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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of reactive oxygen species metabolic process
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Accession:GO:2000378 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.
Synonyms:exact_synonym: negative regulation of ROS metabolic process;   negative regulation of reactive oxygen species metabolism


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negative regulation of reactive oxygen species metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG5 autophagy related 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791 		JBrowse link
G BCL2 BCL2 apoptosis regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCR BCR activator of RhoGEF and GTPase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7889565) Ensembl
MGI		 PMID:7889565 GO_REF:0000107 NCBI chr22:23,180,509...23,318,037
Ensembl chr22:23,179,704...23,318,037 		JBrowse link
G BECN1 beclin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 involved_in ISO (MGI:5315337|PMID:21052097) UniProt PMID:21052097 MGI:5315337 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403 		JBrowse link
G BNIP3 BCL2 interacting protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,967,684...131,981,967 		JBrowse link
G BRCA1 BRCA1 DNA repair associated involved_in IMP (PMID:23415688) BHF-UCL PMID:23415688 NCBI chr17:43,044,295...43,170,327
Ensembl chr17:43,044,295...43,170,245 		JBrowse link
G CRYAB crystallin alpha B involved_in ISO
IEA		 RGD
Ensembl		 PMID:15358243 GO_REF:0000107 RGD:1598485 NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722 		JBrowse link
G ESR2 estrogen receptor 2 ISO RGD PMID:23608653 RGD:7364951 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase involved_in ISO
IEA		 RGD
Ensembl		 PMID:24190878 GO_REF:0000107 RGD:10449133 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G HK2 hexokinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:74,834,127...74,893,359
Ensembl chr 2:74,834,127...74,893,359 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 involved_in ISO (MGI:5315337|PMID:21052097) UniProt PMID:21052097 MGI:5315337 NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086 		JBrowse link
G MIR675 microRNA 675 acts_upstream_of IDA (PMID:31574452) ARUK-UCL PMID:31574452 NCBI chr11:1,996,759...1,996,831
Ensembl chr11:1,996,759...1,996,831 		JBrowse link
G MMP3 matrix metallopeptidase 3 involved_in IDA (PMID:20969476) ParkinsonsUK-UCL PMID:20969476 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609 		JBrowse link
G MYCN MYCN proto-oncogene, bHLH transcription factor involved_in ISO (MGI:5050076|PMID:17357786) UniProt PMID:17357786 MGI:5050076 NCBI chr 2:15,940,550...15,947,004
Ensembl chr 2:15,940,550...15,947,007 		JBrowse link
G PAX2 paired box 2 involved_in IDA (PMID:17357786) UniProt PMID:17357786 NCBI chr10:100,735,396...100,829,944
Ensembl chr10:100,735,396...100,829,944 		JBrowse link
G PINK1 PTEN induced kinase 1 involved_in IMP (PMID:18560593) ParkinsonsUK-UCL PMID:18560593 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511 		JBrowse link
G PLIN5 perilipin 5 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr19:4,522,531...4,535,224
Ensembl chr19:4,522,531...4,535,224 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IGI (PMID:18541373) ParkinsonsUK-UCL PMID:18541373 NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775 		JBrowse link
G SIRT2 sirtuin 2 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr19:38,878,555...38,899,618
Ensembl chr19:38,878,555...38,899,862 		JBrowse link
G SIRT3 sirtuin 3 involved_in ISO
IEA		 RGD
Ensembl		 PMID:23397292 GO_REF:0000107 RGD:9586042 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931 		JBrowse link
G SIRT5 sirtuin 5 involved_in IDA (PMID:24140062) UniProt PMID:24140062 NCBI chr 6:13,574,274...13,615,158
Ensembl chr 6:13,574,227...13,615,158 		JBrowse link
G TFAP2A transcription factor AP-2 alpha involved_in IDA (PMID:20066163) UniProt PMID:20066163 NCBI chr 6:10,396,677...10,419,659
Ensembl chr 6:10,393,186...10,419,659 		JBrowse link
G TIGAR TP53 induced glycolysis regulatory phosphatase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22044588) Ensembl
MGI		 PMID:22044588 GO_REF:0000107 NCBI chr12:4,321,213...4,360,028
