Adora2a (adenosine A2a receptor) - Rat Genome Database

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Gene: Adora2a (adenosine A2a receptor) Rattus norvegicus
Analyze
Symbol: Adora2a
Name: adenosine A2a receptor
RGD ID: 2049
Description: Enables G protein-coupled adenosine receptor activity; alpha-actinin binding activity; and type 5 metabotropic glutamate receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; chemical synaptic transmission; and modulation of chemical synaptic transmission. Located in several cellular components, including axolemma; intermediate filament; and presynaptic active zone. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Used to study lung disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA2A (adenosine A2a receptor); PARTICIPATES IN adenosine signaling pathway; hypoxia inducible factor pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (S)-AMPA; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A2ar; ADENO; adenosine A2a-receptor; adenosine receptor A2a; Adora2l1; MGC93190
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Adora2am1Mcwi ; Adora2am2Mcwi ; Adora2am3Mcwi ; Adora2aem3Mcwi ; Adora2aem5Mcwi
Genetic Models: BN-Adora2am3Mcwi ; BN-Adora2am1Mcwi ; BN-Adora2am2Mcwi ; SS-Adora2aem5Mcwi ; SS-Adora2aem3Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,315,270 - 13,332,802 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2013,315,270 - 13,332,802 (-)EnsemblGRCr8
mRatBN7.22013,315,848 - 13,333,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,315,853 - 13,333,386 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2014,022,398 - 14,039,933 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,383,344 - 13,400,756 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,855,867 - 13,873,399 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02014,265,251 - 14,282,873 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,265,252 - 14,282,873 (-)Ensemblrn6Rnor6.0
Rnor_5.02016,449,385 - 16,466,147 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42013,815,719 - 13,834,131 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2014,801,379 - 14,818,841 (-)NCBICelera
RGSC_v3.12013,815,944 - 13,825,845 (-)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
(S)-AMPA  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
8-(3-chlorostyryl)caffeine  (EXP,ISO)
acetamide  (EXP)
acetylcholine  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
adenosine  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
caffeine  (EXP,ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGS-21680  (EXP,ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clotrimazole  (EXP)
clozapine  (ISO)
cocaine  (ISO)
cordycepin  (EXP)
Cuprizon  (EXP)
curcumin  (ISO)
cytidine  (EXP)
dextran sulfate  (ISO)
diallyl trisulfide  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP)
DPCPX  (ISO)
elemental selenium  (ISO)
ethanol  (EXP,ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
gamma-aminobutyric acid  (EXP)
graphite  (EXP)
GSK-J4  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
haloperidol  (ISO)
istradefylline  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (EXP)
modafinil  (EXP)
morphine  (ISO)
Morroniside  (ISO)
Moxonidine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nicotinic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxidopamine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentetrazol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phencyclidine  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
piroxicam  (ISO)
prazosin  (EXP)
prednisolone  (ISO)
propanal  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
Soman  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
taurine  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
WIN 55212-2  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,IEA,IMP,ISO)
astrocyte activation  (IMP)
eating behavior  (IMP,ISO)
excitatory postsynaptic potential  (IDA)
G protein-coupled adenosine receptor signaling pathway  (IBA,IDA,IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
inhibitory postsynaptic potential  (ISO)
locomotory behavior  (IMP,ISO)
membrane depolarization  (IMP)
negative regulation of alpha-beta T cell activation  (ISO)
negative regulation of cell population proliferation  (IDA)
negative regulation of inflammatory response  (ISO)
negative regulation of neuron apoptotic process  (IDA)
negative regulation of protein kinase activity  (IDA)
negative regulation of vascular permeability  (IMP)
neuron projection morphogenesis  (IDA,IMP)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IDA)
positive regulation of acetylcholine secretion, neurotransmission  (IMP)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of circadian sleep/wake cycle, sleep  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of glutamate secretion  (IDA)
positive regulation of long-term synaptic potentiation  (IMP)
positive regulation of protein secretion  (IDA)
positive regulation of synaptic transmission, GABAergic  (ISO)
positive regulation of synaptic transmission, glutamatergic  (IDA)
positive regulation of urine volume  (IMP)
prepulse inhibition  (IMP)
presynaptic modulation of chemical synaptic transmission  (EXP,IDA,IEP)
regulation of amine transport  (IEA)
regulation of calcium ion transport  (IMP)
regulation of cell communication  (IEA)
regulation of DNA-templated transcription  (IDA)
regulation of mitochondrial membrane potential  (IDA)
regulation of norepinephrine secretion  (IMP)
regulation of secretion by cell  (IEA)
regulation of signaling  (IEA)
response to alkaloid  (IMP)
response to amphetamine  (ISO)
response to caffeine  (IDA)
response to purine-containing compound  (IEA,ISO)
response to xenobiotic stimulus  (IEP)
signal transduction  (IEA)
synaptic transmission, cholinergic  (IMP)
synaptic transmission, dopaminergic  (IBA,ISO)
synaptic transmission, glutamatergic  (IDA)
vasodilation  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices. Almeida T, etal., Neuroscience. 2003;122(1):111-21.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Effect of adenosine A2A receptor activation in murine models of respiratory disorders. Bonneau O, etal., Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L1036-43. Epub 2005 Dec 9.
4. Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes. Brambilla R, etal., Glia. 2003 Aug;43(2):190-4.
5. The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. Burgueno J, etal., J Biol Chem 2003 Sep 26;278(39):37545-52. Epub 2003 Jul 01.
6. Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids. Carriba P, etal., Neuropsychopharmacology. 2007 Nov;32(11):2249-59. Epub 2007 Mar 14.
7. Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway. Carroll MA, etal., Am J Physiol Renal Physiol. 2006 Jul;291(1):F155-61. Epub 2006 Feb 14.
8. Induction of neurite outgrowth in PC12 cells by the bacterial nucleoside N6-methyldeoxyadenosine is mediated through adenosine A2a receptors and via cAMP and MAPK signaling pathways. Charles MP, etal., Biochem Biophys Res Commun. 2003 May 16;304(4):795-800.
9. Protective effects of adenosine A2A receptor agonist in ventilator-induced lung injury in rats. Chen CM, etal., Crit Care Med. 2009 Jul;37(7):2235-41.
10. Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. Ciruela F, etal., J Neurosci. 2006 Feb 15;26(7):2080-7.
11. The role of adenosine A2A and A3 receptors on the differential modulation of norepinephrine and neuropeptide Y release from peripheral sympathetic nerve terminals. Donoso MV, etal., J Neurochem. 2006 Mar;96(6):1680-95.
12. Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats. Duarte JM, etal., Neurochem Int. 2006 Jan;48(2):144-50. Epub 2005 Oct 26.
13. Adenosine A2A activation attenuates nontransplantation lung reperfusion injury. Ellman PI, etal., J Surg Res. 2008 Sep;149(1):3-8. Epub 2007 Sep 12.
14. Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function. Ferre S, etal., Proc Natl Acad Sci U S A 2002 Sep 3;99(18):11940-5.
15. Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum. Fink JS, etal., Brain Res Mol Brain Res 1992 Jul;14(3):186-95.
16. Distinct protein kinase C isoforms mediate regulation of vascular endothelial growth factor expression by A2A adenosine receptor activation and phorbol esters in pheochromocytoma PC12 cells. Gardner AM and Olah ME, J Biol Chem. 2003 Apr 25;278(17):15421-8. Epub 2003 Feb 17.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Adenosine A2A receptor activation reduces lung injury in trauma/hemorrhagic shock. Hasko G, etal., Crit Care Med. 2006 Apr;34(4):1119-25.
20. Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. Kim SH, etal., Respir Med. 2009 Mar;103(3):356-63. Epub 2008 Nov 18.
21. The role of adenosine A2A receptor signaling in bronchiolitis obliterans. Lau CL, etal., Ann Thorac Surg. 2009 Oct;88(4):1071-8.
22. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Ledent C, etal., Nature 1997 Aug 14;388(6643):674-8.
23. Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endings. Magalhaes-Cardoso MT, etal., J Physiol. 2003 Jun 1;549(Pt 2):399-408. Epub 2003 Apr 4.
