Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:excitatory extracellular ligand-gated monoatomic ion channel activity
go back to main search page
Accession:GO:0005231 term browser browse the term
Definition:Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential.
Synonyms:xref: reactome:R-HSA-399711 "Activation of Ca impermeable AMPA receptors";   reactome:R-HSA-399712 "Activation of Ca permeable AMPA receptors";   reactome:R-HSA-420980 "Activation of Ca permeable AMPA receptors";   reactome:R-HSA-432164 "Ca2+ influx into the post-synaptic cell";   reactome:R-HSA-438037 "Membrane depolarization upon activation of Ca impermeable AMPA receptors"


show annotations for term's descendants           Sort by:
excitatory extracellular ligand-gated monoatomic ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRNA1 cholinergic receptor nicotinic alpha 1 subunit enables IEA TreeGrafter GO_REF:0000118 NCBI chr2B:62,022,498...62,039,370
Ensembl chr2B:179,476,677...179,504,763 		JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit enables IEA TreeGrafter GO_REF:0000118 NCBI chr15:57,523,553...57,550,228
Ensembl chr15:76,487,710...76,512,044 		JBrowse link
G CHRNA6 cholinergic receptor nicotinic alpha 6 subunit enables IEA TreeGrafter GO_REF:0000118 NCBI chr 8:42,000,748...42,016,913
Ensembl chr 8:39,444,447...39,460,569 		JBrowse link
G GLRA1 glycine receptor alpha 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 5:147,245,741...147,348,555
Ensembl chr 5:153,248,488...153,350,567 		JBrowse link
G GLRA2 glycine receptor alpha 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr  X:7,145,794...7,349,911
Ensembl chr  X:14,430,441...14,634,973 		JBrowse link
G GLRA3 glycine receptor alpha 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 4:166,865,061...167,045,844
Ensembl chr 4:179,083,211...179,279,232 		JBrowse link
G GLRA4 glycine receptor alpha 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chr  X:92,933,694...92,957,714
Ensembl chr  X:103,317,486...103,338,910 		JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 enables ISO PMID:17582331 UniProt PMID:17582331 RGD:8553505 NCBI chr17:3,612,781...3,658,608
Ensembl chr17:3,609,952...3,637,579 		JBrowse link
acetylcholine-gated monoatomic cation-selective channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRNA1 cholinergic receptor nicotinic alpha 1 subunit contributes_to
enables		 ISO
IEA		 (PMID:2383398) RGD
MGI
Ensembl
InterPro		 PMID:1702709 PMID:2383398 PMID:22461452 GO_REF:0000002 GO_REF:0000107 RGD:68734 RGD:8549758 NCBI chr2B:62,022,498...62,039,370
Ensembl chr2B:179,476,677...179,504,763 		JBrowse link
G CHRNA10 cholinergic receptor nicotinic alpha 10 subunit enables IEA Ensembl
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr11:3,543,450...3,552,036
Ensembl chr11:3,651,580...3,656,780 		JBrowse link
G CHRNA2 cholinergic receptor nicotinic alpha 2 subunit enables ISO
IEA		 RGD
TreeGrafter
Ensembl
InterPro		 PMID:2832952 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:728252 NCBI chr 8:26,729,767...26,749,277
Ensembl chr 8:23,932,846...23,952,377 		JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit enables ISO
IEA		 RGD
Ensembl
InterPro		 PMID:11297818 GO_REF:0000002 GO_REF:0000107 RGD:1643016 NCBI chr15:57,523,553...57,550,228
Ensembl chr15:76,487,710...76,512,044 		JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit enables ISO
IEA		 RGD
TreeGrafter
Ensembl
InterPro		 PMID:11259617 PMID:12202488 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:727641 RGD:8549520 NCBI chr20:59,730,759...59,748,678
