(+)-schisandrin B multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SIRT3 mRNA] CTD PMID:31150632 (-)-epigallocatechin 3-gallate decreases expression ISO Sirt3 (Mus musculus) 6480464 epigallocatechin gallate results in decreased expression of SIRT3 mRNA and epigallocatechin gallate results in decreased expression of SIRT3 protein CTD PMID:29175576 (1->4)-beta-D-glucan multiple interactions ISO Sirt3 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SIRT3 mRNA CTD PMID:36331819 (R)-lipoic acid multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein more ... CTD PMID:22327056 (R)-lipoic acid multiple interactions ISO Sirt3 (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT3 mRNA] CTD PMID:37739047 (R)-lipoic acid increases expression ISO Sirt3 (Rattus norvegicus) 6480464 Thioctic Acid results in increased expression of SIRT3 protein CTD PMID:22327056 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane decreases expression ISO Sirt3 (Mus musculus) 6480464 2 more ... CTD PMID:25575267 1,1-dichloroethene decreases expression ISO Sirt3 (Mus musculus) 6480464 vinylidene chloride results in decreased expression of SIRT3 mRNA CTD PMID:26682919 1,2-dimethylhydrazine decreases expression ISO Sirt3 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of SIRT3 mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO Sirt3 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SIRT3 mRNA CTD PMID:22206623 1,3,7,9-tetramethyluric acid multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 1 more ... CTD PMID:35872049 17alpha-ethynylestradiol decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Ethinyl Estradiol results in decreased expression of SIRT3 mRNA CTD PMID:17557909 17alpha-ethynylestradiol multiple interactions ISO Sirt3 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SIRT3 mRNA CTD PMID:17942748 17beta-estradiol decreases expression ISO Sirt3 (Mus musculus) 6480464 Estradiol results in decreased expression of SIRT3 mRNA CTD PMID:25575267 17beta-estradiol decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Estradiol results in decreased expression of SIRT3 mRNA CTD PMID:32145629 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Sirt3 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SIRT3 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Sirt3 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in increased expression of SIRT3 mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SIRT3 mRNA CTD PMID:28011154 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of SIRT3 mRNA CTD PMID:21724226 and PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Sirt3 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of SIRT3 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Sirt3 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of SIRT3 mRNA CTD PMID:19770486 2,4-dinitrotoluene affects expression ISO Sirt3 (Rattus norvegicus) 6480464 2 and 4-dinitrotoluene affects the expression of SIRT3 mRNA CTD PMID:21346803 3,5-diethoxycarbonyl-1,4-dihydrocollidine decreases expression ISO Sirt3 (Mus musculus) 6480464 Dicarbethoxydihydrocollidine results in decreased expression of SIRT3 mRNA CTD PMID:18098314 4-hydroxynon-2-enal multiple interactions EXP 6480464 4-hydroxy-2-nonenal binds to and results in decreased activity of SIRT3 protein CTD PMID:21449565 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide decreases activity EXP 6480464 6-chloro-2 more ... CTD PMID:26518726 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 6-chloro-2 more ... CTD PMID:31981641 6-propyl-2-thiouracil decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Propylthiouracil results in decreased expression of SIRT3 mRNA CTD PMID:30047161 8-Br-cAMP increases expression ISO Sirt3 (Mus musculus) 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SIRT3 mRNA CTD PMID:23166782 ADP decreases abundance ISO Sirt3 (Mus musculus) 6480464 SIRT3 protein results in decreased abundance of Adenosine Diphosphate CTD PMID:23166782 aldehydo-D-glucose multiple interactions ISO Sirt3 (Mus musculus) 6480464 SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [INS1 protein results in increased uptake of Glucose]] CTD PMID:25979314 aldehydo-D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of SIRT3 protein CTD PMID:37417536 aldehydo-D-glucose increases expression EXP 6480464 Glucose deficiency results in increased expression of SIRT3 protein CTD PMID:23494737 aldehydo-D-glucose