TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2) - Rat Genome Database

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Gene: TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2) Sus scrofa
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Symbol: TAB2
Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 2
RGD ID: 14165879
Description: ENCODES a protein that exhibits K63-linked polyubiquitin modification-dependent protein binding (inferred); kinase activity (inferred); metal ion binding (inferred); INVOLVED IN defense response to bacterium (inferred); heart development (inferred); inflammatory response (inferred); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; interleukin-1 signaling pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH brain disease (ortholog); cardiomyopathy (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl116,533,285 - 16,611,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1116,533,364 - 16,611,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2118,852,316 - 18,930,145 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TAB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl116,533,285 - 16,611,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1116,533,364 - 16,611,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2118,852,316 - 18,930,145 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386149,217,926 - 149,411,607 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6149,218,641 - 149,411,613 (+)EnsemblGRCh38hg38GRCh38
GRCh376149,539,062 - 149,732,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366149,680,756 - 149,774,440 (+)NCBINCBI36Build 36hg18NCBI36
Build 346149,680,755 - 149,774,440NCBI
Celera6150,374,542 - 150,467,843 (+)NCBICelera
Cytogenetic Map6q25.1NCBI
HuRef6147,206,396 - 147,299,504 (+)NCBIHuRef
CHM1_16149,904,215 - 149,997,498 (+)NCBICHM1_1
T2T-CHM13v2.06150,417,736 - 150,611,453 (+)NCBIT2T-CHM13v2.0
Tab2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39107,781,412 - 7,832,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl107,781,417 - 7,831,994 (-)EnsemblGRCm39 Ensembl
GRCm38107,905,648 - 7,956,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl107,905,653 - 7,956,230 (-)EnsemblGRCm38mm10GRCm38
MGSCv37107,625,446 - 7,675,921 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36107,596,328 - 7,615,052 (-)NCBIMGSCv36mm8
Celera107,785,153 - 7,804,378 (-)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.56NCBI
Tab2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814,195,400 - 4,245,485 (-)NCBIGRCr8
mRatBN7.212,375,026 - 2,425,115 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12,375,490 - 2,424,756 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx12,024,841 - 2,074,950 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018,025,244 - 8,075,354 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.012,306,955 - 2,357,065 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.011,999,574 - 2,017,574 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl11,999,596 - 2,073,896 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013,695,737 - 3,770,496 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.412,568,536 - 2,617,742 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.112,568,544 - 2,617,742 (-)NCBI
Celera1924,327 - 972,936 (-)NCBICelera
Cytogenetic Map1p13NCBI
Tab2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543911,826,469 - 11,903,103 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543911,826,469 - 11,903,103 (-)NCBIChiLan1.0ChiLan1.0
TAB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25169,345,036 - 169,438,035 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16167,238,691 - 167,331,654 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06147,138,553 - 147,231,559 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16151,868,513 - 151,936,841 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6151,868,513 - 151,936,841 (+)Ensemblpanpan1.1panPan2
TAB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1140,125,842 - 40,216,455 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl140,149,569 - 40,215,385 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha140,963,295 - 41,053,932 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0140,305,492 - 40,396,387 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl140,326,467 - 40,396,378 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1140,182,019 - 40,272,887 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0140,047,126 - 40,137,980 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0140,387,856 - 40,478,641 (+)NCBIUU_Cfam_GSD_1.0