Ensembl chr20:61,270,631...61,283,005 		JBrowse link
G CHRNA5 cholinergic receptor nicotinic alpha 5 subunit enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:11297818 PMID:12814364 GO_REF:0000002 GO_REF:0000118 RGD:1298760 RGD:1643016 NCBI chr15:57,493,730...57,530,463
Ensembl chr15:76,455,165...76,486,376 		JBrowse link
G CHRNA6 cholinergic receptor nicotinic alpha 6 subunit enables IEA InterPro GO_REF:0000002 NCBI chr 8:42,000,748...42,016,913
Ensembl chr 8:39,444,447...39,460,569 		JBrowse link
G CHRNA9 cholinergic receptor nicotinic alpha 9 subunit enables ISO
IEA		 RGD
TreeGrafter
InterPro
Ensembl		 PMID:7954834 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:728400 NCBI chr 4:34,654,043...34,675,984
Ensembl chr 4:40,509,475...40,528,869 		JBrowse link
G CHRNB1 cholinergic receptor nicotinic beta 1 subunit contributes_to
enables		 ISO
IEA		 (PMID:2383398) RGD
MGI
TreeGrafter
Ensembl
InterPro		 PMID:1702709 PMID:2383398 PMID:22461452 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:68734 RGD:8549758 NCBI chr17:7,479,056...7,490,314
Ensembl chr17:7,465,229...7,476,099 		JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit enables ISO
IEA		 RGD
TreeGrafter
InterPro
Ensembl		 PMID:11259617 PMID:11956333 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:727635 RGD:8549520 NCBI chr 1:129,922,740...129,931,582
Ensembl chr 1:133,535,023...133,547,361 		JBrowse link
G CHRNB3 cholinergic receptor nicotinic beta 3 subunit enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 8:41,947,062...41,987,159
Ensembl chr 8:39,391,001...39,429,926 		JBrowse link
G CHRNB4 cholinergic receptor nicotinic beta 4 subunit enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr15:57,552,697...57,570,828
Ensembl chr15:76,515,455...76,532,712 		JBrowse link
G CHRND cholinergic receptor nicotinic delta subunit contributes_to
enables		 ISO
IEA		 (PMID:2383398) RGD
MGI
TreeGrafter
InterPro
Ensembl		 PMID:1702709 PMID:2383398 PMID:22461452 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:68734 RGD:8549758 NCBI chr2B:119,757,722...119,768,254
Ensembl chr2B:238,676,495...238,686,987 		JBrowse link
G CHRNE cholinergic receptor nicotinic epsilon subunit contributes_to
enables		 ISO
IEA		 (PMID:2383398) RGD
MGI
TreeGrafter
InterPro		 PMID:2383398 PMID:22461452 GO_REF:0000002 GO_REF:0000118 RGD:8549758 NCBI chr17:4,944,046...4,950,288
Ensembl chr17:4,932,862...4,937,963 		JBrowse link
G CHRNG cholinergic receptor nicotinic gamma subunit enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:1702709 PMID:22461452 GO_REF:0000002 GO_REF:0000118 RGD:68734 RGD:8549758 NCBI chr2B:119,770,636...119,779,332
Ensembl chr2B:238,689,935...238,696,526 		JBrowse link
G HTR3A 5-hydroxytryptamine receptor 3A enables IEA TreeGrafter GO_REF:0000118 NCBI chr11:108,851,954...108,869,119
Ensembl chr11:112,695,891...112,711,695 		JBrowse link
G HTR3B 5-hydroxytryptamine receptor 3B enables IEA TreeGrafter GO_REF:0000118 NCBI chr11:108,783,514...108,825,266
Ensembl chr11:112,624,864...112,671,439 		JBrowse link
G HTR3D 5-hydroxytryptamine receptor 3D pseudogene enables IEA TreeGrafter GO_REF:0000118 NCBI chr 3:181,067,881...181,075,251
Ensembl chr 3:189,234,339...189,240,829 		JBrowse link
G LOC100971854 5-hydroxytryptamine receptor 3E enables IEA TreeGrafter GO_REF:0000118 NCBI chr 3:181,133,013...181,142,639
Ensembl chr 3:189,299,453...189,625,179 		JBrowse link
G LOC100977072 neuronal acetylcholine receptor subunit alpha-7 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:11259617 PMID:11297818 PMID:12069582 PMID:16186249 GO_REF:0000002 GO_REF:0000118 RGD:1600971 RGD:1643016 RGD:727702 RGD:8549520 NCBI chr15:10,525,535...10,667,227
