LOC100982404 (5-hydroxytryptamine receptor 3C)

Gene: LOC100982404 (5-hydroxytryptamine receptor 3C) Pan paniscus

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Symbol:

LOC100982404 (Ensembl: HTR3C)

Name:

5-hydroxytryptamine receptor 3C

RGD ID:

11776153

Description:

ENCODES a protein that exhibits acetylcholine-gated monoatomic cation-selective channel activity (inferred); extracellular ligand-gated monoatomic ion channel activity (inferred); serotonin-gated monoatomic cation channel activity (inferred); INVOLVED IN chemical synaptic transmission (inferred); excitatory postsynaptic potential (inferred); inorganic cation transmembrane transport (inferred); ASSOCIATED WITH 3-Methylcrotonyl-CoA carboxylase 1 deficiency (ortholog); autistic disorder (ortholog); congenital disorder of glycosylation Id (ortholog); FOUND IN serotonin-activated cation-selective channel complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

HTR3C

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	181,921,481 - 181,932,967 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	181,926,197 - 181,937,683 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	181,088,791 - 181,096,798 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	189,254,863 - 189,262,486 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	189,254,863 - 189,262,486 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-Methylcrotonyl-CoA carboxylase 1 deficiency (ISO)

autistic disorder (ISO)

congenital disorder of glycosylation Id (ISO)

Currarino syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chemical synaptic transmission (IEA)

excitatory postsynaptic potential (IEA)

inorganic cation transmembrane transport (IEA)

monoatomic ion transmembrane transport (IEA)

nervous system process (IEA)

regulation of membrane potential (IEA)

regulation of postsynaptic membrane potential (IEA)

serotonin receptor signaling pathway (IEA)

signal transduction (IEA)

Cellular Component

membrane (IEA)

neuron projection (IEA)

postsynapse (IEA)

serotonin-activated cation-selective channel complex (IEA,ISO)

synapse (IEA)

Molecular Function

acetylcholine-gated monoatomic cation-selective channel activity (IEA)

extracellular ligand-gated monoatomic ion channel activity (IEA)

protein binding (ISO)

serotonin-gated monoatomic cation channel activity (IEA)

transmembrane signaling receptor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

LOC100982404
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	181,921,481 - 181,932,967 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	181,926,197 - 181,937,683 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	181,088,791 - 181,096,798 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	189,254,863 - 189,262,486 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	189,254,863 - 189,262,486 (+)	Ensembl	panpan1.1		panPan2

HTR3C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	184,053,047 - 184,060,673 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	184,053,047 - 184,060,673 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	183,770,835 - 183,778,461 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	185,253,529 - 185,261,155 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	185,253,536 - 185,261,161	NCBI
Celera	3	182,213,538 - 182,221,192 (+)	NCBI		Celera
Cytogenetic Map	3	q27.1	NCBI
HuRef	3	181,178,270 - 181,185,892 (+)	NCBI		HuRef
CHM1_1	3	183,735,196 - 183,742,818 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	186,862,612 - 186,870,238 (+)	NCBI		T2T-CHM13v2.0

HTR3C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	16,969,213 - 16,976,401 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	21,056,848 - 21,063,332 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	16,876,848 - 16,883,341 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	16,876,848 - 16,883,341 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	16,914,930 - 16,921,428 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	16,910,695 - 16,917,188 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	17,141,032 - 17,147,528 (+)	NCBI		UU_Cfam_GSD_1.0

LOC102163598
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	121,988,806 - 121,994,463 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	121,987,063 - 121,995,297 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	131,407,131 - 131,439,218 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103221320
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	5,367,858 - 5,375,095 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666063	14,149,084 - 14,155,414 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003831995	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000055135 ⟹ ENSPPAP00000032269

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	3	189,254,863 - 189,262,486 (+)	Ensembl

RefSeq Acc Id:

XM_003831995 ⟹ XP_003832043

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	2	181,921,481 - 181,932,967 (+)	NCBI
NHGRI_mPanPan1	3	181,926,197 - 181,937,683 (+)	NCBI
Mhudiblu_PPA_v0	3	181,088,791 - 181,096,798 (+)	NCBI
PanPan1.1	3	189,254,863 - 189,262,486 (+)	NCBI

Sequence:

