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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:toll-like receptor 4 signaling pathway
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Accession:GO:0034142 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to toll-like receptor 4.
Synonyms:exact_synonym: TLR4 signaling pathway;   toll-like receptor 4 signalling pathway


show annotations for term's descendants           Sort by:
toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd14 CD14 molecule involved_in ISO
IBA		 (PMID:27986454)
GO_REF:0000033		 RGD
GO_Central		 PMID:27986454 GO_REF:0000033 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex involved_in ISO (PMID:26189595) RGD PMID:26189595 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Ecsit ECSIT signaling integrator involved_in ISO (PMID:25371197) RGD PMID:25371197 NCBI chr 8:20,605,583...20,618,453
Ensembl chr 8:20,605,583...20,618,390 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:14660645) RGD PMID:14660645 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:10549626)		 GO_Central
RGD		 PMID:10549626 GO_REF:0000033 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 involved_in ISO (PMID:17878161) RGD PMID:17878161 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602 		JBrowse link
G Irf3 interferon regulatory factor 3 involved_in ISO (PMID:25636800) RGD PMID:25636800 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Lgals9 galectin 9 NOT|involved_in ISO (PMID:16116184) RGD PMID:16116184 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Ly96 lymphocyte antigen 96 involved_in ISO (MGI:5645195|PMID:24380872) RGD PMID:24380872 MGI:5645195 NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (MGI:5913054|PMID:28098138) RGD PMID:28098138 MGI:5913054 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 involved_in ISO (PMID:25371197) RGD PMID:25371197 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor involved_in ISO
IBA
IEA		 (PMID:16751103)
GO_REF:0000033
GO_REF:0000118		 RGD
GO_Central
TreeGrafter		 PMID:16751103 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase acts_upstream_of_or_within ISO MGI:1934018 (PMID:29624734) RGD PMID:29624734 NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972 		JBrowse link
G Nfkbia NFKB inhibitor alpha involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA		 (PMID:7479976)
GO_REF:0000033
(PMID:18261938)
GO_REF:0000118		 RGD
GO_Central
TreeGrafter		 PMID:7479976 PMID:18261938 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nmi N-myc (and STAT) interactor involved_in ISO (MGI:6099204|PMID:29038465) RGD PMID:29038465 MGI:6099204 NCBI chr 3:36,415,607...36,439,716
Ensembl chr 3:36,415,607...36,439,498 		JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A involved_in ISO (PMID:30078389) RGD PMID:30078389 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517 		JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (MGI:5305503|PMID:22187460), (MGI:5305504|PMID:22187458) RGD PMID:22187458 PMID:22187460 MGI:5305503 MGI:5305504 NCBI chr 1:240,090,854...240,245,007
Ensembl chr 1:240,093,065...240,204,828 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit involved_in ISO (PMID:25355951) RGD PMID:25355951 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2660793 (PMID:11894098) RGD PMID:11894098 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G S100a14 S100 calcium binding protein A14 involved_in ISO (PMID:17625598) RGD PMID:17625598 NCBI chr 2:176,008,395...176,010,423
Ensembl chr 2:176,008,395...176,010,423 		JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein involved_in ISO (MGI:5913054|PMID:28098138) RGD PMID:28098138 MGI:5913054 NCBI chr10:55,507,646...55,527,764
Ensembl chr10:55,507,519...55,528,171 		JBrowse link
G Tbk1 TANK-binding kinase 1 involved_in ISO (PMID:28747347) RGD PMID:28747347 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 involved_in ISO (PMID:12471095) RGD PMID:12471095 NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147 		JBrowse link
G Ticam2 TIR domain containing adaptor molecule 2 involved_in ISO (PMID:28630139) RGD PMID:28630139 NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462 		JBrowse link
G Tirap TIR domain containing adaptor protein involved_in ISO
IBA		 (PMID:16751103)
(PMID:11526399)
GO_REF:0000033		 RGD
GO_Central		 PMID:11526399 PMID:16751103 GO_REF:0000033 NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
(PMID:25549946)
GO_REF:0000033
(PMID:10196138), (PMID:15618008), (PMID:18222170)
(MGI:5913054|PMID:28098138)		 Ensembl
RGD
GO_Central		 PMID:10196138 PMID:15618008 PMID:18222170 PMID:25549946 PMID:28098138 GO_REF:0000033 GO_REF:0000107 MGI:5913054 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tmem126a transmembrane protein 126A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:25549946)		 Ensembl
RGD		 PMID:25549946 GO_REF:0000107 NCBI chr 1:144,424,481...144,430,730
Ensembl chr 1:144,422,703...144,430,628 		JBrowse link
G Tnip3 TNFAIP3 interacting protein 3 involved_in ISO (PMID:17088249) RGD PMID:17088249 NCBI chr 4:94,867,258...94,908,780
Ensembl chr 4:94,811,097...94,907,605 		JBrowse link
