Chrna2 (cholinergic receptor nicotinic alpha 2 subunit)

Gene: Chrna2 (cholinergic receptor nicotinic alpha 2 subunit) Ictidomys tridecemlineatus

Analyze

Symbol:

Chrna2

Name:

cholinergic receptor nicotinic alpha 2 subunit

RGD ID:

12468797

Description:

ENCODES a protein that exhibits acetylcholine-gated monoatomic cation-selective channel activity (ortholog); heterocyclic compound binding (ortholog); quaternary ammonium group binding (ortholog); INVOLVED IN cellular response to nicotine (ortholog); cerebral cortex GABAergic interneuron development (ortholog); hippocampus development (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH autosomal dominant nocturnal frontal lobe epilepsy (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 4 (ortholog); benign familial infantile seizures 6 (ortholog); FOUND IN neuron projection cytoplasm (ortholog); protein-containing complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

neuronal acetylcholine receptor subunit alpha-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	8,251,532 - 8,258,650 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936675	327,501 - 334,581 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936675	327,501 - 334,493 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant nocturnal frontal lobe epilepsy (ISO)

autosomal dominant nocturnal frontal lobe epilepsy 4 (ISO)

benign familial infantile seizures 6 (ISO)

epilepsy (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Lung Neoplasms (ISO)

Myoclonic Epilepsies (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to nicotine (ISO)

cerebral cortex GABAergic interneuron development (ISO)

excitatory postsynaptic potential (IEA)

hippocampus development (ISO)

modulation of inhibitory postsynaptic potential (ISO)

monoatomic ion transmembrane transport (IEA)

nervous system process (IEA)

regulation of membrane potential (IEA)

regulation of postsynaptic membrane potential (IEA)

response to acetylcholine (ISO)

response to nicotine (IEA)

signal transduction (IEA)

synaptic transmission, cholinergic (IEA)

Cellular Component

acetylcholine-gated channel complex (IEA)

cell periphery (IEA)

intercellular bridge (IEA)

neuron projection (IEA)

neuron projection cytoplasm (ISO)

nucleoplasm (IEA)

plasma membrane (IEA)

postsynaptic membrane (IEA)

protein-containing complex (ISO)

synapse (IEA)

Molecular Function

acetylcholine receptor activity (IEA)

acetylcholine-gated monoatomic cation-selective channel activity (IEA,ISO)

heterocyclic compound binding (ISO)

quaternary ammonium group binding (ISO)

transmembrane signaling receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via nicotinic acetylcholine receptor (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Chrna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	8,251,532 - 8,258,650 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936675	327,501 - 334,581 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936675	327,501 - 334,493 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHRNA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	27,459,756 - 27,479,261 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	27,459,756 - 27,479,883 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	27,317,273 - 27,336,778 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	27,373,195 - 27,392,730 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	27,374,181 - 27,392,675	NCBI
Celera	8	26,277,396 - 26,296,925 (-)	NCBI		Celera
Cytogenetic Map	8	p21.2	NCBI
HuRef	8	25,862,340 - 25,881,872 (-)	NCBI		HuRef
CHM1_1	8	27,519,147 - 27,538,678 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	27,737,110 - 27,756,814 (-)	NCBI		T2T-CHM13v2.0

Chrna2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	66,370,685 - 66,390,397 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	66,372,488 - 66,390,397 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	66,133,236 - 66,152,948 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	66,135,039 - 66,152,948 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	66,759,797 - 66,771,785 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	65,095,070 - 65,107,058 (+)	NCBI		MGSCv36	mm8
Celera	14	63,889,359 - 63,901,395 (+)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI
cM Map	14	34.36	NCBI

Chrna2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	44,517,862 - 44,534,144 (+)	NCBI		GRCr8
mRatBN7.2	15	40,342,317 - 40,358,601 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	40,342,317 - 40,358,601 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	42,209,601 - 42,225,892 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	43,359,798 - 43,376,089 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	41,802,620 - 41,818,906 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	42,808,897 - 42,825,179 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	42,808,897 - 42,825,179 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	48,768,230 - 48,785,192 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	45,570,809 - 45,587,091 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	45,586,588 - 45,602,871 (+)	NCBI
Celera	15	40,015,644 - 40,031,870 (+)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

Chrna2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	49,970,398 - 49,989,137 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	49,970,398 - 49,989,095 (-)	NCBI	ChiLan1.0	ChiLan1.0

CHRNA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	45,990,058 - 46,009,764 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	21,704,317 - 21,723,990 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	26,729,767 - 26,749,277 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	23,932,846 - 23,952,377 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	23,932,846 - 23,952,377 (-)	Ensembl	panpan1.1		panPan2

CHRNA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	30,117,384 - 30,137,223 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	30,117,239 - 30,135,599 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	30,711,637 - 30,723,506 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	30,316,301 - 30,326,148 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	30,307,340 - 30,325,726 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	30,245,712 - 30,257,580 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	30,126,596 - 30,137,323 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	30,292,990 - 30,304,860 (+)	NCBI		UU_Cfam_GSD_1.0

CHRNA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	11,195,228 - 11,207,650 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	11,193,732 - 11,204,334 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	12,374,481 - 12,388,291 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CHRNA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	25,571,958 - 25,591,982 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	25,571,863 - 25,591,788 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	16,552,356 - 16,572,243 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Chrna2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	22,182,951 - 22,200,063 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	22,182,468 - 22,200,076 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005337242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000016060 ⟹ ENSSTOP00000015924