24. Effects on sleep of microdialysis of adenosine A1 and A2a receptor analogs into the lateral preoptic area of rats. Methippara MM, etal., Am J Physiol Regul Integr Comp Physiol. 2005 Dec;289(6):R1715-23. Epub 2005 Aug 18.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice. Mohsenin A, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L753-61. Epub 2007 Jun 29.
27. Enhanced airway reactivity and inflammation in A2A adenosine receptor-deficient allergic mice. Nadeem A, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1335-44. Epub 2007 Feb 9.
28. Effects of an adenosine A2A receptor blockade in the nucleus accumbens on locomotion, feeding, and prepulse inhibition in rats. Nagel J, etal., Synapse. 2003 Sep 15;49(4):279-86.
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. Contribution of adenosine A2A and A2B receptors and heme oxygenase to AMPA-induced dilation of pial arterioles in rats. Ohata H, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R728-35. Epub 2006 Apr 6.
31. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Ohta A and Sitkovsky M, Nature 2001 Dec 20-27;414(6866):916-20.
32. Mechanisms of interaction between adenosine receptor subtypes on hippocampal serotonin release Okada M, etal., Nihon Shinkei Seishin Yakurigaku Zasshi 2002 Apr;22(2):61-9.
33. Tetanic depression is overcome by tonic adenosine A(2A) receptor facilitation of L-type Ca(2+) influx into rat motor nerve terminals. Oliveira L, etal., J Physiol. 2004 Oct 1;560(Pt 1):157-68. Epub 2004 Aug 5.
34. Differential expression of adenosine A1 and A2A receptors after upper cervical (C2) spinal cord hemisection in adult rats. Petrov T, etal., J Spinal Cord Med. 2007;30(4):331-7.
35. Subcellular distributions of adenosine A1 and A2A receptors in the rat dorsomedial nucleus of the solitary tract at the level of the area postrema. Pickel VM, etal., Synapse. 2006 Dec 1;60(7):496-509.
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
38. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
39. Adenosine-mediated alteration of vascular reactivity and inflammation in a murine model of asthma. Ponnoth DS, etal., Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2158-65. Epub 2008 Feb 29.
40. Activation of adenosine A2A receptors alters postsynaptic currents and depolarizes neurons of the supraoptic nucleus. Ponzio TA, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Aug;291(2):R359-66. Epub 2006 Apr 27.
41. Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal. Ramirez SH, etal., J Neurosci Res. 2004 Jul 15;77(2):258-69.
42. Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injury. Reutershan J, etal., J Immunol. 2007 Jul 15;179(2):1254-63.
43. GOA pipeline RGD automated data pipeline
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum. Rodrigues RJ, etal., J Neurochem. 2005 Feb;92(3):433-41.
46. The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion. Scheibner KA, etal., Am J Respir Cell Mol Biol. 2009 Mar;40(3):251-9. Epub 2008 Aug 14.
47. Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury. Sharma AK, etal., J Thorac Cardiovasc Surg. 2010 Feb;139(2):474-82. Epub 2009 Nov 11.
48. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
49. Rescue of p53 blockage by the A(2A) adenosine receptor via a novel interacting protein, translin-associated protein X. Sun CN, etal., Mol Pharmacol. 2006 Aug;70(2):454-66. Epub 2006 Apr 14.
50. Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease. Wallace KL and Linden J, Blood. 2010 Dec 2;116(23):5010-20. Epub 2010 Aug 26.
51. Adenosine A2A receptor modulation of juvenile female rat skeletal muscle microvessel permeability. Wang J and Huxley VH, Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H3094-105. Epub 2006 Jun 30.
52. The role of adenosine-related genes variants in susceptibility to essential hypertension. Wright K, etal., J Hypertens. 2004 Aug;22(8):1519-22.
53. A novel Gαs-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor. Wu YC, etal., Biochim Biophys Acta. 2013 Dec;1833(12):3145-3154. doi: 10.1016/j.bbamcr.2013.08.009. Epub 2013 Aug 27.
