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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2049
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adora2a
Name: adenosine A2a receptor
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adora2amultiple interactionsEXP 6480464CTD[2-n-butyl-9-methyl-8-(1,2,3)triazol-2-yl-9H-purin-6-ylamine binds to ADORA2A protein] which results in decreased susceptibility to Rotenone; [ZM 241385 binds to ADORA2A protein] which results in decreased susceptibility to RotenonePMID:19416678
Adora2aincreases expressionISOAdora2a (Mus musculus)6480464CTDRotenone results in increased expression of ADORA2A mRNAPMID:31820278 PMID:32937126
Adora2amultiple interactionsISOAdora2a (Mus musculus)6480464CTD[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]; carbidopa, levodopa drug combination inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]; Curcumin inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]; Niacin inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]; ZM 241385 inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]PMID:31820278
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