Ensembl chr12:4,307,763...4,360,028 		JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22044588) Ensembl
MGI		 PMID:22044588 GO_REF:0000107 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TRIM22 tripartite motif containing 22 involved_in ISO (MGI:4868339|PMID:21048113) UniProt PMID:21048113 MGI:4868339 NCBI chr11:5,689,790...5,710,863
Ensembl chr11:5,689,610...5,737,089 		JBrowse link
G VDAC1 voltage dependent anion channel 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975 		JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNS cystinosin, lysosomal cystine transporter involved_in ISO
IEA		 RGD
Ensembl		 PMID:26482480 GO_REF:0000107 RGD:12910938 NCBI chr17:3,636,459...3,663,103
Ensembl chr17:3,636,459...3,663,103 		JBrowse link
G CYCS cytochrome c, somatic ISO RGD PMID:21410437 RGD:7349317 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase involved_in ISS (PMID:27525436) ARUK-UCL PMID:27525436 NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452 		JBrowse link
G MPV17L MPV17 mitochondrial inner membrane protein like involved_in IDA (PMID:22306510) BHF-UCL PMID:22306510 NCBI chr16:15,395,754...15,413,271
Ensembl chr16:15,395,754...15,413,271 		JBrowse link
G PRL prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:23590160 RGD:8694322 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
negative regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HP haptoglobin involved_in IDA (PMID:19740759) BHF-UCL PMID:19740759 NCBI chr16:72,054,505...72,061,055
Ensembl chr16:72,054,505...72,061,055 		JBrowse link
G MT3 metallothionein 3 involved_in ISO
IEA		 RGD
Ensembl		 PMID:12058024 GO_REF:0000107 RGD:625483 NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088 		JBrowse link
negative regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDAC6 histone deacetylase 6 involved_in IC (PMID:18606987) BHF-UCL PMID:18606987 NCBI chr  X:48,801,398...48,824,982
Ensembl chr  X:48,801,377...48,824,982 		JBrowse link
G PTGER4 prostaglandin E receptor 4 ISO RGD PMID:11991626 RGD:10003093 NCBI chr 5:40,679,915...40,746,800
Ensembl chr 5:40,679,915...40,693,735 		JBrowse link
negative regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 involved_in ISS UniProt GO_REF:0000024 NCBI chr  X:75,051,048...75,156,283
Ensembl chr  X:75,051,048...75,156,732 		JBrowse link
G ABCD1 ATP binding cassette subfamily D member 1 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:153,724,856...153,744,755
Ensembl chr  X:153,724,856...153,744,755 		JBrowse link
G ABCD2 ATP binding cassette subfamily D member 2 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:39,531,025...39,619,803
Ensembl chr12:39,550,033...39,619,803 		JBrowse link
G ADCY10 adenylate cyclase 10 involved_in ISO
IEA		 RGD
Ensembl		 PMID:32664470 GO_REF:0000107 RGD:329347825 NCBI chr 1:167,809,386...167,914,134
Ensembl chr 1:167,809,386...167,914,215 		JBrowse link
G ATP5MC1 ATP synthase membrane subunit c locus 1 ISO RGD PMID:22209705 RGD:13800744 NCBI chr17:48,892,787...48,895,871
Ensembl chr17:48,892,765...48,895,871 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator involved_in ISO
IEA		 RGD
Ensembl		 PMID:18292530 GO_REF:0000107 RGD:11341712 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687 		JBrowse link
G COA8 cytochrome c oxidase assembly factor 8 involved_in IMP (PMID:25175347) UniProt PMID:25175347 NCBI chr14:103,562,960...103,590,899
Ensembl chr14:103,562,960...103,607,523 		JBrowse link
G CTNS cystinosin, lysosomal cystine transporter involved_in ISO
IEA		 RGD
Ensembl		 PMID:26482480 GO_REF:0000107 RGD:12910938 NCBI chr17:3,636,459...3,663,103
Ensembl chr17:3,636,459...3,663,103 		JBrowse link
G EEF1A1 eukaryotic translation elongation factor 1 alpha 1 ISO RGD PMID:23041468 RGD:10401126 NCBI chr 6:73,515,750...73,521,032
Ensembl chr 6:73,489,308...73,525,587 		JBrowse link
G HBP1 HMG-box transcription factor 1 involved_in ISO (MGI:5754467|PMID:24675724) BHF-UCL PMID:24675724 MGI:5754467 NCBI chr 7:107,169,003...107,202,522
Ensembl chr 7:107,168,961...107,202,522 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO RGD PMID:26071548 RGD:401793712 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 ISO RGD PMID:22547655 RGD:10402548 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737 		JBrowse link