multiple interactions EXP 6480464 polyethylene glycol loxenatide inhibits the reaction [Glucose results in decreased expression of SIRT3 protein] more ... CTD PMID:23494737 and PMID:37417536 alpha-mangostin multiple interactions EXP 6480464 SIRT3 protein affects the reaction [mangostin results in decreased expression of ACTA2 protein] and SIRT3 protein affects the reaction [mangostin results in decreased secretion of HMGB1 protein] CTD PMID:30502394 alpha-mangostin multiple interactions ISO Sirt3 (Mus musculus) 6480464 [mangostin co-treated with Carbon Tetrachloride] results in increased expression of and results in increased secretion of SIRT3 protein CTD PMID:30502394 alpha-mangostin increases expression EXP 6480464 mangostin results in increased expression of SIRT3 protein CTD PMID:30502394 amitrole decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Amitrole results in decreased expression of SIRT3 mRNA CTD PMID:30047161 antimycin A increases expression EXP 6480464 Antimycin A results in increased expression of SIRT3 mRNA CTD PMID:35430258 antimycin A multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of SIRT3 mRNA] CTD PMID:35430258 arsenous acid decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Arsenic Trioxide results in decreased expression of SIRT3 mRNA CTD PMID:29223816 arsenous acid increases expression ISO Sirt3 (Rattus norvegicus) 6480464 Arsenic Trioxide results in increased expression of SIRT3 protein CTD PMID:30385301 arsenous acid multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 [Arsenic Trioxide co-treated with Metformin] results in increased expression of SIRT3 protein CTD PMID:30385301 ATP multiple interactions ISO Sirt3 (Mus musculus) 6480464 SIRT3 protein inhibits the reaction [Metformin results in decreased abundance of Adenosine Triphosphate] CTD PMID:23166782 atrazine affects expression EXP 6480464 Atrazine affects the expression of SIRT3 mRNA CTD PMID:27114639 atrazine decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Atrazine results in decreased expression of SIRT3 mRNA CTD PMID:27114639 benzo[a]pyrene decreases expression ISO Sirt3 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of SIRT3 mRNA CTD PMID:19770486 benzo[a]pyrene multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 ramelteon inhibits the reaction [Benzo(a)pyrene results in increased expression of SIRT3 mRNA] and ramelteon inhibits the reaction [Benzo(a)pyrene results in increased expression of SIRT3 protein] CTD PMID:35940284 benzo[a]pyrene increases expression ISO Sirt3 (Rattus norvegicus) 6480464 Benzo(a)pyrene results in increased expression of SIRT3 mRNA and Benzo(a)pyrene results in increased expression of SIRT3 protein CTD PMID:35940284 benzo[a]pyrene increases methylation EXP 6480464 Benzo(a)pyrene results in increased methylation of SIRT3 3' UTR CTD PMID:27901495 benzo[a]pyrene increases expression ISO Sirt3 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of SIRT3 mRNA CTD PMID:22228805 benzo[a]pyrene diol epoxide I increases expression EXP 6480464 7 more ... CTD PMID:35940284 berberine increases expression EXP 6480464 Berberine results in increased expression of SIRT3 mRNA CTD PMID:27311644 berberine multiple interactions EXP 6480464 [Berberine co-treated with Niacinamide] results in decreased expression of SIRT3 protein CTD PMID:26712469 berberine decreases expression EXP 6480464 Berberine results in decreased expression of SIRT3 mRNA and Berberine results in decreased expression of SIRT3 protein CTD PMID:26712469 bisphenol A decreases expression ISO Sirt3 (Mus musculus) 6480464 bisphenol A results in decreased expression of SIRT3 mRNA CTD PMID:25575267 more ... bisphenol A multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of SIRT3 protein] CTD PMID:30641872 bisphenol A decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of SIRT3 mRNA and bisphenol A results in decreased expression of SIRT3 protein CTD PMID:30641872 more ... bisphenol A increases methylation ISO Sirt3 (Rattus norvegicus) 6480464 bisphenol A results in increased methylation of SIRT3 gene CTD PMID:28505145 bisphenol A increases methylation ISO Sirt3 (Mus musculus) 6480464 bisphenol A results in increased methylation of SIRT3 promoter CTD PMID:27312807 bisphenol A increases expression ISO Sirt3 (Rattus norvegicus) 6480464 bisphenol A results in increased expression of SIRT3 mRNA CTD PMID:25181051 Butylbenzyl phthalate decreases expression EXP 6480464 butylbenzyl