| 71043 | Cdc42 | cell division cycle 42 | ENCODES a protein that exhibits GTP binding; mitogen-activated protein kinase kinase kinase binding; apolipoprotein A-I receptor binding (ortholog); INVOLVED IN actin filament branching; actin filament organization; establishment of Golgi localization; PARTICIPATES IN Rho/Rac/Cdc42 t:700;'>Cdc42 mediated signaling pathway; adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; ASSOCIATED WITH Reperfusion Injury; Spinal Cord Injuries; temporal lobe epilepsy; FOUND IN Golgi membrane; plasma membrane; Schaffer collateral - CA1 synapse; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol | 5 | 154838478 | 154876629 | Rat | 407 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 41142645 | Cdc42-ps1 | cell division cycle 42, pseudogene 1 | | 4 | 71173818 | 71174534 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1561700 | Cdc42se1 | CDC42 small effector 1 | ENCODES a protein that exhibits small GTPase binding (inferred); INVOLVED IN phagocytosis (inferred); regulation of cell shape (inferred); regulation of Rho protein signal transduction (inferred); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cell junction (ortholog); INTERACTS W ITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 2 | 185494692 | 185502519 | Rat | 93 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1563924 | Cdc42se2 | CDC42 small effector 2 | ENCODES a protein that exhibits signaling adaptor activity (ortholog); INVOLVED IN regulation of signal transduction (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; bisphenol A | 10 | 39337269 | 39405772 | Rat | 77 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1311131 | Cdc42ep1 | CDC42 effector protein 1 | INVOLVED IN positive regulation of pseudopodium assembly (ortholog); regulation of cell shape (ortholog); Rho protein signal transduction (ortholog); FOUND IN actin cytoskeleton (ortholog); cytoplasm (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2 -thiouracil; acrylamide | 7 | 112275759 | 112283665 | Rat | 117 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1310253 | Cdc42ep2 | CDC42 effector protein 2 | ENCODES a protein that exhibits GTPase activator activity (ortholog); opioid peptide activity (ortholog); small GTPase binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cellular response to type II interferon (ortholog); positive regulation of actin filament polymerization (ortholog); FOUND IN cytoplasm (ortholog); membrane (ortholog); microtubule cytoskeleton (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 1 | 212631317 | 212640231 | Rat | 124 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1305858 | Cdc42ep3 | CDC42 effector protein 3 | FOUND IN actin cytoskeleton (ortholog); plasma membrane (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 6 | 21463081 | 21483553 | Rat | 134 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1311567 | Cdc42ep4 | CDC42 effector protein 4 | INVOLVED IN cellular response to type II interferon (ortholog); positive regulation of pseudopodium assembly (ortholog); regulation of cell shape (ortholog); FOUND IN actin cytoskeleton (ortholog); adherens junction (ortholog); cytoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlo rodibenzodioxine; 4,4'-sulfonyldiphenol | 10 | 99271750 | 99298551 | Rat | 123 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1308382 | Cdc42ep5 | CDC42 effector protein 5 | ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN JNK cascade (ortholog); positive regulation of actin filament polymerization (ortholog); positive regulation of pseudopodium assembly (ortholog); FOUND IN cytoplasm (ortholog); membrane (ortholog); plasma membrane (ortholog ); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene | 1 | 79108036 | 79110550 | Rat | 101 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 621753 | Cdc42bpb | CDC42 binding protein kinase beta | ENCODES a protein that exhibits protein serine/threonine kinase activity; small GTPase binding; ATP binding (ortholog); INVOLVED IN actin cytoskeleton organization; actomyosin structure organization; cell migration; ASSOCIATED WITH autism spectrum disorder (ortholog); Chilton-Okur-Chung neurodevelop mental syndrome (ortholog); genetic disease (ortholog); FOUND IN actomyosin; cell leading edge (ortholog); cell-cell junction (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 6 | 136154905 | 136241259 | Rat | 156 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 621406 | Cdc42bpa | CDC42 binding protein kinase alpha | ENCODES a protein that exhibits ATP binding; identical protein binding; magnesium ion binding; INVOLVED IN actin cytoskeleton organization; actomyosin structure organization; cell migration; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN actomyosin; cell leading edge; cell-cell junction; INTERACTS WI TH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 13 | 94215359 | 94435681 | Rat | 161 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1307260 | Cdc42bpg | CDC42 binding protein kinase gamma | ENCODES a protein that exhibits ATP binding (ortholog); magnesium ion binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN protein phosphorylation (ortholog); FOUND IN cell leading edge (ortholog); cytosol (ortholog); INTERACTS WITH acrylamide; alpha-Zearalanol; amphe tamine | 1 | 213037603 | 213057764 | Rat | 93 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 41095357 | Cdc42se1-ps1 | CDC42 small effector 1, pseudogene 1 | | 5 | 144646762 | 144648633 | Rat | | symbol , old_gene_name , PhenoGen , name | gene, pseudo, MODEL [RefSeq] |
| 2318957 | Cdc42se2-ps1 | CDC42 small effector 2, pseudogene 1 | | 1 | 100424071 | 100427058 | Rat | | symbol , old_gene_name , PhenoGen , name | gene, pseudo, INFERRED [RefSeq] |
| 620719 | Arhgef9 | Cdc42 guanine nucleotide exchange factor 9 | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN receptor clustering; regulation of postsynaptic specialization assembly (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); developmental and epileptic enceph alopathy 1 (ortholog); FOUND IN cell cortex; GABA-ergic synapse; glycinergic synapse; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil | X | 63929168 | 64087267 | Rat | 118 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1359674 | Arhgef6 | Rac/Cdc42 guanine nucleotide exchange factor 6 | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN lamellipodium assembly (ortholog); PARTICIPATES IN ceramide signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH autistic disorder (ortholog); intellectual disability (ortholog); Leukoencephal opathies (ortholog); FOUND IN cell-cell junction (ortholog); lamellipodium (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | X | 140182734 | 140302812 | Rat | 123 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1305386 | Fnbp1l | formin binding protein 1-like | ENCODES a protein that exhibits GTPase binding (ortholog); INVOLVED IN cilium assembly (ortholog); clathrin-dependent endocytosis (ortholog); membrane invagination (ortholog); ASSOCIATED WITH basal cell carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic vesicle (ortholog); cytosol (ort holog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide | 2 | 213331871 | 213432821 | Rat | 150 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1305957 | Tnk2 | tyrosine kinase, non-receptor, 2 | ENCODES a protein that exhibits protein tyrosine kinase activity; epidermal growth factor receptor binding (ortholog); identical protein binding (ortholog); INVOLVED IN phosphorylation (ortholog); positive regulation of peptidyl-tyrosine phosphorylation (ortholog); regulation of clathrin-dependent e ndocytosis (ortholog); ASSOCIATED WITH Autosomal Recessive Infantile Epilepsy (ortholog); developmental and epileptic encephalopathy (ortholog); epilepsy (ortholog); FOUND IN axon (ortholog); clathrin-coated pit (ortholog); clathrin-coated vesicle (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 11 | 81619795 | 81659074 | Rat | 164 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 735210 | Arhgef25 | Rho guanine nucleotide exchange factor 25 | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN myofibril (ortholog); plasma membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 64891260 | 64898382 | Rat | 80 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 621145 | Trip10 | thyroid hormone receptor interactor 10 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN epithelial to mesenchymal transition; negative regulation of cardiac muscle cell apoptotic process; positive regulation of cell growth involved in cardiac muscle cell development; PARTICIPATES IN insulin responsive fac ilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; ASSOCIATED WITH Diabetic Nephropathies; Huntington's disease (ortholog); FOUND IN cell cortex (inferred); cytoskeleton (inferred); Golgi apparatus (inferred); INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; acrylamide | 9 | 2219695 | 2234771 | Rat | 97 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1306093 | Arhgap31 | Rho GTPase activating protein 31 | ENCODES a protein that exhibits GTPase activator activity (ortholog); SH3 domain binding (ortholog); INVOLVED IN small GTPase-mediated signal transduction (ortholog); ASSOCIATED WITH Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 1 (ortholog); cerebral palsy (ortholog); FOUND IN lamellipodi um (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A | 11 | 75544176 | 75657087 | Rat | 98 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 3250 | Pak1 | p21 (RAC1) activated kinase 1 | ENCODES a protein that exhibits protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; INVOLVED IN cellular response to insulin stimulus; cerebellum development; establishment of cell polarity; PARTICIPATES IN adenosine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Acute Lung Injury; brain ischemia; Neointima; FOUND IN axon; dendrite; intercalated disc; INTERACTS WITH (+)-schisandrin B; (S)-amphetamine; 1-octadec-9-enoylglycero-3-phosphate | 1 | 161522399 | 161637623 | Rat | 339 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 61953 | Pak2 | p21 (RAC1) activated kinase 2 | ENCODES a protein that exhibits identical protein binding (ortholog); protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN cardiac muscle hypertrophy; cellular response to transforming growth factor beta stimulus; adherens junction assembly (ortholog); PARTICIPATES IN v ascular endothelial growth factor signaling pathway; epidermal growth factor/neuregulin signaling pathway; mitogen activated protein kinase signaling pathway; ASSOCIATED WITH Puromycin Aminonucleoside Nephrosis; ureteral obstruction; atrial fibrillation (ortholog); FOUND IN secretory granule; cell-cell junction (ortholog); cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4,6-trinitrobenzenesulfonic acid | 11 | 82212896 | 82273803 | Rat | 210 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 3251 | Pak3 | p21 (RAC1) activated kinase 3 | ENCODES a protein that exhibits GTPase binding; protein kinase activity; protein serine/threonine kinase activity; INVOLVED IN positive regulation of dendritic spine morphogenesis; positive regulation of DNA biosynthetic process; positive regulation of fibroblast migration; PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; renal cell carcinoma pathway; T cell receptor signaling pathway; ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); microcephaly (ortholog); FOUND IN endosome; glutamatergic synapse (ortholog); postsynaptic density (ortholog); INTERACTS WITH (R)-noradrenaline; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | X | 111912967 | 112171037 | Rat | 176 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1307705 | Pak4 | p21 (RAC1) activated kinase 4 | ENCODES a protein that exhibits protein kinase activity (ortholog); protein serine kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN dendritic spine development (ortholog); negative regulation of endothelial cell apoptotic process (ortholog); negative regul ation of triglyceride catabolic process (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; epidermal growth factor/neuregulin signaling pathway; renal cell carcinoma pathway; ASSOCIATED WITH clear cell renal cell carcinoma (ortholog); Experimental Mammary Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN cell junction (ortholog); cytoplasm (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; atrazine | 1 | 92977437 | 93016721 | Rat | 129 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1312009 | Pak5 | p21 (RAC1) activated kinase 5 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN learning (ortholog); locomotory behavior (ortholog); memory (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; renal cell carcinoma pathway; T cell receptor signaling pathw ay; ASSOCIATED WITH congenital myasthenic syndrome 18 (ortholog); developmental and epileptic encephalopathy 12 (ortholog); FOUND IN cytosol (ortholog); mitochondrion (ortholog); nuclear membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 3 | 143848404 | 144156674 | Rat | 83 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1306213 | Pak6 | p21 (RAC1) activated kinase 6 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN learning (ortholog); locomotory behavior (ortholog); memory (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; renal cell carcinoma pathway; T cell receptor signaling pathway; ASSOCIATED WITH clear cell renal cell carcinoma (ortholog); Prostatic Neoplasms (ortholog); FOUND IN fibrillar center (ortholog); nucleoplasm (ortholog); postsynaptic density (ortholog); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; acrylamide | 3 | 126092576 | 126128320 | Rat | 116 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 629617 | Dock9 | dedicator of cytokinesis 9 | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN positive regulation of GTPase activity (ortholog); FOUND IN endomembrane system (inferred); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8- Tetrachlorodibenzofuran | 15 | 105018341 | 105289799 | Rat | 123 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1597791 | Ccdc160 | coiled-coil domain containing 160 | ASSOCIATED WITH genetic disease (ortholog); INTERACTS WITH bisphenol A; gentamycin; 17beta-hydroxy-5alpha-androstan-3-one (ortholog) | X | 137389066 | 137399452 | Rat | 24 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 2059 | Adrb1 | adrenoceptor beta 1 | ENCODES a protein that exhibits amine binding; beta1-adrenergic receptor activity; alpha-2A adrenergic receptor binding (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway; glycogen catabolic process; inhibitory postsynaptic potential; PARTICIPATES IN Rho/Rac/Cdc42 t:700;'>Cdc42 mediated signaling pathway; acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH Anaphylaxis; congestive heart failure; dilated cardiomyopathy; FOUND IN plasma membrane; early endosome (ortholog); membrane (ortholog); INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 3',5'-cyclic AMP | 1 | 265777103 | 265780114 | Rat | 424 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 619814 | Baiap2 | BAR/IMD domain containing adaptor protein 2 | ENCODES a protein that exhibits PDZ domain binding; scaffold protein binding; transcription coregulator binding; INVOLVED IN cellular response to epidermal growth factor stimulus; cellular response to L-glutamate; neuron differentiation; PARTICIPATES IN insulin responsive facilitative sugar transpor ter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH Puromycin Aminonucleoside Nephrosis; Alzheimer's disease (ortholog); attention deficit hyperactivity disorder (ortholog); FOUND IN dendritic shaft; dendritic spine; dendritic spine cytoplasm; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene | 10 | 105721371 | 105788549 | Rat | 236 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1310332 | Cyfip1 | cytoplasmic FMR1 interacting protein 1 | ENCODES a protein that exhibits RNA 7-methylguanosine cap binding; small GTPase binding (ortholog); translation repressor activity (ortholog); INVOLVED IN cellular response to insulin stimulus; negative regulation of synaptic vesicle recycling; positive regulation of axon extension; PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH abnormal brain white matter morphology; decreased myelin sheath thickness; decreased oligodendrocyte number; ASSOCIATED WITH temporal lobe epilepsy; autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN axonal growth cone; central region of growth cone; dendritic growth cone; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,4-methylenedioxymethamphetamine | 1 | 115842754 | 115935163 | Rat | 150 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 68416 | Dlc1 | DLC1 Rho GTPase activating protein | ENCODES a protein that exhibits GTPase activator activity; phospholipase binding; phospholipase C activator activity; INVOLVED IN cellular response to insulin stimulus; actin cytoskeleton organization (ortholog); focal adhesion assembly (ortholog); PARTICIPATES IN Rho/Rac/Cdc42 0;'>Cdc42 mediated signaling pathway; ASSOCIATED WITH amenorrhea (ortholog); colon carcinoma (ortholog); colorectal cancer (ortholog); FOUND IN actin filament; focal adhesion; stress fiber; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 16 | 61954177 | 62374819 | Rat | 213 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 13830868 | Dock8m1Ztm | dedicator of cytokinesis 8;mutant 1, Ztm | ASSOCIATED WITH type 1 diabetes mellitus | | | | Rat | 1 | description | gene, allele |