54. Adenosine A2a blockade prevents synergy between mu-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats. Yao L, etal., Proc Natl Acad Sci U S A. 2006 May 16;103(20):7877-82. Epub 2006 May 9.
55. Role of adenosine A2A receptor in the regulation of gastric somatostatin release. Yip L and Kwok YN, J Pharmacol Exp Ther. 2004 May;309(2):804-15. Epub 2004 Jan 23.
56. Spinal cord injury in neonates alters respiratory motor output via supraspinal mechanisms. Zimmer MB and Goshgarian HG, Exp Neurol. 2007 Jul;206(1):137-45. Epub 2007 May 8.
57. Role of renal medullary adenosine in the control of blood flow and sodium excretion. Zou AP, etal., Am J Physiol 1999 Mar;276(3 Pt 2):R790-8.
Additional References at PubMed
PMID:1599465   PMID:8639269   PMID:8738226   PMID:9269779   PMID:10069416   PMID:10537036   PMID:10704492   PMID:10845921   PMID:10908627   PMID:10934242   PMID:11172060   PMID:11248116  
PMID:11404425   PMID:12167481   PMID:12223546   PMID:12538862   PMID:12654506   PMID:12694400   PMID:12817016   PMID:12832562   PMID:12904509   PMID:14622213   PMID:15044529   PMID:15197743  
PMID:15489334   PMID:15539419   PMID:15689617   PMID:16280580   PMID:16339847   PMID:16413509   PMID:16683708   PMID:16980350   PMID:17181659   PMID:17304576   PMID:17421024   PMID:17481781  
PMID:17516542   PMID:17517168   PMID:17519974   PMID:17548208   PMID:17556415   PMID:17619122   PMID:17664389   PMID:17689978   PMID:17898087   PMID:17934014   PMID:18054436   PMID:18057956  
PMID:18218631   PMID:18313046   PMID:18360306   PMID:18499627   PMID:18506850   PMID:18584206   PMID:18675812   PMID:18800071   PMID:18849328   PMID:19013155   PMID:19110076   PMID:19138885  
PMID:19200339   PMID:19202001   PMID:19204055   PMID:19407255   PMID:19422385   PMID:19467297   PMID:19619617   PMID:19632986   PMID:19666061   PMID:19695259   PMID:19723291   PMID:19801629  
PMID:19822132   PMID:19908252   PMID:20143408   PMID:20385128   PMID:20519378   PMID:20797711   PMID:21062287   PMID:21080412   PMID:21106859   PMID:21144776   PMID:21235574   PMID:21289195  
PMID:21393508   PMID:21443689   PMID:21508927   PMID:21593763   PMID:21615561   PMID:21703281   PMID:21742019   PMID:21867705   PMID:21983553   PMID:22064330   PMID:22298379   PMID:22371048  
PMID:22401823   PMID:22528231   PMID:22715379   PMID:23013133   PMID:23032401   PMID:23154210   PMID:23261865   PMID:23587453   PMID:23637137   PMID:23638679   PMID:23770463   PMID:23783558  
PMID:23965991   PMID:24014158   PMID:24271058   PMID:24293369   PMID:24361450   PMID:24704558   PMID:24777042   PMID:24845382   PMID:24872568   PMID:24912137   PMID:25296982   PMID:25401477  
PMID:25716780   PMID:25891445   PMID:25907806   PMID:25910812   PMID:25936513   PMID:26068054   PMID:26526685   PMID:26728617   PMID:27060487   PMID:27757725   PMID:28294142   PMID:28981089  
PMID:29217157   PMID:29360563   PMID:29568380   PMID:29587249   PMID:29693117   PMID:30017837   PMID:30220081   PMID:30461068   PMID:30507864   PMID:30541517   PMID:31161847   PMID:31206753  
PMID:33616808   PMID:34043863   PMID:34946538   PMID:35907034   PMID:39192377  


Genomics

Comparative Map Data
Adora2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,315,270 - 13,332,802 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2013,315,270 - 13,332,802 (-)EnsemblGRCr8
mRatBN7.22013,315,848 - 13,333,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,315,853 - 13,333,386 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2014,022,398 - 14,039,933 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,383,344 - 13,400,756 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,855,867 - 13,873,399 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02014,265,251 - 14,282,873 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,265,252 - 14,282,873 (-)Ensemblrn6Rnor6.0
Rnor_5.02016,449,385 - 16,466,147 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42013,815,719 - 13,834,131 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2014,801,379 - 14,818,841 (-)NCBICelera
RGSC_v3.12013,815,944 - 13,825,845 (-)NCBI
Cytogenetic Map20p12NCBI
ADORA2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,423,597 - 24,442,357 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,417,879 - 24,443,177 (+)Ensemblhg38GRCh38