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936675	327,501 - 334,581 (-)	Ensembl

RefSeq Acc Id:

XM_005337242 ⟹ XP_005337299

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404943	8,251,532 - 8,258,650 (+)	NCBI
SpeTri2.0	NW_004936675	327,501 - 334,493 (-)	NCBI

Sequence:

show sequence

AAGAACCAAATGATGACCACCAACGTCTGGCTGAGGCAGGAGTGGAGCGACTACAAGCTGCGCT
GGAACCCAGCTGATTTTGGCAACATCACCTCCCTCCGGGTCCCTTCAGAGATGATCTGGATCCC
TGACATTGTCCTTTACAACAATGCAGACGGGGAGTTTGCGGTGACCCACATGACCAAAGCGCAC
CTCTTCTCCACGGGCACGGTGCACTGGGTGCCCCCAGCCATTTACAAGAGCTCCTGCAGCATCG
ACGTCACCTTCTTCCCCTTCGACCAGCAGAACTGCAAGATGAAGTTTGGCTCCTGGACCTATGA
CAAGGCCAAGATCGACCTGGAGCCGATGGAGCAGACGGTGGACCTGAAGGACTACTGGGAGAGC
GGCGAGTGGGCCATCATCAACGCCACGGGCACCTACAACAGCAAGAAGTACGACTGCTGCGCCG
AGATCTACCCCGACGTGACCTACGCCTTCCTCATCCGCCGGCTGCCGCTCTTCTACACCATCAA
CCTCATCATCCCCTGCCTGCTCATCTCCTGCCTCACCGTGCTGGTCTTCTACCTGCCCTCCGAC
TGCGGCGAGAAGGTCACGCTGTGCATCTCGGTGCTGCTCTCGCTCACCGTCTTCCTGCTGCTCA
TCACGGAGATCATCCCGTCCACCTCGCTGGTCATCCCGCTCATCGGCGAGTACCTGCTCTTCAC
CATGACCTTCGTCACCCTCTCCATCGTCATCACCGTCTTCGTGCTCAACGTGCACCACCGCTCC
CCCAGCACCCACAGCATGCCCCGCTGGGTGCGGCTGGCCCTGCTGGGACGTGTGCCCCGGTGGC
TGCTGATGAACCGGCCTCTGCCACCCTTGGAGCCACACGACTCCCCAGGCCTGAAACTCGGCCC
TTCTTGTTACTGGTTGGAGACCAACATGGACGCAGAGGAGAGAGAGGAGGCAGAGGAGGAGGAG
GAGAAAGGCAGAGTGAGAGAAGACTGGAAGTGTGTTGCCATGGTCATCGACAGGATCTTCCTCT
GGCTCTTCATCATCGTCTGCTTCCTGGGAACCCTGGGGCTCTTTCTGCCTCCGTTCCTGGCTGG
AATGATCTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005337299	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000015924.2
GenBank Protein	KAG3294321	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005337299 ⟸ XM_005337242

- UniProtKB:

I3MUX9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMTTNVWLRQEWSDYKLRWNPADFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFS
TGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEPMEQTVDLKDYWESGEW
AIINATGTYNSKKYDCCAEIYPDVTYAFLIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGE
KVTLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMTFVTLSIVITVFVLNVHHRSPST
HSMPRWVRLALLGRVPRWLLMNRPLPPLEPHDSPGLKLGPSCYWLETNMDAEEREEAEEEEEKG
RVREDWKCVAMVIDRIFLWLFIIVCFLGTLGLFLPPFLAGMI

hide sequence

RefSeq Acc Id:

ENSSTOP00000015924 ⟸ ENSSTOT00000016060

Protein Domains

Neurotransmitter-gated ion-channel ligand-binding Neurotransmitter-gated ion-channel transmembrane

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000016060	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000016060.3	UniProtKB/TrEMBL
Gene3D-CATH	1.20.58.390	UniProtKB/TrEMBL
	2.70.170.10	UniProtKB/TrEMBL
InterPro	Neur_chan_lig-bd	UniProtKB/TrEMBL
	Neur_chan_lig-bd_sf	UniProtKB/TrEMBL
	Neur_channel	UniProtKB/TrEMBL
	Neuro-gated_channel_TM_sf	UniProtKB/TrEMBL
	Neuro_actylchol_rec	UniProtKB/TrEMBL
	Neurotrans-gated_channel_TM	UniProtKB/TrEMBL
	Neurotransmitter_ion_chnl_CS	UniProtKB/TrEMBL
	Nicotinic_acetylcholine_rcpt	UniProtKB/TrEMBL
NCBI Gene	Chrna2	ENTREZGENE
PANTHER	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2	UniProtKB/TrEMBL
	PTHR18945	UniProtKB/TrEMBL
Pfam	Neur_chan_LBD	UniProtKB/TrEMBL
	Neur_chan_memb	UniProtKB/TrEMBL
PRINTS	NICOTINICR	UniProtKB/TrEMBL
	NRIONCHANNEL	UniProtKB/TrEMBL
PROSITE	NEUROTR_ION_CHANNEL	UniProtKB/TrEMBL
Superfamily-SCOP	SSF63712	UniProtKB/TrEMBL
	SSF90112	UniProtKB/TrEMBL
UniProt	I3MUX9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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