| 2535 | Ednra | endothelin receptor type A | ENCODES a protein that exhibits endothelin receptor activity; INVOLVED IN cellular response to mechanical stimulus; fibroblast proliferation; glomerular filtration; PARTICIPATES IN endothelin signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediat ed signaling pathway; ASSOCIATED WITH glomerulosclerosis; heart left ventricle hypertrophy; increased systemic arterial systolic blood pressure; ASSOCIATED WITH Acute Experimental Pancreatitis; Diabetic Nephropathies; Experimental Diabetes Mellitus; FOUND IN nuclear membrane; T-tubule; plasma membrane (ortholog); INTERACTS WITH (R)-noradrenaline; 11-deoxycorticosterone; 2,2',4,4'-Tetrabromodiphenyl ether | 19 | 47137360 | 47207961 | Rat | 506 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1560614 | Flna | filamin A | ENCODES a protein that exhibits protein-containing complex binding; SMAD binding; actin filament binding (ortholog); INVOLVED IN cerebral cortex development; establishment of Sertoli cell barrier; formation of radial glial scaffolds; PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; integrin mediated signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH periventricular nodular heterotopia; Aneurysm (ortholog); aortic aneurysm (ortholog); FOUND IN actin cytoskeleton; actin filament; apical dendrite; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | X | 157159051 | 157185559 | Rat | 459 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2943 | Jun | Jun proto-oncogene, AP-1 transcription factor subunit | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; double-stranded DNA binding; INVOLVED IN angiogenesis; cellular response to hypoxia; cellular response to potassium ion starvation; PARTICIPATES IN Rho /Rac/Cdc42 mediated signaling pathway; adenosine signaling pathway; endothelin signaling pathway; ASSOCIATED WITH Alcohol-Related Disorders; depressive disorder; hypertension; FOUND IN chromatin; nucleus; protein-containing complex; INTERACTS WITH (+)-pilocarpine; (-)-anisomycin; (R)-lipoic acid | 5 | 115009900 | 115012993 | Rat | 1797 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 62056 | Limk2 | LIM domain kinase 2 | ENCODES a protein that exhibits protein serine/threonine kinase activity; protein kinase activity (ortholog); INVOLVED IN protein phosphorylation; astral microtubule organization (ortholog); cornea development in camera-type eye (ortholog); PARTICIPATES IN Rho/Rac/Cdc42 2 mediated signaling pathway; Fc gamma receptor mediated signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN centrosome (ortholog); cis-Golgi network (ortholog); cytoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol | 14 | 82384256 | 82509755 | Rat | 158 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1307040 | Map2k4 | mitogen activated protein kinase kinase 4 | ENCODES a protein that exhibits JUN kinase kinase activity; MAP kinase kinase activity; molecular adaptor activity (ortholog); INVOLVED IN cell growth involved in cardiac muscle cell development; cellular response to sorbitol; JNK cascade; PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling path way; Rho/Rac/Cdc42 mediated signaling pathway; ceramide signaling pathway; ASSOCIATED WITH Brain Death; Retina Reperfusion Injury; Sleep Deprivation; FOUND IN axon; dendrite cytoplasm; perikaryon; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | 10 | 50842348 | 50947063 | Rat | 261 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 621506 | Mapk8 | mitogen-activated protein kinase 8 | ENCODES a protein that exhibits JUN kinase activity; kinesin binding; enzyme binding (ortholog); INVOLVED IN cellular response to amyloid-beta; cellular response to interleukin-1; cellular response to oxygen-glucose deprivation; PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; inflam matory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH alcohol use disorder; anti-basement membrane glomerulonephritis; brain ischemia; FOUND IN axon; dendrite cytoplasm; perikaryon; INTERACTS WITH (+)-taxifolin; (-)-anisomycin; (-)-epigallocatechin 3-gallate | 16 | 8645171 | 8728225 | Rat | 1586 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 619809 | Ntn1 | netrin 1 | INVOLVED IN Cdc42 protein signal transduction; positive regulation of axon extension; positive regulation of cell motility; ASSOCIATED WITH Oxygen-Induced Retinopathy; Alzheimer's disease (ortholog); brain edema (ortholog); FOUND IN basement membrane (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 10 | 53398852 | 53597595 | Rat | 173 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1310790 | Plekhg4 | pleckstrin homology and RhoGEF domain containing G4 | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH spinocerebellar ataxia 31 (ortholog); INTERACTS WITH alpha-Zearalanol; atrazine; bisphenol A | 19 | 50161722 | 50176491 | Rat | 78 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 68415 | Ppp5c | protein phosphatase 5, catalytic subunit | ENCODES a protein that exhibits G-protein