GRCh372224,819,565 - 24,838,325 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,153,530 - 23,168,325 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342223,153,645 - 23,162,878NCBI
Celera228,623,253 - 8,638,061 (+)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,769,458 - 7,788,241 (+)NCBIHuRef
CHM1_12224,778,238 - 24,796,999 (+)NCBICHM1_1
T2T-CHM13v2.02224,885,210 - 24,903,991 (+)NCBIT2T-CHM13v2.0
Adora2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,152,711 - 75,170,626 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,152,711 - 75,170,618 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381075,316,877 - 75,334,792 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,316,877 - 75,334,784 (+)Ensemblmm10GRCm38
MGSCv371074,779,688 - 74,797,533 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361074,769,745 - 74,777,652 (+)NCBIMGSCv36mm8
Celera1076,364,032 - 76,382,114 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.52NCBI
Adora2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554557,895,974 - 7,906,505 (+)Ensembl
ChiLan1.0NW_0049554557,886,720 - 7,906,214 (+)NCBIChiLan1.0ChiLan1.0
ADORA2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22334,212,582 - 34,231,247 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12236,943,248 - 36,961,861 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0225,233,876 - 5,248,622 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12222,099,404 - 22,114,189 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,104,253 - 22,114,189 (+)EnsemblpanPan2panpan1.1
ADORA2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,141,076 - 28,150,600 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2628,141,076 - 28,150,598 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2627,207,866 - 27,225,894 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02629,536,347 - 29,554,384 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2629,534,227 - 29,554,392 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12627,619,698 - 27,637,726 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,237,300 - 27,255,320 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,226,384 - 28,244,417 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adora2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118142,136,447 - 142,156,176 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936619608,441 - 616,779 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936619597,970 - 618,564 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADORA2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,468,877 - 49,485,850 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11449,467,186 - 49,485,845 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,914,635 - 52,931,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADORA2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,691,678 - 7,706,781 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,691,536 - 7,706,926 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660854,894,557 - 4,913,637 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adora2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247479,851,153 - 9,860,094 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247479,846,254 - 9,860,938 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Adora2a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11812,103,177 - 12,112,112 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Adora2a
81 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:340
Count of miRNA genes:207
Interacting mature miRNAs:247
Transcripts:ENSRNOT00000001759
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
RH129254  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22013,315,860 - 13,316,030 (+)MAPPERmRatBN7.2
Rnor_6.02014,265,259 - 14,265,428NCBIRnor6.0
Rnor_5.02016,449,392 - 16,449,561UniSTSRnor5.0
RGSC_v3.42013,815,726 - 13,815,895UniSTSRGSC3.4
Celera2014,801,386 - 14,801,555UniSTS
Cytogenetic Map20p12UniSTS


Genetic Models
This gene Adora2a is modified in the following models/strains:
BN-Adora2am3Mcwi     BN-Adora2am1Mcwi     BN-Adora2am2Mcwi     SS-Adora2aem5Mcwi     SS-Adora2aem3Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 135 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000001759   ⟹   ENSRNOP00000001759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2013,315,270 - 13,332,802 (-)Ensembl
