CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit) - Rat Genome Database

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Gene: CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit) Pan paniscus
Analyze
Symbol: CHRNA2
Name: cholinergic receptor nicotinic alpha 2 subunit
RGD ID: 11838730
Description: ENCODES a protein that exhibits acetylcholine-gated monoatomic cation-selective channel activity (ortholog); heterocyclic compound binding (ortholog); quaternary ammonium group binding (ortholog); INVOLVED IN cellular response to nicotine (ortholog); cerebral cortex GABAergic interneuron development (ortholog); hippocampus development (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH autosomal dominant nocturnal frontal lobe epilepsy (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 4 (ortholog); benign familial infantile seizures 6 (ortholog); FOUND IN neuron projection cytoplasm (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neuronal acetylcholine receptor subunit alpha-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2745,990,058 - 46,009,764 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1821,704,317 - 21,723,990 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0826,729,767 - 26,749,277 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1823,932,846 - 23,952,377 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl823,932,846 - 23,952,377 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CHRNA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2745,990,058 - 46,009,764 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1821,704,317 - 21,723,990 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0826,729,767 - 26,749,277 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1823,932,846 - 23,952,377 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl823,932,846 - 23,952,377 (-)Ensemblpanpan1.1panPan2
CHRNA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38827,459,756 - 27,479,261 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,459,756 - 27,479,883 (-)EnsemblGRCh38hg38GRCh38
GRCh37827,317,273 - 27,336,778 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,373,195 - 27,392,730 (-)NCBINCBI36Build 36hg18NCBI36
Build 34827,374,181 - 27,392,675NCBI
Celera826,277,396 - 26,296,925 (-)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef825,862,340 - 25,881,872 (-)NCBIHuRef
CHM1_1827,519,147 - 27,538,678 (-)NCBICHM1_1
T2T-CHM13v2.0827,737,110 - 27,756,814 (-)NCBIT2T-CHM13v2.0
Chrna2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,370,685 - 66,390,397 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,372,488 - 66,390,397 (+)EnsemblGRCm39 Ensembl
GRCm381466,133,236 - 66,152,948 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,135,039 - 66,152,948 (+)EnsemblGRCm38mm10GRCm38
MGSCv371466,759,797 - 66,771,785 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361465,095,070 - 65,107,058 (+)NCBIMGSCv36mm8
Celera1463,889,359 - 63,901,395 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Chrna2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81544,517,862 - 44,534,144 (+)NCBIGRCr8
mRatBN7.21540,342,317 - 40,358,601 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,342,317 - 40,358,601 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,209,601 - 42,225,892 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,359,798 - 43,376,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,802,620 - 41,818,906 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,808,897 - 42,825,179 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,808,897 - 42,825,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,768,230 - 48,785,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,570,809 - 45,587,091 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,586,588 - 45,602,871 (+)NCBI
Celera1540,015,644 - 40,031,870 (+)NCBICelera
Cytogenetic Map15p12NCBI
Chrna2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540349,970,398 - 49,989,137 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,970,398 - 49,989,095 (-)NCBIChiLan1.0ChiLan1.0
CHRNA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12530,117,384 - 30,137,223 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2530,117,239 - 30,135,599 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,711,637 - 30,723,506 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02530,316,301 - 30,326,148 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2530,307,340 - 30,325,726 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12530,245,712 - 30,257,580 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02530,126,596 - 30,137,323 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02530,292,990 - 30,304,860 (+)NCBIUU_Cfam_GSD_1.0
Chrna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,251,532 - 8,258,650 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675327,501 - 334,581 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936675327,501 - 334,493 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,195,228 - 11,207,650 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,193,732 - 11,204,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,374,481 - 12,388,291 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1825,571,958 - 25,591,982 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl825,571,863 - 25,591,788 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605216,552,356 - 16,572,243 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrna2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475822,182,951 - 22,200,063 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,182,468 - 22,200,076 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000061513   ⟹   ENSPPAP00000038609
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl823,932,846 - 23,952,377 (-)Ensembl
RefSeq Acc Id: XM_003830804   ⟹   XP_003830852
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2745,990,058 - 46,009,764 (-)NCBI
NHGRI_mPanPan1821,704,317 - 21,723,990 (-)NCBI
Mhudiblu_PPA_v0826,729,767 - 26,749,277 (-)NCBI
PanPan1.1823,932,846 - 23,952,377 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034965875   ⟹   XP_034821766
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2745,990,059 - 45,997,811 (-)NCBI
NHGRI_mPanPan1821,704,319 - 21,712,039 (-)NCBI
Mhudiblu_PPA_v0826,729,767 - 26,737,327 (-)NCBI
RefSeq Acc Id: XM_055116384   ⟹   XP_054972359
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2745,990,059 - 45,997,815 (-)NCBI
NHGRI_mPanPan1821,704,318 - 21,712,043 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003830852 (Get FASTA)   NCBI Sequence Viewer  
  XP_034821766 (Get FASTA)   NCBI Sequence Viewer  
  XP_054972359 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000038609
  ENSPPAP00000038609.1
Reference Protein Sequences
RefSeq Acc Id: XP_003830852   ⟸   XM_003830804
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C9T0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034821766   ⟸   XM_034965875
- Peptide Label: isoform X3
RefSeq Acc Id: ENSPPAP00000038609   ⟸   ENSPPAT00000061513
RefSeq Acc Id: XP_054972359   ⟸   XM_055116384
- Peptide Label: isoform X2
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042024 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000061513.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/TrEMBL
  Neur_channel UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/TrEMBL
KEGG Report pps:100992507 UniProtKB/TrEMBL
NCBI Gene CHRNA2 ENTREZGENE
PANTHER NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2 UniProtKB/TrEMBL
  PTHR18945 UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/TrEMBL
PRINTS NICOTINICR UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/TrEMBL
  SSF90112 UniProtKB/TrEMBL
UniProt A0A2R9C9T0 ENTREZGENE, UniProtKB/TrEMBL