ZNF525 (zinc finger protein 525) - Rat Genome Database

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Gene: ZNF525 (zinc finger protein 525) Homo sapiens
Analyze
No known orthologs.
Symbol: ZNF525
Name: zinc finger protein 525
RGD ID: 1345310
HGNC Page HGNC:29423
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KIAA1979
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381953,365,705 - 53,386,590 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1953,365,693 - 53,392,217 (+)EnsemblGRCh38hg38GRCh38
GRCh371953,868,958 - 53,889,843 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361958,560,780 - 58,581,655 (+)NCBINCBI36Build 36hg18NCBI36
Build 341958,576,613 - 58,581,658NCBI
Celera1950,910,346 - 50,931,227 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1950,189,270 - 50,210,089 (+)NCBIHuRef
CHM1_11953,870,886 - 53,891,749 (+)NCBICHM1_1
T2T-CHM13v2.01956,445,220 - 56,466,092 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11853319   PMID:14702039   PMID:16344560   PMID:21145461   PMID:21873635   PMID:29180619  


Genomics

Variants

.
Variants in ZNF525
1 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:49907832-58557889)x3 copy number gain See cases [RCV000052925] Chr19:49907832..58557889 [GRCh38]
Chr19:50411089..59069256 [GRCh37]
Chr19:55102901..63761068 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:50191219-58535818)x3 copy number gain See cases [RCV000050883] Chr19:50191219..58535818 [GRCh38]
Chr19:50694476..59047185 [GRCh37]
Chr19:55386288..63738997 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:52955056-58581203)x3 copy number gain See cases [RCV000134139] Chr19:52955056..58581203 [GRCh38]
Chr19:53458309..59092570 [GRCh37]
Chr19:58150121..63784382 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:52612432-58581203)x3 copy number gain See cases [RCV000134174] Chr19:52612432..58581203 [GRCh38]
Chr19:53115685..59092570 [GRCh37]
Chr19:57807497..63784382 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:50152520-58581203)x3 copy number gain See cases [RCV000135843] Chr19:50152520..58581203 [GRCh38]
Chr19:50655777..59092570 [GRCh37]
Chr19:55347589..63784382 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:52143873-58445521)x3 copy number gain See cases [RCV000142008] Chr19:52143873..58445521 [GRCh38]
Chr19:52647126..58956888 [GRCh37]
Chr19:57338938..63648700 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:51141518-58539965)x3 copy number gain See cases [RCV000052926] Chr19:51141518..58539965 [GRCh38]
Chr19:51644775..59051332 [GRCh37]
Chr19:56336587..63743144 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4624
Count of miRNA genes:1018
Interacting mature miRNAs:1211
Transcripts:ENST00000355326, ENST00000467003, ENST00000474037, ENST00000475179, ENST00000491101, ENST00000497729, ENST00000593918, ENST00000600148, ENST00000601790
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH76350  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371953,888,884 - 53,889,129UniSTSGRCh37
Build 361958,580,696 - 58,580,941RGDNCBI36
Celera1950,930,268 - 50,930,513RGD
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map19q13.42UniSTS
HuRef1950,209,130 - 50,209,375UniSTS
SHGC-37292  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371953,889,687 - 53,889,836UniSTSGRCh37
GRCh37853,358,265 - 53,358,415UniSTSGRCh37
Build 36853,520,818 - 53,520,968RGDNCBI36
Celera1950,931,071 - 50,931,220RGD
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map19q13.41UniSTS
HuRef1950,209,933 - 50,210,082UniSTS
GeneMap99-G3 RH Map192757.0UniSTS
DXS8214  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXq24UniSTS
Cytogenetic Map3q27UniSTS
Cytogenetic Map19q13.42UniSTS
RH118661  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19q13.42UniSTS
TNG Radiation Hybrid Map1919622.0UniSTS
STS-N54526  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19q13.42UniSTS
GeneMap99-GB4 RH Map19278.44UniSTS
NCBI RH Map19573.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 32 1 7 3 294 4 172 15 3 22 295 79 1 2
Low 2382 2235 1594 500 1123 340 3452 1226 3240 390 1153 1521 172 1 1202 2063 4 2
Below cutoff 23 753 122 118 522 118 729 953 491 7 11 12 2 2 724