phthalate results in decreased expression of SIRT3 mRNA and butylbenzyl phthalate results in decreased expression of SIRT3 protein CTD PMID:26520405 Butylbenzyl phthalate decreases expression ISO Sirt3 (Mus musculus) 6480464 butylbenzyl phthalate results in decreased expression of SIRT3 mRNA and butylbenzyl phthalate results in decreased expression of SIRT3 protein CTD PMID:27923775 and PMID:34520170 caffeine multiple interactions EXP 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2 more ... CTD PMID:30555576 carbon nanotube decreases expression ISO Sirt3 (Mus musculus) 6480464 Nanotubes and Carbon analog results in decreased expression of SIRT3 mRNA CTD PMID:25554681 CGS-21680 multiple interactions EXP 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2 and 2'-azobis(2-amidinopropane) results in decreased expression of SIRT3 protein]] CTD PMID:30555576 chloroquine increases stability EXP 6480464 Chloroquine results in increased stability of SIRT3 mRNA CTD PMID:35302183 chloroquine multiple interactions EXP 6480464 Chloroquine inhibits the reaction [hydroquinone results in decreased expression of SIRT3 mRNA] and Chloroquine inhibits the reaction [hydroquinone results in decreased expression of SIRT3 protein] CTD PMID:35302183 choline multiple interactions ISO Sirt3 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SIRT3 gene CTD PMID:20938992 chromium(6+) affects response to substance EXP 6480464 SIRT3 affects the susceptibility to chromium hexavalent ion CTD PMID:30715550 chromium(6+) multiple interactions EXP 6480464 chromium hexavalent ion promotes the reaction [NFE2L2 protein binds to SIRT3 promoter] CTD PMID:30715550 chromium(6+) increases expression EXP 6480464 chromium hexavalent ion results in increased expression of SIRT3 mRNA and chromium hexavalent ion results in increased expression of SIRT3 protein CTD PMID:30715550 cisplatin multiple interactions ISO Sirt3 (Mus musculus) 6480464 SIRT3 promotes the reaction [Metformin inhibits the reaction [Cisplatin affects the localization of SLC2A4 protein]] more ... CTD PMID:36800006 cisplatin decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Cisplatin results in decreased expression of SIRT3 mRNA and Cisplatin results in decreased expression of SIRT3 protein CTD PMID:36800006 cisplatin affects response to substance EXP 6480464 SIRT3 protein affects the susceptibility to Cisplatin CTD PMID:27722009 cisplatin multiple interactions EXP 6480464 Cisplatin results in decreased expression of and results in decreased activity of SIRT3 protein more ... CTD PMID:27722009 cisplatin multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 Cisplatin results in decreased expression of and results in decreased activity of SIRT3 protein more ... CTD PMID:28698153 and PMID:36800006 cisplatin decreases response to substance EXP 6480464 SIRT3 protein results in decreased susceptibility to Cisplatin CTD PMID:21472714 copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of SIRT3 mRNA CTD PMID:19549813 curcumin multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 mRNA] more ... CTD PMID:28698153 and PMID:28951138 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [[GYY 4137 results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA]] CTD PMID:26422756 D-glucose multiple interactions ISO Sirt3 (Mus musculus) 6480464 SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [INS1 protein results in increased uptake of Glucose]] CTD PMID:25979314 D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of SIRT3 protein CTD PMID:37417536 D-glucose multiple interactions EXP 6480464 polyethylene glycol loxenatide inhibits the reaction [Glucose results in decreased expression of SIRT3 protein] more ... CTD PMID:23494737 and PMID:37417536 D-glucose increases expression EXP 6480464 Glucose deficiency results in increased expression of SIRT3 protein CTD PMID:23494737 deguelin decreases expression EXP 6480464 deguelin results in decreased expression of SIRT3 mRNA CTD PMID:33512557 diarsenic trioxide multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 [Arsenic Trioxide co-treated with Metformin] results in increased expression of SIRT3 protein CTD PMID:30385301 diarsenic trioxide increases expression ISO Sirt3 (Rattus norvegicus) 6480464 Arsenic Trioxide results in increased expression of SIRT3 protein CTD PMID:30385301 diarsenic trioxide decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Arsenic Trioxide results in decreased