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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2049
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adora2a
Name: adenosine A2a receptor
Acc ID: CHEBI:34018
Term: (S)-AMPA
Definition: A non-proteinogenic alpha-amino acid that has formula C7H10N2O4.
Chemical ID: MESH:D018350
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adora2aincreases activityEXP 6480464CTDalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased activity of ADORA2A proteinPMID:16601261
Adora2amultiple interactionsEXP 6480464CTD[ZM 241385 binds to and results in decreased activity of ADORA2A protein] which results in decreased susceptibility to alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; ZM 241385 inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased activity of ADORA2A protein]PMID:16601261
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