G Traf3 Tnf receptor-associated factor 3 involved_in ISO (PMID:18222170) RGD PMID:18222170 NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481 		JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in IEA
ISO		 GO_REF:0000107
(PMID:25371197)		 Ensembl
RGD		 PMID:25371197 GO_REF:0000107 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Tril TLR4 interactor with leucine-rich repeats involved_in ISO
IBA		 (PMID:19710467)
GO_REF:0000033		 RGD
GO_Central		 PMID:19710467 GO_REF:0000033 NCBI chr 4:82,922,327...82,927,172
Ensembl chr 4:82,922,328...82,927,172 		JBrowse link
MyD88-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrfip2 LRR binding FLII interacting protein 2 acts_upstream_of_or_within ISO (PMID:19265123) RGD PMID:19265123 NCBI chr 8:111,091,453...111,193,947
Ensembl chr 8:111,091,503...111,193,255 		JBrowse link
negative regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 involved_in ISO (MGI:5490396|PMID:23609450) RGD PMID:23609450 MGI:5490396 NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529 		JBrowse link
G Bpifb1 BPI fold containing family B, member 1 involved_in ISO
IBA
IEA		 (PMID:21900486)
GO_REF:0000033
GO_REF:0000118
GO_REF:0000107		 RGD
GO_Central
TreeGrafter
Ensembl		 PMID:21900486 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:142,672,995...142,706,258
Ensembl chr 3:142,672,995...142,706,256 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:19948740)		 UniProt
Ensembl
RGD		 PMID:19948740 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISS
ISO		 GO_REF:0000024
(MGI:4456928|PMID:20385881)		 UniProt
RGD		 PMID:20385881 GO_REF:0000024 MGI:4456928 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Mfhas1 multifunctional ROCO family signaling regulator 1 involved_in ISO (PMID:28609714) RGD PMID:28609714 NCBI chr16:56,545,462...56,633,649
Ensembl chr16:56,546,207...56,633,743 		JBrowse link
G Mir140 microRNA 140 involved_in ISO UniProtKB:O00206 (PMID:30233718), (PMID:30321456) RGD PMID:30233718 PMID:30321456 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675 		JBrowse link
G Mir200b microRNA 200b involved_in ISO (PMID:22522429) RGD PMID:22522429 NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366 		JBrowse link
G Mir200c microRNA 200c involved_in ISO (PMID:22522429) RGD PMID:22522429 NCBI chr 4:157,523,679...157,523,747 JBrowse link
G Mir20a microRNA 20a involved_in ISO (PMID:29653364) RGD PMID:29653364 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir708 microRNA 708 involved_in ISO (PMID:31599428) RGD PMID:31599428 NCBI chr 1:150,599,876...150,599,963
Ensembl chr 1:150,599,876...150,599,963 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in ISO
IEA		 (PMID:18511497)
GO_REF:0000107		 RGD
Ensembl		 PMID:18511497 GO_REF:0000107 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Rab7b Rab7b, member RAS oncogene family involved_in ISO (MGI:3834524|PMID:17395780) RGD PMID:17395780 MGI:3834524 NCBI chr13:43,121,168...43,147,581
Ensembl chr13:43,121,226...43,147,581 		JBrowse link
G Sqstm1 sequestosome 1 involved_in ISO (PMID:31281713) RGD PMID:31281713 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tax1bp1 Tax1 binding protein 1 involved_in ISO (PMID:28898289) RGD PMID:28898289 NCBI chr 4:81,821,991...81,877,906
Ensembl chr 4:81,821,989...81,879,100 		JBrowse link
G Ticam2 TIR domain containing adaptor molecule 2 involved_in ISO (PMID:19412184) RGD PMID:19412184 NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6152919|PMID:29407460), (MGI:6695864|PMID:31134514) RGD PMID:29407460 PMID:31134514 MGI:6152919 MGI:6695864 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Trim32 tripartite motif-containing 32 involved_in ISO (PMID:28898289) RGD PMID:28898289 NCBI chr 5:79,005,139...79,016,615
Ensembl chr 5:78,999,389...79,022,018 		JBrowse link
positive regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd14 CD14 molecule involved_in ISS
ISO		 GO_REF:0000024
(MGI:5645195|PMID:24380872)		 UniProt
RGD		 PMID:24380872 GO_REF:0000024 MGI:5645195 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:18622013) RGD PMID:18622013 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (MGI:5788395|PMID:16267105) RGD PMID:16267105 MGI:5788395 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Ifi35 interferon-induced protein 35 involved_in ISO (PMID:29038465) RGD PMID:29038465 NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952 		JBrowse link
G Lbp lipopolysaccharide binding protein involved_in ISO
IEA		 (PMID:11528597)
GO_REF:0000107		 RGD
Ensembl		 PMID:11528597 GO_REF:0000107 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586 		JBrowse link
G Ltf lactotransferrin involved_in ISO (PMID:20345905) RGD PMID:20345905 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795 		JBrowse link
G Ninj1 ninjurin 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6694429|PMID:25860173)		 UniProt
RGD		 PMID:25860173 GO_REF:0000024 MGI:6694429 NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 involved_in ISO (PMID:18511497) RGD PMID:18511497 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO MGI:4361448 (PMID:19734906) RGD PMID:19734906 NCBI chr14:95,254,274...95,309,168
Ensembl chr14:95,254,589...95,308,285 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO (PMID:23871208)