expression of SIRT3 mRNA CTD PMID:29223816 diazinon increases methylation EXP 6480464 Diazinon results in increased methylation of SIRT3 gene CTD PMID:22964155 dibutyl phthalate decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Dibutyl Phthalate results in decreased expression of SIRT3 mRNA CTD PMID:21266533 diethylstilbestrol decreases expression ISO Sirt3 (Mus musculus) 6480464 Diethylstilbestrol results in decreased expression of SIRT3 mRNA CTD PMID:25575267 diisononyl phthalate decreases expression EXP 6480464 diisononyl phthalate results in decreased expression of SIRT3 mRNA and diisononyl phthalate results in decreased expression of SIRT3 protein CTD PMID:31423773 doxorubicin decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Doxorubicin results in decreased expression of SIRT3 protein CTD PMID:26678157 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of SIRT3 mRNA CTD PMID:29803840 estriol decreases expression ISO Sirt3 (Mus musculus) 6480464 Estriol results in decreased expression of SIRT3 mRNA CTD PMID:25575267 ethanol increases metabolic processing ISO Sirt3 (Mus musculus) 6480464 Ethanol results in increased metabolism of SIRT3 protein CTD PMID:21449565 ethanol increases expression ISO Sirt3 (Rattus norvegicus) 6480464 Ethanol results in increased expression of SIRT3 mRNA CTD PMID:18793633 ethanol multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 1 more ... CTD PMID:18793633 and PMID:35872049 flutamide decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Flutamide results in decreased expression of SIRT3 mRNA CTD PMID:24136188 folic acid multiple interactions ISO Sirt3 (Mus musculus) 6480464 [1 more ... CTD PMID:20938992 and PMID:22206623 gentamycin increases expression ISO Sirt3 (Rattus norvegicus) 6480464 Gentamicins results in increased expression of SIRT3 mRNA CTD PMID:33387578 glucose multiple interactions ISO Sirt3 (Mus musculus) 6480464 SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [INS1 protein results in increased uptake of Glucose]] CTD PMID:25979314 glucose decreases expression EXP 6480464 Glucose results in decreased expression of SIRT3 protein CTD PMID:37417536 glucose increases expression EXP 6480464 Glucose deficiency results in increased expression of SIRT3 protein CTD PMID:23494737 glucose multiple interactions EXP 6480464 polyethylene glycol loxenatide inhibits the reaction [Glucose results in decreased expression of SIRT3 protein] more ... CTD PMID:23494737 and PMID:37417536 hesperetin affects binding EXP 6480464 hesperetin binds to SIRT3 protein CTD PMID:37487865 hexadecanoic acid decreases expression EXP 6480464 Palmitic Acid results in decreased expression of SIRT3 protein CTD PMID:30958623 Honokiol multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 honokiol inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of SIRT3 protein] more ... CTD PMID:33522075 and PMID:34752757 hydrogen peroxide multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA] more ... CTD PMID:30104959 hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of SIRT3 mRNA and Hydrogen Peroxide results in decreased expression of SIRT3 protein CTD PMID:26422756 hydrogen peroxide multiple interactions EXP 6480464 [GYY 4137 results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA] more ... CTD PMID:26422756 hydrogen peroxide decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Hydrogen Peroxide results in decreased expression of SIRT3 mRNA and Hydrogen Peroxide results in decreased expression of SIRT3 protein CTD PMID:30104959 hydrogen sulfide multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 [sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in decreased expression of SIRT3 protein] and NFE2L2 protein affects the reaction [[sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in decreased expression of SIRT3 protein]] CTD PMID:32064027 hydrogen sulfide multiple interactions EXP 6480464 [GYY 4137 results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA] more ... CTD PMID:26422756 hydroquinone decreases expression EXP 6480464 hydroquinone results in decreased expression of SIRT3 mRNA and hydroquinone results in decreased expression of SIRT3 protein CTD PMID:35302183 hydroquinone increases degradation EXP 6480464 hydroquinone results in increased degradation of SIRT3 mRNA CTD PMID:35302183 hydroquinone multiple interactions EXP 6480464 [[NOX4 protein results in decreased expression of ELAVL2 protein] which promotes