mRatBN7.2 Ensembl2013,315,853 - 13,333,386 (-)Ensembl
Rnor_6.0 Ensembl2014,265,252 - 14,282,873 (-)Ensembl
RefSeq Acc Id: NM_001357942   ⟹   NP_001344871
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,315,270 - 13,332,802 (-)NCBI
mRatBN7.22013,315,853 - 13,333,386 (-)NCBI
RefSeq Acc Id: NM_053294   ⟹   NP_445746
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,315,270 - 13,332,802 (-)NCBI
mRatBN7.22013,315,853 - 13,333,386 (-)NCBI
Rnor_6.02014,265,252 - 14,282,873 (-)NCBI
Rnor_5.02016,449,385 - 16,466,147 (-)NCBI
RGSC_v3.42013,815,719 - 13,834,131 (-)RGD
Celera2014,801,379 - 14,818,841 (-)RGD
Sequence:
RefSeq Acc Id: XM_017601552   ⟹   XP_017457041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,315,270 - 13,332,553 (-)NCBI
mRatBN7.22013,315,848 - 13,333,191 (-)NCBI
Rnor_6.02014,265,251 - 14,282,672 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098459   ⟹   XP_038954387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,315,270 - 13,319,424 (-)NCBI
mRatBN7.22013,315,848 - 13,320,014 (-)NCBI
RefSeq Acc Id: XM_063278978   ⟹   XP_063135048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,315,270 - 13,323,849 (-)NCBI
RefSeq Acc Id: NP_445746   ⟸   NM_053294
- Peptide Label: A2AR
- UniProtKB: P30543 (UniProtKB/Swiss-Prot),   A6JKL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457041   ⟸   XM_017601552
- Peptide Label: isoform X1
- UniProtKB: P30543 (UniProtKB/Swiss-Prot),   A6JKL4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001759   ⟸   ENSRNOT00000001759
RefSeq Acc Id: XP_038954387   ⟸   XM_039098459
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001344871   ⟸   NM_001357942
- Peptide Label: uORF5
RefSeq Acc Id: XP_063135048   ⟸   XM_063278978
- Peptide Label: isoform X3
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30543-F1-model_v2 AlphaFold P30543 1-410 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2049 AgrOrtholog
BioCyc Gene G2FUF-4108 BioCyc
Ensembl Genes ENSRNOG00000001302 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001759 ENTREZGENE
  ENSRNOT00000001759.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7121208 IMAGE-MGC_LOAD
InterPro Adeno_A2A_rcpt UniProtKB/Swiss-Prot
  Adenosn_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:25369 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93190 IMAGE-MGC_LOAD
NCBI Gene 25369 ENTREZGENE
PANTHER ADENOSINE RECEPTOR A2A UniProtKB/Swiss-Prot
  OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB ADORA2A RGD
PhenoGen Adora2a PhenoGen
PRINTS ADENOSINA2AR UniProtKB/Swiss-Prot
  ADENOSINER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001302 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6JKL4 ENTREZGENE, UniProtKB/TrEMBL
  AA2AR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-30 Adora2a  adenosine A2a receptor  Adora2l1    Data merged from RGD:619948 737654 APPROVED
2002-11-06 Adora2a  adenosine A2a receptor    Adenosine A2a-receptor  Name updated 625702 APPROVED
2002-08-07 Adora2l1        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Adora2a  Adenosine A2a-receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain striatum 631807
gene_expression expression in straital neurons is coincident with D2 dopamine receptor expression, however, co-expression with D1 dopamine receptor is not detected 631807
gene_expression highly expressed in the aminobutyric acid (GABA)ergic striatopallidal neurons of striatum 628573
gene_expression 3,7-dimethyl-1-prparglylxanthine (DMPX) decreases outer and inner medullary blood flows, urine flow and sodium excretion 628573
gene_function diuretic and natriuretic adenosine receptor 628573
gene_function G-protein coupled receptor for adenoisne 625594
gene_process may be involved in regulation of motor behavior 631807
gene_process modulates glutamatergic input to striatal GABAergic neurons 625594
gene_process acts synergistically with glutamate mGlu5 receptor to increase c-fos expression in striatal sections and on counteracting phencyclidine-induced motor activation 628573
gene_process may promote adenosine mediated dilation of medullary vessels and increase medullary blood flow 628573
gene_product member of the G-protein coupled receptor family 631807
gene_regulation upon activation dilates pre- and postglomerular vessels and inhibits reabsorption of tubular sodium 628573