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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:Toll-like receptor signaling pathway
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Accession:PW:0000814 term browser browse the term
Definition:Toll-like receptors represent a large and the better understood family of pattern recognition receptors that sense an array of exogenous structures, and recent evidence shows they can also recognize defective endogenous molecules. The intracellular signaling cascades they set in motion lead to the expression of inflammatory mediators.
Synonyms:related_synonym: TLR signaling pathway;   Toll-Like Receptors Cascades
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Toll-like receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule ISO RGD PMID:22119168 RGD:7247704 NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581 		JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 ISO RGD PMID:21235323 RGD:5685014 NCBI chr  X:124,717,604...124,724,855
Ensembl chr  X:124,717,612...124,724,860 		JBrowse link
G IRAK2 interleukin 1 receptor associated kinase 2 ISO RGD PMID:21235323 RGD:5685014 NCBI chr13:66,350,606...66,416,834
Ensembl chr13:66,350,606...66,416,827 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 ISO RGD PMID:28954388 RGD:34888230 NCBI chr 5:30,524,704...30,601,067
Ensembl chr 5:30,526,793...30,609,921 		JBrowse link
G IRAK4 interleukin 1 receptor associated kinase 4 ISO RGD PMID:21235323 RGD:5685014 NCBI chr 5:74,842,184...74,858,125
Ensembl chr 5:74,834,600...74,859,344 		JBrowse link
G IRF3 interferon regulatory factor 3 ISO RGD PMID:21235323 RGD:5685014 NCBI chr 6:54,701,733...54,706,079
Ensembl chr 6:54,701,668...54,707,151 		JBrowse link
G LBP lipopolysaccharide binding protein ISO RGD PMID:22119168 RGD:7247704 NCBI chr17:41,398,935...41,429,467
Ensembl chr17:41,393,818...41,429,551 		JBrowse link
G LY96 lymphocyte antigen 96 ISO RGD PMID:21741580 PMID:22119168 RGD:5685019 RGD:7247704 NCBI chr 4:61,919,806...61,950,712
Ensembl chr 4:61,926,064...61,950,697 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 ISO RGD PMID:21235323 RGD:5685014 NCBI chr 1:58,482,046...58,548,087
Ensembl chr 1:58,481,956...58,548,057 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor ISO RGD PMID:21235323 RGD:5685014 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 ISO RGD PMID:21235323 RGD:5685014 NCBI chr 7:1,841,143...1,880,705
Ensembl chr 7:1,841,239...1,880,699 		JBrowse link
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 ISO RGD PMID:20940366 RGD:5685016 NCBI chr 5:8,827,363...8,852,814
Ensembl chr 5:8,826,840...8,852,776 		JBrowse link
G TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 ISO RGD PMID:20940366 RGD:5685016 NCBI chr 1:16,533,364...16,611,879
Ensembl chr 1:16,533,285...16,611,884 		JBrowse link
G TAB3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 ISO RGD PMID:20940366 RGD:5685016 NCBI chr  X:26,632,547...26,729,039
Ensembl chr  X:26,632,551...26,729,051 		JBrowse link
G TBK1 TANK binding kinase 1 ISO RGD PMID:21235323 RGD:5685014 NCBI chr 5:28,880,210...28,929,964
Ensembl chr 5:28,880,205...28,929,963 		JBrowse link
G TICAM1 TIR domain containing adaptor molecule 1 ISO RGD PMID:21235323 RGD:5685014 NCBI chr 2:74,004,566...74,021,100
Ensembl chr 2:74,004,308...74,021,873 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 ISO RGD PMID:21235323 RGD:5685014 NCBI chr 2:119,758,622...119,778,650 JBrowse link
G TIRAP TIR domain containing adaptor protein ISO RGD PMID:21235323 RGD:5685014 NCBI chr 9:53,374,559...53,394,172
Ensembl chr 9:53,375,644...53,394,165 		JBrowse link
G TLR1 toll like receptor 1 ISO RGD PMID:16973131 PMID:21235323 RGD:1643119 RGD:5685014 NCBI chr 8:30,147,600...30,155,454
Ensembl chr 8:30,147,624...30,155,466 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:16973131 PMID:18353287 PMID:21235323 RGD:1643119 RGD:5684896 RGD:5685014 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