the reaction SIDT2 protein] promotes the reaction [hydroquinone results in decreased degradation of SIRT3 protein] more ... CTD PMID:35302183 icariin multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 Histone Deacetylase Inhibitors inhibits the reaction [icariin inhibits the reaction [Rotenone results in decreased expression of SIRT3 protein]] and icariin inhibits the reaction [Rotenone results in decreased expression of SIRT3 protein] CTD PMID:31251943 L-methionine multiple interactions ISO Sirt3 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SIRT3 gene CTD PMID:20938992 lead diacetate multiple interactions ISO Sirt3 (Mus musculus) 6480464 PPARGC1A protein affects the reaction [lead acetate results in increased expression of SIRT3 protein] CTD PMID:27236077 lead diacetate increases expression ISO Sirt3 (Mus musculus) 6480464 lead acetate results in increased expression of SIRT3 protein CTD PMID:27236077 linalool multiple interactions EXP 6480464 linalool inhibits the reaction [SOD2 protein binds to SIRT3 protein] CTD PMID:28567457 linalool decreases expression EXP 6480464 linalool results in decreased expression of SIRT3 mRNA and linalool results in decreased expression of SIRT3 protein CTD PMID:28567457 lipoic acid multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein more ... CTD PMID:22327056 lipoic acid multiple interactions ISO Sirt3 (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT3 mRNA] CTD PMID:37739047 lipoic acid increases expression ISO Sirt3 (Rattus norvegicus) 6480464 Thioctic Acid results in increased expression of SIRT3 protein CTD PMID:22327056 lipopolysaccharide multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 [Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 mRNA more ... CTD PMID:28951138 mancozeb decreases activity EXP 6480464 mancozeb results in decreased activity of SIRT3 protein CTD PMID:21251949 maneb decreases activity EXP 6480464 Maneb results in decreased activity of SIRT3 protein CTD PMID:21251949 metformin decreases expression ISO Sirt3 (Mus musculus) 6480464 Metformin results in decreased expression of SIRT3 mRNA and Metformin results in decreased expression of SIRT3 protein CTD PMID:23166782 and PMID:24687991 metformin multiple interactions EXP 6480464 Metformin results in increased expression of and results in increased activity of SIRT3 protein CTD PMID:33147367 metformin multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 [Arsenic Trioxide co-treated with Metformin] results in increased expression of SIRT3 protein more ... CTD PMID:30385301 and PMID:36800006 metformin increases expression ISO Sirt3 (Rattus norvegicus) 6480464 Metformin results in increased expression of SIRT3 protein CTD PMID:30385301 metformin multiple interactions ISO Sirt3 (Mus musculus) 6480464 Metformin inhibits the reaction [GCG protein results in increased expression of SIRT3 mRNA] more ... CTD PMID:23166782 and PMID:36800006 metformin decreases response to substance ISO Sirt3 (Mus musculus) 6480464 SIRT3 protein results in decreased susceptibility to Metformin CTD PMID:23166782 methimazole decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Methimazole results in decreased expression of SIRT3 mRNA CTD PMID:30047161 methotrexate affects expression ISO Sirt3 (Mus musculus) 6480464 Methotrexate affects the expression of SIRT3 mRNA CTD PMID:18502557 metiram decreases activity EXP 6480464 polymarcine results in decreased activity of SIRT3 protein CTD PMID:21251949 mono(2-ethylhexyl) phthalate increases expression ISO Sirt3 (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of SIRT3 mRNA CTD PMID:25543134 and PMID:32522588 mono(2-ethylhexyl) phthalate decreases expression ISO Sirt3 (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT3 mRNA and mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT3 protein CTD PMID:31016965 N-acetyl-L-cysteine multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of SIRT3 protein] more ... CTD PMID:30104959 and PMID:30641872 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of SIRT3 mRNA] CTD PMID:35430258 N-methyl-4-phenylpyridinium increases expression ISO Sirt3 (Rattus norvegicus) 6480464 1-Methyl-4-phenylpyridinium results in increased expression of SIRT3 mRNA CTD PMID:28801915 nebivolol multiple interactions ISO Sirt3 (Mus musculus) 6480464 3-(2-ethylphenoxy)-1-(1 more ... CTD PMID:23886954 nebivolol increases expression ISO Sirt3 (Mus musculus) 6480464 Nebivolol results in