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000467003   ⟹   ENSP00000419136
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1953,365,707 - 53,386,593 (+)Ensembl
RefSeq Acc Id: ENST00000474037   ⟹   ENSP00000417696
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1953,365,705 - 53,386,590 (+)Ensembl
RefSeq Acc Id: ENST00000475179   ⟹   ENSP00000418468
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1953,365,713 - 53,386,581 (+)Ensembl
RefSeq Acc Id: ENST00000491101   ⟹   ENSP00000420476
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1953,365,704 - 53,376,442 (+)Ensembl
RefSeq Acc Id: ENST00000497729
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1953,365,693 - 53,376,157 (+)Ensembl
RefSeq Acc Id: ENST00000593918   ⟹   ENSP00000470407
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1953,365,729 - 53,392,217 (+)Ensembl
RefSeq Acc Id: ENST00000600148
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1953,379,381 - 53,381,049 (+)Ensembl
RefSeq Acc Id: ENST00000601790
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1953,383,923 - 53,385,231 (+)Ensembl
RefSeq Acc Id: NM_001348156   ⟹   NP_001335085
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381953,365,705 - 53,386,590 (+)NCBI
T2T-CHM13v2.01956,445,220 - 56,466,092 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001348157   ⟹   NP_001335086
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381953,365,705 - 53,386,590 (+)NCBI
T2T-CHM13v2.01956,445,220 - 56,466,092 (+)NCBI
Sequence:
RefSeq Acc Id: NR_145445
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381953,365,705 - 53,386,590 (+)NCBI
T2T-CHM13v2.01956,445,220 - 56,466,092 (+)NCBI
Sequence:
RefSeq Acc Id: NR_145446
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381953,365,705 - 53,386,590 (+)NCBI
T2T-CHM13v2.01956,445,220 - 56,466,092 (+)NCBI
Sequence:
RefSeq Acc Id: NR_145447
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381953,365,705 - 53,386,590 (+)NCBI
T2T-CHM13v2.01956,445,220 - 56,466,092 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001335085   ⟸   NM_001348156
- Peptide Label: isoform 1
- UniProtKB: Q8N782 (UniProtKB/Swiss-Prot),   Q8TF23 (UniProtKB/Swiss-Prot),   J3KR51 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001335086   ⟸   NM_001348157
- Peptide Label: isoform 2
- UniProtKB: J3KR62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000420476   ⟸   ENST00000491101
RefSeq Acc Id: ENSP00000419136   ⟸   ENST00000467003
RefSeq Acc Id: ENSP00000417696   ⟸   ENST00000474037
RefSeq Acc Id: ENSP00000418468   ⟸   ENST00000475179
RefSeq Acc Id: ENSP00000470407   ⟸   ENST00000593918
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8N782-F1-model_v2 AlphaFold Q8N782 1-479 view protein structure

Promoters
RGD ID:6795737
Promoter ID:HG_KWN:30820
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   K562,   Lymphoblastoid,   NB4
Transcripts:NR_003699,   UC002QBL.2
Position:
Human AssemblyChrPosition (strand)Source
Build 361958,560,566 - 58,561,066 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
COSMIC ZNF525 COSMIC
Ensembl Genes ENSG00000203326 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000467003 ENTREZGENE
  ENST00000467003.1 UniProtKB/TrEMBL
  ENST00000474037 ENTREZGENE
  ENST00000474037.6 UniProtKB/Swiss-Prot
  ENST00000475179 ENTREZGENE
  ENST00000475179.5 UniProtKB/TrEMBL
  ENST00000491101.5 UniProtKB/TrEMBL
  ENST00000593918.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000203326 GTEx
HGNC ID HGNC:29423 ENTREZGENE
Human Proteome Map ZNF525 Human Proteome Map
InterPro KRAB UniProtKB/Swiss-Prot
  KRAB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:170958 UniProtKB/Swiss-Prot
NCBI Gene 170958 ENTREZGENE
PANTHER KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRAB DOMAIN-CONTAINING PROTEIN 5-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam KRAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-H2C2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134989094 PharmGKB
PROSITE KRAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART KRAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E7ENB8_HUMAN UniProtKB/TrEMBL
  E7EUL5_HUMAN UniProtKB/TrEMBL
  J3KR51 ENTREZGENE
  J3KR62 ENTREZGENE, UniProtKB/TrEMBL
  M0QZA4_HUMAN UniProtKB/TrEMBL
  Q8N782 ENTREZGENE
  Q8TF23 ENTREZGENE
  ZN525_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary J3KR51 UniProtKB/Swiss-Prot
  Q8TF23 UniProtKB/Swiss-Prot