Ensembl chr15:29,565,885...29,705,194 		JBrowse link
G LOC100982404 5-hydroxytryptamine receptor 3C enables IEA TreeGrafter GO_REF:0000118 NCBI chr 3:181,088,791...181,096,798
Ensembl chr 3:189,254,863...189,262,486 		JBrowse link
G ZACN zinc activated ion channel enables IEA TreeGrafter GO_REF:0000118 NCBI chr17:70,028,902...70,033,013
Ensembl chr17:75,582,443...75,586,058 		JBrowse link
extracellularly ATP-gated monoatomic cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RX1 purinergic receptor P2X 1 enables ISO
IEA		 RGD
TreeGrafter
UniProt
InterPro		 PMID:16934235 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 RGD:1642659 NCBI chr17:3,944,636...3,965,260
Ensembl chr17:3,935,982...3,956,595 		JBrowse link
G P2RX2 purinergic receptor P2X 2 enables ISO
IEA		 RGD
TreeGrafter
Ensembl
UniProt
InterPro		 PMID:15317863 PMID:16190872 PMID:16857707 PMID:16934235 PMID:17517890 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1642653 RGD:1642659 RGD:1642661 RGD:1642665 RGD:1642666 NCBI chr12:129,969,793...129,974,399 JBrowse link
G P2RX3 purinergic receptor P2X 3 enables ISO
IEA		 RGD
TreeGrafter
UniProt
Ensembl
InterPro		 PMID:12581826 PMID:16934235 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1642659 RGD:1642675 NCBI chr11:52,579,190...52,614,329
Ensembl chr 3:160,070,875...160,106,120 		JBrowse link
G P2RX4 purinergic receptor P2X 4 enables ISO
IEA		 PMID:12819199 RGD
TreeGrafter
UniProt
InterPro
Ensembl		 PMID:12819199 PMID:16934235 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1642659 RGD:1642695 NCBI chr12:118,807,961...118,832,267
Ensembl chr12:122,178,672...122,202,959 		JBrowse link
G P2RX5 purinergic receptor P2X 5 enables ISO
IEA		 RGD
TreeGrafter
InterPro
Ensembl
UniProt		 PMID:12135987 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:729229 NCBI chr17:3,722,117...3,745,833
Ensembl chr17:3,719,457...3,739,709 		JBrowse link
G P2RX6 purinergic receptor P2X 6 enables ISO
IEA		 RGD
TreeGrafter
UniProt
InterPro		 PMID:8786426 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 RGD:729425 NCBI chr22:3,239,019...3,251,966
Ensembl chr22:19,728,644...19,741,078 		JBrowse link
G P2RX7 purinergic receptor P2X 7 enables ISO
IEA		 RGD
TreeGrafter
InterPro
Ensembl		 PMID:17394459 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1642698 NCBI chr12:118,731,761...118,786,039
Ensembl chr12:122,102,888...122,154,068 		JBrowse link
extracellularly glutamate-gated chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC17A7 solute carrier family 17 member 7 enables ISO (PMID:19169251) MGI PMID:19169251 NCBI chr19:46,443,076...46,455,195
Ensembl chr19:55,365,811...55,377,438 		JBrowse link
G SLC1A7 solute carrier family 1 member 7 enables ISO (MGI:7294459|PMID:32233906), (MGI:7310191|PMID:16973698) UniProt PMID:16973698 PMID:32233906 MGI:7294459 MGI:7310191 NCBI chr 1:52,359,809...52,415,466
Ensembl chr 1:53,960,400...54,015,396 		JBrowse link
extracellularly glutamate-gated ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GRIA2 glutamate ionotropic receptor AMPA type subunit 2 enables ISO (PMID:14687553) MGI PMID:14687553 NCBI chr 4:149,566,563...149,712,135
Ensembl chr 4:161,380,933...161,524,376 		JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 ISO RGD PMID:1977421 RGD:61622 NCBI chr21:15,976,931...16,357,578
Ensembl chr21:29,364,269...29,743,379 		JBrowse link
G GRIK2 glutamate ionotropic receptor kainate type subunit 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 6:98,720,430...99,903,582