Tab2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946135,120,261 - 135,169,883 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364892,372,216 - 2,424,515 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364892,371,953 - 2,421,882 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11322,234,736 - 22,312,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1322,234,012 - 22,282,562 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040198,258,272 - 198,349,280 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tab2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247858,690,039 - 8,747,160 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TAB2
1246 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 2 17 1 3 3
Low 2 6 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000058535   ⟹   ENSSSCP00000036269
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl116,533,285 - 16,611,884 (-)Ensembl
RefSeq Acc Id: XM_013992499   ⟹   XP_013847953
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1116,533,364 - 16,611,879 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021086945   ⟹   XP_020942604
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1116,533,364 - 16,611,234 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021086951   ⟹   XP_020942610
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1116,533,364 - 16,611,234 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021086959   ⟹   XP_020942618
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1116,535,190 - 16,611,235 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021086965   ⟹   XP_020942624
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1116,533,364 - 16,611,234 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021086968   ⟹   XP_020942627
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1116,533,364 - 16,611,233 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_013847953   ⟸   XM_013992499
- Peptide Label: isoform X1
- UniProtKB: A0A4X1VL37 (UniProtKB/TrEMBL),   F1S7S1 (UniProtKB/TrEMBL),   A0A0B8RZZ8 (UniProtKB/TrEMBL),   A0A8D0LE20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020942610   ⟸   XM_021086951
- Peptide Label: isoform X1
- UniProtKB: A0A4X1VL37 (UniProtKB/TrEMBL),   F1S7S1 (UniProtKB/TrEMBL),   A0A0B8RZZ8 (UniProtKB/TrEMBL),   A0A8D0LE20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020942624   ⟸   XM_021086965
- Peptide Label: isoform X3
- UniProtKB: A0A8D0LE20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020942604   ⟸   XM_021086945
- Peptide Label: isoform X1
- UniProtKB: A0A4X1VL37 (UniProtKB/TrEMBL),   F1S7S1 (UniProtKB/TrEMBL),   A0A0B8RZZ8 (UniProtKB/TrEMBL),   A0A8D0LE20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020942627   ⟸   XM_021086968
- Peptide Label: isoform X4
- UniProtKB: A0A8D0LE20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020942618   ⟸   XM_021086959
- Peptide Label: isoform X2
- UniProtKB: A0A8D0LE20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000036269   ⟸   ENSSSCT00000058535
Protein Domains
CUE   RanBP2-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004110 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005003534 UniProtKB/TrEMBL
  ENSSSCG00015047068 UniProtKB/TrEMBL
  ENSSSCG00025026816 UniProtKB/TrEMBL
  ENSSSCG00030023733 UniProtKB/TrEMBL
  ENSSSCG00035025927 UniProtKB/TrEMBL
  ENSSSCG00040049278 UniProtKB/TrEMBL
  ENSSSCG00045025110 UniProtKB/TrEMBL
  ENSSSCG00055015361 UniProtKB/TrEMBL
  ENSSSCG00060005054 UniProtKB/TrEMBL
  ENSSSCG00065049318 UniProtKB/TrEMBL
  ENSSSCG00070026109 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000058535 ENTREZGENE
  ENSSSCT00000058535.3 UniProtKB/TrEMBL
  ENSSSCT00005005274.1 UniProtKB/TrEMBL
  ENSSSCT00005005294.1 UniProtKB/TrEMBL
  ENSSSCT00015062825.1 UniProtKB/TrEMBL
  ENSSSCT00015062976.1 UniProtKB/TrEMBL
  ENSSSCT00025036327.1 UniProtKB/TrEMBL
  ENSSSCT00030032989.1 UniProtKB/TrEMBL
  ENSSSCT00035034177.1 UniProtKB/TrEMBL
  ENSSSCT00040066485.1 UniProtKB/TrEMBL
  ENSSSCT00045042810.1 UniProtKB/TrEMBL
  ENSSSCT00055030234.1 UniProtKB/TrEMBL
  ENSSSCT00060006318.1 UniProtKB/TrEMBL
  ENSSSCT00065067525.1 UniProtKB/TrEMBL
  ENSSSCT00070052265.1 UniProtKB/TrEMBL
  ENSSSCT00070052266.1 UniProtKB/TrEMBL
  ENSSSCT00070052267.1 UniProtKB/TrEMBL
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
  Zn-finger domain of Sec23/24 UniProtKB/TrEMBL
InterPro CUE UniProtKB/TrEMBL
  TAB2/3_CUE UniProtKB/TrEMBL
  Znf_RanBP2 UniProtKB/TrEMBL
  Znf_RanBP2_sf UniProtKB/TrEMBL
NCBI Gene TAB2 ENTREZGENE
PANTHER TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 2 UniProtKB/TrEMBL
  TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN TAB UniProtKB/TrEMBL
Pfam CUE UniProtKB/TrEMBL
PROSITE CUE UniProtKB/TrEMBL
  ZF_RANBP2_1 UniProtKB/TrEMBL
  ZF_RANBP2_2 UniProtKB/TrEMBL
SMART CUE UniProtKB/TrEMBL
  ZnF_RBZ UniProtKB/TrEMBL
Superfamily-SCOP SSF90209 UniProtKB/TrEMBL
UniProt A0A0B8RZZ8 ENTREZGENE
  A0A4X1VL37 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0LE20 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1C373_PIG UniProtKB/TrEMBL
  F1S7S1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:103186 ENTREZGENE