show sequence

ATCCCCAGAGAAGAGTCCAGAAAGAAGAATGGAAGGAGGGTGGCCTGCAAGGCAGAGTGCCCTC
CTCTGCCTCACTGTCAGTCTTCTGCTTCAAGGAAGAGGCGACGCTTTTACCATCAATTGCTCAG
GCTTTGACCAGCATGGGGTTGACCCTGCTGTCTTCCAAGCAGTGTTTGACAGAAAGGCCTTCCG
TCCATTCACCAACTACAGCATCCCTACCCGTGTCAACATCTCCTTCACCCTGTCTGCCATCCTG
GGAGTGGATGCACAGCTCCAGCTGCTGACATCATTCCTGTGGATGGATTTGGTATGGGACAATC
CTTTCATTAATTGGAACCCAAAAGAGTGTGTTGGCATCAATAAACTCACGGTATTAGCTGAAAA
CCTGTGGCTCCCAGACATCTTCATCATGGAATCCATGGATGTGGATCAGACGCCTTCCGGTCTC
ACTGCCTATATCAGCAGTGAAGGTCGAATAAAGTATGATAAGCCAATGAGGGTGACCAGCATCT
GTAATCTGGACATCTTCTACTTCCCTTTTGACCAACAGAACTGTACCTTCACCTTCAGTTCTTT
CCTCTACACAGTGGACAGCATGCTGCTGGGCATGGACAAGGAGGTGTGGGAGATCACAGACACG
TCTCGCAAAGTCATCCAAACCCAGGGGGAGTGGGAGCTCTTGGGCATCAACAAGGCCACCCCAA
AGATGTCCGTGGGCAACAACCTATATGACCAGATCATGTTTTATGTGGCCATCAGGCGCAGGCC
AAGCCTCTACATCATAAATCTGCTGGTGCCCAGTAGCTTTCTGGTTGCCATTGACGCCCTCAGC
TTCTACCTGCCAGCAGAGAGCGAGAATCGTGCCCCATTCAAGATAACACTTCTGCTGGGCTACA
ATGTCTTCCTGCTCATGATGAATGACTTGCTCCCTGCCAGTGGCACCCCCCTCATCAGTGTCTA
CTTCGCCCTGTGCCTGTCCCTGATGGTGGTCAGCCTGCTGGAGACCGTCTTCATCACCCACCTG
CTGCACGTGGCCACCACCCAGCCCCCACCCATGCCTAGGTGGCTTCACTCCCTGCTGCTCCACC
GCACCAGCCCAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAGGGCCTGGGTCTCAC
CCTCACCCACCTGCCTGGCCCAAAGGAGCCGGGGGAGTTAGCAGGGAAGAAGCTGGGACCCAGA
GAGACCGAGCCAGATGGGGGCTCAGGATGGACAAAGACCCAGCTAATGGGGCTGTGGGTGCAGT
TCAGCCACGCGATGGACACCCTGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCCATCCT
TACTGTCATTGTCCTCTGGAACACCTAGGCAGACATCCCCCCTCTCTGGCAAACAACAGCTTGG
AGTCTCTGCTGGTCTTGGGCCAGCCGGACTCATTTTCCTAATCTTAGCCACTTATCCCCAGTGA
CTACCATGTCCCCTTCTAAATTCCAAAAACTCCAATGCAGCACTAGCAAGCAGGTTCGGGACAG
CCCTGGACGATTTCCCGACTGCTGCTCAGGCTGCTCATTCCTGCTCACCCTCAGTCTCCCTGAG
CTACCACCTAACTCCTCACTCCCTGATCAATGGAAGTCCAGGTCAGTGGAGTCTCTCCTTGATT
GATCACCCCAATAAACAACTTTCCAGGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003832043	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000032269.1

RefSeq Acc Id:

XP_003832043 ⟸ XM_003831995

- UniProtKB:

A0A2R9C0J2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEGGWPARQSALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNYSIPT
RVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFIM
ESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLL
GMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSVGNNLYDQIMFYVAIRRRPSLYIINLLV
PSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPASGTPLISVYFALCLSLMV
VSLLETVFITHLLHVATTQPPPMPRWLHSLLLHRTSPGRCCPTAPQKGNKGLGLTLTHLPGPKE
PGELAGKKLGPRETEPDGGSGWTKTQLMGLWVQFSHAMDTLLFRLYLLFMASSILTVIVLWNT

hide sequence

RefSeq Acc Id:

ENSPPAP00000032269 ⟸ ENSPPAT00000055135

Protein Domains

Neurotransmitter-gated ion-channel ligand-binding Neurotransmitter-gated ion-channel transmembrane

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000039021	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000055135.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.58.390	UniProtKB/TrEMBL
	2.70.170.10	UniProtKB/TrEMBL
InterPro	Neur_chan_lig-bd	UniProtKB/TrEMBL
	Neur_chan_lig-bd_sf	UniProtKB/TrEMBL
	Neur_channel	UniProtKB/TrEMBL
	Neuro-gated_channel_TM_sf	UniProtKB/TrEMBL
	Neuro_actylchol_rec	UniProtKB/TrEMBL
	Neurotrans-gated_channel_TM	UniProtKB/TrEMBL
	Neurotransmitter_ion_chnl_CS	UniProtKB/TrEMBL
KEGG Report	pps:100982404	UniProtKB/TrEMBL
NCBI Gene	HTR3C	ENTREZGENE
PANTHER	5-HYDROXYTRYPTAMINE RECEPTOR 3C	UniProtKB/TrEMBL
	PTHR18945	UniProtKB/TrEMBL
Pfam	Neur_chan_LBD	UniProtKB/TrEMBL
	Neur_chan_memb	UniProtKB/TrEMBL
PRINTS	NRIONCHANNEL	UniProtKB/TrEMBL
PROSITE	NEUROTR_ION_CHANNEL	UniProtKB/TrEMBL
Superfamily-SCOP	SSF63712	UniProtKB/TrEMBL
	SSF90112	UniProtKB/TrEMBL
UniProt	A0A2R9C0J2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-07-01	LOC100982404	5-hydroxytryptamine receptor 3C	HTR3C	5-hydroxytryptamine receptor 3C	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD