Zfp268 (zinc finger protein 268) - Rat Genome Database

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Gene: Zfp268 (zinc finger protein 268) Mus musculus
Analyze
Symbol: Zfp268
Name: zinc finger protein 268
RGD ID: 1625155
MGI Page MGI
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol. Predicted to be active in nucleus. Orthologous to human ZNF268 (zinc finger protein 268) and ZNF616 (zinc finger protein 616).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gm13212; hypothetical protein LOC433801; novel KRAB box containing protein; RP23-285N14.1; uncharacterized protein LOC433801
RGD Orthologs
Human
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394145,311,770 - 145,351,915 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4145,311,736 - 145,351,915 (+)EnsemblGRCm39 Ensembl
GRCm384145,585,172 - 145,625,343 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4145,585,166 - 145,625,345 (+)EnsemblGRCm38mm10GRCm38
MGSCv374145,207,049 - 145,214,297 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364144,883,805 - 144,892,028 (+)NCBIMGSCv36mm8
Cytogenetic Map4E1NCBI
cM Map478.22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
cytosol  (ISO)
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:18799693   PMID:21873635  


Genomics

Comparative Map Data
Zfp268
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394145,311,770 - 145,351,915 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4145,311,736 - 145,351,915 (+)EnsemblGRCm39 Ensembl
GRCm384145,585,172 - 145,625,343 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4145,585,166 - 145,625,345 (+)EnsemblGRCm38mm10GRCm38
MGSCv374145,207,049 - 145,214,297 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364144,883,805 - 144,892,028 (+)NCBIMGSCv36mm8
Cytogenetic Map4E1NCBI
cM Map478.22NCBI
ZNF841
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381952,058,095 - 52,095,765 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1952,064,465 - 52,095,765 (-)EnsemblGRCh38hg38GRCh38
GRCh371952,561,348 - 52,599,018 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361957,259,531 - 57,289,340 (-)NCBINCBI36Build 36hg18NCBI36
Celera1949,617,277 - 49,648,580 (-)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1948,898,349 - 48,929,657 (-)NCBIHuRef
CHM1_11952,569,596 - 52,600,895 (-)NCBICHM1_1
T2T-CHM13v2.01955,145,315 - 55,182,977 (-)NCBIT2T-CHM13v2.0
ZNF841
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22058,107,042 - 58,138,056 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11960,030,864 - 60,062,464 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01949,007,787 - 49,038,770 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11957,886,770 - 57,917,515 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1957,937,313 - 57,946,400 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl1957,886,770 - 57,917,499 (-)Ensemblpanpan1.1panPan2
ZNF841
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1644,880,949 - 44,904,825 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl644,881,040 - 44,899,539 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607324,938,360 - 24,961,686 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Zfp268
1198 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:426
Count of miRNA genes:184
Interacting mature miRNAs:189
Transcripts:ENSMUST00000097794, ENSMUST00000105739, ENSMUST00000119718
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137674005150676858Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse
12738431Lfibq20_mliver fibrosis QTL 20 (mouse)4144699835148907426Mouse

Markers in Region
RH136534  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384145,624,950 - 145,625,147UniSTSGRCm38
GRCm384147,259,760 - 147,259,957UniSTSGRCm38
MGSCv374146,633,869 - 146,634,066UniSTSGRCm37
MGSCv374145,214,853 - 145,215,050UniSTSGRCm37
Cytogenetic Map4E1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000097794   ⟹   ENSMUSP00000095402
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4145,343,716 - 145,349,785 (+)Ensembl
GRCm38.p6 Ensembl4145,617,146 - 145,623,215 (+)Ensembl
RefSeq Acc Id: ENSMUST00000105739   ⟹   ENSMUSP00000101365
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4145,311,736 - 145,351,915 (+)Ensembl
GRCm38.p6 Ensembl4145,585,166 - 145,625,345 (+)Ensembl
RefSeq Acc Id: ENSMUST00000119718   ⟹   ENSMUSP00000112918
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4145,311,773 - 145,351,911 (+)Ensembl
GRCm38.p6 Ensembl4145,585,203 - 145,625,341 (+)Ensembl
RefSeq Acc Id: NM_001324416   ⟹   NP_001311345
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394145,311,770 - 145,351,913 (+)NCBI
GRCm384145,585,200 - 145,625,343 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164220   ⟹   XP_036020113
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394145,343,655 - 145,351,915 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001311345 (Get FASTA)   NCBI Sequence Viewer  
  XP_036020113 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH55069 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000095402.4
  ENSMUSP00000101365
  ENSMUSP00000101365.2
  ENSMUSP00000112918.2
Reference Protein Sequences
RefSeq Acc Id: NP_001311345   ⟸   NM_001324416
- UniProtKB: B1ASQ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000112918   ⟸   ENSMUST00000119718
RefSeq Acc Id: ENSMUSP00000101365   ⟸   ENSMUST00000105739
RefSeq Acc Id: ENSMUSP00000095402   ⟸   ENSMUST00000097794
RefSeq Acc Id: XP_036020113   ⟸   XM_036164220
- Peptide Label: isoform X1
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1ASQ7-F1-model_v2 AlphaFold B1ASQ7 1-799 view protein structure

Promoters
RGD ID:6885422
Promoter ID:EPDNEW_M6162
Type:multiple initiation site
Name:Gm13212_2
Description:Mus musculus predicted gene 13212 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6163  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384145,575,292 - 145,575,352EPDNEW
RGD ID:6885424
Promoter ID:EPDNEW_M6163
Type:initiation region
Name:Gm13212_1
Description:Mus musculus predicted gene 13212 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6162  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384145,585,190 - 145,585,250EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3651014 AgrOrtholog
Ensembl Genes ENSMUSG00000078502 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000097794.4 UniProtKB/TrEMBL
  ENSMUST00000105739 ENTREZGENE
  ENSMUST00000105739.8 UniProtKB/TrEMBL
  ENSMUST00000119718.8 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report mmu:433801 UniProtKB/TrEMBL
MGD MGI:3651014 ENTREZGENE
NCBI Gene 433801 ENTREZGENE
PANTHER GENE 10130-RELATED UniProtKB/TrEMBL
  KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/TrEMBL
  KRAB DOMAIN-CONTAINING PROTEIN 5-RELATED UniProtKB/TrEMBL
  SPERM MOTILITY KINASE X-LIKE UniProtKB/TrEMBL
  ZINC FINGER AND SCAN DOMAIN-CONTAINING UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 142 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 983 UniProtKB/TrEMBL
  ZNF44 PROTEIN UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp268 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt B1ASQ6_MOUSE UniProtKB/TrEMBL
  B1ASQ7 ENTREZGENE, UniProtKB/TrEMBL
  E9PWQ2_MOUSE UniProtKB/TrEMBL
  Q7TPN0_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-11-09 Zfp268  zinc finger protein 268  Gm13212  predicted gene 13212  Symbol and/or name updated 27372883 PROVISIONAL