G TLR3 toll like receptor 3 ISO RGD PMID:16973131 PMID:21235323 RGD:1643119 RGD:5685014 NCBI chr15:46,966,262...46,977,774
Ensembl chr15:46,969,006...46,979,291 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:16973131 PMID:21235323 PMID:22119168 RGD:1643119 RGD:5685014 RGD:7247704 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TLR5 toll like receptor 5 ISO RGD PMID:16973131 PMID:21235323 RGD:1643119 RGD:5685014 NCBI chr10:19,387,666...19,410,024
Ensembl chr10:19,387,666...19,410,024 		JBrowse link
G TLR6 toll like receptor 6 ISO RGD PMID:16973131 PMID:18353287 PMID:21235323 RGD:1643119 RGD:5684896 RGD:5685014 NCBI chr 8:30,159,744...30,180,650
Ensembl chr 8:30,159,754...30,180,650 		JBrowse link
G TLR7 toll like receptor 7 ISO RGD PMID:21235323 RGD:5685014 NCBI chr  X:9,573,178...9,576,987 JBrowse link
G TLR8 toll like receptor 8 ISO RGD PMID:21235323 RGD:5685014 NCBI chr  X:9,551,284...9,616,762
Ensembl chr  X:9,597,604...9,616,757 		JBrowse link
G TLR9 toll like receptor 9 ISO RGD PMID:16973131 PMID:21235323 RGD:1643119 RGD:5685014 NCBI chr13:34,353,444...34,370,990
Ensembl chr13:34,349,609...34,357,673 		JBrowse link
G TRADD TNFRSF1A associated via death domain ISO RGD PMID:21235323 RGD:5685014 NCBI chr 6:27,797,594...27,804,654
Ensembl chr 6:27,797,607...27,804,423 		JBrowse link
G TRAF3 TNF receptor associated factor 3 ISO RGD PMID:21235323 RGD:5685014
G TRAF6 TNF receptor associated factor 6 ISO RGD PMID:21235323 RGD:5685014 NCBI chr 2:24,602,749...24,628,263
Ensembl chr 2:24,602,804...24,626,072 		JBrowse link
G UBE2N ubiquitin conjugating enzyme E2 N ISO RGD PMID:21235323 RGD:5685014 NCBI chr 5:89,673,306...89,716,345
Ensembl chr 5:89,702,682...89,714,279 		JBrowse link
G UBE2V1 ubiquitin conjugating enzyme E2 V1 ISO RGD PMID:21235323 RGD:5685014 NCBI chr17:51,630,233...51,664,498
Ensembl chr17:51,629,964...51,666,701 		JBrowse link
G UNC93B1 unc-93 homolog B1, TLR signaling regulator ISO RGD PMID:21235323 RGD:5685014 NCBI chr 2:4,898,414...4,909,833
Ensembl chr 2:4,898,409...4,909,856 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4047
    signaling pathway 1931
      signaling pathway pertinent to immunity 417
        signaling pathway in the innate immune response 35
          pattern recognition receptor mediated signaling pathway 34
            Toll-like receptor signaling pathway 33
              Toll-like receptor 1 signaling pathway 0
              Toll-like receptor 10 signaling pathway 0
              Toll-like receptor 2 signaling pathway 0
              Toll-like receptor 3 signaling pathway 0
              Toll-like receptor 4 signaling pathway 0
              Toll-like receptor 5 signaling pathway 0
              Toll-like receptor 6 signaling pathway 0
              Toll-like receptor 7 signaling pathway 0
              Toll-like receptor 8 signaling pathway 0
              Toll-like receptor 9 signaling pathway 0
              Toll-like receptor TLR1:TLR2 signaling pathway 0
              Toll-like receptor TLR6:TLR2 signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 4047
    regulatory pathway 2501
      immune response pathway 179
        innate immune response pathway 153
          inflammatory response pathway 150
            pattern recognition receptor mediated signaling pathway 34
              Toll-like receptor signaling pathway 33
                Toll-like receptor 1 signaling pathway 0
                Toll-like receptor 10 signaling pathway 0
                Toll-like receptor 2 signaling pathway 0
                Toll-like receptor 3 signaling pathway 0
                Toll-like receptor 4 signaling pathway 0
                Toll-like receptor 5 signaling pathway 0
                Toll-like receptor 6 signaling pathway 0
                Toll-like receptor 7 signaling pathway 0
                Toll-like receptor 8 signaling pathway 0
                Toll-like receptor 9 signaling pathway 0
                Toll-like receptor TLR1:TLR2 signaling pathway 0
                Toll-like receptor TLR6:TLR2 signaling pathway 0
paths to the root