Ensembl chr 6:103,334,707...103,783,092 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A contributes_to ISO PMID:9425000 UniProt PMID:9425000 RGD:8554578 NCBI chr16:8,682,169...9,105,581
Ensembl chr16:9,919,143...10,336,167 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B ISO RGD PMID:1350383 RGD:727540 NCBI chr12:13,543,104...13,987,437
Ensembl chr12:13,969,387...14,388,799 		JBrowse link
extracellularly glycine-gated chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLRA1 glycine receptor alpha 1 enables ISO
IEA		 RGD
Ensembl
InterPro		 PMID:12223345 GO_REF:0000002 GO_REF:0000107 RGD:625689 NCBI chr 5:147,245,741...147,348,555
Ensembl chr 5:153,248,488...153,350,567 		JBrowse link
G GLRA2 glycine receptor alpha 2 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr  X:7,145,794...7,349,911
Ensembl chr  X:14,430,441...14,634,973 		JBrowse link
G GLRA3 glycine receptor alpha 3 enables ISO
IEA		 RGD
Ensembl
InterPro		 PMID:2176214 GO_REF:0000002 GO_REF:0000107 RGD:728440 NCBI chr 4:166,865,061...167,045,844
Ensembl chr 4:179,083,211...179,279,232 		JBrowse link
G GLRA4 glycine receptor alpha 4 enables IEA Ensembl GO_REF:0000107 NCBI chr  X:92,933,694...92,957,714
Ensembl chr  X:103,317,486...103,338,910 		JBrowse link
G GLRB glycine receptor beta contributes_to
enables		 ISO
IEA		 (PMID:8717357) UniProtKB
TreeGrafter
Ensembl
InterPro		 PMID:8717357 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:149,422,654...149,518,669
Ensembl chr 4:161,236,610...161,333,035 		JBrowse link
extracellularly glycine-gated ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLRA1 glycine receptor alpha 1 ISO RGD PMID:15574743 RGD:1598572 NCBI chr 5:147,245,741...147,348,555
Ensembl chr 5:153,248,488...153,350,567 		JBrowse link
G GLRB glycine receptor beta enables ISO
IEA		 RGD
Ensembl		 PMID:15574743 GO_REF:0000107 RGD:1598572 NCBI chr 4:149,422,654...149,518,669
Ensembl chr 4:161,236,610...161,333,035 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17493
    transporter activity 1158
      transmembrane transporter activity 1070
        monoatomic ion transmembrane transporter activity 716
          monoatomic ion channel activity 438
            ligand-gated monoatomic ion channel activity 185
              extracellular ligand-gated monoatomic ion channel activity 74
                excitatory extracellular ligand-gated monoatomic ion channel activity 42
                  acetylcholine-gated monoatomic cation-selective channel activity 22
                  extracellularly ATP-gated monoatomic cation channel activity 7
                  extracellularly glutamate-gated ion channel activity + 7
                  extracellularly glycine-gated ion channel activity + 5
Path 2
Term Annotations click to browse term
  molecular_function 17493
    transporter activity 1158
      transmembrane transporter activity 1070
        passive transmembrane transporter activity 497
          channel activity 497
            gated channel activity 320
              ligand-gated channel activity 189
                ligand-gated monoatomic ion channel activity 185
                  extracellular ligand-gated monoatomic ion channel activity 74
                    excitatory extracellular ligand-gated monoatomic ion channel activity 42
                      acetylcholine-gated monoatomic cation-selective channel activity 22
                      extracellularly ATP-gated monoatomic cation channel activity 7
                      extracellularly glutamate-gated ion channel activity + 7
                      extracellularly glycine-gated ion channel activity + 5
paths to the root