increased expression of SIRT3 protein CTD PMID:23886954 nicotinamide multiple interactions EXP 6480464 [Berberine co-treated with Niacinamide] results in decreased expression of SIRT3 protein CTD PMID:26712469 paracetamol affects expression ISO Sirt3 (Mus musculus) 6480464 Acetaminophen affects the expression of SIRT3 mRNA CTD PMID:17562736 paracetamol increases expression ISO Sirt3 (Rattus norvegicus) 6480464 Acetaminophen results in increased expression of SIRT3 mRNA CTD PMID:33387578 paraquat decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Paraquat results in decreased expression of SIRT3 protein CTD PMID:32064027 paraquat multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 [sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in decreased expression of SIRT3 protein] more ... CTD PMID:32064027 perfluorooctane-1-sulfonic acid increases expression ISO Sirt3 (Mus musculus) 6480464 perfluorooctane sulfonic acid results in increased expression of SIRT3 mRNA CTD PMID:31016965 perfluorooctane-1-sulfonic acid multiple interactions ISO Sirt3 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SIRT3 mRNA CTD PMID:36331819 perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of SIRT3 mRNA and perfluorooctane sulfonic acid results in decreased expression of SIRT3 protein CTD PMID:31508952 perfluorooctanoic acid increases expression ISO Sirt3 (Mus musculus) 6480464 perfluorooctanoic acid results in increased expression of SIRT3 mRNA CTD PMID:31016965 pregnenolone 16alpha-carbonitrile decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Pregnenolone Carbonitrile results in decreased expression of SIRT3 mRNA CTD PMID:30047161 propiconazole decreases expression ISO Sirt3 (Mus musculus) 6480464 propiconazole results in decreased expression of SIRT3 mRNA CTD PMID:21278054 propionic acid increases expression EXP 6480464 propionic acid results in increased expression of SIRT3 mRNA and propionic acid results in increased expression of SIRT3 protein CTD PMID:31526819 reactive oxygen species multiple interactions EXP 6480464 SIRT3 protein inhibits the reaction [Particulate Matter results in increased abundance of Reactive Oxygen Species] CTD PMID:27125970 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of SIRT3 mRNA CTD PMID:21980390 resveratrol decreases expression ISO Sirt3 (Mus musculus) 6480464 resveratrol results in decreased expression of SIRT3 mRNA CTD PMID:23525482 resveratrol increases activity EXP 6480464 resveratrol results in increased activity of SIRT3 protein CTD PMID:24178296 resveratrol multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 resveratrol inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 protein] and resveratrol inhibits the reaction [Ethanol results in increased expression of SIRT3 mRNA] CTD PMID:18793633 and PMID:25686565 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of SIRT3 mRNA CTD PMID:25522270 resveratrol multiple interactions EXP 6480464 PPARGC1A mutant form inhibits the reaction [resveratrol results in increased expression of SIRT3 mRNA] more ... CTD PMID:22585829 and PMID:25522270 rotenone multiple interactions EXP 6480464 SIRT3 protein inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:27053302 rotenone decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Rotenone results in decreased expression of SIRT3 protein CTD PMID:31251943 rotenone multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 Histone Deacetylase Inhibitors inhibits the reaction [icariin inhibits the reaction [Rotenone results in decreased expression of SIRT3 protein]] and icariin inhibits the reaction [Rotenone results in decreased expression of SIRT3 protein] CTD PMID:31251943 sodium arsenite multiple interactions ISO Sirt3 (Mus musculus) 6480464 SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [FOXO3 protein binds to PPARGC1A promoter]] more ... CTD PMID:25979314 sodium arsenite decreases expression ISO Sirt3 (Mus musculus) 6480464 sodium arsenite results in decreased expression of SIRT3 protein CTD PMID:25979314 sodium fluoride multiple interactions ISO Sirt3 (Mus musculus) 6480464 [Sodium Fluoride results in increased abundance of Fluorides] which results in decreased expression of SIRT3 protein and Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT3 mRNA] CTD PMID:34780879 and PMID:37739047 sodium fluoride decreases expression ISO Sirt3 (Mus musculus) 6480464 Sodium Fluoride results in decreased expression of SIRT3 mRNA CTD