alpha-subunit binding; heat shock protein binding; Hsp70 protein binding; INVOLVED IN cellular response to cadmium ion; cellular response to hydrogen peroxide; negative regulation of apoptotic process; PARTICIPATES IN Rho/Rac/Cdc42 dc42 mediated signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; mitogen activated protein kinase signaling pathway; ASSOCIATED WITH Left Ventricular Hypertrophy (ortholog); FOUND IN neuronal cell body; perikaryon; proximal dendrite; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol | 1 | 86818297 | 86842505 | Rat | 197 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1306534 | Prex1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | ENCODES a protein that exhibits phospholipid binding (ortholog); INVOLVED IN positive regulation of cell migration; regulation of actin filament polymerization; regulation of dendrite development; PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; R ho/Rac/Cdc42 mediated signaling pathway; chemokine mediated signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); Lymphatic Metastasis (ortholog); prostate cancer (ortholog); FOUND IN dendritic shaft; growth cone; perinuclear region of cytoplasm; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 3 | 175724939 | 175875764 | Rat | 158 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 628758 | Ptk2b | protein tyrosine kinase 2 beta | ENCODES a protein that exhibits 3-phosphoinositide-dependent protein kinase binding; calcium/calmodulin-dependent protein kinase activity; enzyme binding; INVOLVED IN actin filament organization; activation of GTPase activity; activation of Janus kinase activity; PARTICIPATES IN Jak-Stat signaling p athway; Rho/Rac/Cdc42 mediated signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH anti-basement membrane glomerulonephritis; brain ischemia; diabetic angiopathy; FOUND IN apical dendrite; axon; cell body; INTERACTS WITH (+)-pilocarpine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine | 15 | 44536275 | 44656754 | Rat | 446 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 619755 | Rac1 | Rac family small GTPase 1 | ENCODES a protein that exhibits ATPase binding; GTP binding; GTPase activity; INVOLVED IN actin cytoskeleton organization; actin filament organization; bone resorption; PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; Arf family mediated signaling pathw ay; azathioprine pharmacodynamics pathway; ASSOCIATED WITH congestive heart failure; Left Ventricular Hypertrophy; autosomal dominant intellectual developmental disorder 48 (ortholog); FOUND IN cytosol; GABA-ergic synapse; Golgi membrane; INTERACTS WITH 11-deoxycorticosterone; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 12 | 16150411 | 16170864 | Rat | 639 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 621626 | Rhoq | ras homolog family member Q | ENCODES a protein that exhibits GBD domain binding (ortholog); GTPase activity (ortholog); profilin binding (ortholog); INVOLVED IN cellular response to insulin stimulus (ortholog); cortical actin cytoskeleton organization (ortholog); GTP metabolic process (ortholog); PARTICIPATES IN insulin respons ive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN actin filament (ortholog); membrane raft (ortholog); plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 1-naphthyl isothiocyanate | 6 | 13368499 | 13403929 | Rat | 167 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1311558 | Shtn1 | shootin 1 | ENCODES a protein that exhibits actin filament binding; cell adhesion molecule binding; identical protein binding (ortholog); INVOLVED IN actin filament bundle retrograde transport; axonogenesis; Cdc42 protein signal transduction; FOUND IN axonal growth cone; fi lopodium; lamellipodium; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 268108095 | 268211947 | Rat | 152 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1586598 | Sorbs1 | sorbin and SH3 domain containing 1 | ENCODES a protein that exhibits insulin receptor binding; ubiquitin protein ligase binding; protein kinase binding (ortholog); INVOLVED IN response to activity; response to insulin; response to L-glutamate; PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH Insulin Resistance (ortholog); obesity (ortholog); prostate cancer (ortholog); FOUND IN insulin receptor complex; adherens junction (ortholog); cell-substrate junction (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 249057324 | 249279703 | Rat | 240 | description | gene, protein-coding, VALIDATED [RefSeq] |