(MGI:5562517|PMID:23871208)		 RGD PMID:23871208 MGI:5562517 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Ticam2 TIR domain containing adaptor molecule 2 involved_in ISO (PMID:19412184)
(PMID:22685567)		 RGD PMID:19412184 PMID:22685567 NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462 		JBrowse link
G Tirap TIR domain containing adaptor protein involved_in ISO (PMID:19509286) RGD PMID:19509286 NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432 		JBrowse link
G Wdfy1 WD repeat and FYVE domain containing 1 involved_in ISO
IBA		 (PMID:25736436)
GO_REF:0000033
(MGI:5688815|PMID:25736436)		 RGD
GO_Central		 PMID:25736436 GO_REF:0000033 MGI:5688815 NCBI chr 9:81,034,852...81,092,823
Ensembl chr 9:81,034,849...81,092,775 		JBrowse link
G Znrf1 zinc and ring finger 1 involved_in ISO (PMID:28593998) RGD PMID:28593998 NCBI chr19:39,496,414...39,581,600
Ensembl chr19:39,496,527...39,580,969 		JBrowse link
regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (MGI:6270783|PMID:27219021) RGD PMID:27219021 MGI:6270783 NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692 		JBrowse link
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISO (MGI:6270783|PMID:27219021) RGD PMID:27219021 MGI:6270783 NCBI chr 7:20,135,248...20,184,757
Ensembl chr 7:20,135,375...20,184,754 		JBrowse link
G Flot1 flotillin 1 NOT|involved_in ISO (PMID:25204797) RGD PMID:25204797 NCBI chr20:2,917,864...2,927,993
Ensembl chr20:2,917,137...2,927,978 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO
IEA		 (PMID:19289601)
GO_REF:0000107		 RGD
Ensembl		 PMID:19289601 GO_REF:0000107 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
TIRAP-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tirap TIR domain containing adaptor protein involved_in ISO (PMID:11544529) RGD PMID:11544529 NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432 		JBrowse link
TRAM-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkce protein kinase C, epsilon involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:3652658|PMID:16757566)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16757566 GO_REF:0000024 GO_REF:0000107 MGI:3652658 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Rab11fip2 RAB11 family interacting protein 2 involved_in ISO (PMID:30883606) RGD PMID:30883606 NCBI chr 1:258,950,535...259,094,555
Ensembl chr 1:258,923,873...259,093,752 		JBrowse link
G Ticam2 TIR domain containing adaptor molecule 2 involved_in ISO (PMID:22685567)
(PMID:19412184)		 RGD PMID:19412184 PMID:22685567 NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    immune system process 3017
      activation of immune response 572
        immune response-activating signaling pathway 485
          immune response-activating cell surface receptor signaling pathway 304
            innate immune response activating cell surface receptor signaling pathway 90
              cell surface pattern recognition receptor signaling pathway 77
                cell surface toll-like receptor signaling pathway 72
                  toll-like receptor 4 signaling pathway 63
                    MyD88-dependent toll-like receptor 4 signaling pathway 1
                    TIRAP-dependent toll-like receptor 4 signaling pathway 1
                    TRAM-dependent toll-like receptor 4 signaling pathway 3
                    TRIF-dependent toll-like receptor 4 signaling pathway 0
                    negative regulation of toll-like receptor 4 signaling pathway 17
                    positive regulation of toll-like receptor 4 signaling pathway 14
                    regulation of toll-like receptor 4 signaling pathway + 34
Path 2
Term Annotations click to browse term
  biological_process 20413
    response to stimulus 10919
      response to external stimulus 2746
        response to external biotic stimulus 1854
          response to other organism 1850
            defense response to other organism 1305
              defense response to symbiont 1169
                innate immune response 996
                  regulation of innate immune response 458
                    positive regulation of innate immune response 375
                      activation of innate immune response 304
                        innate immune response-activating signaling pathway 278
                          innate immune response activating cell surface receptor signaling pathway 90
                            cell surface pattern recognition receptor signaling pathway 77
                              cell surface toll-like receptor signaling pathway 72
                                toll-like receptor 4 signaling pathway 63
                                  MyD88-dependent toll-like receptor 4 signaling pathway 1
                                  TIRAP-dependent toll-like receptor 4 signaling pathway 1
                                  TRAM-dependent toll-like receptor 4 signaling pathway 3
                                  TRIF-dependent toll-like receptor 4 signaling pathway 0
                                  negative regulation of toll-like receptor 4 signaling pathway 17
                                  positive regulation of toll-like receptor 4 signaling pathway 14
                                  regulation of toll-like receptor 4 signaling pathway + 34
paths to the root