PMID:37739047 sodium fluoride multiple interactions EXP 6480464 [Sodium Fluoride results in increased abundance of Fluorides] which results in decreased expression of SIRT3 protein more ... CTD PMID:34780879 sodium sulfide (anhydrous) multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 [sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in decreased expression of SIRT3 protein] and NFE2L2 protein affects the reaction [[sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in decreased expression of SIRT3 protein]] CTD PMID:32064027 Soman decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Soman results in decreased expression of SIRT3 mRNA CTD PMID:19281266 stavudine increases expression EXP 6480464 Stavudine results in increased expression of SIRT3 protein CTD PMID:27041070 sulfadimethoxine decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Sulfadimethoxine results in decreased expression of SIRT3 mRNA CTD PMID:30047161 tenofovir disoproxil fumarate increases expression EXP 6480464 Tenofovir results in increased expression of SIRT3 protein CTD PMID:27041070 tert-butyl hydroperoxide multiple interactions EXP 6480464 SIRT3 mutant form inhibits the reaction [resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of and results in increased acetylation of SOD2 protein]] and SIRT3 mutant form inhibits the reaction [resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of IDH2 protein]] CTD PMID:25522270 tetrachloromethane decreases expression ISO Sirt3 (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of SIRT3 mRNA and Carbon Tetrachloride results in decreased expression of SIRT3 protein CTD PMID:27339419 more ... tetrachloromethane decreases response to substance ISO Sirt3 (Mus musculus) 6480464 SIRT3 protein results in decreased susceptibility to Carbon Tetrachloride CTD PMID:30368983 tetrachloromethane decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in decreased expression of SIRT3 mRNA CTD PMID:31150632 tetrachloromethane multiple interactions ISO Sirt3 (Mus musculus) 6480464 [mangostin co-treated with Carbon Tetrachloride] results in increased expression of and results in increased secretion of SIRT3 protein more ... CTD PMID:30368983 and PMID:30502394 tetrachloromethane multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 1 more ... CTD PMID:31150632 and PMID:35872049 thapsigargin decreases expression EXP 6480464 Thapsigargin results in decreased expression of SIRT3 mRNA CTD PMID:22378314 thioacetamide multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 honokiol inhibits the reaction [Thioacetamide results in decreased expression of and results in decreased activity of SIRT3 protein] and Thioacetamide results in decreased expression of and results in decreased activity of SIRT3 protein CTD PMID:33522075 thioacetamide decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 Thioacetamide results in decreased expression of SIRT3 mRNA CTD PMID:34492290 trichloroethene increases expression ISO Sirt3 (Rattus norvegicus) 6480464 Trichloroethylene results in increased expression of SIRT3 mRNA CTD PMID:33387578 trilobatin multiple interactions ISO Sirt3 (Rattus norvegicus) 6480464 trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA] and trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 protein] CTD PMID:30104959 triptonide increases expression ISO Sirt3 (Mus musculus) 6480464 triptonide results in increased expression of SIRT3 mRNA CTD PMID:33045310 tris(2-chloroethyl) phosphate decreases expression EXP 6480464 tris(chloroethyl)phosphate results in decreased expression of SIRT3 mRNA and tris(chloroethyl)phosphate results in decreased expression of SIRT3 protein CTD PMID:30090360 tunicamycin decreases expression EXP 6480464 Tunicamycin results in decreased expression of SIRT3 mRNA CTD PMID:22378314 urethane decreases expression EXP 6480464 Urethane results in decreased expression of SIRT3 mRNA CTD PMID:28818685 valdecoxib decreases expression ISO Sirt3 (Rattus norvegicus) 6480464 valdecoxib results in decreased expression of SIRT3 mRNA CTD PMID:24136188 valproic acid decreases methylation EXP 6480464 Valproic Acid results in decreased methylation of SIRT3 gene CTD PMID:29154799 vancomycin increases expression ISO Sirt3 (Mus musculus) 6480464 Vancomycin results in increased expression of SIRT3 mRNA CTD PMID:18930951 zidovudine increases expression EXP 6480464 Zidovudine results in increased expression of SIRT3 protein CTD PMID:27041070
