IRAK3 (interleukin 1 receptor associated kinase 3) - Rat Genome Database

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Gene: IRAK3 (interleukin 1 receptor associated kinase 3) Sus scrofa
Analyze
Symbol: IRAK3
Name: interleukin 1 receptor associated kinase 3
RGD ID: 14200541
Description: ENCODES a protein that exhibits ATP binding (inferred); magnesium ion binding (inferred); protein heterodimerization activity (inferred); INVOLVED IN response to Gram-negative bacterium; response to Gram-positive bacterium; toll-like receptor signaling pathway; PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; ASSOCIATED WITH Escherichia Coli Infections; Porcine Postweaning Multisystemic Wasting Syndrome; Porcine Reproductive and Respiratory Syndrome; FOUND IN cytoplasm (inferred); nucleus (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interleukin-1 receptor-associated kinase 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl530,526,793 - 30,609,921 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1530,524,704 - 30,601,067 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2533,798,256 - 33,873,173 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
nucleus  (IBA,IEA)
plasma membrane  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of Toll-like receptor signaling-related genes in pigs co-infected with porcine reproductive and respiratory syndrome virus and porcine circovirus type 2. Dong VH, etal., Res Vet Sci. 2015 Aug;101:180-6. doi: 10.1016/j.rvsc.2015.05.006. Epub 2015 May 21.
2. Lactobacillus acidophilus alleviates the inflammatory response to enterotoxigenic Escherichia coli K88 via inhibition of the NF-κB and p38 mitogen-activated protein kinase signaling pathways in piglets. Li H, etal., BMC Microbiol. 2016 Nov 10;16(1):273. doi: 10.1186/s12866-016-0862-9.
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IRAK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl530,526,793 - 30,609,921 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1530,524,704 - 30,601,067 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2533,798,256 - 33,873,173 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IRAK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381266,189,214 - 66,254,622 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1266,189,195 - 66,254,622 (+)EnsemblGRCh38hg38GRCh38
GRCh371266,582,994 - 66,648,402 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361264,869,284 - 64,928,652 (+)NCBINCBI36Build 36hg18NCBI36
Build 341264,869,283 - 64,928,652NCBI
Celera1266,247,192 - 66,312,632 (+)NCBICelera
Cytogenetic Map12q14.3NCBI
HuRef1263,633,632 - 63,699,237 (+)NCBIHuRef
CHM1_11266,549,846 - 66,615,516 (+)NCBICHM1_1
T2T-CHM13v2.01266,168,706 - 66,234,159 (+)NCBIT2T-CHM13v2.0
Irak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910119,977,553 - 120,038,035 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10119,977,553 - 120,038,035 (-)EnsemblGRCm39 Ensembl
GRCm3810120,141,648 - 120,202,130 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,141,648 - 120,202,130 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710119,578,710 - 119,638,593 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610119,544,714 - 119,604,597 (-)NCBIMGSCv36mm8
Celera10122,502,683 - 122,562,840 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1067.94NCBI
Irak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8757,538,522 - 57,600,166 (-)NCBIGRCr8
mRatBN7.2755,653,949 - 55,714,371 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl755,653,962 - 55,713,121 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx757,560,397 - 57,619,471 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0759,763,565 - 59,822,652 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0759,540,938 - 59,599,993 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0764,922,830 - 64,982,224 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl764,923,615 - 64,982,281 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0765,142,540 - 65,201,013 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4759,408,198 - 59,467,821 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1759,429,927 - 59,488,412 (-)NCBI
Celera752,409,359 - 52,468,444 (-)NCBICelera
Cytogenetic Map7q22NCBI
Irak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545812,846,237 - 12,879,316 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545812,839,995 - 12,880,285 (+)NCBIChiLan1.0ChiLan1.0
IRAK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21028,101,928 - 28,166,967 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11228,098,693 - 28,163,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01222,661,613 - 22,721,203 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11223,168,346 - 23,282,903 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1223,168,346 - 23,227,148 (-)Ensemblpanpan1.1panPan2
IRAK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1108,683,541 - 8,730,757 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl108,684,242 - 8,729,268 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha108,615,238 - 8,661,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0108,796,309 - 8,841,957 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl108,796,309 - 8,842,463 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1108,672,755 - 8,718,373 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0108,918,266 - 8,964,392 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0109,039,804 - 9,085,368 (+)NCBIUU_Cfam_GSD_1.0
Irak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494549,820,793 - 49,925,781 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365454,233,358 - 4,282,806 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365454,233,353 - 4,284,324 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRAK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11161,868,817 - 61,920,896 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1161,869,173 - 61,920,406 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037183,796,994 - 183,855,987 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irak3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248022,047,409 - 2,098,545 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248022,042,486 - 2,098,921 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IRAK3
2120 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 4 2 5 1 2
Low 6 2 3 2 22 2 2 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000000513   ⟹   ENSSSCP00000000505
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl530,526,954 - 30,609,921 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000035165   ⟹   ENSSSCP00000029997
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl530,525,948 - 30,599,116 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000077997   ⟹   ENSSSCP00000060667
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl530,526,793 - 30,609,921 (+)Ensembl
RefSeq Acc Id: XM_021091960   ⟹   XP_020947619
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1530,524,704 - 30,601,067 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020947619 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000000505.4
  ENSSSCP00000060667
  ENSSSCP00000060667.2
  ENSSSCP00025012227.1
  ENSSSCP00070048724.1
Reference Protein Sequences
RefSeq Acc Id: XP_020947619   ⟸   XM_021091960
- UniProtKB: A0A8D0R7L6 (UniProtKB/TrEMBL),   A0A4X1W2N3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000000505   ⟸   ENSSSCT00000000513
RefSeq Acc Id: ENSSSCP00000029997   ⟸   ENSSSCT00000035165
RefSeq Acc Id: ENSSSCP00000060667   ⟸   ENSSSCT00000077997
Protein Domains
Death   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000475 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025021202 UniProtKB/TrEMBL
  ENSSSCG00070028568 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000000513.5 UniProtKB/TrEMBL
  ENSSSCT00000077997 ENTREZGENE
  ENSSSCT00000077997.2 UniProtKB/TrEMBL
  ENSSSCT00025028831.1 UniProtKB/TrEMBL
  ENSSSCT00070057316.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  IRAK3_death UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
NCBI Gene IRAK3 ENTREZGENE
PANTHER INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1 UniProtKB/TrEMBL
  INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE UniProtKB/TrEMBL
  OS01G0253100 PROTEIN UniProtKB/TrEMBL
  PTHR24419:SF7 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART DEATH UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A4X1W2N3 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QF58_PIG UniProtKB/TrEMBL
  A0A8D0R7L6 ENTREZGENE, UniProtKB/TrEMBL
  F1SH73_PIG UniProtKB/TrEMBL
VGNC ID VGNC:89201 ENTREZGENE