap: 41285 ENTREZGENE Superfamily-SCOP: Kinase_like IPI PANTHER: Ca/CaM-dep_prot_kinase-like IPI PANTHER: CaMKII IPI
Sequences	Nucleotide: M16960 Get FASTA Search GEO Profiles Nucleotide: J02942 Get FASTA Search GEO Profiles Nucleotide: AF237778 Get FASTA Search GEO Profiles Nucleotide: AB056125 Get FASTA Search GEO Profiles Nucleotide: CH473971 Get FASTA Search GEO Profiles Nucleotide: AB059432 Get FASTA Search GEO Profiles Nucleotide: NM_012920 Get FASTA Search GEO Profiles (View all 7 Nucleotide Accessions) Protein: Q924T0 Get FASTA Protein: P11275 Get FASTA Protein: AAA41855 Get FASTA Protein: AAA41870 Get FASTA Protein: EDM14582 Get FASTA Protein: EDM14581 Get FASTA Protein: EDM14580 Get FASTA Protein: EDM14579 Get FASTA Protein: BAB61066 Get FASTA Protein: NP_037052 Get FASTA (View all 10 Protein Accessions)
Clusters	UniGene: 107499
References
Curated References	9 references in RGD related to Camk2a
Other References	80 other references at PubMed related to Camk2a
Database Information
RGD ID	2261
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 11-NOV-08: Camk2a calcium/calmodulin-dependent protein kinase II alpha Camk2a calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 24-OCT-08: Camk2a calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha Camk2a calcium/calmodulin-dependent protein kinase II, alpha APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 30-MAR-06: Camk2a calcium/calmodulin-dependent protein kinase II, alpha calcium/calmodulin-dependent protein kinase II alpha subunit APPROVED Name updated 1299863 06-NOV-02: Camk2a calcium/calmodulin-dependent protein kinase II alpha subunit Ca2+/calmodulin-dependent protein kinase II alpha APPROVED Name updated 625702 10-JUN-02: Camk2a Ca2+/calmodulin-dependent protein kinase II alpha APPROVED Symbol and Name status set to approved 70586