G INS insulin involved_in IGI (PMID:19188609) ARUK-UCL PMID:19188609 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221 		JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:28483668 RGD:12910717 NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211 		JBrowse link
G MIR140 microRNA 140 ISO RGD PMID:32519270 RGD:329347827 NCBI chr16:69,933,081...69,933,180
Ensembl chr16:69,933,081...69,933,180 		JBrowse link
G MIR181A1 microRNA 181a-1 involved_in IDA (PMID:23516523) ARUK-UCL PMID:23516523 NCBI chr 1:198,859,044...198,859,153
Ensembl chr 1:198,859,044...198,859,153 		JBrowse link
G MIR181A2 microRNA 181a-2 involved_in IDA (PMID:23516523) ARUK-UCL PMID:23516523 NCBI chr 9:124,692,442...124,692,551
Ensembl chr 9:124,692,442...124,692,551 		JBrowse link
G MIR21 microRNA 21 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MIR590 microRNA 590 involved_in IDA (PMID:26648441) BHF-UCL PMID:26648441 NCBI chr 7:74,191,198...74,191,294
Ensembl chr 7:74,191,198...74,191,294 		JBrowse link
G NDUFC2 NADH:ubiquinone oxidoreductase subunit C2 ISO RGD PMID:26888427 RGD:11040458 NCBI chr11:78,068,297...78,079,862
Ensembl chr11:78,068,297...78,079,862 		JBrowse link
G PAGE4 PAGE family member 4 involved_in IDA (PMID:25374899) UniProt PMID:25374899 NCBI chr  X:49,829,260...49,834,264
Ensembl chr  X:49,793,653...49,834,264 		JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha acts_upstream_of IMP (PMID:31574452) ARUK-UCL PMID:31574452 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:24096089 RGD:10413842 NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775 		JBrowse link
G PTGR1 prostaglandin reductase 1 ISO RGD PMID:9667737 RGD:401959219 NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893 		JBrowse link
G RHOA ras homolog family member A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998 		JBrowse link
G SIRT1 sirtuin 1 ISO RGD PMID:23422569 RGD:9585767 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SLC18A2 solute carrier family 18 member A2 involved_in NAS (PMID:24252804) ParkinsonsUK-UCL PMID:24252804 NCBI chr10:117,241,114...117,279,430
Ensembl chr10:117,241,093...117,279,430 		JBrowse link
G TRAP1 TNF receptor associated protein 1 involved_in TAS (PMID:18221368) ParkinsonsUK-UCL PMID:18221368 NCBI chr16:3,658,037...3,717,524
Ensembl chr16:3,651,639...3,717,553 		JBrowse link
negative regulation of superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP5 acid phosphatase 5, tartrate resistant involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11168643) Ensembl
MGI		 PMID:11168643 GO_REF:0000107 NCBI chr19:11,574,660...11,578,975
Ensembl chr19:11,574,653...11,579,993 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO RGD PMID:24601882 RGD:39128160 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G CRP C-reactive protein ISO RGD PMID:9767445 RGD:9586000 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G PON3 paraoxonase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:95,359,872...95,396,375
Ensembl chr 7:95,359,872...95,396,375 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    cellular process 18244
      cellular metabolic process 10621
        negative regulation of cellular metabolic process 3300
          negative regulation of reactive oxygen species metabolic process 68
            negative regulation of hydrogen peroxide metabolic process + 10
            negative regulation of reactive oxygen species biosynthetic process + 34
            negative regulation of removal of superoxide radicals + 0
            negative regulation of superoxide anion generation 4
Path 2
Term Annotations click to browse term
  biological_process 19612
    biological regulation 13365
      regulation of biological process 12981
        negative regulation of biological process 6433
          negative regulation of cellular process 6047
            negative regulation of cellular metabolic process 3300
              negative regulation of reactive oxygen species metabolic process 68
                negative regulation of hydrogen peroxide metabolic process + 10
                negative regulation of reactive oxygen species biosynthetic process + 34
                negative regulation of removal of superoxide radicals + 0
                negative regulation of superoxide anion generation 4
paths to the root